The role of calcineurin in normal myelination and disease.
I am working on my PhD in the lab of Lawrence Wrabetz, PhD, in the Hunter James Kelly Research Institute (HJKRI) at the University at Buffalo. My research focuses on Charcot Marie Tooth (CMT), a peripheral neuropathy that has no treatment and can be severely disabling. Particularly, I am working on understanding the mechanism that causes the demyelinating phenotype seen in CMT type 1 B- S63del mice. Deletion of a serine (S63del) in myelin protein zero (P0) causes accumulation of P0 in the endoplasmic reticulum of human and mouse Schwann cells, inducing a robust unfolded protein response (UPR). We have hypothesized that activation of protein kinase R-like endoplasmic reticulum kinase (PERK) by the UPR perturbs the promyelinating signaling pathway mediated by calcineurin and NFATc4. During my PhD work, I intend to further study the role of calcineurinin myelination throughout development in addition to its role in the pathogenesis of S63del and connection to the UPR.
Traveling, running, cooking, exploring Buffalo, spending time with family, friends, and my cats