James N. Jarvis MD

James Jarvis

James N. Jarvis
MD

Clinical Professor

Department of Pediatrics

Jacobs School of Medicine & Biomedical Sciences

Specialty/Research Focus

Pediatric Rheumatology; Pediatrics

Contact Information
Clinical and Translational Research Center
875 Ellicott Street
Room 8026
Buffalo, New York 14203
Phone: (716) 888-4796
jamesjar@buffalo.edu
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Overview Research Publications Activities Latest News

Professional Summary:

I have a broad interest in rheumatic diseases in children. I am particularly interested in juvenile idiopathic arthritis (JIA) and improving the time frame over which we can achieve remission in this family of illnesses. With newer medications, we are making significant progress, but we still have much to learn.

I also have a keen interest in children with systemic lupus and inflammatory muscle disease. Over time, because of my own Native American ancestry (Mohawk), I have particularly enjoyed the opportunity to work with indigenous American children, whose expression of rheumatic disease and treatment response are slightly different from the broader population. We hope that tribal health systems will see our pediatric rheumatology service as the “go-to” place for children with arthritis and related illnesses.

The current focus of my laboratory is understanding genetic mechanisms that drive risk for childhood onset rheumatic diseases, such as juvenile idiopathic arthritis (JIA) and systemic lupus erythematosus (SLE). We are particularly interested in how genetic variants alter epigenetically-mediated genome functions. To address these questions, we use a broad variety of genomic techniques, including ChIPseq, massively parallel reporter assays, and CRISPR interference assays (CRISPRi).

I also spend considerable time working with indigenous American communities on a broad range of child health issues. I served as chair of the American Academy of Pediatrics Committee on Native American Child Health, and continue to be involved in advocacy efforts for indigenous children. I am especially interested in how so-called epigenetic factors, stemming from historical traumas and cultural dislocation that may play a role in how rheumatic diseases are expressed in indigenous children.

One of the most rewarding parts of my career has been the opportunity to mentor talented Native American students and assist them in developing their interests in science and medicine. Previous students include a veritable “Who’s Who” among young Native American physicians, and I am working to establish and foster partnerships for UB with local colleges and tribes to develop a rich resource of Native American physician scientists in New York State.

Education and Training:
  • Fellowship, Rheumatology and Immunogenetics, Washington University School of Medicine (1989)
  • Residency, Pediatrics, St. Louis Children‘s Hospital (1986)
  • Residency, Pediatrics, St. Louis Children‘s Hospital (1982)
  • Internship, Pediatrics, St. Louis Children's Hospital (1980)
  • MD, Medicine, University of Vermont College of Medicine (1979)
  • BA, Liberal Arts, St. John‘s College, Cum Laude (1975)

Employment:
  • Clinical Professor, Pediatrics, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (2012-present)
  • Director of Research, Allergy/Immunology and Rheumatology, UBMD Pediatrics (2014–2017)
  • Division Chief, Allergy/Immunology and Rheumatology, UBMD Pediatrics (2012–2014)
  • Professor, Clinical Pediatrics, Columbia University Medical Center (2011–2012)
  • Endowed Chair, Children‘s Medical Research Institute/Arthritis Foundation, Oklahoma Chapter (2009–2011)
  • Professor, Pediatrics, University of Oklahoma College of Medicine (2006–2011)
  • Consultant Rheumatologist, W.W. Hastings Indian Hospital (2003–2011)
  • Adjunct Associate Professor, Pediatrics, University of Oklahoma College of Medicine (1997–2011)
  • Director, Children‘s Hospital of Oklahoma/University of Oklahoma Children‘s Physicians (1997–2011)
  • Clinical Professor, Pediatrics, University of Oklahoma College of Medicine (2005)
  • Clinical Associate Professor, Pediatrics, University of Oklahoma College of Medicine (1997–2005)
  • Chief, Rheumatology, University of Oklahoma College of Medicine (1997–2002)
  • Associate Professor, Pediatrics, Wayne State University School of Medicine (1996–1997)
  • Associate, Molecular Medicine and Genetics, Wayne State University School of Medicine (1994–1997)
  • Associate, Immunology/Microbiology, Wayne State University School of Medicine (1992–1997)
  • Associate, Children's Hospital of Michigan (1989–1997)
  • Assistant Professor, Pediatrics, Wayne State University School of Medicine (1989–1996)
  • Clinical Instructor, Washington University in St. Louis School of Medicine (1985–1989)
  • Attending Pediatrician, Little River Medical Center (1983–1984)
  • Attending Pediatrician/Chief of Pediatrics, Loris Community Hospital (1982–1984)
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Awards and Honors:
  • American College of Rheumatology: Master (2019)
  • St. John’s College: Alumni Award of Merit (2015)
  • Who's Who in Medicine Higher Education (2015)
  • University at Buffalo Office of Inclusion and Cultural Enhancement: Faculty Award of Excellence for Promoting Inclusion and Cultural Diversity (2014)
  • American College of Rheumatology/Immunex: Visiting Professor (Meharry Medical College) (2014)
  • OU Medical Center: Golden Pillar (2011)
  • Consumer Research Council of America: America's Top Pediatricians (2009)
  • Arthritis Foundation, Oklahoma Chapter: John A. Blashke Award (2006)
  • IBC Cambridge: One Thousand Great Scientists (2003)
  • Guide to America‘s Top Pediatricians (2002)
  • International Registry of Who‘s Who (2000)
  • Wayne State Alumni Association: Dr. Jack Ryan Award for Medical Research (1996)
  • Who's Who in Science and Engineering (1996)
  • Michigan State University Department of Pediatrics: William Weil Award (1995)
  • American Rheumatism Association: Central Region Fellows‘ Award (1988)
  • American College of Rheumatology: Clinician Scholar-Educator Award (2002-2005)
  • Who‘s Who in America (2003, 2005-2009)

Research Expertise:
  • Genetics of rheumatic disease
  • Genomics
  • Inflammatory muscle disease
  • Juvenile idiopathic arthritis
  • Systemic lupus

