David M. Mattson, Jr. MD
David M. Mattson, Jr.
MD
Clinical Associate Professor, University at Buffalo School of Medicine
Department of Radiation Oncology
Jacobs School of Medicine & Biomedical Sciences
Specialty/Research Focus
Radiation Medicine; Radiation Oncology
Education and Training:
- BA, University of Hawaii at Manoa
- MD, John A. Burns School of Medicine, University of Hawaii at Manoa
Employment:
- Program Director, Roswell Park Cancer Institute (2016-present)
- Assistant Professor, Radiation Medicine, Roswell Park Cancer Institute University at Buffalo School of Medicine (2012-present)
- Associate Program Director, Roswell Park Cancer Institute (2015–2016)
- Assistant Professor, Radiation Medicine, Roswell Park Cancer Institute University at Buffalo School of Medicine (2008–2012)
- Resident, Department of Radiation Oncology, University of Iowa Hospitals and Clinics (2004–2008)
- Research Fellow, Radiation Oncology Sciences Program, National Institutes of Health (2002–2003)
- Intern, Department of General Surgery, SUNY Health Sciences Center at Syracuse (2001–2002)
Awards and Honors:
- B. Leonard Holman Research Pathway Resident in Radiation Oncology (2008)
- RSNA Research & Educational Foundation Roentgent Resident Research Award (2007)
- ASTRO Translational Research Symposium Travel Award (2006)
- NIH Young Investigator Workshop Travel Award (2005)
Grants and Sponsored Research:
- January 2006–January 2007
RSNA Research and Education Foundation Holman Pathway Resident Research Seed Grant (HPSD0602)
RSNA
Role: Consultant - January 2012
Phase II Trial of Single Fraction Radiation Therapy (SFRT) at Roswell Park Cancer Institute for Select Patients with Early Stage Breast Cancer
Cianna Medical Research
Role: Consultant
Journal Articles:
- Al-Sukhni E, Attwood K, Mattson DM, Gabriel E, Nurkin SJ. (2016) Predictors of Pathologic Complete Response Following Neoadjuvant Chemoradiotherapy for Rectal Cancer. Ann Surg Oncol (Apr), 23(4): 1177-1186.
- Kukar, M., Alnaji, R.M., Jabi, F., Platz, T.A., Attwood, K., Nava, H., Ben-David, K., Mattson, D., Salerno, K., Malhotra, U., Kanehira, K., Gannon, J., Hochwald, S.N. (2015) Role of Repeat 18F-Fluorodeoxyglucose Positron Emission Tomography Examination in Predicting Pathologic Response Following Neoadjuvant Chemoradiotherapy for Esophageal Adenocarcinoma. JAMA (Jun), 150(6): 555-562.
- Khoury, T., Karabakhtsian, R.G., Mattson, D., Yan, L., Syriac, S., Habib, F., Liu, S., Desouki, M.M. (2014) Pleomorphic lobular carcinoma in situ of the breast: clinicopathological review of 47 cases. Histopathology (Jun), 64(7): 981-993.
- Khoury T, Karabakhtsian RG, Mattson D, Yan L, Syriac S, Habib F, Liu S, Desouki MM, Mattson, Jr. DM. (2014) Pleomorphic lobular carcinoma in situ of the breast: clinicopathological review of 47 cases. Histopathology (Jun), 64(7): 981-993.
- Schnur JB, Graff Zivin J, Mattson DM, Green S, Jandorf LH, Wernicke AG, Montgomery GH. (2012) Acute skin toxicity-related, out-of-pocket expenses in patients with breast cancer treated with external beam radiotherapy: a descriptive, exploratory study. Support Care Cancer (Dec), 20(12): 3105-3113.
- Scarbrough PM, Mapuskar KA, Mattson DM, Gius D, Watson WH, Spitz DR. (2012) Simultaneous inhibition of glutathione- and thioredoxin-dependent metabolism is necessary to potentiate 17AAG-induced cancer cell killing via oxidative stress. Free Radic Biol Med (Jan), 52(2): 436-443.
- Wilson, J.P., Mattson, D., Edge, S.B. (2011) Is there a need for axillary dissection in breast cancer?. J Natl Compr Canc Netw (Feb), 9(2): 225-230.
- Simons AL, Mattson DM, Dornfeld K, Spitz DR. (2009) Glucose deprivation-induced metabolic oxidative stress and cancer therapy. J Cancer Res Ther (Sep), 5 Sup: 2-6.
