Keith L. Kirkwood

Keith Kirkwood

Keith L. Kirkwood

Professor

Department of Oral Biology

School of Dental Medicine


Specialty/Research Focus

Periodontics

Contact Information
University of Buffalo School of Dental Medicine 3435 Main Street 250 Squire Hall
645 BRB
Buffalo, New York 14214
Phone: (716)829-3845
klkirk@buffalo.edu



Professional Summary:

My research program has been focused on innate immune signaling and cytokine biology as it relates to inflammation, bone loss, and oral cancer progression. My translational research explores the roles of posttranscriptional cytokine regulation in oral inflammation with the ultimate possibilities of developing novel therapies to control chronic oral inflammation.

Education and Training:

  • Fellowship, Department of Pharmacology and Toxicology, University of Buffalo (1999)
  • University of Buffalo (1997)
  • PhD, University of Buffalo (1997)
  • DDS, West Virginia University (1991)
  • BA, West Virginia University (1987)

Employment:

  • Professor, Oral Biology, University at Buffalo School of Dental Medicine (2017-present)
  • Professor and Chair, Oral Health Sciences, Medical University of South Carolina College of Dental Medicine (2008–2017)
  • Associate Professor, Periodontics and Oral Medicine, University of Michigan School of Dentistry (2003–2008)
  • Research Assistant Professor, Pharmacology and Toxicology, University of Buffalo (2002–2003)
  • Assistant Professor, Periodontics And Endodontics, University of Buffalo (2000–2003)
  • Clinical Assistant Professor, Oral Biology, University of Buffalo (1997–2003)
  • Clinical Assistant Professor, Periodontics And Endodontics, University of Buffalo (1997–2000)
  • Post Doctoral Fellow, Pharmacology and Toxicology, University of Buffalo (1997–1999)
  • Clinical Instructor, Periodontics And Endodontics, University of Buffalo (1995–1997)

Awards and Honors:

  • Innovative approaches to prevention and non-surgical treatment of periodontal and peri-implant diseases (2018)
  • Sunstar - AAP Foundation Research Fellowship (2016)
  • Fellow of the AADR (2016)
  • IADR/GSK Innovation in Oral Care Award (2014)
  • IADR Distinguished Scientist Award for Pharmacology/Therapeutics/Toxicology Research (2013)
  • IADR/GSK Innovation in Oral Care Award (2008)
  • Tarrson Fellowship Career Development Award (2005)
  • Young Investigator Award (2002)
  • Osseointegration Foundation Research Grant Award (2000)
  • Quintessence Research Award (1990)
  • Student Clinician Award (1990)
  • Dentist- Scientist Award
  • Individual National Research Service Award
  • American Dental Association Student Clinician Program
  • Mary Baab Randolph Student Research Fellowship
  • Mark Diamond Research Award

Research Expertise:

  • Oral Biology: Cytokine gene regulation in bone with identification of novel therapeutics targets and applied nolecular pharmacology targeting signaling mechanisms for therapeutic purposes in inflammatory bone diseases.


Professional Memberships:

  • American Association of Dental Research; Secretary/Treasurer (2002–2005)
  • American Academy of Periodontology; Subcommittee on Research Submission (2001–present)
  • American Association for Bone and Mineral Research
  • Academy of Osseointegration
  • American Dental Association
  • Eight District Dental & Erie County Dental Societies
  • New York State Dental Association
  • New York State Society of Periodontists

Presentations:

  • "Differential Regulation of MMP-13 by Chemical Modified Tetracyclines in Osteoblasts" 8oth Annual Session of the IADR/31th (2002)
  • "Dental Implications of the 40 Most Commonly Prescribed Medications" Continuing Dental Medicine; University of Buffalo Dental Medicine (2001)
  • "Systemic Medications and Dental Implications" ; University of Rochester (2001)
  • "Impact of Herbal Therapies on Dental Practice" Continuing Dental Education; University of Buffalo Dental Medicine (2001)
  • "Expression Profiling of Genes Regulated by Chemically Modified Tetracycline-8 in Murine Osteoblasts Cellsc Cells" Annual Session of the AADR (2001)
  • "The Effects of Titanium-Immobilized bioactive Peptides on Osteoblast Differentiation" Osseointegration Academy Meeting (2001)
  • "Chemically Modified Tetracyclines Inhibit IL-6 Expression in Murine Osteoblasts" 78th Annual Session of the IADR/29th (2000)
  • "Gene regulation by chemically Modifed Tetracylines in Murine Osteoblasts" Gordon Research Conference (1999)
  • "Non-Antimicrobial and Antimicrobial Tetracyclines Inhibit IL-6 Expression in Murine Osteoblasts" New York Academy of Sciences Meeting (1998)
  • "OP-1 Induction of the Inositol Trisphosphate Receptor in Human Osteosarcoma Cells" 75th Annual Session of the AADR/25th (1997)
  • "Inositol Trisphosphate Receptor Subtype Analysis in Human Osteosarcoma Cells" 24th Session of ther AADR (1995)
  • "IgG Antibodies to A.Actinomycetemconitans 16.6 Kda OMP In Juvenile Periodontitis" 72nd Annual Session of the IADR/23th (1994)
  • "Selective Expression of Inositol Trisphosphate Rectptor Gene In Human Osteosarcoma Cells" 22nd Annual Session of the AADR (1993)
See all (3 more)

Service Activities:

  • School of Dental Medicine, Executive Council; Member (2019–present)
  • School of Dental Medicine, Graduate Committee, Recruiting; Member (2019–present)
  • School of Dental Medicine, Student Research and Honors Committee (2017–2020)
  • School of Dental Medicine, Research Committee; Member (2017–2020)
  • NIH; Oral Dental Craniofacial Sciences;; Panel Member (2016–present)
  • Ad Hoc committee for accreditation; Chair (2002–2003)
  • Institute on Research in Women and Gender Grant; Evaluation of the Molecular Events; Evaluation of the Molecular Events Underlying the Enchancement of Osteobast Activity by Immobilized BMP-7 Derived Bioactive Peptides. the goal of this ongoing pilot project is to measure osteoblast specific differentiation gene expression of primary rat calvarial cells grown in tissue culture on glass coverslips where BMP-7 derived eptides are covalently attached.; (2001–2002)
  • International Federation of Endodontists; In Vitro Biomineralization of Cenemtoblasts on MTA; The major goal of this project is to determine if immortalized cementoblasy poulations can differentiation on the endodontic material mineral trioxide aggregate uner tissue culture conditions.; (2001–2002)
  • American Academy of Endodontists Association Foundation; Attachment and Differentiation of Cementoblasts on MTA; The major goal of this project is to determine if immortalized cementoblast populations can attach on the endodontic material mineral trioxide aggregate under tissue culture conditions; (2001)
  • The Osseointegration Foundation; Titanium-Immobilized; The Effects of Titanium-Immobilized Bioactive Peptides on Osteoblast Differentiation; (2000–2001)
  • School of Dental Medicine, Curriculum Committee (2000–present)
  • School of Dental Medicine, Student Research and Honors Committee (2000–present)
  • School of Dental Medicine, ByLaws Committee (2000–present)
  • American Academy of Implant Dentistry Foundation; Effects of DGEA; The In Vitro Effects of The In Viitro Effects of DGEA Peptide and Bone Morphogenetic Protein-7 on Bone Formation ; (1999–2001)
  • CollaGenex Pharmaceuticals; Therapeutic Targets; Analysis of Novel CMT Theraeutic Targets through Gene Arrays; (1999–2000)
  • ADA Health foundation; Tetracycline Analogs; Molecular Studies of Tetracycline Analogs in Osteoporisis and Oral Bone Loss; (1999–2000)
  • Moir P. Tanner Research Fund; Modified Tetracyclines; Inhibition of IL-6 Expression in Osteoblasts by Chemically Modified Tetracyclines; (1999–2000)
  • CollaGenex Pharmaceuticals; Cytokine Secretions; The role of Chemically Modified Tetracyclines in Agonist Induced Cytokine Secretion in Osteoblastic Cells.; (1997–1998)
  • National Institute of Dental research (RO3); Estrogen Regulation; Estrogen Regulation of the Osteoblast InsP3 Receptor.; (1997–1999)

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Contact Information

University of Buffalo School of Dental Medicine 3435 Main Street 250 Squire Hall
645 BRB
Buffalo, New York 14214
Phone: (716)829-3845
klkirk@buffalo.edu