Reproductive Endocrinology; Apoptosis and cell death; Cell growth, differentiation and development; Endocrinology; Gene Expression; Molecular genetics; Signal Transduction; Toxicology and Xenobiotics; Vitamins and Trace Nutrient
My research and practice focuses on developing, promoting, and evaluating effective means of pharmacology instruction at the undergraduate, graduate, professional, and interprofessional levels. Developing a competency-based curriculum in pharmacology for students at all levels, I have incorporated specific instructional methods into existing core courses that has, in effect, taken a sometimes intimidating subject like pharmacology and presented it to students in manageable ways. Studies of the effectiveness of these methods are conducted in collaboration with professional societies, including ASPET and its Division of Pharmacology Education. Specific instructional methods in the study include: patient case presentations by professional students utilizing rubric descriptors of performance quality and 360 feedback; Pharm Fridays throughout the second year medical curriculum incorporating organized lists of pertinent drugs to recognize, student-oriented learning objectives, pharmacology study guides focusing on essential therapeutics, their indications, mechanisms of action, adverse drug reactions, and drug interactions; active participation clicker sessions with relevant board-style pharmacology questions; development of performance-based pharmacology questions within the multidisciplinary objective structured clinical exam (OSCE) taken by all DDS candidates; and video presentations demonstrating pertinent pharmacology topics such as medical sedation, use of emergency drugs in the clinic, and safe and effective means for pain management with interviews of clinical experts. These and other instructional methods in the study are highly rated by students and proven effective by outcomes on standardized exams. For the last several years, I have been co-director of the endocrine-reproductive biology module for second-year medical students. As an ongoing means to improve pharmacology instruction, I coordinated the recent survey of pharmacology instruction in the medical curriculum, assessing adequacy of pharmacology learning objectives, utility of various instructional methods, coverage of USMLE Step 1 pharmacology expectations, and incorporated mechanisms to improve instruction and medical student preparation in pharmacology. Other recent advancements include the launching of an online pre-professional undergraduate pharmacology course with all presentations fully accessible to persons with disabilities.
Oncology; Cell Cycle; Cell growth, differentiation and development; Gene Expression; Molecular Basis of Disease; Molecular and Cellular Biology; Signal Transduction; Transcription and Translation
Protein phosphorylation is an essential mechanism by which intercellular signals regulate specific intracellular events. Protein kinases, the enzymes catalyzing protein phosphorylation reactions, represent a major superfamily of genes, collectively representing 2% of the protein coding potential of the human genome. Current projects in Dr. Edelman‘s lab are devoted to the role of protein kinases in prostate and ovarian cancer. These projects utilize a wide range of techniques and involve, collaboration with investigators at Roswell Park Cancer Institute to develop protein kinase-targeted therapies for both types of cancer.