Faculty Profiles

Vivian, Cody
Cody, Vivian, PhDProfessor, Structural Biology Department,Jacobs School of Medicine and Biomedical Sciences
Email: vcody@buffalo.edu
Phone: (716) 829-2519

Specialty/Research Focus:
Computational Chemistry; Drug Design; Structural Biology; X-ray Crystallography; Bioinformatics; Protein Folding

Research Summary:
The long-term goal of my research has been to understand the role of key active site residues in the mechanism of molecular recognition among various classes of proteins. The primary focus has been study of folate-dependent enzyme pathways, in particular dihydrofolate reductase (DHFR). These enzymes from pathogenic Pneumocystis species are of interest for the design of selective inhibitors for the treatment of AIDS-related pneumonia. Analysis of the structural data from several classes of protein has revealed a great degree of conformational flexibility for ligand binding that result in novel modes of binding to the same active site. Understanding the role of such flexibility has aided in the design of new scaffolds for inhibitor design. Additionally, my lab has the expertise to carry out the necessary molecular biology experiments to clone, express and purify proteins for crystallographic study using both bacterial and insect cell host systems. We have a long-standing, successful collaboration with the Queener lab to study DHFR, particularly from the opportunistic pathogens Pneumocystis jirovecii (pj) and Pneumocystis carinii (pc), found in man and rats, respectively. Our lab is also studying transthyretin (TTR), the thyroid hormone transport protein, characterizing the human protein bound to inhibitors with potential to stabilize the tetrameric structure and ameliorate the effects of filbril formation. Transthyrtetin from lamprey is of interest as it is thought to be the cross-over species in the change of function from a hydrolase to hormone transport function.

Andrew, Gulick
Gulick, Andrew, PhDAssociate Professor
Email: amgulick@buffalo.edu
Phone: (716)829-3696

Specialty/Research Focus:
Structural Biology; X-ray Crystallography; Microbial Pathogenesis; Microbiology; Protein Function and Structure; Proteins and metalloenzymes

Research Summary:
Our lab is interested in natural product biosynthesis and the fascinating proteins that bacteria use to make novel chemicals. We use a variety of techniques, including molecular and structural biology, as well as enzymology and other biophysical tools to understand protein structure and function. We are particularly interested in understanding the enzymatic basis for these biosynthetic pathways, as well as the role that novel compounds play in bacterial growth and pathogenesis.