Grants and Sponsored Research:
  • October 2022–September 2027
    Epigenetic Mechanisms That Drive Genetic Risk for Juvenile Arthritis
    NIH/NIAMS
    Role: Principal Investigator
    $3,047,449
  • November 2021–October 2023
    3D Chromatin Studies in Pediatric B Cells To Study the Genetics of Autoimmunity
    NIH
    Role: Principal Investigator
  • August 2020–August 2022
    Using Chromatin Architecture to Develop of Therapeutic Pipeline for Juvenile Arthritis
    NIH
    Role: Principal Investigator
  • September 2018–August 2020
    Identifying Causal Variants in Juvenile Arthritis Using a Massively Parallel Reporter Assay
    National Institute of Arthritis and Musculoskeletal and Skin Diseases
    Role: Principal Investigator
    $385,990
  • July 2017–June 2019
    Genetics and Epigenetics in JIA CD4+ T Cells
    Rheumatology Research Foundation
    Role: Principal Investigator
    $400,000
  • June 2015–May 2019
    Arthritis Small Grant - Equipment
    Fraternal Order of Eagles
    Role: Principal Investigator
    $3,344
  • June 2015–May 2019
    Arthritis Small Grant - Gift Cards
    Fraternal Order of Eagles
    Role: Principal Investigator
    $1,000
  • December 2016–November 2018
    Interplay Between Genetics and Epigenetics in Polyarticular JIA
    Arthritis Foundation
    Role: Principal Investigator
    $730,998
  • June 2017–May 2018
    Developing Biomarkers for Juvenile Arthritis from Plasma Exosomes
    Wildermuth Foundation
    Role: Principal Investigator
    $25,000
  • July 2016–May 2018
    Plasma Exosomes in Juvenile Dermatomyositis
    Cure JM Foundation
    Role: Principal Investigator
    $25,000
  • July 2016–June 2017
    Defining and Treating a New Pediatric Asthma Endotype: Depression-Related Asthma Mediated by the Cholinergic Pathway
    University at Buffalo
    Role: Co-Investigator
    $47,000
  • February 2011–December 2016
    Microarray-Based Biomarkers in Juvenile Idiopathic Arthritis
    NIH/NIAMS
    Role: Principal Investigator
    $1,250,000
  • July 2014–June 2016
    Trophoblasts and Inflammation: An Epigenetic Approach
    NIH/National Institute of Child Health and Human Development
    Role: Principal Investigator
    $275,000
  • September 2013–January 2016
    Workforce Diversity Supplement to Microarray-Based Biomarkers in Juvenile Idiopathic Arthritis
    NIH/National Institute of Child Health and Human Development
    Role: Principal Investigator
    $72,606
  • July 2014–June 2015
    Expression-Based Biomarkers in Cystic Fibrosis
    University at Buffalo Clinical and Translational Research Fund
    Role: Principal Investigator
    $34,190
  • January 2013–December 2014
    Epigenetic Regulation of JIA Neutrophils
    Arthritis Foundation (National) Innovative Research Grant Program
    Role: Principal Investigator
    $200,000
  • January 2011–December 2013
    Epigenetic Alterations in JIA Neutrophils
    McBride Foundation
    Role: Principal Investigator
    $75,000
  • January 2010–December 2012
    Genome-Wide Mapping of Hepatocyte Nuclear Factor 4a in Human T Cells
    McBride Foundation
    Role: Principal Investigator
    $75,000
  • September 2009–September 2011
    Dynamics of Therapeutic Response within the TREAT Trial
    NIH
    Role: Principal Investigator
    $400,000
  • September 2010–August 2011
    Dynamics of Therapeutic Response within the TREAT Trial (Administrative Supplement)
    NIH
    Role: Principal Investigator
    $378,306
  • July 2009–June 2010
    Trophoblast Responses to Inflammation: A Genomic Approach
    College of Medicine Alumni Association Funding
    Role: Principal Investigator
    $26,000
  • July 2007–June 2010
    Neutrophil Biomarkers in Polyarticular JRA
    Oklahoma Center for the Advancement of Science and Technology
    Role: Principal Investigator
    $135,000
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Journal Articles:

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Books and Book Chapters:

  • Jarvis JN. (2011) In: "Juvenile Idiopathic Arthritis". Elsevier Publishing Co., 1001-1006.
  • Jarvis JN. (2011) In: "Rheumatologic Disorders". Brown Walker Press, 565-586.
  • Jarvis JN. (2010) In: "Arthritis in Children". AAP Publishing

Abstracts:

  • Jarvis JN, Levine RP, Kishore NS. (1989) IgM Rheumatoid Factor Inhibits the Covalent Binding of C4b to Immune Complexes. Arthritis Rheum, (Jan) R32-R32
  • Jiang K, Park Y, Tarbell E, Liu T, Jarvis JN. (2019) The Juvenile Idiopathic Arthritis-Associated IL2RA Haplotype Contains an Intronic Enhancer Whose Function is Diminished By JIA-Associated Genetic Variants. Ann Rheum Dis, (Jan) 662-662
  • Kessler H, Tarbell E, Park Y, Jarvis JN. (2019) Broadening Our Understanding of the Genetics of Juvenile Idiopathic Arthritis: Interrogation of Three Dimensional Chromatin Structures within JIA-Associated Risk Loci. Ann Rheum Dis, (Jan) 151-152
  • Frank MB, Jiang K, Chen Y, Osban J, Wallace CA, Thompson S, Jarvis JN. (2010) A Whole Blood Gene Expression Profile of Untreated Children with Polyarticular Juvenile Idiopathic Arthritis Enrolled in the TREAT Trial. Arthritis Rheum, (Nov) 243-243
  • Frank MB, Jiang K, Chen Y, Osban J, Gellert P, Jarvis JN. (2010) Characterization of Granulocyte Transcriptome in Polyarticular Juvenile Idiopathic Arthritis (JIA). Arthritis Rheum, (Nov) 247-247
  • Frank MB, Jiang K, Chen Y, Jarvis JN. (2010) Differences in Transcription Profiles in Juvenile Idiopathic Arthritis (JIA) Patients who Achieved Remission Using Different Therapies. Arthritis Rheum, (Nov) 251-251
  • Knowlton N, Frank MB, Armstrong NE, Chen Q, Jiang K, Chen Y, Osban J, Jarvis JN. (2010) Gene Expression Profiling in Peripheral Blood Mononuclear Cells Predicts Disease Flares in Children with Polyarticular Juvenile Idiopathic Arthritis who Have Achieved Inactive Disease Status. Arthritis Rheum, (Nov) 655-655
  • Jiang K, Chen Y, Frank MB, Jarvis JN. (2010) Leukocyte Expression of the Transcription Factor HNF4a, a Regulator of Gene Expression in Polyarticular Juvenile Idiopathic Arthritis. Arthritis Rheum, (Nov) 258-258
  • Jarvis JN, Frank MB, Knowlton NS, Jiang K, Chen Y, Centola M. (2008) In Silico Models of Leukocyte Gene Expression Data in Children with Polyarticular JIA Show Hub-and-Node Structures Typical of Scale-free Networks: Implications for Pathogenesis and Treatment. Ann Rheum Dis, (Jan) 144-144
  • Wang SY, Knowlton N, Aggarwal A, McGhee T, Jiang K, Chen Y, Frank MB, Centola M, Jarvis JN. (2008) Gene Expression Profiling in Juvenile Dermatomositis Suggests Complex Interactions Between Innane and Adaptive Immunity. Arthritis Rheum, (Jan) 501-501
  • Brown B, Frank MB, Knowlton NS, Jiang K, Chen Y, Centola M, Jarvis JN. (2008) Neutrophil Regulation of Adaptive Immunity: An In Vitro Model Identifies Hubs and Nodes with Similarities to Those Seen in Polyarticular JIA. Ann Rheum Dis, (Jan) 144-144
  • Jarvis JN, Frank MB, Knowlton NS, Jiang K, Chen Y, O'Neil K, McKee R, Chaser B, McGhee JL, Centola M. (2008) Defining Remission in Polyarticular JIA: A Systems Biology Approach. Ann Rheum Dis, (Jan) 71-71
  • Jarvis JN, Knowlton N, Frank MB, Aggarwal A, Jiang K, Chen Y, McKee R, McGhee T, O‘Neil KM, Chaser B, Centola M. (2007) A Systems Biology Approach to JIA: Gene Expression Profiling Detects Only Small Differences Between Children with Pauciarticular and Polyarticular Disease. Arthritis Rheum, (Jan) 670-670
  • O'Neil KM, Dozmorov I, Neff J, Kickingbird LM, Jarvis JN, Cadwell C, Centola M, Frank MB. (2007) Pathway Analysis of Genes Differentially Expressed in Peripheral Blood Mononuclear Cells of Children with Stable, Flaring, or Improving Systemic Lupus Erythematosus. Arthritis Rheum, (Jan) 675-675
  • Jarvis JN, Knowlton N, Frank MB, Aggarwal A, Jiang K, Chen Y, McKee R, McGhee JL, O'Neil KM, Chaser B, Centola M. (2007) The Biological Meaning of Clinical Remission in JIA: A Systems Biology Approach. Arthritis Rheum, (Jan) 671-671
  • Wang SY, Knowlton N, Aggarwal A, McGhee T, Jiang K, Chen Y, Frank MB, Centola M, Jarvis JN. (2007) Gene Expression Profiling in Neutrophils and PBMC in Juvenile Dermatomyositis. Arthritis Rheum, (Jan) 678-678
  • O'Neil KM, Nguyen AB, Frank MB, Cadwell C, Jarvis JN, Centola M, Dozmorov I. (2007) Gene Expression Profiles in Children with SLE: Abnormal Regulation of Apoptosis-related Genes Suggests a Role for Neutrophils in SLE. Arthritis Rheum, (Jan) 675-675
  • Aggarwal A, Dozmorov I, Frank MB, Jiang K, Chen Y, Centola M, Jarvis JN. (2006) Neutrophils from Children with Polyarticular and Pauciarticular Juvenile Rheumatoid Arthritis (JRA) Shown Distinct Gene Expression Profiles. Arthritis Rheum, (Jan) 694-694
  • Jarvis JN, Petty HR, Kindzelski A, Tessier P, Jiang K, Tang Y, McGhee JL, Centola M. (2005) Is Polyarticular JRA a Disease of Neutrophils? Evidence for an Intrinsic Defect in Neutrophil Activation in Polyarticular JRA. Arthritis Rheum, (Jan) 446-446
  • Jiang K, Chen Y, Jarvis JN. (2005) HCG Secretion in Human Choriocarcinoma Jar Cells is MAPK but Not STAT3 Dependent: Contributions of TNF Alpha and IL-1-Beta Inflammation-induced hCG Secretion. PAS Meeting Abstracts, (Jan) 1791-1791
  • O‘Neil KM, Kickingbird L, Madduri D, McGhee JL, Jarvis JN. (2005) Clinical and Laboratory Associations in Childhood Systemic Lupus Erythematosus. PAS Meeting Abstracts, (Jan) 1485-1485
  • Chaser B, Dozmorov I, Frank MB, Tang Y, Cadwell C, McGhee JL, Centola M, Jarvis JN. (2005) Discriminant Function Analysis of Gene Expression Arrays Reveals Distinct Subsets of Children with Polyarticular-Onset Juvenile Rheumatoid Arthritis. Arthritis Rheum, (Jan) 4066-4066
  • Jarvis JN, Cobb E, Evard M, Jiang K. (2005) Evidence for Chronic Dysregulation in Neutrophils of Children with Polyarticular JRA. PAS Meeting Abstracts, (Jan) 1482-1482
  • Jarvis JN, Tang Y, Dozmorov D, Jiang K, Frank MB, Chen Y, McGhee JL, Centola M. (2005) Gene Expression Arrays Reveal Chronic, Intrinsic Activation of Neutrophils in Children with Polyarticular JRA. Is JRA Primarily a Neutrophil Disorder?. PAS Meeting Abstracts, (Jan) 1481-1481
  • Jiang K, Chen Y, Jarvis JN. (2005) Soluble Factors from LPS-Activated PBMC Induce MAPK and STAT3 Phosphorylation in Primary Cultures of Human Placental Trophoblasts: Implications for Infection and Prematurity. PAS Meeting Abstracts, (Jan) 1790-1790
  • Lawrence S, Tang Y, Dozmorov I, Jiang K, Chen Y, Frank MB, Turner S, Centola M, Jarvis JN. (2004) Gene Expression Arrays Reveal Distinct Patterns of Activation that Differ Between Adult and Neonatal Monocytes. Pediatr Res, (Jan) 468A-468A
  • Jarvis JN, Tang Y, Dozmorov I, Jiang K, Frank MB, Chen Y, McGhee JL, Centola M. (2004) Gene Expression Arrays Reveal Chronic, Intrinsic Activation of Neutrophils in Children with Polyarticular JRA. Is JRA a Neutrophil Disorder?. Arthritis Rheum, (Jan) S443-S443
  • Jiang K, Chen Y, Jarvis JN. (2004) Cord Blood and Adult T Cells Show Different Responses to C1q-bearing Immune Complexes. Pediatr Res, (Jan) 19A-19A
  • Jarvis JN, Zospah R, Tang Y, Dozmorov I, Jiang K, Chen Y, Frank MB, Centola M. (2004) Gene Expression Arrays Exclude Immune Complex Accumulation as a Critical Factor in the Leukocyte Activation of Polyarticular JRA. Arthritis Rheum, (Jan) S363-S363
  • O'Neil KO, Kickingbird LN, Jarvis JN. (2004) Characteristics of Children with SLE: Clinical and Laboratory Associations. Arthritis Rheum, (Jan) S531-S531
  • Jarvis JN, Dozmorov I, Jiang K, Chen Y, Frank MB, Turner S, Centola M. (2004) Using a Gene Microarray to Dissect Immunologic Responses in a Trophoblast Model: Evidence that Immunologic Challenge Enhances Trophoblast Growth and Differentiation. Pediatr Res, (Jan) 18A-18A
