Speaker:
Anindita Basu, Ph.D.,
Assistant Professor, Genetic Medicine
University of Chicago
Host: Michael Buck
Title: Our efforts in creating Human Cell Atlases: Lessons learned and future directions
Abstract: We are performing matched single-cell gene expression and chromatin accessibility assays in three organs: heart (atrial and ventricular walls, septum, apex), gut (terminal ileum, ascending colon, mesenteric fat), and the female reproductive system (fallopian tube, ovary, uterus), using surgical tissues and pinch biopsies. We then compare our findings from healthy tissues to diseases and patients: in inflammatory bowel disease (in the gut) and ovarian cancer (in the female reproductive system). These studies allow us to examine gene expression patterns and their regulatory elements in different disease loci across cell-types, as well as tissue-specific functions and pathways between shared cell-types.
Sara Thomas
Email: msthomas@buffalo.edu