Devrim Acehan
Devrim Acehan
Research Assistant Professor
Department of Structural Biology
Jacobs School of Medicine & Biomedical Sciences
Professional Summary:
Research interests include development of single particle and tomography cryogenic electron microscopy methods for challenging samples. In particular, we are interested in improving three-dimensional structures for low copy number biological structures in isolation and within cells. We are also working to find ways to obtain three-dimensional structures of very small protein molecules in isolation. Also, in collaboration with other researchers at the HWI, we develop methods to increase the success rates of micro-crystal electron diffraction experiments. At the HWI Cryogenic Electron Microscopy Center, we provide high throughput sample screening, data collection and analysis for biological samples from many research groups.
Education and Training:
- Other, Postdoctoral Training, New York University (2009)
- Other, Postdoctoral Training, Boston University (2003)
- PhD, Biophysics, Boston University (2002)
- BS, Physics, Bilkent University (1997)
Employment:
- Research Assistant Professor, Structural Biology, University at Buffalo (2024-present)
- Adjunct Associate Professor, Biochemistry and Biophysics, University of Rochester (2023-present)
- Director of Cryo-EM Center, Hauptman Woodward Medical Research Institute (2022-present)
- Investigator, Hauptman Woodward Medical Research Institute (2022-present)
- Assistant Professor of Research, Biochemistry, Weill Cornell Medical College (2017–2022)
- Director of Cryo-EM Center, Biochemistry, Weill Cornell Medical College (2017–2022)
- Assistant Research Professor, Cell Biology, New York University (2009–2012)
- Instructor, Boston College (2000–2001)
Journal Articles:
- Riessland M, Kolisnyk B, Kim TW, Cheng J, Ni J, Pearson JA, Park EJ, Dam K, Acehan D, Ramos-Espiritu LS, Wang W, Zhang J, Shim JW, Ciceri G, Brichta L, Studer L, Greengard P. (2019) Loss of SATB1 Induces p21-Dependent Cellular Senescence in Post-mitotic Dopaminergic Neurons. Cell stem cell (Oct), 25(4): 514-530.e8. doi:10.1016/j.stem.2019.08.013
- Govek EE, Wu Z, Acehan D, Molina H, Rivera K, Zhu X, Fang Y, Tessier-Lavigne M, Hatten ME. (2018) Cdc42 Regulates Neuronal Polarity during Cerebellar Axon Formation and Glial-Guided Migration. iScience (Mar), 1: 35-48. doi:10.1016/j.isci.2018.01.004
- Wang WJ, Acehan D, Kao CH, Jane WN, Uryu K, Tsou MF. (2015) De novo centriole formation in human cells is error-prone and does not require SAS-6 self-assembly. eLife (Nov), 4. doi:10.7554/eLife.10586
- Ronchi P, Tischer C, Acehan D, Pepperkok R. (2014) Positive feedback between Golgi membranes, microtubules and ER exit sites directs de novo biogenesis of the Golgi. Journal of cell science (Nov), 127(Pt 21): 4620-33.
- Acehan D, Santarella-Mellwig R, Devos DP. (2014) A bacterial tubulovesicular network. Journal of cell science (Jan), 127(Pt 2): 277-80.
- Henning JR, Graffeo CS, Rehman A, Fallon NC, Zambirinis CP, Ochi A, Barilla R, Jamal M, Deutsch M, Greco S, Ego-Osuala M, Bin-Saeed U, Rao RS, Badar S, Quesada JP, Acehan D, Miller G. (2013) Dendritic cells limit fibroinflammatory injury in nonalcoholic steatohepatitis in mice. Hepatology (Baltimore, Md.) (Aug), 58(2): 589-602. doi:10.1002/hep.26267
- Rehman A, Hemmert KC, Ochi A, Jamal M, Henning JR, Barilla R, Quesada JP, Zambirinis CP, Tang K, Ego-Osuala M, Rao RS, Greco S, Deutsch M, Narayan S, Pachter HL, Graffeo CS, Acehan D, Miller G. (2013) Role of fatty-acid synthesis in dendritic cell generation and function. Journal of immunology (Baltimore, Md. : 1950) (May), 190(9): 4640-9. doi:10.4049/jimmunol.1202312
- Schlame M, Acehan D, Berno B, Xu Y, Valvo S, Ren M, Stokes DL, Epand RM. (2012) The physical state of lipid substrates provides transacylation specificity for tafazzin. Nature chemical biology (Oct), 8(10): 862-9. doi:10.1038/nchembio.1064