  • Jiang K, Chen Y, Jarvis JN. (2004) Soluble Factors from Activated Lymphocytes Induce MAPK and STAT3 Phosphorylation in Primary Cultures of Human Placental Trophoblasts. Pediatr Res, (Jan) 467A-467A
  • Jarvis JN, Jiang K, Chen Y, Dozmorov I, Frank MB, Centola M. (2003) Cocultivation of Trophoblast-like JAR Cells Results in Transcriptional Activation of Multiple Genes: Further Evidence for Maternal-Fetal Immunologic Cross-Talk. Pediatr Res, (Jan) 57A-57A
  • Cleland SY, Fishinghawk B, Burks FN, Sullivan K, Jarvis JN. (2003) A Clinical and Immunogenetic Comparison of Caucasian and Native American Children with Juvenile Rheumatoid Arthritis. Pediatr Res, (Jan) 17A-17A
  • Jiang K, Chen Y, Jarvis JN. (2003) Activated Lymphocytes Induce p44/42 MAP Kinase Phosphorylation in Trophoblast-like JAR Cells, but the Capacity of JAR Cells to Inhibit IL-2 Expression is Not MAPK Dependent. Pediatr Res, (Jan) 53A-53A
  • McGhee JL, Kickingbird LM, Jarvis JN. (2003) Use of ANA Tests and Clinical Findings to Identify Children with Systemic Lupus Erythematosus. Arthritis Rheum, (Jan) S508-S508
  • Jarvis JN, Frank MB, Dozmorov I, Jiang K, Cadwell C, McGhee JL, Centola M. (2002) Gene Expression Analysis of Children with Active Polyarticular JRA. Arthritis Rheum, (Jan) S474-S474
  • Dozmorov I, Jarvis JN, Frank MB, Jiang K, Cadwell C, Centola M. (2002) Novel and Mathematical Modeling Identifies Leukocyte Gene Expression Patterns that are Disrupted in Polyarticular JRA. Arthritis Rheum, (Jan) S474-S474
  • Jarvis JN, Xiao S, Xu C-S. (2000) Regulation of IL-8 Secretion from Immune Complex Activated Human Umbilical Vein Endothelial Cells. Arthritis Rheum, (Jan) S356-S356
  • Jarvis JN, Xiao S, Xu C-S, Ramachandaran V, McEver R. (2000) Activation of Human Umbilical Vein Endothelial Cells by C1q-bearing Immune Complexes: Mechanisms Leading to Neutrophil Adhesion. Arthritis Rheum, (Jan) S274-S274
  • Jarvis JN, Solomon G, Menifee L. (2000) Juvenile Rheumatoid Arthritis in Native Americans in Oklahoma. Arthritis Rheum, (Jan) S324-S324
  • Jarvis JN, Xiao S, Ramachandaran V, McEver R. (1999) Activation of Cultured Human Vein Endothelial Cells by C1q-bearing Immune Complexes. FASEB J, (Jan) A281-A281
  • Jarvis JN, Xiao S. (1999) Activation of Human Umbilical Vein Endothelial Cells by C1q-bearing Immune Complexes. Pediatr Res, (Jan) 358A-358A
  • Jarvis JN, Wang S-H. (1999) Phosphorylation of the Complement Receptor, CR1 (CD35) and Its Association with the Syk Protein Tyrosine Kinase in Immune Complex-stimulated HL-60 Cells. Pediatr Res, (Jan) 358A-358A
  • Quintero Del-Rio A, Jarvis JN. (1999) Lymphocyte Activation by Immune Complexes. FASEB J, (Jan) A950-A950
  • Quintero Del-Rio A, Jarvis JN. (1998) Lymphocyte Activation by Immune Complexes: A Possible Role for CR1 (CD35). Arthritis Rheum, (Jan) S36-S36
  • Jarvis JN, Solomon G. (1998) High Incidence of Juvenile Dermatomyositis in Native American Children in Oklahoma. Arthritis Rheum, (Jan) S264-S264
  • Jarvis JN, Wang S-H, Xu C-S. (1998) Immune Complex Binding to Human Monocytes and Monocytic Cell Lines Leads to Serine/Threonine Phosphorylation of the C3b Receptor, CR1 (CD35). Arthritis Rheum, (Jan) S144-S144
  • Jarvis JN, Xiao S. (1998) Immune Complexes Induce IL-8 Secretion from Human Umbilical Vein Endothelial Cells by a Tyrosine Phosphokinase-dependent Mechanism. Arthritis Rheum, (Jan) S351-S351
  • Jarvis JN, Wang W, Amit A, Xu C-S. (1998) Role of Immune Complex Size and Complement in Regulating Monocyte Responses to Immune Complexes. Pediatr Res, (Jan) 338A-338A
  • Jarvis JN, Wang W, Amit A, Xu C-S. (1997) Regulation of Monocytes Through Complement Receptor CR1: Binding of C4b to Immune Complexes Enhances IL-1Beta Secretion. Arthritis Rheum, (Jan) S127-S127
  • Jarvis JN, Amit A, McLaughlin J, Xu C-S, Wang W. (1997) Influence of Size and C4b Binding on the Pro-Inflammatory Properties of Immune Complexes. Pediatr Res, (Jan) 309A-309A
  • Schwartz M, Davis P, Simpson P, Wooley P, Kerr KL, Jarvis JN. (1997) Juvenile Rheumatoid Arthritis in African-American Children. Pediatr Res, (Jan) 311A-311A
  • Jarvis JN, Xu C-S, Wang W, Amit A, Kindzelski A, Petty HR. (1997) Complement Opsonization Reduces the Pro-Inflammatory Capacity of Immune Complexes. Pediatr Res, (Jan) 309A-309A
  • Jarvis JN, Xu C-S, Amit A. (1997) Direct Quantification of Complement Binding to Immune Complexes. Pediatr Res, (Jan) 309A-309A
  • Petty HR, Kindzelski AL, Amit A, Jarvis JN. (1996) Effect of Complement on Immune Complex-induced Metabolic Oscillations in Migrating Neutrophils. FASEB J, (Jan) A1328-A1328
  • Jarvis JN, Xu C-S, Wang W, Amit A. (1996) Complement Reduces the Capacity of Immune Complexes to Induce Pro-Inflammatory Cytokines from Leukocytes. Arthritis Rheum, (Jan) S82-S82
  • Jarvis JN, Xu C-S. (1996) Complement Regulates the Capacity of Immune Complexes to Elicit Cytokine Secretion from Leukocytes. Mol Immunol, (Jan) 26-26
  • Kerr KL, Jarvis JN, Moore EC, Spencer L, Abramson J. (1996) Development of a Critical Pathway for IV Cyclophosphamide Therapy in the Treatment of Pediatric Systemic Lupus Erythematosus. Arthritis Rheum, (Jan) A214-A214
  • Schwartz MM, Simpson P, Kerr KL, Jarvis JN. (1996) Juvenile Rheumatoid Arthritis in African-Americans. Arthritis Rheum, (Jan) S168-S168
  • Jarvis JN, Wang W, Xu C-S. (1996) Juvenile Rheumatoid Arthritis Synovial Fluid Immune Complexes Induce a Broad Spectrum of Pro-Inflammatory Cytokines from Peripheral Blood Mononuclear Cells. Arthritis Rheum, (Jan) S52-S52
  • Kerr KL, Jarvis JN. (1996) Comparison of the Cost-Effectiveness of EMLA Cream vs. Oral Midazolam for Analgesia During Pediatric Anthrocentesis. Arthritis Rheum, (Jan) S263-S263
  • Jarvis JN, Xu C-S. (1996) Induction of IL-8 from Promonocytic U937 Cells and Peripheral Blood Mononuclear Cells by Soluble Immune Complexes. Pediatr Res, (Jan) 394A-394A
  • Erlandson D, Kerr KL, Jarvis JN, Bowyer S, Marsh M, Miller M, Miller J, Peterson K, Singsen B. (1996) Research Issues Associated with the Study of Ethnically-Diverse Chronically-Ill Children. Arthritis Rheum, (Jan) S169-S169
  • Jarvis JN, Moore HT, Zhao L, Xu C-S. (1996) Trophoblast-like JAR Cells Contain Pro-IL-1Beta which is Released with FcyR Engagement. Pediatr Res, (Jan) 61A-61A
  • Jarvis JN, Wang W, Xu C-S, Zhao L. (1996) JRA Synovial Fluid IgG Fractions Induce a Broad Spectrum of Pro-Inflammatory Cytokines from Peripheral Blood Mononuclear Cells. Pediatr Res, (Jan) 393A-393A
  • Cuesta I, Simpson P, Kerr KL, Jarvis JN. (1996) Orthopedics Referral for Pauciarticular JRA. Arthritis Rheum, (Jan) S59-S59
  • Jarvis JN, Taylor H, Iobidze M, Cohen F. (1992) IgA Rheumatoid Factor Expression Associated with Alternative Complement Pathway Activation in Congenital HIV Infection. Arthritis Rheum, (Jan) S118-S118
  • Duncan D, Taylor H, Cohen F, Jarvis JN. (1992) Deposition of C4 onto Lymphocytes of Children with JRA: Comparison with Congenital HIV Infection. Arthritis Rheum, (Jan) S118-S118
  • Mayes MD, Jarvis JN, Long PM, Gutta V. (1990) Membrane Cofactor Protein in Scleroderma. Arthritis Rheum, (Jan) S64-S64
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Professional Memberships:
  • American Pediatric Society (2006–present)
  • American Society for Pediatric Research (1995–present)
  • American Association of Immunologists (1994–present)
  • American College of Rheumatology: Fellow (1985–present)
  • American Academy of Pediatrics: Fellow (FAAP) (1984–present)

