Allen Y. Chung.

Allen Y. Chung

Department

Microbiology and Immunology

Thesis

PhD Thesis Title: Oral IL10 nanoparticles alleviate polyposis via site-specific neutralization of pathogenic T-regulatory cells. (Completed 2013)

The immune-modulatory cytokine interleukin-10 (IL10) is essential for maintaining immune homeostasis at mucosal surfaces. The therapeutic potential of applying IL10 towards the treatment of inflammation-driven diseases has, however, been limited by both an incomplete understanding of IL10 biology and an inability to locally target IL10 to mucosal surfaces in a specific and sustainable fashion.

My thesis work utilized bio-polymer nanotechnology to show that orally-administered IL10 formulations can successfully recondition the intestinal immune system and ameliorate established colitis. Utilizing the APCmin mouse model of spontaneous gastrointestinal polyposis, our mechanistic studies revealed the efficacy of therapy to be partially dependent on the conditioning effect of IL10 upon T-regulatory cells. In situ reprogrammed T-regulatory cells regained their native immunosuppressive potential and became more efficient at controlling intestinal inflammation. Oral IL10 nanoparticles alleviated constitutional symptoms, corrected fatal anemia and extended natural lifespan in our experimental animals.

Translation of our basic scientific discoveries into the clinical setting has revealed an important role for the immune system in the development of disease in patients with inherited polyposis syndromes (Familial Adenomatous Polyposis and Hereditary Nonpolyposis Colorectal Cancer). In collaboration with partners from both academia and industry, ongoing studies are attempting to explore the broader applicability of nanoparticle biologics in the treatment of a wide array of immune-pathologic disease.

Residency Placement

Medicine Prelim, University at Buffalo

Radiation-Oncology, University of Minnesota, Minneapolis

Undergraduate Education

Biological Sciences and Physics, Cornell University

Thesis Advisor

Nejat Egilmez, PhD

Publications

  • Ozblige H, LeVea C, Chung AY, Li Q and Egilmez NK. “Modulating Gut Immunity and Neoplasia with Oral Cytokine Adjuvants.” (2015) Oncoimmunology. 4(4): e1002724
  • Chung AY, Li Q, Blair SJ, De Jesus M, Dennis KL, … and Egilmez NK. “Oral Interleukin-10 Alleviates Polyposis via Neutralization of Pathogenic T-regulatory Cells.” (2014) Cancer Research. 74(13): 5377-5385
  • Xu H, Zhu J, Smith S, Foldi J, Zhao B, Chung AY, … and Hu X. “ Notch-RBP-J signaling regulates thetranscription factor IRF8 to promote inflammatory macrophage polarization.” (2012) Nat Immunol., 13(7): 642-650
  • Foldi J, Chung AY, Xu H, Zhu J, Outtz H.H., … Ivashkiv LB. “Autoamplification of Notch Signaling in Macrophages by TLR-induced and RBP-J-dependent induction of Jagged1.” (2010) J Immunol.,185(9): 5023-5031
  • Foldi J, Hu X, Chung AY, and Ivashkiv LB. “Regulation of Notch ligands by the TLR an IFN-y pathways in macrophages.” J. Immunol., (2009); 182: 135.63
  • Hu X, Chung AY, Wu I, Foldi J, Chen J, Ji JD, Tateya T, ..., Ivashkiv LB. “Integrated Regulation of Toll-like Receptor Responses by Notch and Interferon-gamma Pathways.” (2008) Immunity, 29 (5): 691-703

Professional/Educational Meetings Attended & Abstracts Presented

  • AMA-MSS Interim Meeting Research Symposium, Nov 2010, Manchester Grand Hyatt, San Diego, CA
  • 9th Annual Buffalo Conference on Immunology, Sep 2009, Canandaigua, NY.
  • 17th Annual Henry Kunkel Society Meeting. April 2009, The Rockefeller University, New York, NY.
  • Keystone Symposium- Innate Immunity, February 2008, Keystone, CO.

Awards/Honors

  • Pediatric Oncology Education Fellowship, St. Jude Children’s Research Hospital (2010)
  • Gilbert D. Moore Fellowship (2009-2010)

Medical School Activities

  • Professional Conduct Committee (2010-Present)
  • Society for Internal Medicine-Executive Board (2010-Present)
  • Orthopedics Interest Group-Treasurer (2010-Present)
  • MSTP Student Council (2010-Present)
  • Medical Society of the State of New York (2009-Present)
  • American Medical Association (2009-Present)

Extracurricular Interests

  • Travel
  • Triathlon
  • Underwater Photography
  • Drawing Maps
  • Learning Arabic
  • Reading Haruki Murakami
  • Cooking