Anthony A. Campagnari PhD

Anthony Campagnari

Anthony A. Campagnari
PhD

SUNY Distinguished Professor of Microbiology/Immunology and Medicine

Department of Microbiology and Immunology

Jacobs School of Medicine & Biomedical Sciences


Specialty/Research Focus

Bacterial Pathogenesis; Infectious Disease; Microbial Pathogenesis; Microbiology

Contact Information
955 Main Street
5206 Jacobs School of Medicine and Biomedical Sciences
Buffalo, New York 14203
Phone: (716) 829-2593
Fax: 716-829-3889
aac@buffalo.edu



Professional Summary:

My research interests focus on bacterial pathogenesis, emphasizing bacterial biofilms, antimicrobial therapies and vaccine antigens. One major area of my research lab is otitis media (OM) or middle ear disease. Approximately 80 percent of children experience one episode of OM while others have recurrent infections. Chronic OM infection causes hearing impairment leading to developmental problems as these children reach school age. My laboratory has concentrated on two major causes of OM, Moraxella catarrhalis and Streptococcus pneumoniae. Our recent work suggests that M. catarrhalis colonization predisposes patients to colonization with S. pneumoniae in polymicrobial biofilms. The goals of this work are to define biofilm-associated factors and to identify signals that induce bacteria to transition from asymptomatic colonizers to pathogenic organisms leading to OM.

Our second major research focus is the identification of novel antimicrobial therapies. Chronic OM is likely a biofilm-associated disease and biofilms are highly antibiotic resistant. Antibiotic resistance is a major problem worldwide and new drug development is both time consuming and extremely expensive. We have demonstrated that photodynamic therapy (PDT), an FDA-approved cancer treatment, is also bactericidal against the three major otopathogens. Thus, the goal of this research is to adapt PDT into a clinically effective treatment for chronic OM.

Our third research area involves novel antimicrobial treatments for orthopedic/prosthetic infections. Infections after orthopedic intervention, including knee/hip replacements and insertion of prosthetic devices, are devastating to the patient and these infections will likely increase over the next 20 years. This is particularly relevant to the military where improvised explosive devices cause severe extremity injuries requiring amputation. Antibiotic-resistant biofilms are the primary source of these infections. In collaboration with colleagues at UB, we are testing a novel electrical stimulation method for prevention/eradication of biofilm infections on implant materials. The goals of this research are to define the optimal antimicrobial parameters that are broadly effective against multiple pathogens, including Staphylococcus aureus, Acinetobacter baumannii, Staphylococcus epidermidis and Klebsiella pneumoniae.

The members of my research team typically include a combination of graduate students, lab technicians and a junior faculty member. In the summer, I usually mentor medical students or undergraduates who are interested in the fundamentals of basic science and translational research focused on microbial pathogenesis.

Education and Training:

  • PhD, Tumor Immunology, University at Buffalo (1984)
  • MS, Natural Science, University at Buffalo (1981)

Employment:

  • SUNY Distinguished Professor, Microbiology/Immunology, State University of New York (2019-present)
  • Professor of Microbiology, Immunology and Medicine, Microbiology and Immunology, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (2001-present)
  • Associate Professor, Medicine, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (1999–2001)
  • Associate Professor, Microbiology and Immunology, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (1996–2001)
  • Research Assistant Professor, Medicine, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (1987–1999)
  • Adjunct Assistant Professor, Microbiology and Immunology, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (1992–1996)
  • Instructor, Medicine, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (1985–1987)
  • Post Doctoral Fellow, Division of Infectious Diseases, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (1983–1985)

Awards and Honors:

  • UB Distinguished Biomedical Alumnus (2107)
  • SUNY Distinguished Professor (2019)
  • Fellow in the American Academy for Microbiology (2017)
  • SUNY Chancellor's Award (2017)
  • Deans Award 2016 (2016)
  • Stockton Kimball (2016)
  • UB Excellence in Graduate Student Mentoring Award (2015)
  • Elected to the College of CSR Reviewers National Institutes of Health (2010)
  • UB Inventor and Entrepreneur Award (2009)
  • UB Visionary Innovator Award (2008)
  • Sustained Achievement Award (2002)