Presentations:
  • "Epigenetics and Trauma: Exploring the Historical and Biological Basis of Rheumatic Disease Inequities" International Blackfoot Research Conference, Culture as Medicine (2023)
  • "The Social and Biological Ecology of Chronic Disease in Indigenous People: Development of a New Multi-Dimensional Model" American Academy of Pediatrics/Canadian Paediatric Society 10th International Meeting on Indigenous Children’s Health (2023)
  • "Epigenetics and the Social-Biological Determinants of Health" American Academy of Pediatrics/Canadian Paediatric Society: 8th International Meeting on Indigenous Children’s Health (2021)
  • "Juvenile Arthritis and the Genetics of Complex Traits" Hofstra-Northwell Rheumatology Grand Rounds (2021)
  • "Understanding Genetic Mechanisms in Scleroderma By Querying 3D Chromatin Architecture" International Symposium on Advances in Scleroderma Research (2021)
  • "Understanding the Genetics of Complex Traits" Pediatric Research Conference; University at Buffalo (2021)
  • "The Biology of Acute and Chronic Stress." Pediatric Academic Societies: Symposium on Racism as a Public Health Issue: At the Intersection of Equity, Science, and Social Justice. (Online) (2021)
  • "Epigenetics and Trauma: Exploring the Biological Basis of Health Inequities" Health Disparities Facing Native American and Indigenous Communities Symposium (online), Penn State University School of Medicine (2020)
  • "When Illness Intrudes" National Juvenile Arthritis Meeting (2020)
  • "Clinical Correlations of Autoantibodies Against Heat Shock Cognate 71 kDa Protein in Patients with Juvenile Dermatomyositis" Annual Meeting; American College of Rheumatology (2019)
  • "Broadening Our Understanding of the Genetics of Juvenile Idiopathic Arthritis: Interrogation of Three Dimensional Chromatin Structures Within JIA-Associated Risk Loci" Annual European Congress of Rheumatology; European League Against Rheumatism (2019)
  • "The Juvenile Idiopathic Arthritis-Associated IL2RA Haplotype Contains an Intronic Enhancer Whose Function is Diminished By JIA-Associated Genetic Variants" Annual European Congress of Rheumatology; European League Against Rheumatism (2019)
  • "Juvenile Arthritis and the Genetics of Complex Traits" Pediatric Research Conference; University at Buffalo (2019)
  • "CD4+ T Cells from Children with Active Juvenile Idiopathic Arthritis Show Aberrant CTCF Localization Associated with Transcriptional Abnormalities" Annual Meeting; Pediatric Academic Societies; Allergy, Immunology & Rheumatology 1 (2019)
  • "Chromatin Landscapes of the Vascular Endothelium in Systemic Lupus" Annual Meeting; Pediatric Academic Societies; Genomics/Epigenomics: Epigenetics and Gene Expression (2019)
  • "Differences in Chromatin Architecture in Treatment Naïve Pediatric Lupus Patients" Annual Meeting; Pediatric Academic Societies; Genomics/Epigenomics: Epigenetics and Gene Expression (2019)
  • "Genetic (Re)Definition of JIA Disease State" Annual Meeting; Pediatric Academic Societies; Juvenile Idiopathic Arthritis in the 21st Century (2019)
  • "Interrogating HiC Data within JIA-Associated Risk Loci Reveals Complex Chromatin Structures and Identifies Novel Target Genes" Annual Meeting; Pediatric Academic Societies; Allergy, Immunology & Rheumatology 1 (2019)
  • "The Juvenile Arthritis-Associated IL2RA Haplotype Contains an Intronic Enhancer Whose Function is Diminished By JIA-Associated Genetic Variants" Annual Meeting; Pediatric Academic Societies; Genomics/Epigenomics (2019)
  • "The Non-Coding Genome and the Genetics of JIA" Annual Meeting; Pediatric Academic Societies (2019)
  • "Adverse Childhood Experiences and the High Rates of Rheumatic Disease in Indigenous People: Are They Linked?" International Meeting on Indigenous Children’s Health; Canadian Paediatric Society/American Academy of Pediatrics (2019)
  • "Chromatin Architecture and the Genetics/Transcriptomics of Juvenile Idiopathic Arthritis" Invited Presentation; Hospital for Sick Children (2019)
  • "Anti-Endothelial Cell Antibodies in Patients with Juvenile Dermatomyositis: Correlations with Previously Described Autoantibodies and Clinical Phenotype" Annual Meeting; American College of Rheumatology (2018)
  • "Differences in Chromatin Architecture in Treatment Naïve Pediatric Lupus Patients" Annual Meeting; American College of Rheumatology (2018)
  • "Juvenile Arthritis-Associated Single Nucleotide Polymorphisms Identified on Whole Genome Sequencing Show Enrichment within H3K9me3-Marked Regions" Annual Meeting; American College of Rheumatology (2018)
  • "The Chromatin Landscape Around the Juvenile Arthritis-Associated CXCR4 Locus Suggests Regulatory Functions and Genetic Roles in Both Innate and Adaptive Immunity" Annual Meeting; American College of Rheumatology (2018)
  • "Biomarkers for Juvenile Idiopathic Arthritis: Pitfalls and Promise" Curso Internacional de Reumatologia Pediatrica; Mexican College of Rheumatology (2018)
  • "The Genetics of Juvenile Idiopathic Arthritis: An Update for Clinicians" Curso Internacional de Reumatologia Pediatrica; Mexican College of Rheumatology (2018)
  • "Genetic and Epigenetic Regulation of Gene Expression in Juvenile Arthritis" Division of Rheumatology Seminar; Seattle Children's Hospital (2018)
  • "Plasma Exosome Small RNA Expression Profiles: A Liquid Biopsy for JIA?" Annual Meeting; Pediatric Academic Societies (2018)
  • "The Chromatin Landscape Around the Juvenile Arthritis-Associated CXCR4 Locus Suggests Regulatory Functions and Genetic Roles in Both Innate and Adaptive Immunity" Annual Meeting; Pediatric Academic Societies (2018)
  • "The Adverse Childhood Experiences Study: Raising Awareness among Tribal Nations" Annual Meeting; Southern Plains Tribal Health Board (2018)
  • "Evaluating Children with Musculoskeletal Complaints: An Evidence-Based Approach" Pediatric Grand Rounds; University of South Dakota School of Medicine (2018)
  • "Anti-Endothelial Cell Antibodies in Juvenile Dermatomyositis: A Proteomics-Based Approach" Annual Meeting; American College of Rheumatology (2017)
  • "Modeling Transcriptional Rewiring in Neutrophils Through the Course of Treated Juvenile Idiopathic Arthritis" Annual Meeting; American College of Rheumatology (2017)
  • "Plasma Exosomes from Children with Juvenile Dermatomyositis are Taken Up by Human Aortic Endothelial Cells and are Associated with Altered Gene Expression in Those Cells" Annual Meeting; American College of Rheumatology (2017)
  • "Treatment Response in Polyarticular JIA is Associated with Transcriptional Changes and Chromatin Reorganization in CD4+ T Cells" Annual Meeting; American College of Rheumatology (2017)
  • "Combined Genetics-Genomics Approaches To Rheumatic Disease: What Multi-Dimensional Genomic Data Can Teach Us" Translational Genomics and Epigenomics Symposium; Buffalo Niagara Medical Campus (2017)
