Brian A. MacDonald, Jr.

Brian A. MacDonald, Jr.


Microbiology and Immunology


PhD Thesis Title: Influenza and Secondary Bacterial Pneumonia: Modulation of the Host anti-Viral Immune Response and the Interferon Paradox (completed 2012)

Investigation of the alteration of the host immune system following influenza infection, and design of novel therapeutics to beneficially modulate impaired host immune responses.

Residency Placement

Internal Medicine, University at Buffalo

Undergraduate Education

Biology, Boston College

Thesis Advisor


  • MacDonald B, Chakravarthy K, Davidson B, Mullan B, Alluri R, Helinski J, Hakansson A, Russo T, Knight P. Anesthesiology. Halothane modulates the type I interferon response to influenza and minimizes the risk of secondary bacterial pneumonia through maintenance of neutrophil recruitment in an animal model. In Press.
  • MacDonald B and Charytan D, Sugimoto H, Pastan S, Staton G, Hennigar R, and Kalluri R. American Journal of Kidney Diseases. An Unusual Case of Pulmonary-Renal Syndrome Associated with Defects in Type IV Collagen Composition and Anti–Glomerular Basement Membrane Autoantibodies. MacDonald and Charytan, et al. Am J Kidney Dis. Vol 45, No 4 (April), 2005: 743-748
  • MacDonald B, Sund M, Grant M, Pfaff K, Holthaus K, Zon L, Kalluri R. Blood: Journal of the American Society of Hematology. Zebrafish to humans: evolution of the a3-chain of type IV collagen and emergence of the autoimmune epitopes associated with Goodpasture's Syndrome. MacDonald et al. Blood. 2006 March 1; 107(5):1908-15.
  • LeBleu V, MacDonald B, Kalluri R. Experimental Biology and Medicine. Structure and Function of Basement Membranes. LeBleu, MacDonald, et al. Exp Biol Med. 2007 Oct; 232(9):1121-9.
  • Xie L, Palmsten K, MacDonald B, Kieran MW, Potenta S, Vong S, Kalluri R. Experimental Biology and Medicine. Basement membrane derived fibulin-1 and fibulin-5 function as angiogenesis inhibitors and suppress tumor growth. Xie, Palmsten, MacDonald, et al. Exp Biol Med 2008 Feb; 233(2):155-62.

Professional/Educational Meetings/Abstracts

  • Mayo Clinic Angiogenesis Symposium, “From Bench to Bedside to Bench”                     Rochester, MN    
    Research Presenter                                                                                                   October 2004
    Selected to present a poster of my work investigating and comparing human and zebrafish tumstatin, endostatin, arresten, and canstatin. The research displayed the remarkable conservation between these zebrafish proteins and human proteins (which are currently being investigated as non-toxic cancer therapeutics). This work was valuable for elucidating key amino acids conserved between these analogous proteins despite 450 million years since the divergence of humans and zebrafish. These conserved similarities are critical to their function of inhibiting tumor progression. 


  • British Journal of Surgery- Invited Peer-Reviewer of Manuscript Submissions; Glasgow, U.K. (April 2013-Present)
  • University at Buffalo School of Medicine and Biomedical Sciences Dean’s Letter of Commendation (2007-2008 Academic Year)

Medical School Activities

  • American Medical Association

Extracurricular Interests

Hiking, Skiing, Fishing, Running, Working out, and enjoying anything outdoors.