Aaron Kaplan.

Aaron Kaplan

Department

Physiology and Biophysics

Thesis

PhD Thesis Title: Cardiac Electrophysiology in Induced Pluripotent Stem Cells (Completed 2015)

Residency

Internal Medicine/Research Pathway, University of Maryland, Baltimore

Undergraduate Education

Chemical Engineering,
Columbia University

Thesis Advisor

I have previously carried out Master’s level research on the culture, differentiation, and characterization of cardiac myocytes derived from embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). I have also had a significant amount of quantitative training in my Chemical and Biomedical engineering degrees. My thesis work involves, learning new skills including electrophysiology and mathematical modeling of ion channels.

Publications

  • Kaplan, Aaron D, Agnieszka Lis, Thomas R Cimato, Emmanuel S Tzanakakis, Qinlian Zhou, Michael J Morales, Randall L Rasmusson and Glenna CL Bett. "Enhanced Differentiation of Stem Cell Derived Cardiac Myocytes by Electronic Expression of Ik1 Reveals an Atrial-Specific Kv1. 5-Like Current." Biophysical Journal 106, no. 2 (2014): 631a.              
  • C Terrenoire,  G.K  Wang,  E  Adler,  A.D  Kaplan,  K.J  Sampson,  J  Lu,  R  Kass  “KCNQ1/KCNE1  K+ Channels  Associated with Long QT Syndrome are Expressed in Early Stage Human Embryonic Stem Cell-Derived Cardiomyocytes” Biophysical Journal, vol. 98, issue 3, pp. 335a-335a
  • X Carvajal-Vergara, A Sevilla, S D'Souza, Y Ang, C Schaniel, A D Kaplan, E Adler, D F Lee, R Rozov, Y C Ge,    N Cohen, L Edelman, S Pardo, K D Lischtenbelt, M Tartaglia, B Gelb, I Lemischka "Generation of Reprogrammed Induced Pluripotent Stem (iPS) Cells from Patients With LEOPARD Syndrome" Nature. 2010 June 2010;465(7299):808-12 [Cover Article]
  • Eric D. Adler, Vincent C. Chen, Anne Bystrup, Aaron D. Kaplan, Steven Giovannone, Karen Briley-Saebo, Wilson Young, Steve Kattman, Venkatesh Mani, Michael Laflamme, Wei-Zhong Zhu, Zahi Fayad, and Gordon Keller “The cardiomyocyte lineage is critical for optimization of stem cell therapy in a mouse model of myocardial infarction” FASEB J. (2010) 24: 1073-108
  • Aaron D. Kaplan, Ariel J. Jaffa, Ilan E. Timor, and David Elad. “Hemodynamic Analysis of Arterial Blood Flow in the Coiled Umbilical Cord” Reproductive Sciences 2010 17: 258-268
  • Bett, G. C. L., A. D. Kaplan, A. Lis, T. R. Cimato, E. S. Tzanakakis, Q. L. Zhou, M. J. Morales and R. L. Rasmusson. "Electronic "Expression" of the Inward Rectifier in Cardiocytes Derived from Human-Induced Pluripotent Stem Cells." Heart Rhythm 10, no. 12 (2013): 1903-1910.