Research Expertise:

  • Antibody development: Development of monoclonal and polyclonal antibodies.
  • Bacterial pathogenesis: Identification of biofilm associated factors. Characterizing bacterial components involved in biofilm formation and stability.
  • Microbial pathogenesis: Colonization factors; virulence determinants
  • Novel antimicrobial therapy: Analyzing photo dynamic therapy and electrical stimulation as potential treatments for infections caused by antibiotic resistant bacteria.
  • Vaccine development: Identification of colonization and virulence factors and vaccine antigens

Research Centers:

  • Witebsky Center for Microbial Pathogenesis and Immunology

UB 2020 Strategic Strengths:

  • Health and Wellness Across the Lifespan

Grants and Sponsored Research:

  • September 2020–August 2022
    Electrical Stimulation for Infection Control of the Skin-Implant Interface of Osseointegrated Prostheses
    Peer Reviewed Orthopedic Research Program of the Congressionally Directed Medical Research Program
    Role: Co-Investigator
    $7,490,000
  • May 2016–April 2021
    Targeting M. catarrhalis for Prevention and Treatment of Otitis Media
    National Institutes of Deafness and Communicative Disorders
    Role: Principal Investigator
    $1,982,425
  • March 2014–February 2019
    Pneumococcal transition from nasopharyngeal biofilm carriage to otitis media
    NIH/NIDCD
    Role: Principal Investigator
    $1,840,000
  • October 2012–September 2014
    Analysis of Novel Acinetobacter baumannii Adhesions
    NIAID
    Role: Principal Investigator
    $435,875
  • April 2013–April 2014
    A Novel Electrical Stimulation Method for the Eradication/Preventions of Orthopedic Biofilms
    Bruce Holm Memorial Catalyst Fund
    Role: Co-Principal Investigator
    $50,000
  • October 2010–October 2013
    Electrical Stimulation of Titanium for the Prevention and/or Eradication of A. baumannii and S. aureus Biofilm Infections on Osseointegrated Prostheses
    Congressionally Directed Medical Research Program-Peer Reviewed Orthopaedic Research Program
    Role: Co-Investigator
    $621,591
  • November 2007–December 2012
    Genetics & Biology of M. catarrhalis LOS in Otitis Media
    NIDCD
    Role: Principal Investigator
    $1,846,053
  • September 2002–September 2007
    Genetics & Biology of M. catarrhalis LOS in Otitis Media
    NIDCD
    Role: Principal Investigator
    $1,725,060
  • November 2002–November 2005
    Comprehensive Analysis of Virulence Factors and Potential Vaccine Antigens of Haemophilus ducreyi.
    The John R. Oishei Foundation
    Role: Principal Investigator
    $300,000
  • August 2001–July 2005
    Analysis of Moraxella catarrhalis LOS: Role in Immunity
    National Institute of Allergy and Infectious Diseases
    Role: Principal Investigator
    $851,269
  • February 2000–January 2005
    Analysis of M. catarrhalis receptors as Vaccine Antigens
    National Institute of Allergy and Infectious Diseases
    Role: Principal Investigator
    $906,722
  • June 2002–May 2004
    Capture, Isolation and Identification of Biologic Agents
    New York State Center for Applied Technology
    Role: Principal Investigator
    $428,000
  • June 2001–May 2002
    Development of Monoclonal Antibodies
    University Service Account
    Role: Principal Investigator
    $59,108
  • June 1997–May 2002
    Structure of Haemophilus ducreyi LOS: Role in Adherence/Invasion
    National Institute of Allergy and Infectious Diseases
    Role: Principal Investigator
    $806,769
See all (4 more)

Patents:

