Study: Brain Lesion Atrophy Could Mean Worsening MS

Updated August 21, 2018

New UB research has shown that, for patients with multiple sclerosis, the disappearance of lesions into the cerebrospinal fluid is a better indicator of who will develop disability than the appearance or expansion of the lesions, and quotes Robert Zivadinov, professor of neurology. “Using the appearance of new brain lesions and the enlargement of existing ones as the indicator of disease progression, there was no sign of who would develop disability during five or 10 years of follow-up, but when we used the amount of brain lesion volume that had atrophied, we could predict within the first six months who would develop disability progression over long-term follow-up,” said Zivadinov, who serves as director of the Buffalo Neuroimaging Analysis Center (BNAC) in the Jacobs School of Medicine and Biomedical Sciences and directs the Center for Biomedical Imaging at UB’s Clinical and Translational Science Institute (CTSI).