- Ibrahim J, Nguyen AH, Rehman A, Ochi A, Jamal M, Graffeo CS, Henning JR, Zambirinis CP, Fallon NC, Barilla R, Badar S, Mitchell A, Rao RS, Acehan D, Frey AB, Miller G. (2012) Dendritic cell populations with different concentrations of lipid regulate tolerance and immunity in mouse and human liver. Gastroenterology (Oct), 143(4): 1061-72. doi:10.1053/j.gastro.2012.06.003
- Phoon CK, Acehan D, Schlame M, Stokes DL, Edelman-Novemsky I, Yu D, Xu Y, Viswanathan N, Ren M. (2012) Tafazzin knockdown in mice leads to a developmental cardiomyopathy with early diastolic dysfunction preceding myocardial noncompaction. Journal of the American Heart Association (Apr), 1(2). doi:10.1161/JAHA.111.000455
- Bedrosian AS, Nguyen AH, Hackman M, Connolly MK, Malhotra A, Ibrahim J, Cieza-Rubio NE, Henning JR, Barilla R, Rehman A, Pachter HL, Medina-Zea MV, Cohen SM, Frey AB, Acehan D, Miller G. (2011) Dendritic cells promote pancreatic viability in mice with acute pancreatitis. Gastroenterology (Nov), 141(5): 1915-26.e1-14. doi:10.1053/j.gastro.2011.07.033
- Acehan D, Malhotra A, Xu Y, Ren M, Stokes DL, Schlame M. (2011) Cardiolipin affects the supramolecular organization of ATP synthase in mitochondria. Biophysical journal (May), 100(9): 2184-92. doi:10.1016/j.bpj.2011.03.031
- Acehan D, Vaz F, Houtkooper RH, James J, Moore V, Tokunaga C, Kulik W, Wansapura J, Toth MJ, Strauss A, Khuchua Z. (2011) Cardiac and skeletal muscle defects in a mouse model of human Barth syndrome. The Journal of biological chemistry (Jan), 286(2): 899-908. doi:10.1074/jbc.M110.171439
- Xu FY, McBride H, Acehan D, Vaz FM, Houtkooper RH, Lee RM, Mowat MA, Hatch GM. (2010) The dynamics of cardiolipin synthesis post-mitochondrial fusion. Biochimica et biophysica acta (Aug), 1798(8): 1577-85.
- Acehan D, Khuchua Z, Houtkooper RH, Malhotra A, Kaufman J, Vaz FM, Ren M, Rockman HA, Stokes DL, Schlame M. (2009) Distinct effects of tafazzin deletion in differentiated and undifferentiated mitochondria. Mitochondrion (Apr), 9(2): 86-95. doi:10.1016/j.mito.2008.12.001
- Akcora P, Liu H, Kumar SK, Moll J, Li Y, Benicewicz BC, Schadler LS, Acehan D, Panagiotopoulos AZ, Pryamitsyn V, Ganesan V, Ilavsky J, Thiyagarajan P, Colby RH, Douglas JF. (2009) Anisotropic self-assembly of spherical polymer-grafted nanoparticles. Nature materials (Apr), 8(4): 354-9.
- Acehan D, Petzold C, Gumper I, Sabatini DD, Müller EJ, Cowin P, Stokes DL. (2008) Plakoglobin is required for effective intermediate filament anchorage to desmosomes. The Journal of investigative dermatology (Nov), 128(11): 2665-2675.
- Owen GR, Acehan D, Derr KD, Rice WJ, Stokes DL. (2008) Cryoelectron tomography of isolated desmosomes. Biochemical Society transactions (Apr), 36(Pt 2): 173-9.
- Acehan D, Xu Y, Stokes DL, Schlame M. (2007) Comparison of lymphoblast mitochondria from normal subjects and patients with Barth syndrome using electron microscopic tomography. Laboratory investigation; a journal of technical methods and pathology (Jan), 87(1): 40-8. doi:10.1038/labinvest.3700480
- Yu X, Wang L, Acehan D, Wang X, Akey CW. (2006) Three-dimensional structure of a double apoptosome formed by the Drosophila Apaf-1 related killer. Journal of molecular biology (Jan), 355(3): 577-89.
- Yu X, Acehan D, Ménétret JF, Booth CR, Ludtke SJ, Riedl SJ, Shi Y, Wang X, Akey CW. (2005) A structure of the human apoptosome at 12.8 A resolution provides insights into this cell death platform. Structure (London, England : 1993) (Nov), 13(11): 1725-35.
- Acehan D, Jiang X, Morgan DG, Heuser JE, Wang X, Akey CW. (2002) Three-dimensional structure of the apoptosome: implications for assembly, procaspase-9 binding, and activation. Molecular cell (Feb), 9(2): 423-32.