  • "Combined Genetics-Genomics Approaches to Complex Traits: What Multi-Dimensional Genomic Data Can Teach Us" Seminar Series; Buffalo Clinical and Translational Science Institute (2017)
  • "Evaluation of Children with Musculoskeletal Complaints: An Evidence-Based Approach" Pediatric Grand Rounds; University at Buffalo (2017)
  • "Modeling Transcriptional Rewiring in Neutrophils Through the Course of Treated Juvenile Idiopathic Arthritis" Annual Meeting; Pediatric Academic Societies (2017)
  • "Transcriptional Changes in Chorionic Trophoblasts in an In Vitro Model of Inflammation are Independent of DNA Methylation Changes" Annual Meeting; Pediatric Academic Societies (2017)
  • "Treatment Response in Polyarticular JIA is Associated with Transcriptional Changes and Chromatin Rearrangements in CD4+ T Cells" Annual Meeting; Pediatric Academic Societies (2017)
  • "Evaluating Children with Musculoskeletal Complaints: An Evidence-Based Approach" Pediatric Grand Rounds; Rush University Medical Center (2017)
  • "A Multi-Dimensional Genomic Map for Polyarticular Juvenile Idiopathic Arthritis" Annual Meeting; American College of Rheumatology (2016)
  • "Genetic Insights into Juvenile Idiopathic Arthritis Derived from Deep Whole Genome Sequencing" Annual Meeting; American College of Rheumatology (2016)
  • "Identification of Target Antigens for Anti-Endothelial Cells in Patients with Pediatric Rheumatic Diseases by Proteomics" Annual Meeting; American College of Rheumatology (2016)
  • "RNAseq Reveals Treatment-Associated Gene Expression Dynamics in Juvenile Idiopathic Arthritis CD4+ T Cells" Annual Meeting; American College of Rheumatology (2016)
  • "The Non-Coding Genome and the Genetics of Systemic Lupus" Annual Meeting; American College of Rheumatology (2016)
  • "Building Multi-Dimensional Genomic Models for Complex Traits" Center for Molecular Medicine and Genetics; Wayne State University (2016)
  • "Epigenetics and the Social Determinants of Health" Annual Meeting; Association of American Indian Physicians (2016)
  • "Epigenetics and the Social Determinants of Health" Pediatric Grand Rounds; Mercy Hospital of Buffalo (2016)
  • "A Multi-Dimensional Genomic Map for Polyarticular Juvenile Idiopathic Arthritis" Annual Meeting; Pediatric Academic Societies (2016)
  • "Integrating Variation in Juvenile Idiopathic Arthritis from Deep Whole Genome Sequencing with Molecular Phenotypes" Annual Meeting; Pediatric Academic Societies (2016)
  • "Our Most Precious Resource" Media Interview; National Public Radio (NPR); Native America Calling (2016)
  • "RNAseq Reveals Treatment-Associated Gene Expression Dynamics in Juvenile Idiopathic Arthritis CD4+ T Cells" Annual Meeting; Pediatric Academic Societies (2016)
  • "Epigenetics and Health Disparities: Linking Biology and Social Science" Annual Meeting; Collaborative Research Center for American Indian Health (2016)
  • "Epigenetics and the Social Determinants of Health" Indigenous Health Conference; McMaster University (2016)
  • "What Genome Science Tells Us About the Social Determinants of Health" Pediatric Grand Rounds; University at Buffalo (2016)
  • "Epigenetics and the Social Determinants of Health" Department of Physical and Occupational Therapy; University at Buffalo (2015)
  • "Epigenetics and Complex Traits: How Toxic Stress Leads to Changes in the Genome" National Conference and Exhibition; American Academy of Pediatrics (2015)
  • "Children at Risk: Our Call to Improve Minority Health" 15th Annual Conference on Health Disparities; Loma Linda University (2015)
  • "Genetics, Epigenetics, and Complex Traits, Developing New Paradigms and Insights Into Health Disparities" 15th Annual Conference on Health Disparities; Loma Linda University (2015)
  • "A Bioinformatics Approach for Developing Biomarkers from RNAseq Data: Overcoming Methodologic Limitations and Disparities" Annual Meeting; Pediatric Academic Societies (2015)
  • "Developing Prognostic Biomarkers from Whole Blood Expression Profiling in Juvenile Idiopathic Arthritis: Influence of Early Therapy on Treatment Outcomes" Annual Meeting; Pediatric Academic Societies (2015)
  • "Disease-Associated SNPs from Non-Coding Regions in Juvenile Idiopathic Arthritis are Located Within or Adjacent to Functional Genomic Elements of Human Neutrophils" Annual Meeting; Pediatric Academic Societies (2015)
  • "Gene Expression Profiling Reveals Common Immunologic Pathways Between Oligoarticular and Polyarticular Juvenile Idiopathic Arthritis" Annual Meeting; Pediatric Academic Societies (2015)
  • "RNA Sequencing of Peripheral Blood Mononuclear Cells: Tracking Reproducibility for Biomarker Development" Annual Meeting; Pediatric Academic Societies (2015)
  • "Epigenetics and Child Health" 6th International Meeting on Indigenous Children’s Health; American Academy of Pediatrics/Canadian Paediatric Society (2015)
  • "Epigenetics and the Social Determinants of Health" Invited Presentation; Meharry Medical College (2015)
  • "Evaluating Children with Musculoskeletal Complaints: An Evidence-Based Approach" Invited Presentation; Meharry Medical College (2015)
  • "Deep Sequencing Reveals Differential RNA Expression During Malignant Transformation in Major Salivary Glands in a Mouse Model of Sjogren‘s Syndrome" Annual Meeting; American College of Rheumatology (2014)
  • "What‘s in Our Genes?" Media Interview; National Public Radio (NPR); Native America Calling (2014)
  • "Deep Sequencing Reveals Differential Small RNA Expression in Serum Exosomes from Children with Juvenile Idiopathic Arthritis" Annual Meeting; European League Against Rheumatism (2014)
  • "Developing Prognostic Biomarkers from Whole Blood Expression Profiling Juvenile Idiopathic Arthritis: Influence of Early Therapy on Treatment Outcome" Annual Meeting; European League Against Rheumatism (2014)
  • "Disease-Associated SNPs from Non-Coding Regions in Juvenile Idiopathic Arthritis are Located Within or Adjacent to Functional Genomic Elements of Human Neutrophils" Annual Meeting; European League Against Rheumatism (2014)
  • "Early Treatment with Methotrexate is Associated with Extensive Re-Ordering of the Neutrophil Transcriptome in Juvenile Idiopathic Arthritis" Annual Meeting; European League Against Rheumatism (2014)
  • "Functional Genomics and Rheumatic Diseases: Biomarkers and Beyond" Invited Presentation; St. Marianna University (2014)
  • "A Primer of Epigenetics and Its Role in Toxic Stress and Disease Susceptibility" California Chapter 1 Annual CME; American Academy of Pediatrics (2014)
  • "Deep Sequencing Reveals Differential Small RNA Expression in Serum Exosomes from Children with Juvenile Idiopathic Arthritis" Annual Meeting; American College of Rheumatology (2014)
  • "Evaluation of Children with Musculoskeletal Complaints: A Case-Based Approach" California Chapter 1 Annual CME; American Academy of Pediatrics (2014)
  • "Health Status of Native American Children: Why Every Pediatrician Should Care" Pediatric Grand Rounds; New York Medical College (2014)