  • Han, Lu, Yang Li, Jason Tchao, Aaron D Kaplan, Bo Lin, You Li, Jocelyn Mich-Basso, Agnieszka Lis, Narmeen Hassan and Barry London. "Study Familial Hypertrophic Cardiomyopathy Using Patient Specific Induced Pluripotent Stem Cells." Cardiovascular Research,  (2014): cvu205.
  • Han, Lu, Yang Li, Jason Tchao, Aaron D Kaplan, Bo Lin, You Li, Jocelyn Mich-Basso, Agnieszka Lis, Narmeen Hassan and Barry London. "Reconciling Computer Models and Stem Cell Models of Human Cardiac Repolarization: Reply." Cardiovascular research,  (2015): cvv039.
  • Kim, Jong J, Lei Yang, Bo Lin, Xiaodong Zhu, Bin Sun, Aaron D Kaplan, Glenna CL Bett, Randall L Rasmusson, Barry London and Guy Salama. "Mechanism of Automaticity in Cardiomyocytes Derived from Human Induced Pluripotent Stem Cells." Journal of molecular and cellular cardiology 81,  (2015): 81-93.
  • Cordeiro, Jonathan M., Tanya Zeina, Robert Goodrow, Aaron D. Kaplan, Lini M. Thomas, Vladislav V. Nesterenko, Jacqueline A. Treat, Leo Hawel, III, Craig Byus, Glenna C. Bett, Randall L. Rasmusson and Brian K. Panama. "Regional Variation of the Inwardly Rectifying Potassium Current in the Canine Heart and the Contributions to Differences in Action Potential Repolarization." Journal of Molecular and Cellular Cardiology.
  • Parikh, A., D. Patel, C. F. McTiernan, W. Y. Xiang, J. Haney, L. Yang, B. Lin, A. D. Kaplan, G. C. L. Bett, R. L. Rasmusson, S. G. Shroff, D. Schwartzman and G. Salama. "Relaxin Suppresses Atrial Fibrillation by Reversing Fibrosis and Myocyte Hypertrophy and Increasing Conduction Velocity and Sodium Current in Spontaneously Hypertensive Rat Hearts." Circulation Research 113, no. 3 (2013): 313-321.
  • Lin, Bo, Yang Li, Lu Han, Aaron D Kaplan, Ying Ao, Spandan Kalra, Glenna CL Bett, Randall L Rasmusson, Chris Denning and Lei Yang. "Modeling and Studying Mechanism of Dilated Cardiomyopathy Using Induced Pluripotent Stem Cells Derived from Duchenne Muscular Dystrophy (Dmd) Patients." Disease Models & Mechanisms,  (2015): dmm. 019505.
  • Daniel A Gold, Aaron D Kaplan, Agnieszka Lis, Glenna CL Bett, Emily E Rosowski, Kimberly M Cirelli, Alexandre Bougdour, Saima M Sidik, Josh R Beck, Sebastian Lourido, Pascal F Egea, Peter J Bradley, Mohamed-Ali Hakimi, RandallL Rasmusson, and Jeroen PJ Saeij. “The Toxoplasma dense granule proteins GRA17 and GRA23 mediate the movement of small molecules between the host and the parasitophorous vacuole.” Cell Host and Microbe. In Press
  • Aaron D Kaplan, et al.  “IK1 Is Essential For Chamber Specific Properties In Human Myocytes” In Preparation
  • Aaron D Kaplan, et al. “Human Induced Pluripotent Stem Cells Can Recapitulate Human Ventricular Electrophysiology.” In Preparation

