Periprosthetic joint infection (PJI) is a devastating outcome of total joint arthroplasty that gives rise to increased patient morbidity and rising costs to the health care system. PJI can develop clinically, even in the presence of antibiotic treatment, and antibiotic resistance of bacterial biofilms limits the effectiveness of available treatment methods for implant-associated orthopaedic infections. The current treatment for refractory joint infections involves removal of the implant, debridement of the tissue, immobilization of the patient and prolonged antibiotic therapy.
Previous work from our lab has shown cathodic voltage-controlled electrical stimulation (CVCES) of commercially pure titanium is an effective method to eradicate and prevent the association of gram-positive or gram-negative pathogens to the titanium surface in vitro and in vivo. Gram-negative Acinetobacter baumannii (A. baumannii) is a multidrug-resistant pathogen known to cause healthcare and nosocomial-acquired infections, including PJI. We have shown a time and magnitude-dependent effect of CVCES against A. baumannii; however, little is known about the mechanistic bacterial response to the stimulation.
My research goal is to characterize the changes in gene expression that occur in A. baumannii following exposure to CVCES to further understand the effect of this technology and its utility against other multi-drug resistant orthopaedic implant associated pathogens.
Mary Canty, PhD
955 Main Street, Suite 5209
Phone: (716) 829-2673