Xiuqian Mu MD, PhD

Xiuqian Mu

Xiuqian Mu
MD, PhD

Associate Professor

Department of Ophthalmology

Jacobs School of Medicine & Biomedical Sciences


Specialty/Research Focus

Bioinformatics; Cell growth, differentiation and development; Gene Expression; Genomics and proteomics; Molecular genetics; Stem Cells; Transcription and Translation; Transgenic organisms; Vision science

Contact Information
701 Ellicott Street
Rm B4-307
Buffalo, NY 14203
Phone: 716-881-7463
Fax: 716-849-6651
xmu@buffalo.edu



Professional Summary:

We are interested in the fundamental mechanisms underlying the shift of cellular states from progenitors to fully functional mature cell types along individual cell lineages during development. We address this issue by studying cell fate specification and differentiation in the developing neural retina. Our efforts are on identifying key regulators, uncovering their roles in individual lineages, and understanding how they carry out these roles. One area of our research is focused on how transcription factors influence the epigenetic landscape along the retinal ganglion cell lineage. We have also begun to investigate how posttranscriptional control of gene expression affects retinal cell differentiation. We conduct our research using a combinatorial approach encompassing genetics, molecular biology, genomics, and bioinformatics. Most recently we are using single cell RNA-seq and single ATAC-seq technologies extensively to address the fundamental questions in retinal development.

Education and Training:

  • PhD, Biochemistry and Molecular Biology, Peking Union Medical College (1994)
  • MD, Medicine, Qingdao Medical College (1989)

Employment:

  • Associate Professor (with tenure), Ophthalmology, University at Buffalo, School of Medicine and Biological Sciences (2015-present)
  • Assistant Professor, Ophthalmology, University at Buffalo, School of Medicine and Biological Sciences (2008–2015)
  • Assistant Professor, Biochemistry and Molecular Biology, The University of Texas MD Anderson Cancer Center (2003–2008)
  • Instructor, Biochemistry and Molecular Biology, The University of Texas MD Anderson Cancer Center (2002–2003)
  • Postdoctoral Associate, Biochemistry and Molecular Biology, The University of Texas MD Anderson Cancer Center (1999–2001)
  • Postdoctoral Fellow, National Institutes of Health (1994–1999)

Research Expertise:

  • Developmental biology: mouse retinal development, neural development, cell fate specification, cell differentiation
  • Genomics: genomics, transcriptomics, epigenomics, single cell RNA-seq, single cell ATAC-seq
  • Molecular biology: gene regulation, transcription factors, enhancers, epigenetics, post-transcriptional regulation
  • Mouse genetics: genetically modified mice, gene targeting, CRISPR/cas9, genetic labeling

Research Centers:

  • Ira G. Ross Eye Institute Research Center
  • Center of Excellence in Bioinformatics and Life Sciences

UB 2020 Strategic Strengths:

  • Molecular Recognition in Biological Systems and Bioinformatics

Grants and Sponsored Research:

  • April 2020–March 2024
    Regulation of mRNA decay in retinal development and maintenance
    National Eye Institute
    Role: Principal Investigator
    $2,024,085
  • September 2017–May 2022
    Regulatory mechanisms for retinal ganglion cell genesis
    National Institutes of Health
    Role: Principal Investigator
    $1,960,167
  • June 2016–May 2018
    Generation of retinal ganglion cells by direct reprograming
    BrightFocus Foundation
    Role: Principal Investigator
    $150,000
  • March 2011–February 2016
    Interaction of Isl1 and Pou4f2 in retinal development
    National Institutes of Health
    Role: Principal Investigator
    $1,950,000
  • January 2013–December 2014
    Function of Onecut transcription factors in retinal development and vision
    SUNY Research Foundation
    Role: Principal Investigator
    $100,000
  • January 2010–December 2013
    Molecular mechanism for the formation of retinal ganglion cells
    The Whitehall Foundation
    Role: Principal Investigator
    $225,000
  • January 2009–December 2009
    Math5 target genes in retinal ganglion cell formation
    The Glaucoma Foundation
    Role: Principal Investigator
    $40,000
  • July 2005–June 2007
    Investigating retinal ganglion cell development using purified progenitor cells
    The E. Matilda Ziegler Foundation for the Blind
    Role: Principal Investigator
    $210,000

Journal Articles:

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Contact Information

701 Ellicott Street
Rm B4-307
Buffalo, NY 14203
Phone: 716-881-7463
Fax: 716-849-6651
xmu@buffalo.edu