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Karin                          Provost

Karin Provost DO, PhD

Department of Medicine

Research Assistant Professor

Specialty/Research Focus

Immunology; Membrane Transport (Ion Transport); Pulmonary & Critical Care Medicine

Professional Summary:

My clinical responsibilities include working as one of five Intensive Care Unit physicians at the Buffalo VA Medical Center (Buffalo VAMC). I also have a pulmonary medicine outpatient clinic at the UBMD multispecialty practice in Williamsville.

My outpatient clinic accepts all patients, with a focus on interstitial lung disease (associated with collagen vascular disorders such as systemic lupus erythematousus [SLE]), scleroderma, rheumatoid arthritis, Sarcoidosis, the idiopathic pulmonary pneumonitis syndromes (IPF/UIP) and advanced chronic obstructive pulmonary disease (COPD). We are one of the founding sites of the Greater New York Sarcoidosis Consortium and work closely with our neurology colleagues in managing patients with respiratory complications of neuromuscular disorders such as ALS, Duchenne‘s Muscular Dystrophy and others.

I focus my research on understanding the impaired immune response to infection that occurs in patients with COPD. This impaired immune response leads to more frequent disease exacerbations and more rapid disease progression. My lab has optimized a noninvasive macrophage model (monocyte-derived macrophage) to study how to restore the immune function of alveolar macrophages in patients with COPD. Using this model, we study cell surface receptor expression, cytokine responses and intracellular signaling using flow cytometry, bead arrays and molecular biology techniques.

My research team collaborates with Dr. Sanjay Sethi and other researchers in the areas of pulmonary, sleep medicine, critical care, infectious disease and microbiology. Undergraduates, medical students, residents and fellows are welcome in my lab.

I am committed to teaching the next generation of physicians. I teach medical students in years two through four; in addition, I teach the residents and the pulmonary and critical care medicine fellowship trainees who rotate with me on the inpatient and outpatient services. I also teach the internal medicine and anesthesia residents and provide grand rounds lectures for the Buffalo VAMC, Buffalo General Medical Center and Erie County Medical Center.

I serve on the Resident Clinical Competency Committee and as a formal resident advisor, shepherding my mentees through residency and helping them launch their professional careers. My door is always open to any trainee at any level.

Education and Training:
  • PhD, Investigative Medicine, Yale University School of Graduate Studies (2010)
  • Fellowship, Pulmonary and Critical Care, Yale University School of Medicine (2006)
  • Residency, Categorical Internal Medicine, George Washington University Hospital (2002)
  • Internship, Categorical Internal Medicine, George Washington University Hospital (2000)
  • DO, Medicine, Midwestern University, Chicago College of Osteopathic Medicine (1999)
  • BS, Molecular and Cellular Biology, University of Arizona, Cum Laude (1995)
  • Research Assistant Professor, Division of Pulmonary, Critical Care and Sleep Medicine, State University of New York (2008-present)
Awards and Honors:
  • F. Carter Pannill Jr MD Outstanding Teaching Award to Junior Faculty (2011)
  • American Thoracic Society Fellows Career Development Award (2007)
  • Ruth L. Kirshstein National Service Award (2005)
  • Undergraduate Summer Research Program (1994)
  • Golden Key National Honor Society (1993)
  • Alpha Epsilon Delta (1993)

Research Expertise:
  • Characterization of alveolar macrophages
  • Clinical studies in sarcoidosis
  • Host immunity in COPD
Grants and Sponsored Research:
  • November 2013–December 2013
    ASPIRE Young Investigator AwardDefining the Epidemiologic Burden of Streptococcus Pneumoniae Colonization and Infection in COPD
    Role: Principal Investigator
  • May 2011–May 2013
    VA Cooperative Study No. 574ESCAPe [Extended Steroid (in) CAP(e)]
    Veterans Administration
    Role: Co-Investigator
  • April 2011–April 2013
    Defining the Mechanisms of the Increased Risk of Community Acquired Pneumonia in COPD Patients Treated with Inhaled Corticosteroids
    Astra Zeneca
    Role: Principal Investigator
  • December 2010–December 2012
    Defining a Role for Inhaled Calcium in Augmenting the Alveolar Macrophage Innate Immune Response to Infection in COPD
    Role: Principal Investigator
  • July 2009–June 2012
    A six month Randomized Controlled Trial of Lung Flute in Patients with COPD
    Medical Acoustics, Inc
    Role: Co-Investigator
  • September 2007–September 2008
    American Thoracic Society Fellows Career Development Award
    American Thoracic Society
    Role: Co-Investigator
  • August 2005–August 2007
    F32 Ruth L. Kirshstein National Research Service Award
    Role: Co-Investigator
  • July 2003–July 2005
    T32 Institutional National Research Service Award
    Role: Co-Investigator

