Harvey A. Berman PhD, MPH

Harvey Berman

Harvey A. Berman
PhD, MPH

Associate Professor

Department of Pharmacology and Toxicology

Jacobs School of Medicine & Biomedical Sciences


Specialty/Research Focus

Molecular and Cellular Biology; Neuropharmacology; Protein Function and Structure

Contact Information
955 Main Street
Room 3218
Buffalo, New York 14203
Phone: 716-829-2658
Fax: 716-829-2001
hberman@buffalo.edu



Education and Training:

  • MPH, Epidemiology, SUNY at Buffalo (2010)
  • PhD, Chemistry, University of Massachusetts (1974)
  • BS, Chemistry, Brooklyn College of CUNY (1966)

Employment:

  • Associate Professor, Pharmacology and Toxicology, SUNY at Buffalo Jacobs School of Medicine & Biomedical Sciences (2000-present)
  • Associate Professor, Biochemical Pharmacology, SUNY at Buffalo School of Pharmacy (1987–2000)
  • Assistant Professor, Biochemical Pharmacology, SUNY at Buffalo School of Pharmacy (1981–1987)
  • Assistant Research Pharmacologist & Lecturer, Dept. of Medicine - Pharmacology Division, University of California (1978–1982)
  • NIH Postdoctoral Fellow, Department of Medicine - Pharmacology, University of California (1975–1978)


Journal Articles:

  • Kovarik Z, Radic Z, Berman HA, Taylor P. (2007) Mutation of acetylcholinesterase to enhance oxime-assisted catalytic turnover of methylphosphonates. Toxicology (Apr), 233(1-3): 79-84.
  • Luo ZD, Berman HA. (2004) Pb2+-mediated down-regulation of dihydropyridine receptors in skeletal muscle. Toxicol Lett (Sep), 152(2): 167-173.
  • Kovarik Z, Radic Z, Berman HA, Simeon-Rudolf V, Reiner E, Taylor P. (2004) Mutant cholinesterases possessing enhanced capacity for reactivation of their phosphonylated conjugates. Biochemistry (Mar), 43(11): 3222-3229.
  • Kovarik Z, Radic Z, Berman HA, Simeon-Rudolf V, Reiner E, Taylor P. (2003) Acetylcholinesterase active centre and gorge conformations analysed by combinatorial mutations and enantiomeric phosphonates. Biochem J (Jul), 373(Pt 1): 33-40.
  • Wong L, Radic Z, Br├╝ggemann RJ, Hosea N, Berman HA, Taylor P. (2000) Mechanism of oxime reactivation of acetylcholinesterase analyzed by chirality and mutagenesis. Biochemistry (May), 39(19): 5750-5757.
  • Taylor P, Wong L, Radic Z, Tsigelny I, Br├╝ggemann R, Hosea NA, Berman HA. (1999) Analysis of cholinesterase inactivation and reactivation by systematic structural modification and enantiomeric selectivity. Chem Biol Interact (May), 119-1: 3-15.
  • Luo ZD, Berman HA. (1997) The influence of Pb2+ on expression of acetylcholinesterase and the acetylcholine receptor. Toxicol Appl Pharmacol (Aug), 145(2): 237-245.
  • Phillips RR, Lee MY, Berman HA, Madoff MA. (1997) The Tufts partnership for managed care education. Acad Med (May), 72(5): 347-356.
  • Taylor P, Hosea NA, Tsigelny I, Radic Z, Berman HA. (1997) Determining ligand orientation and transphosphonylation mechanisms on acetylcholinesterase by Rp, Sp enantiomer selectivity and site-specific mutagenesis. Enantiomer (Jan), 2(3-4): 249-260.
  • Hosea NA, Radic Z, Tsigelny I, Berman HA, Quinn DM, Taylor P. (1996) Aspartate 74 as a primary determinant in acetylcholinesterase governing specificity to cationic organophosphonates. Biochemistry (Aug), 35(33): 10995-11004.
  • Taylor P, Radic Z, Hosea NA, Camp S, Marchot P, Berman HA. (1995) Structural bases for the specificity of cholinesterase catalysis and inhibition. Toxicol Lett (Dec), 82-83: 453-458.
  • Hosea NA, Berman HA, Taylor P. (1995) Specificity and orientation of trigonal carboxyl esters and tetrahedral alkylphosphonyl esters in cholinesterases. Biochemistry (Sep), 34(36): 11528-11536.
  • Berman HA, Leonard K. (1992) Interaction of tetrahydroaminoacridine with acetylcholinesterase and butyrylcholinesterase. Mol Pharmacol (Feb), 41(2): 412-418.
  • Jo SA, Higgins DM, Berman HA. (1992) Regulation of acetylcholinesterase in avian heart. Studies on ontogeny and the influence of vagotomy. Circ Res (Jan), 70: 633-643.
  • Nowak MW, Berman HA. (1991) Fluorescence studies on the interactions of myelin basic protein in electrolyte solutions. Biochemistry (Jul), 30(30): 7642-7651.
  • Berman HA, Leonard K. (1990) Ligand exclusion on acetylcholinesterase. Biochemistry (Nov), 29(47): 10640-10649.
  • Decker MM, Berman HA. (1990) Denervation-induced alterations of acetylcholinesterase in denervated and nondenervated muscle. Exp Neurol (Aug), 109(2): 247-255.
  • Decker MM, Berman HA. (1990) Dihydropyridine receptor regulation of acetylcholinesterase biosynthesis. J Biol Chem (Jul), 265(20): 11796-11803.
  • Conti CR, Williams JF, Anderson JL, Berman HA, Gunnar RM, Herman GP, Lyons FW, Passamani ER, Reid PR, Silverman ME. (1990) Ethics in cardiovascular medicine. Task Force V: The relation of cardiovascular specialists to industry, institutions and organizations. J Am Coll Cardiol (Jul), 16(1): 30-33.
  • Berman HA, Decker MM. (1989) Chiral nature of covalent methylphosphonyl conjugates of acetylcholinesterase. J Biol Chem (Mar), 264(7): 3951-3956.
  • Berman HA, Leonard K. (1989) Chiral reactions of acetylcholinesterase probed with enantiomeric methylphosphonothioates. Noncovalent determinants of enzyme chirality. J Biol Chem (Mar), 264(7): 3942-3950.
  • Johnson DA, Brown RD, Herz JM, Berman HA, Andreasen GL, Taylor P. (1987) Decidium. A novel fluorescent probe of the agonist/antagonist and noncompetitive inhibitor sites on the nicotinic acetylcholine receptor. J Biol Chem (Oct), 262(29): 14022-14029.