  • Electrochemical Eradication of Microbes on Surfaces of Objects (2018)
  • Novel stimulation technology Electrochemical eradication of microbes on surfaces of objects (2017)
  • Tools for Detecting Moraxella catarrhalis (2008)
  • PCR modification USA patent No. 5,871,906 titled; Method for the Detection of Amplified Nucleic Acid Products and Related Diagnostic Assays, 1999. (1999)
  • Moraxella catarrhalis a vaccine antigen. USA patent No. 6,004,562 (1999)
  • Concentrator/Detector USA patent No. 4,859,421 titled; Disposable Antigen Concentrator and Detector and Methods for Using Same. (1989)

Journal Articles:

See all (74 more)

Professional Memberships:

  • American Association for the Advancement of Science (2010–present)
  • New York Academy of Sciences (1997–present)
  • Western New York Branch of ASM (1987–present)
  • American Society for Microbiology (1986–present)

Presentations:

  • "Antimicrobial photodynamic therapy for treatment of biofilm-associated infections" Division of Infectious Diseases Research Series (2020)
  • "Novel Treatment for Otitis Media" Department of Pediatrics Seminar Series Oishei Children’s Hospital (2020)
  • "Although There Is an “I” in Science, It Takes a Great Team To Be Successful" Stockton Kimball Lecture (2017)
  • "A Novel Electrical Stimulation Technology for the Treatment and Prevention of Orthopedic-related Infections" Seminar Western Kentucky University (2017)
  • "Targeting Moraxella catarrhalis for the Prevention and Treatment of Otitis Media" Seminar (2016)
  • "Drug Delivery to the Middle Ear and Innovative Therapies" 18th International Symposium on Recent Advances in Otitis Media (2015)
  • "Did I Choose Science of Did Science Choose Me?" Buffalo Summer Research Day (2014)
  • "Identification and Characterization of an Acinetobacter baumannii Surface Component Involved in Biofilm Formation and Stability" Conversations in Global Health.; SUNY Upstate Medical University (2013)
  • "Potential Vaccine Antigens Versus Moraxella catarrhalis" 10th International Symposium on Recent Advances in Otitis Media. (2011)
  • "Biofilm factors of Acinetobacter baumannii" Departmental Seminar; University of Nebraska Medical Center (2011)
  • "The Role of Surface Carbohydrates in Acinetobacter baumannii Pathogenesis" Departmental Seminar; Emory University (2010)
  • "Identification and Characterization of Acinetobacter baumannii Surface Components Involved in Biofilm Formation and Stability" Departmental Seminar; University of Texas, Southwest Medical Center (2009)
  • "Identification and Characterization of an Acinetobacter baumannii Biofilm-Associated Protein" USAMRMC MIDRP W Wound Conference; WRAIR/NMRC facility (2009)
  • "Expression of a large Surface Protein on Acinetobacter baumannii Correlates with Biofilm Formation and Stability" Departmental Seminar; University of Oklahoma Health Sciences Center (2008)
  • "A Novel Two-Partner Secretion Pathway of Moraxella catarrhalis" Departmental Seminar; SUNY at Buffalo/Oral Biology (2006)
  • "Type IV Pilus Expression by Moraxella catarrhalis" Departmental Seminar; Wake Forest University School of Medicine (2006)
  • "Is Type IV Pilus Expression by Moraxella catarrhalis Essential for Pathogenesis?" Departmental Seminar; Medical College of Ohio (2005)