Journal Articles:
Books and Book Chapters:
  • Provost K, El Solh AA. Complications Associated with Mechanical Ventilation..
  • Provost K Desai H Sethi S. Infectious Mechanisms Regulating Susceptibility to AECOPD..
  • Kraskovsky V., Smith M., Sethi S, Provost K. Differences in COPD blood monocyte populations do not affect maturation to mature tissue macrophage by ex-vivo GMCSF. ATS International Conference, San Francisco, CA. 2016.
  • Provost K, Smith M., Mohan A., Sahib K., Conway S., Sethi S. The Epidemiologic Burden of Streptococcus Pneumoniae Colonization and Infection in Chronic Obstructive Pulmonary Disease. ATS International Conference, Denver, CO. 2015.
  • Provost K, Smith M., Kaushal G., Arold S.P., Hava D.L., Sethi S. Extracellular Calcium During Bacterial Challenge Augments The Innate Immune Response Of Monocyte Derived Macrophages. ATS International Conference, San Francisco, CA. 2012.
  • Karin A. Provost DO,PhD, Miyuki Smith, Anna Miller-Larsson PhD, Gregory D. Gudleski PhD, Sanjay Sethi MD. Bacterial regulation of pathogen recognition receptors in macrophages in COPD are differentially modified by budesonide and fluticasone propionate ex vivo..

Professional Memberships:
  • Society for Clinical and Translational Science; Member (2010–present)
  • American College of Chest Physicians; Fellow (2009–present)
  • Society of Critical Care Medicine; member (2003–2008)
  • American College of Chest Physicians; Member (2002–2008)
  • American Thoracic Society; Member (2002–present)
  • "The Epidemiologic Burden Of Streptococcus Pneumoniae Colonization And Infection In Chronic Obstructive PulmonaryDisease" American Thoracic Society Annual Conference (2015)
  • "When and How to Evaluate for Immunodeficiency in Adult Lung Disease" American Thoracic Society, Sunrise Seminar (2015)
  • "2013 “Extracellular calcium Augments the Innate Immune Response of Monocyte Derived Macrophages in Patients with COPD By Augmenting Pattern Recognition Receptor Expression" American Thoracic Society Annual Conference (2013)
  • "Extracellular Calcium During Bacterial Challenge Augments the Innate Immune Response of Monocyte Derived Macrophages" American Thoracic Society Annual Meeting, American Thoracic Society, Clinical Problems Assembly (2012)
  • "IFN-Gamma Inhibits Goblet Cell Differentiation" Annual Meeting, American Thoracic Society (2011)
  • "Interferon Gamma acts on the Airway Epithelium to Regulate Allergic Airway Inflammation" Annual Meeting, American Thoracic Society (2010)
  • "Interferon Gamma Inhibits Th2 Induced Mucus Metaplasia in vivo Through Effects on Epithelial IL-4 and IL-13 Receptor Expression, and Inhibition of Stat-6 Phosphorylation" Annual Meeting, American Thoracic Society (2010)
  • "Interferon Gamma Modulates Allergic Airway Disease through Effects on the Airway Epithelium" Keystone Symposia, Immunology, Allergy and Asthma (2009)
  • "Interferon Gamma Inhibits Mucus, Esoinophilia and Chitinase Activity by Multiple Different Mechanisms" Annual Meeting, American Thoracic Society (2005)
  • "Formal Resident Central Line Procedure Training Increases Confidence and Knowledge in Internal Medicine Housestaff" Annual Meeting, Society of General Internal Medicine (2002)
  • "Elucidating a Role for p53 in Bone Differentiation and a Potential role in the Treatment of Osteosarcoma" Annual Meeting, American Association of Cancer Researchers (1997)
See all (1 more)
Service Activities:
  • Editorial Board Member; OMICS Group, Journal of Occupational Medicine and Health Affairs; Editorial Board Member (2012–present)
  • Project Review Committee; Review Scientific Merit of research proposals submitted to the VAWNY Research Program; Peer Reviewer (2012–present)
  • American Thoracic Society Program Committee, Clinical Problems Assembly; Programming for the American Thoracic Society Annual Meeting. Including review and rating of all abstracts submitted, review of session topic submissions and planning of selected abstracts into educational sessions; Member (2012–present)
  • Journal Reviewer; Reviewer, Current Respiratory Medicine Reviews; Peer Reviewer (2012–present)
  • Journal Reviewer; Journal of Hospital Medicine; Peer Reviewer (2012–present)
  • Journal Reviewer; British Journal of Medicine and Medical Research; Peer Reviewer (2012–present)
  • Journal Reviewer; The Open Respiratory Medicine Journal; Peer Reviewer (2011–present)
  • Institutional Review Board; Reviewing research proposals for safety and scientific integrity; Member (2010–present)
  • Faculty Advisor; Faculty advisor to Internal Medicine residents. Meet with them annually to review rotation evaluations, 360 evaluations, in-service exam scores. Review career plans, provide guidance on fellowship acquisition, transition between intern and resident mode and from resident to attending. Provide research guidance, identify research mentors, resolve career and personal issues as they arise throughout the residency training.; Advisor (2009–present)
  • Housestaff Evaluation Committee; Review each individual resident bi-annually for appropriate progression and advancement based on rotation reviews, 360 evaluations, inservice exam scores; Committee Member (2009–present)

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Contact Information

VA WNY Healthcare System
3495 Bailey Avenue
Buffalo, NY 14215
Phone: (716) 862-8634
Fax: 716-862-8632

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