Pediatric Surgery; Pediatric Urology; Pulmonary Disease; Surgery; Surgical Critical Care - Surgery; Thoracic Surgery; Surgery - Trauma; Surgery - Laparoscopic; Prenatal Diagnosis; Fetal Surgery; Miniature Access Surgery; Cell growth, differentiation and development; Molecular Basis of Disease
-To be a recognized leader in academic pediatric surgery (clinical surgery, clinical/basic science research, teaching and administration), -To build a state of the art surgical department, divisions, and programs congruent withthe mission goals, and needs of institutions (university, hospital, other departments), patients and their families and faculty (full time and volunteer) -To create the requiste environment for students, residents, and faculty to optimize career development -To maintain a busy clinical pratice of open and miniature access surgery for fetuses, infants, children -To cross train students (MD, RN, DDS, Phar D.,MPH, Basic Science, Residents and Fellows(all specialties), Faculty (all Health Science Schools),and Community Healthcare Professionals in the requisite MBA Skill Sets, Entrepreneurism, and Big Data analysis to optimize their professional development, careers and their patients‘ outcomes in this complicated and ever changing Healthcare environment -To be actively involved in teaching and practicing Interprofessional Care (IPC) and Interprofessional Education (IPE) -To continue to train and mentor academic gerneral surgeons -To continue to train and mentor academic pediatric surgeons -To continue to teach and mentor students at various levels -To continue laboratory and clinical incestifations in the following areas: lung development, congenital diaphragmatic hernia, fetal physiology, birth defects, prenatal diagnosis of surgical problems, fetal surgery, the genetic aspects of surgical disease, fetal frowth factors, the physiology miniature access surgery, surgical robotics, ECMO, trauma, the education process for students, residents, and fellows virtual reality, surgical simulation, telelmedicine, telesurgery, teleconferencing, telementoring, and computer applications in medicein -To continue research and development with corporate biomedical parners -To continue to advocate for children and children‘s health care
Critical Care Medicine; Pulmonary & Critical Care Medicine; Internal Medicine; Pulmonary Disease; Pulmonary; Bioinformatics
I am engaged in clinical, teaching and research responsibilities related to the evaluation and treatment of patients with pulmonary disease or patients who are critically ill. My inpatient practice is primarily located at the medical intensive care unit (MICU) at the Buffalo General Medical Center (BGMC). The MICU provides ongoing medical care to patients who are critically ill and require significant life support therapies to sustain life or vital bodily functioning. I am specifically interested in asthma, COPD and lung cancer, but deal with a variety of disease. I evaluate patients with pulmonary disorders including shortness of breath, lung masses, abnormal chest imaging, abnormal pulmonary function tests, chronic obstructive pulmonary disease (COPD), asthma, interstitial lung disease, pulmonary hypertension and lung cancer, at the lung and heart outpatient clinic located in BGMC. The pulmonary team to which I belong also provides inpatient pulmonary consultation at both BGMC and Roswell Park Cancer Institute. Currently I am pursuing additional training in the analysis of Big Data in medical/healthcare fields. I am particularly focused on the application of drug repurposing in translation and clinic research. I also am heavily focused on the specific analysis of large VA associated clinical and genomic data sets as a fellow in the VA and NCI sponsored Big-Data Scientist Enhancement Program. I am engaged in the study of the human airways microbiome and metagenome. The human microbiome is the the collection of all the microbial organisms in a human body, and the corresponding metagenome is the collection of the genes, and gene products of the microbes. Due the potential impact of the microbiome on human health and disease, I am interested in studying the putative effects the interaction with human hosts, specifically innate immunity interaction with the metagenome in lung disease. Additionally, I collaborate with the Division of Allergy and Immunology and the Institute of Laser, Photonics and Biophotonics to elucidate immune cell function in airway diseases such as asthma and COPD. Our research focuses on the development of therapeutics aimed at novel targets identified as important in the molecular basis of pulmonary disease; efficacious laboratory results will generate more effective treatment plans for patients. I am actively involved in teaching medical students, residents and fellows about the appropriate care of the critically ill patient, as these trainees rotate in the MICU.
Internal Medicine; Pulmonary Disease; Infectious Disease
My area of expertise is in infectious diseases in adults and I evaluate and treat adults with all infections, without restriction to a special area, and see patients within the Veterans Affairs hospital system. I act as a consultant for other physicians treating patients who have, or are suspected to have, infectious diseases in hospital settings or outside the hospital. Prior to becoming an infectious disease specialist, I had training and work experience in surgery as well as internal medicine. This exposure has helped me in my current clinical practice since infections occur in patients after surgical procedures. Having a firsthand understanding of what surgeons do allows me to understand the patient’s overall situation better. I teach first- and second-year medical students, primarily in pulmonary, in small group sessions. My research is focused on bacterial infections in patients with chronic obstructive pulmonary disease (emphysema and chronic bronchitis, known also as COPD). I am especially interested in how the host (the human body) reacts to the pathogen (the bacteria), and how differences in the host determine the outcome of the encounter between host and pathogen. Recently, we found that airway epithelial cells from patients with COPD respond to pathogenic bacteria in a manner that is different from healthy, non-COPD people. My goal is to further characterize and understand the cellular mechanisms underlying this aberrant behavior in COPD. I expect this research to open new avenues of therapy specially tailored to intervene in the host-pathogen interaction. Students and fellows have the opportunity to conduct research with me. I collaborate with Sanjay Sethi, MD and Charles Berenson, MD from the department of medicine and with Anders Hakansson, PhD, from the department of microbiology and immunology.