  • "Virulence Factors for Moraxella catarrhalis" Departmental Seminar; Allegheny-Singer Research Institute; Center for Genomic Sciences, Allegheny General Hospital (2004)
  • "Potential Vaccine Antigens for the Prevention of Moraxella catarrhalis Induced Otitis Media." Otitis Media: New Approaches for Analysis, Treatment and Prevention; NIH; NICDCD (2000)
  • "Moraxella catarrhalis Lipooligosaccharides; Unique Glycolipids" Departmental Seminar; Ohio State University; Department of Molecular Microbiology, Immunology and Bacteriology (2000)
  • "Iron-regulated Proteins of Moraxella catarrhalis" Departmental Seminar; SUNY@Buffalo; Oral Biology (1999)
  • "Iron-regulated Protein Expression by Moraxella catarrhalis may be Important for Sensitivity to Human Complement." Research Exchange Series; SUNY@Buffalo; Center for Advanced Molecular Biology and Immunology (1997)
  • "Potential Cell Surface Receptors for Haemophilus ducreyi LOS Expressed on Human Keratinocytes" Departmental Seminar; University of California at San Francisco; Pharmaceutical Chemistry (1997)
  • "Iron-repressible proteins expressed during infections caused by Moraxella (Branhamella) catarrhalis" Fall Conference Microbial Pathogenesis; SUNY@Buffalo; Microbial Pathogenesis Graduate Group (1996)
  • "The immune response to Iron-regulated proteins expressed during otitis media caused by Moraxella catarrhalis" Departmental Seminar; Children’s Hospital of Buffalo; Department of Pediatric Infectious Diseases (1996)
  • "The major lipooligosaccharide (LOS) structure conserved on the surface of different Haemophilus ducreyi strains, binds to proteins expressed by human keratinocytes in vitro." American Society for Microbiology, 95th general meeting.; American Society for Microbiology; Microbial Pathogenesis (1995)
  • "The role of the Lipooligosaccharides in Haemophilus ducreyi adherence and invasion of human cells" Departmental Seminar; SUNY at Buffalo; Department of Microbiology (1995)
  • "Iron-regulated proteins of Moraxella catarrhalis" Infectious Diseases Research Conference; SUNY at Buffalo; Department of Medicine (1994)
  • "A Tn916 Lipooligosaccharide (LOS) Mutant of Haemophilus ducreyi Shows a Decreased Ability to Adhere to and Invade Human Keratinocytes." 94th General Meeting; American Society for Microbiology; Microbial Pathogenesis (1994)
  • "Development and Current Uses for Monoclonal Antibodies." Current Trends in Clinical Laboratory Medicine; SUNY at Buffalo; Department of Medical Technology (1994)
  • "The Role of the Lipooligosaccharides in the Pathogenesis of Haemophilus ducreyi" Western New York Branch of the American Society for Microbiology; WNY ASM (1993)
  • "Advancements in the Development of Bacterial Vaccines; Anti-idiotypic Antibodies" City Wide Grand Rounds; SUNY at Buffalo; Department of Medicine (1992)
  • "The Role of LOS in Experimental Dermal Lesions Caused by Haemophilus ducreyi" The Molecular Immunology of Sexually Transmitted Diseases; NIH, Rocky Mountain Laboratories; NIAID, National Vaccine Program, CDC, FDA and the Department of Defense (1991)
  • "Monoclonal Antibodies and Recombinant DNA Technology" Advances in Immunology; New State Council of Hospital Pharmacists (1989)
See all (24 more)