  • "JIA-Associated SNPs from Non-Coding Regions are Located within or Adjacent to Functional Genomic Elements of Human Neutrophils" Pediatric Rheumatology Symposium; American College of Rheumatology (2014)
  • "Detection of State-Specific RNA Transcripts in Juvenile Idiopathic Arthritis Neutrophils Using RNA Sequencing" Annual Meeting; American College of Rheumatology (2013)
  • "Early Treatment with Methotrexate as Associated with Extensive Re-Ordering of the Neutrophil Transcriptome in Juvenile Idiopathic Arthritis" Annual Meeting; American College of Rheumatology (2013)
  • "Exon and miRNA Arrays Reveal Complexity and Specificity of the JIA Neutrophil Transcriptome" Annual Meeting; American College of Rheumatology (2013)
  • "RNA-Sequencing in PBMC Identifies Novel Differentially Expressed Coding and Non-Coding Transcripts in Juvenile Idiopathic Arthritis" Annual Meeting; American College of Rheumatology (2013)
  • "Juvenile Idiopathic Arthritis: An International Perspective and Look to the Future" Clinical Conference; Mexican College of Rheumatology (2013)
  • "Limits and Uses of the Laboratory in Pediatric Rheumatology" Clinical Conference; Mexican College of Rheumatology (2013)
  • "Use of the Laboratory in Evaluating Children With Musculoskeletal Complaints" Holiday Valley Pediatric Symposium; Women and Children‘s Hospital of Buffalo (2013)
  • "Health Status of American Indian Children and Youth: Why Every Pediatrician Should Care" Pediatric Grand Rounds; University at Buffalo (2013)
  • "Evaluation of Children with Musculoskeletal Complaints: An Evidence-Based Approach" Annual Meeting; Central NY Pediatric Society (2013)
  • "Evaluating Children with Musculoskeletal Complaints: An Evidence-Based Approach" Pediatric Grand Rounds; University at Buffalo (2013)
  • "Epigenetics and Rheumatic Diseases" Annual Meeting; Mexican College of Rheumatology (2013)
  • "Developing a Career as a Physician-Scientist" Annual Meeting; American College of Rheumatology; Fellows (2011)
  • "A Whole Blood Gene Expression Profile of Untreated Children with Polyarticular JIA Enrolled in the TREAT Trial" Annual Meeting; Pediatric Academic Societies (2011)
  • "Differences in Transcription Profiles in Juvenile Idiopathic Arthritis (JIA) Patients who Achieved Remission Using Different Therapies" Annual Meeting; Pediatric Academic Societies (2011)
  • "Interferon Gamma Priming Alone Does Not Alter the Methylation Status of CpG Islands in CD4+ T Cells" Annual Meeting; Pediatric Academic Societies (2011)
  • "LPS-Driven Inflammation Alters Gene Expression and Methylation Patterns in Trophoblast-like JEG-3 Cells, but Methylation Alterations Occur Distal from Differentially Expressed Genes" Annual Meeting; Pediatric Academic Societies (2011)
  • "Rheumatoid Factor-Positive and Rheumatoid Factor-Negative Children with Polyarticular Juvenile Idiopathic Arthritis Display Extensive Differences in Whole Blood Gene Expression Profiles" Annual Meeting; Pediatric Academic Societies (2011)
  • "Functional Genomics and Complex Childhood Diseases" Department of Pediatrics; Columbia University (2011)
  • "Complex Human Traits: Is Functional Genomics Ready to Take Them on?" Invited Presentation; Washington University School of Medicine (2011)
  • "A Whole Blood Gene Expression Profile of Untreated Children with Polyarticular Juvenile Idiopathic Arthritis Enrolled in the TREAT Trial" Annual Meeting; American College of Rheumatology (2010)
  • "Characterization of Granulocyte Transcriptome in Polyarticular Juvenile Idiopathic Arthritis (JIA)" Annual Meeting; American College of Rheumatology (2010)
  • "Developing a Career in Basic Research" Annual Meeting; American College of Rheumatology; Fellows (2010)
  • "Differences in Transcription Profiles in Juvenile Idiopathic Arthritis (JIA) Patients who Achieved Remission Using Different Therapies" Annual Meeting; American College of Rheumatology (2010)
  • "Gene Expression Profiling in Peripheral Blood Mononuclear Cells Predicts Disease Flares in Children with Polyarticular Juvenile Idiopathic Arthritis who Have Achieved Inactive Disease Status" Annual Meeting; American College of Rheumatology (2010)
  • "Leukocyte Expression of the Transcription Factor HNF4a, a Regulator of Gene Expression in Polyarticular Juvenile Idiopathic Arthritis" Annual Meeting; American College of Rheumatology (2010)
  • "Fever Syndromes: Common and Unusual" National Conference and Exhibition; American Academy of Pediatrics (2010)
  • "Update on the Laboratory Evaluation of Potential Rheumatic Diseases" National Conference and Exhibition; American Academy of Pediatrics (2010)
  • "Rheumatoid Arthritis and Its Effects on the Native American Family" 5th Annual Family Preservation Conference; Association of American Indian Physicians (2010)
  • "Functional Genomics and Complex Traits: Are We Ready to Take Them On?" Invited Presentation; Cold Spring Harbor Laboratory (2010)
  • "Arthritis in Indigenous North American Populations" Public Lecture; Royal University Hospital (2010)
  • "Systems Biology of Complex Diseases" Pediatric Grand Rounds; University of Saskatchewan (2010)
  • "Systems Biology and Complex Traits" Advances in Medicine Conference (2010)
  • "Systems Biology Approaches to Rheumatic Disease" Rheumatic Disease Research Institute; University of Guadalajara (2010)
  • "Systems Biology Approaches to Rheumatic Disease" Invited Presentation; Japanese Immunology Association (2009)
  • "Juvenile Idiopathic Arthritis in Native American Children" International Symposium on Rheumatic Diseases in Indigenous North American Populations…from Molecules to Communities; University of Manitoba (2009)
  • "The Perils and Promise of Genetic Research with Indigenous Americans" International Symposium on Rheumatic Diseases in Indigenous North American Populations…from Molecules to Communities; University of Manitoba (2009)
  • "Control of Inflammation at the Maternal-Fetal Interface: A Systems Biology Approach" Ottawa Health Research Institute; University of Ottawa (2009)
  • "Juvenile Idiopathic Arthritis as a Complex Trait" Annual Meeting; Japanese College of Rheumatology (2009)
  • "Defining Phenotypes in Childhood Arthritis: Beyond the Text Books" Congreso; Colegio Mexicano de Reumatologia (2009)
  • "Systems Biology and Complex Traits: The Future of Pediatric Rheumatology" Congreso; Colegio Mexicano de Reumatologia (2009)
  • "Systems Biology Approaches to Complex Illnesses in Children" Pediatric Grand Rounds; University of West Virginia (2008)
  • "Systems Biology Approaches to Chronic Arthritis in Children" Lecture; St. Louis University (2008)
  • "Systemic Lupus in Indigenous Americans: Special Concerns in a Unique Population" Wellness Meeting; The Shakopee Mdewakanton Sioux (Dakota) Community (2008)
  • "Systems Biology and Juvenile Arthritis" Invited Presentation; Cincinnati Children‘s Hospital (2008)