Professional/Educational Meetings/Abstracts

  • Aaron Kaplan, Agnieszka Lis, Thomas R. Cimato, Glenna C L Bett,  Michael J. Morales, and Randall L. Rasmusson. HUMAN INDUCED PLURIPOTENT STEM CELL DERIVED CARDIOMYOCYTES INCLUDE T-TYPE CALCIUM CURRENTS. Upstate New York Cardiac Electrophysiology Society Meeting. Rochester, NY. October 19. 2012
  • M Park, A D Kaplan, C Nwasike, D O'Connor, W Young S McClelland, E Adler. The Use of Human Embryonic Stem Cell – Derived Cardiomyocytes as a Model of Hypertrophy in Response to Stress" Keystone Symposia Common Mechanisms in Arrhythmias and Heart Failure 2009
  • Aaron D Kaplan, Daniel O'Conner, Stephen Kattman, Michael Leflamme, Roger Hajjar, Gordon Keller, Eric Adler, "HNK+ Embryonic Stem Cell Derived Cardiac Progenitor Cells Are Enriched for a Pacemaker Phenotype" Keystone Symposia Cardiac Disease: Development, Regeneration, and Repair. March 18, 2009
  • Aaron Kaplan, Agnieszka Lis, Thomas R. Cimato, Glenna C L Bett, Michael J. Morales, and Randall L. Rasmusson. Human Induced Pluripotent Stem Cell Derived Cardiomyocytes Include T-Type Calcium Currents. Upstate New York Cardiac Electrophysiology Society Meeting. Rochester, NY. 10/19/12
  • Kaplan, Aaron D, Agnieszka Lis, Thomas R Cimato, Emmanuel S Tzanakakis, Qinlian Zhou, Michael J Morales, Randall L Rasmusson and Glenna CL Bett. “Electronic Expression of IK1 in Human Induced Pluripotent Stem Cell Derived Cardiac Myocytes” Upstate New York Cardiac Electrophysiology Society Meeting. Toronto, ON. Oct., 11, 2013. [Oral Presentation]
  • Kaplan, Aaron D, Agnieszka Lis, Carlos Li, Thomas R Cimato, Emmanuel S Tzanakakis, Qinlian Zhou, Michael J Morales, Randall L Rasmusson and Glenna CL Bett. “Electronic Expression of IK1 Restores Physiological Properties to APs in Human Induced Pluripotent Stem Cells” Upstate New York Cardiac Electrophysiology Society Meeting. Buffalo, NY. Nov., 3, 2013. [Oral Presentation]
  • Kaplan, Aaron D, Agnieszka Lis, Carlos Li, Thomas R Cimato, Emmanuel S Tzanakakis, Qinlian Zhou, Michael J Morales, Randall L Rasmusson and Glenna CL Bett. “Electronic Expression of IK1 Restores Physiological Properties to APs in Human Induced Pluripotent Stem Cells” MD-PhD Seminar - SUNYAB. March, 11, 2014 [Oral Presentation]
  • Kaplan, Aaron D, Randall L Rasmusson and Glenna CL Bett. “Electronic Expression of IK1 Restores Physiological Properties to APs in Human Induced Pluripotent Stem Cells” ASCI/AAP Joint Meeting. Chicago, IL. Apr., 25, 2015. [Poster]
  • Kaplan, Aaron D, Glenna CL Bett and Randall L Rasmusson. "Electronic Expression of Ik1 in Human Induced Pluripotent Stem Cell Derived Cardiocytes Reveals Atrial Vs Ventricular Specific Properties." Biophysical Journal 108, no. 2 (2015): 112a.
  • Kaplan, Aaron D, Agnieszka Lis, Thomas R Cimato, Emmanuel S Tzanakakis, Qinlian Zhou, Michael J Morales, Randall L Rasmusson and Glenna CL Bett. "Enhanced Differentiation of Stem Cell Derived Cardiac Myocytes by Electronic Expression of Ik1 Reveals an Atrial-Specific Kv1. 5-Like Current." Biophysical Journal 106, no. 2 (2014): 631a.
  • Kaplan, Aaron D, Agnieszka Lis, Carlos Li, Lei Yang, Michael J Morales, Glenna CL Bett and Randall L Rasmusson. "A Comparison of Acutely Isolated Human Ventricular Myocytes with Stem Cell Derived Cardiocytes." Biophysical Journal 108, no. 2 (2015): 271a.
  • Kaplan, Aaron D, Agnieszka Lis, Randall L Rasmusson and Glenna CL Bett. "Normalization of Action Potential Properties in Human Induced Pluripotent Stem Cell Derived Cardiocytes by Electronic Expression of Ik1." Biophysical Journal 108, no. 2 (2015): 112a.

Awards/Honors

  • Dean’s List, Columbia University                                                                                   
  • Keystone Symposia Travel Award                                                                               
  • Medical Scientist Training Program, University at Buffalo                                     
  • Gordon K. Moe Young Investigator Award in Cardiac Electrophysiology                                        
  • ASCI/AAP Joint Meeting Travel Award                                                                   

Medical School Activities

  • American Medical Association
  • American Heart Association
  • Society for Internal Medicine, University at Buffalo
  • Biophysical Society
  • American Physician Scientists Association

Extracurricular Interests

Crossfit, Long Distance Running, Gourmet cooking with my wife, Guitar, Golf