Service Activities:

  • CRFS Special Emphasis Panel; Ad hoc reviewer (2021)
  • Producing Viral Transport Media for COVID19 testing; Director (2020–present)
  • NIH-ZRG1 IDM-T NIDCD; Ad hoc reviewer (2018)
  • NIH-CDRC NIDCD; Ad hoc reviewer (2018)
  • LCME; Department Representative (2017–2019)
  • NIH-CDRC; Ad hoc reviewer (2017)
  • NIH-ZDC1 SRB-K; Ad hoc reviewer (2017)
  • Research Strategic Planning Committee; Co-Chairman (2017–2018)
  • Champion of the Medical Education Strategic Plans; Assisting in develop of new medical school curriculum (2017–present)
  • CDRC-NIDCD; Ad hoc reviewer (2016)
  • Over see distribution of research space and LAF space.; Jacobs School of Medicine Facilities Committee (2015–present)
  • Member of Search Committee Faculty Hires; Reviewed applicants CV's and interviewed candidates (2015–2017)
  • CDRC;; Ad Hoc Reviewer (2015)
  • ID and Microbiology Integrated Review Group;; Chair (2014)
  • Infectious diseases, Microbiology and Drug Discovery Panel;; Ad Hoc Reviewer (2014)
  • Medical School Research Day; Judge of poster session (2014–2018)
  • Research Laboratory Design Work Group; Assist in the equipping and designing labs in the new medical school (2013–2015)
  • Executive Committee; Attend monthly meetings with Dean and both basic science and clinical administrators and chairs (2013–present)
  • Basic Science Council; Attend monthly meetings with Dean and chairs (2013–present)
  • Associate Deans Graduate Council; Representative for the Jacobs School of Medicine (2013–present)
  • NIAID; IAM Bacteriology;; Chair (2013)
  • Chair of search committee for hiring new faculty; Evaluated applicant CV's, set up review meetings and interviewed candidates (2012–2013)
  • NIAID; CSR IAM;; Grant Reviewer (2012)
  • Student Academic Progress Committee; Design learning plans for students having academic difficulties (2012–2017)
  • Student Appeals Committee; Participate in hearings students appeal dismissal medical students (2012–2014)
  • Search committee member for the Chair of Microbiology/Immunology; Reviewed CV's and interviewed applicants (2011–2012)
  • Held in lab teaching for HS seniors; Bishop Timon St Jude Learning Laboratory Techniques (2011–2018)
  • Mentoring Committee for Faculty; Advised junior faculty on requirements to achieve tenure (2011–2015)
  • PPBS Steering Committee; Provide curriculum advice and review graduate students academics (2011–2014)
  • NIAID; IDM-JO4;; Chair (2010)
  • Provided advice and career path guidance for junior faculty; Mentoring Committee for Junior Faculty (2010–2015)
  • NIDCD; CFRS;; Ad Hoc Reviewer (2009)
  • Advised graduate students and monitored academic progress; Director of the Microbiology/Immunology graduate program (2008–2010)
  • NIAID; BACP;; Chair (2005–2007)
  • National Institute of Allergy and Infectious Diseases; National Institute of Allergy and Infectious Diseases; Bacteriology and Mycology 1;; Ad Hoc Reviewer (2002)
  • The Wellcome Trust; The Wellcome Trust; The Wellcome Trust;; Ad Hoc Reviewer (2002)
  • National Institute on Deafness and other Communication Disorders; National Institute on Deafness and other Communication Disorders; SEP ICNF-4;; Panel Member (2002)
  • National Institute of Allergy and Infectious Diseases; National Institute of Allergy and Infectious Diseases; Bacteriology and Mycology 2;; Panel Member (2002–2006)
  • Medical Scientist Training Program steering committee; Provided guidance to curriculum and student academics (2001–2003)
  • Set up meetings, advised students and invited speakers; Director of the Microbial Pathogenesis Graduate Group (2000–2005)
  • Infection and Immunity.; Manuscript reviewer (2000–present)
  • Admissions and Recruiting IGPBS; Reviewed applications, interviewed applicants, ran decision making meetings (2000–2002)
  • Admissions and Recruiting for the MSTP; Reviewed applications, interviewed applicants and made offers (2000–2001)
  • Graduate Affairs; Director (2000–2002)
  • Director of Graduate Studies. Director of the graduate program, Department of Microbiology.; Director (2000–2002)
  • Faculty Search Committee. Member of the Immunology Faculty Search Committee, Department of Microbiology.; Member (2000)
  • Masters Program. Director of the masters program, Department of Microbiology.; Director (1999–2000)
  • Recruiting for the IGPBS; Recruiting Interdisciplinary Graduate Program in the Biomedical Sciences (1999–2001)
  • Graduate Affairs; Member (1998–2000)
  • IAACUC; Member (1997–1999)
  • Presented talk to student at OLSH; Guest speaker HIV and AIDS (1997)
  • Push-Excel Career Awareness Day Academic Challenge Center; Guest Speaker (1993)
  • Monoclonal Center Director of the Monoclonal Antibody Center.; Director (1992–present)
  • Attica Middle School career day; Guest speaker (1992)
  • HIV and AIDS WNY Association of Hospital Security Guards; Guest Speaker (1988)

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Contact Information

955 Main Street
5206 Jacobs School of Medicine and Biomedical Sciences
Buffalo, New York 14203
Phone: (716) 829-2593
Fax: 716-829-3889
aac@buffalo.edu