Portrait of Chelsey Reed.

Chelsey Reed

Department

Neuroscience

Thesis Title

The role of calcineurin in normal myelination and disease.

Email

Undergraduate Education

Biological Sciences, University at Buffalo

Thesis Advisor

I am working on my PhD in the lab of Lawrence Wrabetz, PhD, in the Hunter James Kelly Research Institute (HJKRI) at the University at Buffalo. My research focuses on Charcot Marie Tooth (CMT), a peripheral neuropathy that has no treatment and can be severely disabling. Particularly, I am working on understanding the mechanism that causes the demyelinating phenotype seen in CMT type 1 B- S63del mice. Deletion of a serine (S63del) in myelin protein zero (P0) causes accumulation of P0 in the endoplasmic reticulum of human and mouse Schwann cells, inducing a robust unfolded protein response (UPR). We have hypothesized that activation of protein kinase R-like endoplasmic reticulum kinase (PERK) by the UPR perturbs the promyelinating signaling pathway mediated by calcineurin and NFATc4. During my PhD work, I intend to further study the role of calcineurinin myelination throughout development in addition to its role in the pathogenesis of S63del and connection to the UPR.

Publications

  • Eng JW.-L, Mace TA, Sharma R, Twum D, Peng P, Gibbs JF, Pitoniak R, Reed CB, Abrams SI, Repasky EA, Hylander BL. Pancreatic cancer stem cells in patient pancreatic xenografts are sensitive to drozitumab, an agonistic antibody against DR5. Journal for ImmunoTherapy of Cancer. Vol , No. 1: pg 33. June 21, 2016
  • Eng, Jason W-L., Chelsey B. Reed, Kathleen M. Kokolus, Rosemarie Pitoniak, Adam Utley, Mark J. Bucsek, Wen Wee Ma, Elizabeth A. RepaskyBonnie L. Hylander.  "Housing temperature-induced stress drives therapeutic resistance in murine tumour models through β2-adrenergic receptor activation." Nature communications 6 (2015).
  • Jason W.-L. Eng*Chelsey B. Reed*, Kathleen M. Kokolus, Elizabeth A. Repasky. "Housing temperature influences the pattern of heat shock protein induction in mice following mild whole body hyperthermia." International Journal of Hyperthermia 30.8 (2014): 540-546.
  • Eng, Jason W-L., Kathleen M. Kokolus, Chelsey B. Reed, Bonnie L. Hylander, Wen W. Ma, Elizabeth A. Repasky. "A nervous tumor microenvironment: the impact of adrenergic stress on cancer cells, immunosuppression, and immunotherapeutic response." Cancer Immunology, Immunotherapy 63.11 (2014): 1115-1128.

Professional/Educational Meetings/Abstracts

  • Chelsey Reed, Mariapaola Sidoli, M. Laura Feltri, Lawrence Wrabetz. The role of calcineurin in Schwann cells and myelination. Poster presentation at: Peripheral Nerve Society. July 22-25, 2018. 
  • Chelsey Reed, Mariapaola Sidoli, M. Laura Feltri, Lawrence Wrabetz. Understanding the role of calcineurin in a CMT1B mouse model. Poster presentation at: Society for Neuroscience. November 11-15, 2017. Washington DC 
  • Understanding the role of calcineurin in normal myelination and demyelinating neuropathy. Oral presentation for the SUNY at Buffalo Society for Neuroscience Research day. October 13, 2017. Buffalo, NY 
  • Chelsey Reed, Mariapaola Sidoli, Lawrence Wrabetz. Understanding the role of PERK and calcineurin in S63del CMT1B mouse model. Poster presentation at: Dept of Genetics, Genomics, and Bioinformatics Research Day. January 27, 2017. Buffalo, NY *poster competition winner 
  • Understanding the role of PERK and calcineurin in S63del CMT1B mouse model. Oral presentation for University at Buffalo Developmental Genetics and Genomics Seminar Series. January 20, 2017. Buffalo, NY 
  • Chelsey Reed, Jason Eng, Kathleen Kokolus, Elizabeth Repasky, Bonnie Hylander. Efficacy of gemcitabine in a mouse model of pancreatic cancer is lost at thermoneutrality: role of cold-stress in preclinical models. Poster presentation at: 16th Annual Upstate New York Immunology Conference October 20-23, 2013. Bolton Landing, NY 
  • Understanding the Differences in Chemotherapeutic Responses in Mouse Models and Patients. Oral presentation at: University at Buffalo’s Dept of Biological Sciences Honor’s Symposium. 2013 May 6; Buffalo, NY 
  • Chelsey Reed, Jason Eng, Kathleen Kokolus, Elizabeth Repasky, Bonnie Hylander. Understanding the difference in Gemcitabine response between mouse models and patients. Poster presentation at: The 30th Annual Society for Thermal Medicine Meeting, 2013 April 19. Aruba 
  • Chelsey Reed, Jason Eng, Bonnie Hylander, Elizabeth Repasky. Mechanisms of stress-induced inhibition of tumor therapeutic response. Poster presentation at: The Celebration of Academic Excellence. 2013 April 12; University at Buffalo, Buffalo, NY 
  • Chelsey Reed, Jason Eng, Bonnie Hylander, Elizabeth Repasky. Understanding metabolic stress-induced tumor response to therapy. Poster and oral presentation at: The 60th Annual Summer Research Program Research Symposium. 2012 Aug 9; Roswell Park, Buffalo, NY

Awards/Honors

  • F30 Ruth L. Kirschstein Individual Predoctoral NRSA for MD-PhD and other Dual Degree Fellowships Recipient 
  • Genetics, Genomics, and Bioinformatics Research Day Poster Presentation Winner, University at Buffalo 2017 
  • Co-winner of the International Journal of Hyperthermia Young Investigator Editor’s Award for Biology, 2015

Medical School Activities

  • APSA Buffalo Chapter Vice President, 2017-2018
  • APSA Fundraising Committee Member, 2017
  • APSA Buffalo Chapter Medical School Liason, 2014-2016
  • MD-PhD Program Medical Student Government Representative, 2014-2016
  • Nutrition Counselor at Good Neighbor's Free Clinic, 2015
  • Lighthouse Free Clinic, 2014-2016

Extracurricular Interests

Traveling, running, cooking, exploring Buffalo, spending time with family, friends, and my cats