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Jun-Xu                         Li

Jun-Xu Li MD, PhD

Department of Pharmacology and Toxicology

Assistant Professor

Specialty/Research Focus

Behavioral pharmacology; Drug abuse; Neurobiology

 
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Professional Summary:

We have two primary research interests.
First, we utilize pharmacological approaches to seek novel therapeutics for pain. Pain is an agonizing symptom and disease that impacts millions. Analgesics like opioids (e.g., OxyContin) are powerful for treating many pain conditions. However, opioids are not efficacious for some pain (e.g., neuropathic pain) and prolonged use of opioids has many side effects, including tolerance and dependence. We find that drugs acting on imidazoline I2 receptors may produce analgesic effects that are devoid of opioid-like side effects. We continue this line of research to further delineate the pharmacological properties of these drugs (how they work, how effective and safe they are, and how long the beneficial effects last) as a novel class of analgesics.

Second,we are interested in pharmacotheray of stimulant abuse. Stimulants represent a big family of abused drugs including traditional drugs of abuse (e.g., cocaine and METH) and valuable pharmacotherapies (e.g., Adderall and Ritalin). Stimulant abuse and addiction remains a challenging problem that lacks FDA-approved pharmacotherapties.We use powerful behavioral pharmacological approaches to validate novel drug targets, understand and exmaine potential novel medications for stimulant abuse.

One unifying theme of the ongoing research is the application of receptor theory to the guidance and interpretation of the drug interactions in behaving animals. The long-term goal of this laboratory is to develop new analgesics for pain control and pharmacotherapeutics for stimulant addiction.

Education and Training:
  • Postdoctoral Fellow, Behavioral Pharmacology, University of Texas Health Science Center at San Antonio (2008)
  • PhD, Pharmacology, Peking University (2005)
  • MD, Medicine, Binzhou Medical University (2000)
Employment:
  • Instructor, Pharmacology, University of Texas Health Science Center at San Antonio, Graduate School of Biomedical Sciences (2008–2010)
Awards and Honors:
  • Maharaj Ticku Memorial Travel Fellowship (2012)
  • ASPET Young Scientist Travel Award (2009)
  • ASPET Best Paper Award (2009)
  • CPDD Early Career Investigator Award (2007)
  • ASPET Young Scientist Travel Award (2007)

Research Expertise:
  • Behavioral Pharmacology: We use various behavioral pharmacological procedures to understand how drugs work at the behavioral level. Procedures used include drug discrimination, schedule-controlled responding, drug self-administration, delay discounting, place conditioning, locomotor activity and various acute and chronic pain tests.
  • Pain and Addiction: We are interested in understanding the neurobiological crosstalk between pain and addiction. To reach this goal, we are developing novel behaivoral procedures to simultaneously measure pain affect and addiction-related behaviors.
  • Quantitative Pharmacological Analysis: The precise understanding of the interactions between drugs from the same or different classes requires quantitative analysis methods. These analytical strategies help to ascertain the behavioral effects of drugs in an quantitative manner.
Grants and Sponsored Research:
  • March 2013–November 2018
    Imidazoline I2 receptors as targets for the treatment of pain
    National Institute on Drug Abuse
    Role: Principal Investigator
    $1,624,680
  • June 2013–May 2015
    Behavioral effects of methamphetamine & imidazoline I2 receptor ligands
    National Institute on Drug Abuse
    Role: Principal Investigator
    $463,845
  • January 2010–January 2015
    Delay discounting: effects of drug dependence and withdrawal.
    NIDA/NIH
    Role: Co-Investigator
  • January 2010–January 2015
    Discriminative stimulus effects of opioid withdrawal.
    NIDA/NIH
    Role: Co-Investigator

Journal Articles:
See All (56 Total) >
Books and Book Chapters:
  • Li JX, Gerak LR, France CP. Drug discrimination studies in rhesus monkeys: drug dependence and withdrawal. In: RA Glennon, R Young. Drug Discrimination: Applications to Medicinal Chemistry and Drug Studies. New York: John Wiley & Sons Inc; 2010..

Professional Memberships:
  • International Association for the Study of Pain (2010)
  • Behavioral Pharmacology Society (2009)
  • Sigma Xi (2008)
  • American Society for Pharmacology and Experimental Therapeutics (2007)
  • The College on Problems of Drug Dependence (2007)
Presentations:
  • "Interactions between serotonin (5-HT) receptor agonists and opioids in rhesus monkeys: effects of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM) on i.v. heroin self-administration." CPDD 73th annual meeting (2011)
  • "5-HT and opioid drug interactions in rats and monkeys: drug discrimination." European Behavioural Pharmacology Society 13th biennial meeting (2010)
  • "Delta9-tetrahydrocannabinol decreases the heroin self-administration behavior in rhesus monkeys." International Study Group Investigating Drugs as Reinforcers annual meeting (2010)
  • "Effects of contingent and noncontingent THC treatment on heroin self administration in rhesus monkeys." CPDD 72th annual meeting (2010)
  • "Differential modification of the antinociceptive and discriminative stimulus effects of morphine by 5-HT1A and 5-HT2A receptor agonists in rhesus monkeys" CPDD 71th annual meeting (2009)
  • "Discriminative stimulus effects of DOM in rhesus monkeys: interactions between 5-HT1A and 5-HT2A receptor agonists" Experimental Biology 2009 annual meeting (2009)
  • "Interactions between serotonin ligands: rat¡Ùmonkey." 2009 Behavioral Pharmacology Society meeting (2009)
  • "Food restriction and streptozotocin decrease sensitivity of rats to hypothermic effects of direct- and indirect-acting serotonin receptor agonists." American College of Neuropsychopharmacology 2008 annual meeting (2008)
  • "Interactions between direct- and indirect-acting 5-HT2 receptor agonists and the discriminative stimulus effects of morphine in rhesus monkeys: perceptual masking?" CPDD 70th annual meeting (2008)
  • "Apparent pA2 analysis of 5-HT2A receptor antagonists in rhesus monkeys discriminating DOM" Experimental Biology 2008 annual meeting (2008)
  • "Is there behavioral evidence for constitutive activity at 5-HT2A receptors?" Texas Research Society on Alcoholism 2008 annual meeting (2008)
  • "Comparison of the discriminative stimulus effects of DOM, MDL100907 and ketanserin in rats: inverse agonism?" CPDD 69th annual meeting (2007)
  • "Behavioral effects of dipropyltryptamine (DPT) in rats: role of 5-HT1A and 5-HT2A receptors" Experimental Biology 2007 annual meeting (2007)
  • "Interaction between ¦¤9-THC, DOM, quipazine and the discriminative stimulus effects of morphine in rhesus monkeys: perceptual masking?" Society for Neuroscience 36th annual meeting (2006)
  • "Behavioral effects of thienorphine in rhesus monkeys." CPDD 68th annual meeting (2006)
See All (15 Total) >

Clinical Specialties:
Clinical Offices:
Insurance Accepted:

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Contact Information

311 BRB, South Campus
3435 Main Street
Buffalo, NY 14214
Phone: (716) 829-2482
Email: junxuli@buffalo.edu


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