Portrait of Lauren Burkard.

Lauren Burkard-Mandel

Department

Immunology - Roswell Park Comprehensive Cancer Center

Thesis Title

Tumor-derived Thymic Stromal Lymphopoietin Modulates Alveolar Macrophage Function in Neoplastic Disease

Residency

Medicine-Prelim, University at Buffalo
Radiology-Diagnostic, Case Western Reserve University

Undergraduate Education

Biomedical Sciences, University at Buffalo

Thesis Advisor

Research Description:

Tumor-derived factors that influence metastasis.

Publications

  • Banerjee D, Burkard L, Panepinto JC. Inhibition of nucleotide biosynthesis potentiates the antifungal activity of amphotericin B. PLoS One. 2014, Jan; 9(1): e87246. 
  • Burkard-Mandel L, O'Neill R, Colligan S, Seshadri M, Abrams SI. Tumor-derived Thymic Stromal Lymphopoietin Enhances Lung Metastasis through an Alveolar Macrophage-Dependent Mechanism. Oncoimmunology. 2018, Jan; 7(5): e1419115. 
  • Netherby CS*, Messmer MN*, Burkard-Mandel L, Miller A, Cortez Gomez E, Wang J, Nemeth MJ, Abrams SI. The Granulocyte Progenitor Stage Is a Key Target of IRF8-Mediated Regulation of Myeloid-Derived Suppressor Cell Production. Journal of Immunology. 2017, May; 198(10): 4129-4139. 
  • Twum D*, Burkard-Mandel L*, Abrams SI. The Dr. Jekyll and Mr. Hyde complexity of the macrophage response in disease. Journal of Leukocyte Biology. 2017, Aug; 102(2): 307-315.

Professional/Educational Meetings/Abstracts

  • Burkard-Mandel L, Abrams SI. (February, 2014). The role of tumor-derived TSLP in macrophage-tumor biology Po ster presented at: Translational Research Cancer Centers Consortium Annual Meeting; Seven Springs, PA, USA. 
  • Burkard-Mandel L, Abrams SI. (October, 2016). Tumor-derived TSLP augments metastasis by altering alveolar macrophage-dependent mechanisms Poster presented at: American Physician Scientists Association NE Regional Meeting; Buffalo, NY, USA. 
  • Burkard-Mandel L, Abrams SI. (June, 2016). Tumor-derived TSLP augments metastasis via macrophage-tumor interactions Poster presented at: Regulatory Myeloid Suppressor Cells Conference, Wistar Institute; Philadelphia, PA, USA. 
  • Burkard-Mandel L, Abrams SI. (July, 2016). Tumor-derived TSLP augments metastasis via macrophage-tumor interactions Poster presented at: RPCI Scientific Retreat; Ellicottville, NY, USA. 
  • Burkard-Mandel L, Abrams SI. (January, 2016). TSLP, a Novel Tumor-Secreted Cytokine, Manipulates the Host Macrophage Response to Enhance Metastasis Poster presented at: Roswell Park Tumor Immunology Department and Program Winter Retreat; Holiday Valley, NY, USA. 
  • Burkard-Mandel L, Abrams SI. (October, 2014). The role of tumor-derived TSLP in macrophage-tumor biology Pos ter presented at: Tri-Institutional M.D./Ph.D. Conference; Rochester, NY, USA. 
  • Burkard-Mandel L, Abrams SI. (April, 2014). The role of tumor-derived TSLP in macrophage-tumor biology Poster presented at: 13th Annual Buffalo Conference on Immunology; Chautauqua, NY, USA. 
  • Burkard-Mandel L, Abrams SI. (April, 2015). The role of tumor-derived TSLP in macrophage-tumor biology Poster presented at: 11th Annual APSA and ASCI/AAP Joint National Meeting; Chicago, IL, USA. 
  • Burkard-Mandel L, Abrams SI. (July, 2015). TSLP, a Novel Tumor-Secreted Cytokine, Manipulates the Host Macrophage Response to Enhance Metastasis Poster presented at: Roswell Park Comprehensive Cancer Center Science Retreat; Geneseo, NY, USA. 
  • Burkard-Mandel L, Abrams SI. (September, 2015). TSLP, a Novel Tumor-Secreted Cytokine, Manipulates the Host Macrophage Response to Enhance Metastasis Poster presented at: 18th Annual Upstate Immunology Conference; Buffalo, NY, USA. 
  • Burkard-Mandel L, Hakansson A. (November, 2011). ABC transporters with a lipoyl-domain are regulated by pneumococcal DLDH Poster presented at: AMA National Conference; New Orleans, LA, USA. 
  • Burkard-Mandel L, Hakansson A. (April, 2011). ABC transporters with a lipoyl-domain are regulated by pneumococcal DLDH Poster presented at: Celebration of Academic Excellence; Buffalo, NY, USA. 
  • Burkard-Mandel L. (February, 2017). Tumor-derived TSLP augments metastasis via macrophage-tumor interactions Oral Presentation presented at: Student Seminar Series; Buffalo, NY, USA. 
  • Burkard-Mandel L. (October, 2016). Tumor-derived TSLP augments metastasis by altering alveolar macrophage-dependent mechanisms Oral Presentation presented at: American Physician Scientist Association NE Regional Meeting; Buffalo, NY, USA. 
  • Burkard-Mandel L. (September, 2015). TSLP, a Novel Tumor-Secreted Cytokine, Manipulates the Host Macrophage Response to Enhance Metastasis Oral Presentation presented at: Upstate Immunology Conference; Bolton Landing, NY, USA.

Awards/Honors

  • Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral M.D./Ph.D. or Other Dual Doctoral Degree Fellowship (Parent F30) (2015-2019) 
  • Invited Speaker, American Physician Scientists Association (APSA) North East Regional Meeting (2016) 
  • Invited Speaker, Upstate Immunology Conference (2015) 
  • eBiosciences Travel Award, Upstate Immunology Conference (2015)
  • George Mayers Award for Academic Excellence, (2015)

Medical School Activities

  • 1) American Physician Scientists Association, Local Chapter President, Institutional Representative 
  • Lighthouse Manager 
  • American Medical Association, Medical Student Section

Extracurricular Interests

Cooking traditional Sicilian family recipes, hiking with my husband and our dog (a beagle mix), strength training and yoga