  • Berman HA, Decker MM, Nowak MW, Leonard KJ, McCauley M, Baker WM, Taylor P. (1987) Site selectivity of fluorescent bisquaternary phenanthridinium ligands for acetylcholinesterase. Mol Pharmacol (Jun), 31(6): 610-616.
  • Berman HA, Decker MM, Jo S. (1987) Reciprocal regulation of acetylcholinesterase and butyrylcholinesterase in mammalian skeletal muscle. Dev Biol (Mar), 120(1): 154-161.
  • Edery H, Geyer MA, Taylor P, Berman HA. (1986) Target sites for anticholinesterases on the ventral surface of the medulla oblongata: hypotension elicited by organophosphorus agents. J Auton Pharmacol (Sep), 6(3): 195-205.
  • Berman HA, Decker MM. (1986) Kinetic, equilibrium, and spectroscopic studies on dealkylation ("aging") of alkyl organophosphonyl acetylcholinesterase. Electrostatic control of enzyme topography. J Biol Chem (Aug), 261(23): 10646-10652.
  • Berman HA, Decker MM. (1986) Kinetic, equilibrium, and spectroscopic studies on dealkylation ('aging') of alkyl organophosphonyl acetylcholinesterase. Electrostatic control of enzyme topography. J Biol Chem (Aug), 261(23): 10646-10652.
  • Berman HA, Decker MM. (1986) Kinetic, equilibrium and spectroscopic studies on cation association at the active center of acetylcholinesterase: topographic distinction between trimethyl and trimethylammonium sites. Biochim Biophys Acta (Jul), 872(1-2): 125-133.
  • Berman HA, Yguerabide J, Taylor P. (1985) Flexibility of the molecular forms of acetylcholinesterase measured with steady-state and time-correlated fluorescence polarization spectroscopy. Biochemistry (Dec), 24(25): 7140-7147.
  • Edery H, Berman HA. (1985) Yohimbine antagonism of the vasodepression elicited by organophosphates applied on ventral medulla oblongata. J Auton Nerv Syst (Nov), 14(3): 229-238.
  • Berman HA, Olshefski DF, Gilbert M, Decker MM. (1985) Fluorescent phosphonate labels for serine hydrolases. Kinetic and spectroscopic properties of (7-nitrobenz-2-oxa-1,3-diazole)aminoalkyl methylphosphonofluoridates and their conjugates with acetylcholinesterase molecular forms. J Biol Chem (Mar), 260(6): 3462-3468.
  • Zheng S, Berman HA, Geyer MA. (1983) Behavior during hippocampal microinfusions: anticholinesterase-induced locomotor activation. Behav Brain Res (Sep), 9(3): 295-304.
  • Berman HA, Becktel W, Taylor P. (1981) Spectroscopic studies on acetylcholinesterase: influence of peripheral-site occupation on active-center conformation. Biochemistry (Aug), 20(16): 4803-4810.
  • Berman HA, Yguerabide J, Taylor P. (1980) Fluorescence energy transfer on acetylcholinesterase: spatial relationship between peripheral site and active center. Biochemistry (May), 19(10): 2226-2235.
  • Epstein DJ, Berman HA, Taylor P. (1979) Ligand-induced conformational changes in acetylcholinesterase investigated with fluorescent phosphonates. Biochemistry (Oct), 18(21): 4749-4754.
  • Berman HA, Taylor P. (1978) Fluorescent phosphonate label for serine hydrolases, pyrenebutyl methylphosphonofluoridate: reaction with acetylcholinesterase. Biochemistry (May), 17(9): 1704-1713.
  • Berman HA, Barza M, Weinstein L. (1972) Serum sulfonamide concentration after oral administration: comparison of results of chemical assay with two bioassay techniques. Antimicrob Agents Chemother (Mar), 1(3): 268-273.
  • Berman HA, Weinstein L. (1971) Antibiotics and nutrition. Am J Clin Nutr (Feb), 24(2): 260-264.
  • Berman HA, Weinstein L. (1970) Search for trichinella infection in Western Samoa and Fiji. Med J Aust (Sep), 2(13): 583-584.
  • Grossman W, Berman HA. (1968) Typhoid fever in the previously immunised. Lancet (Oct), 2(7573): 867-868.
  • Klocke RA, Augerson WS, Berman HH, Burgos FL, Rivera RA. (1967) Desquamative interstitial pneumonia. A disease with a wide clinical spectrum. Ann Intern Med (Mar), 66(3): 498-506.
  • Taylor P, Hosea NA, Tsigelny I, Radic Z, Berman HA. (1900) Determining ligand orientation and transphosphonylation mechanisms on acetylcholinesterase by Rp, Sp enantiomer selectivity and site-specific mutagenesis. Enantiomer (Jan), 2(3-4): 249-260.
  • Berman HA. (1900) Physicians must share in costs, savings. Internist (Jan), 26(5): 17-17.
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Contact Information

955 Main Street
Room 3218
Buffalo, New York 14203
Phone: 716-829-2658
Fax: 716-829-2001
hberman@buffalo.edu