- Mattson DM, Ahmad IM, Dayal D, Parsons AD, Aykin-Burns N, Li L, Orcutt KP, Spitz DR, Dornfeld KJ, Simons AL. (2009) Cisplatin combined with zidovudine enhances cytotoxicity and oxidative stress in human head and neck cancer cells via a thiol-dependent mechanism. Free Radic Biol Med (Jan), 46(2): 232-237.
- Simons AL, Fath MA, Mattson DM, Smith BJ, Walsh SA, Graham MM, Hichwa RD, Buatti JM, Dornfeld K, Spitz DR. (2007) Enhanced response of human head and neck cancer xenograft tumors to cisplatin combined with 2-deoxy-D-glucose correlates with increased 18F-FDG uptake as determined by PET imaging. Int J Radiat Oncol Biol Phys (Nov), 69(4): 1222-1230.
- Simons AL, Ahmad IM, Mattson DM, Dornfeld KJ, Spitz DR. (2007) 2-Deoxy-D-glucose combined with cisplatin enhances cytotoxicity via metabolic oxidative stress in human head and neck cancer cells. Cancer Res (Apr), 67(7): 3364-3370.
- Terada, K., Mattson, D., Goo, D., Shimizu, D. (2004) DNA Aneuploidy is Associated with Increased Mortality for Stage I Endometrial Cancer. Gynecol Oncol (Dec), 95(3): 483-487.
- Gius, D., Cui, H., Bradbury, C.M., Cook, J., Smart, D.K., Zhao, S., Young, L., Brandenburg, S.A., Hu, Y., Bisht, K.S., Ho, A.S., Mattson, D., Sun, L., Munson, P.J., Chuang, E.Y., Mitchell, J.B., Feinberg, A.P. (2004) Distinct effects on gene expression of chemical and genetic manipulation of the cancer epigenome revealed by a multimodality approach. Cancer Cell. (Oct), 6(4): 361-371.
- Smart, D.K., Ortiz, K.L., Mattson, D., Bradbury, C.M., Bisht, K.S., Sieck, L.K., Brechbiel, M.W., Gius, D. (2004) Thioredoxin reductase as a potential molecular target for anticancer agents that induce oxidative stress. Cancer Res (Sep), 64(18): 6716-6724.
- Gius, D., Mattson, D., Bradbury, C.M., Smart, D.K., Spitz, D.R. (2004) Thermal stress and the disruption of redox-sensitive signaling and transcription factor activation: possible role in radiosensitization. Int J Hyperthermia (Mar), 20(2): 213-223.
- Mattson, D., Bradbury, C.M., Bisht, K.S., Curry, H.A., Spitz, D.R., Gius, D. (2004) Heat shock and the activation of AP-1 and inhibition of NF-kappa B DNA-binding activity: possible role of intracellular redox status. Int J Hyperthermia (Mar), 20(2): 224-233.
- Bisht, K.S., Bradbury, C.M., Mattson, D., Kaushal, A., Sowers, A., Markovina, S., Ortiz, K.L., Sieck, L.K., Isaacs, J.S., Brechbiel, M.W., Mitchell, J.B., Neckers, L.M., Gius, D. (2003) Geldanamycin and 17-allylamino-17-demethoxygeldanamycin potentiate the in vitro and in vivo radiation response of cervical tumor cells via the heat shock protein 90-mediated intracellular signaling and cytotoxicity. Cancer Res (Dec), 63(24): 8984-8995.
Professional Memberships:
- American Brachytherapy Society (2009–present)
- American College of Radiation Oncology (2009–present)
- American Society of Therapeutic Radiation Oncology (2004–present)
- American Medical Association (1997–present)
Presentations:
- "Breast Cancer" Annual Dosimetrist Training Program Lecture; Roswell Park Cancer Institute; Dosimetrists (2012)
- "Strut-Adjusted Volume Implant (SAVI) Technique at Roswell Park Cancer Institute" ; Roswell Park Cancer Institute (2012)
- "Current Status of Accelerated Parital Breast Irradiation" 12th Annual Conference on Radiation Oncology for Therapists and Dosimitrists; Roswell Park Cancer Institute (2011)
- "Current Status of Accelerated Parital Breast Irradiation" Surgical Grand Rounds; Roswell Park Cancer Institute (2011)
Service Activities:
- Program Evaluation Committee; Member (2013–present)
- Scientific Review Committee; Member (2012–present)
- Conflict of Interest Committee; Member (2011–present)
- Project Cancer Education Program Committee; Member (2010–present)
- Institutional Review Board; Member (2009–present)