Endocrinology, Diabetes and Metabolism; Neurodegenerative disorders; Pathophysiology; Endocrinology; Molecular Basis of Disease
Dr. Browne’s research is focused primarily on the clinical biochemistry of oxidative stress (OS) in human health and disease. Specifically, his research focuses on mechanisms of oxidative lipid damage and the antioxidant roles of high-density lipoproteins (HDL. This research includes pure biomarker method development and validation employing primarily high pressure liquid chromatography (HPLC) and liquid chromatography-mass spectrometry (LC-MS) along with collaborative clinical studies of the role of oxidative stress in cancer, infertility and women’s health, and neurological disease. Current studies on-going in Dr. Browne’s laboratory include investigations of the role of HDL and PON1 in embryo morphology outcomes during in vitro fertilization (IVF), a study of the role of oxysterols in Multiple Sclerosis disease progression and investigations of the role of bioactive lipid mediators in response to air pollution.
Endocrinology, Diabetes and Metabolism
Vascular cell reactivity encompassing platelet function, endothelial function, monocyte/macrophage function and the interactions between them (adhesion molecules viz lCAM, VCAM, P-selectin, L-selectin, E-selectin, etc.). Reactive Oxygen Species (ROS) in diabetes, atherosclerosis, hypertension, aging, infection, etc. and a consequential damage to lipids, proteins and DNA. Regulation of aromatase, the effect of estrogen on estrogen receptor, androgen receptor and glucocortico receptor (elucidationi of pre- and post-receptor mechanisms in menopause, etc.). Venous reactivity with measurements of venous diameter and flow velocity and the effect of various drugs in NIDDM, IDDM, and IGT. Genetic regulation of aromatase and estrogen receptor. The role of nitric oxide in vascular reactivity, vis-a-vis various complications of diabetes and other factors involved with vascular reactivity. Effects of endotoxin on adhesion molecules, PAF, platelets, ROS and procalcitonin.
Endocrinology, Diabetes and Metabolism; Psychiatry; Behavioral pharmacology; Endocrinology; Neurobiology
My research is broadly concerned with studies of the biology of affective disorders and the development of biological markers and clinical laboratory tests for major depressive disorder. Hormonal modulation of brain and behavior with the emphasis on gonadal hormones and the hypothalamic-pituitary-adrenal system neurotransmitter and their metabolites. A second area of work involves studies of premenstrual changes and menopause and hormone related changes in mood and behavior in women. Studies include: influence of hormonal replacement therapy; the development of clinical and diagnostic procedures; the association between gonadal hormones and other hormones, their change over time and clinical pathology, and the relationship between affective symptomatology during periods of change in the woman‘s life cycle and affective disorders.
Endocrinology, Diabetes and Metabolism
I am a board-certified endocrinologist with a special interest in diabetes and thyroid- and cancer-associated endocrinological issues. My clinical expertise is in diabetes, thyroid nodules and the endocrine side effects of cancer drugs. I work in tandem with a team of nurses, certified diabetes educators (CDEs) and physicians to provide the best possible care to my endocrine patients. I see patients at UBMD Internal Medicine at the Conventus Center for Collaborative Medicine located on Main St. in Buffalo. I have a simple approach toward my patients: I want them to see me as a true friend for whom their health is a top priority. I get to know my patients by asking about their hobbies, travel plans and daily chores. I avoid medical terminologies so that we can communicate without confusion and develop as equal partners in their care. I believe that the relationships I develop with my patients, along with aggressive care, help prevent long-term complications and facilitate excellent diabetes-related outcomes--in many instances avoiding amputations or stopping diabetes from progressing to chronic kidney disease (CKD). My current research interests include checkpoint inhibitors (as a new cancer therapy), related endocrine dysfunction and the methods to recognize and manage these toxicities. I encourage residents and fellows to work with me on small research projects and present them at national meetings. I teach medical students and residents on topics related to endocrine issues in adult patients. I also lecture to residents and fellows on diabetes, thyroid disorders and endocrine-related cancers. I emphasize with all my trainees that patients benefit maximally if health care professionals work as a team: team work minimizes errors, and it also elicits new ideas.