  • "Systems Biology Approaches to Complex Illnesses in Children" Pediatric Grand Rounds; State University of New York at Stony Brook (2008)
  • "Systems Biology Approaches to Complex Illnesses in Children" Pediatric Grand Rounds; University of Minnesota School of Medicine (2008)
  • "Evaluation of a Prolonged, Persistent, or Otherwise Annoying Fever" National Conference and Exhibition; American Academy of Pediatrics (2007)
  • "Systemic Lupus in Children" Symposium for Health Professionals; Arthritis Foundation (2007)
  • "Systems Biology Approaches to Complex Traits" Institute for Child Health; Great Ormand Street Hospital for Children (2007)
  • "Use of Laboratory in Evaluating Children with Musculoskeletal Complaints" National Conference and Exhibition; American Academy of Pediatrics (2007)
  • "Evaluation of Musculoskeletal Complaints in Children: An Evidence-Based Approach" Department of Pediatrics Alumni Day; Monmouth Medical Center (2007)
  • "Healthy Children: The Foundation for Healthy Communities" Native Youth in Distress Conference; National American Indian Court Judges and Association of American Indian Physicians (2007)
  • "Systems Biology Approaches to Complex Traits in Children" Department of Pediatrics; Monmouth Medical Center (2007)
  • "Systemic Lupus in Indigenous Teenagers and Young Adults: Special Concerns in a Unique Population" Annual Meeting; Association of American Indian Physicians (2007)
  • "Genomic Evidence that Juvenile Dermatomyositis is a Neutrophil-driven Auto-Inflammatory Disorder" Annual Meeting; Pediatric Academic Societies (2007)
  • "Poly- and Pauci-Articular JRA Show Distinct Neutrophil Gene Expression Profiles but More Closely Resemble Each Other than They Do Healthy Controls" Annual Meeting; Pediatric Academic Societies (2007)
  • "STAT3 is a Transcriptional Repressor in Choriocarcinoma-like Jeg-3 Cells" Annual Meeting; Pediatric Academic Societies (2007)
  • "Diagnostic Genomics: Ready for Clinical Implementation?" 13th International Vasculitis and ANCA Workshop; Vasculitis Foundation (2007)
  • "Proteomics: Complementing Systems Biology Approaches to Vasculitis" 13th International Vasculitis and ANCA Workshop; Vasculitis Foundation (2007)
  • "Diagnosing Common and Uncommon Rheumatic Diseases-Not a Trivial Pursuit" National Conference and Exhibition; American Academy of Pediatrics (2006)
  • "Juvenile Rheumatoid Arthritis in Native American Children" Annual Meeting; Association of American Indian Physicians (2006)
  • "Gene Microarrays in Rheumatic Disease: Will the Blind Men Finally See the Elephant?" Annual Meeting; European League Against Rheumatism (2006)
  • "Genomic Approaches to Rheumatic Diseases: The Blind Men Finally See the Elephant" Immunology Research Seminar; Boston Children‘s Hospital (2006)
  • "Lupus Nephritis: The Rheumatologist‘s Point of View" Annual Meeting; American Society for Pediatric Nephrology/Pediatric Academic Societies (2006)
  • "Rashes You Will See: Or Why Pediatric Rheumatologists Frequently Give Dermatology Grand Rounds" Pediatric Grand Rounds; University of Arizona School of Medicine (2006)
  • "Neutrophils in Juvenile Rheumatoid Arthritis: Time to Revise the Pathogenic Paradigm?" Invited Presentation; DuPont Children‘s Hospital (2006)
  • "Evaluation of Musculoskeletal Complaints in Children" Pediatric Grand Rounds; Robert Wood Johnson School of Medicine (2006)
  • "Is Polyarticular JRA a Disease of Neutrophils? Evidence for an Intrinsic Defect in Neutrophil Activation in Polyarticular JRA" Annual Meeting; American College of Rheumatology (2005)
  • "Clinical and Laboratory Associations in Childhood Systemic Lupus Erythematosus" Annual Meeting; Pediatric Academic Societies (2005)
  • "Evidence for Chronic Dysregulation in Neutrophils of Children with Polyarticular JRA" Annual Meeting; Pediatric Academic Societies (2005)
  • "Gene Expression Arrays Reveal Chronic, Intrinsic Activation of Neutrophils in Children with Polyarticular JRA. Is JRA Primarily a Neutrophil Disorder?" Annual Meeting; Pediatric Academic Societies (2005)
  • "Gene Expression Studies in JRA: Promises and Pitfalls" Annual Meeting; Pediatric Academic Societies (2005)
  • "HCG Secretion in Human Choriocarcinoma Jar Cells is MAPK but Not STAT3 Dependent: Contributions of TNF Alpha and IL-1-Beta Inflammation-induced hCG Secretion" Annual Meeting; Pediatric Academic Societies (2005)
  • "Pediatric Rheumatology: The Future is Here" Annual Meeting; Pediatric Academic Societies (2005)
  • "Soluble Factors from LPS-Activated PBMC Induce MAPK and STAT3 Phosphorylation in Primary Cultures of Human Placental Trophoblasts: Implications for Infection and Prematurity" Annual Meeting; Pediatric Academic Societies (2005)
  • "Rheumatic Disease in Native American Children" Invited Presentation; Hospital for Special Surgery (2004)
  • "Health Status of American Indian Children" Urban Indian Health Summit; Urban Indian Health Institute (2004)
  • "Autonomy and the Enlightenment Origins of Medical Ethics" Annual Meeting; Pediatric Academic Societies; Ethics Special Interest Group (2004)
  • "Ethical Considerations in Research with Socially Identifiable Populations" Annual Meeting; Pediatric Academic Societies; Ethics Special Interest Group (2004)
  • "Evaluation of Children with Musculoskeletal Complaints" Pediatric Grand Rounds; University of Arizona (2004)
  • "Genomic Approaches to Complex Disease" Faculty Seminar; University of Arizona (2004)
  • "Genomic Approaches to Complex Disease" Pediatric Grand Rounds; Seattle Children‘s Hospital (2004)
  • "Rheumatic Disease in Native American Children" Invited Presentation; Seattle Children‘s Hospital (2004)
  • "Evaluation of Children with Musculoskeletal Complaints" Pediatric Grand Rounds; Rapid City Hospital (2003)
  • "Evaluating Children with Musculoskeletal Complaints" Pediatrics Workshop; Indian Health Service (2003)
  • "Rheumatic Disease in Native American Children" Primary Care Conference; Billings Area Indian Health Service (2003)
  • "Juvenile Rheumatoid Arthritis: A Comparison of European and Non-European Populations" Pediatric Grand Rounds; University of Vermont College of Medicine (2003)
  • "Rheumatic Disease in Native American Children" Invited Presentation; Dartmouth College Medical College (2003)
  • "Juvenile Rheumatoid Arthritis: A Guide for Practitioners" Oklahoma Chapter; Pediatric Nurse Practitioners Association (2002)
See all (162 more)

Service Activities:
  • Agence du Recherche Sante (France); Ad hoc grant reviewer (2021)
  • External advisory board; Montana State University IDeA Network of Biomedical Research Excellence (INBRE) (2021–present)
  • American College of Rheumatology: Abstract review committee; Abstract reviewer (2021)
  • Anti-Racism Curriculum Committee; Committee Member (2021–present)
  • Pediatric Academic Societies; Abstract Reviewer (2021)
  • JCI Insight, Frontiers in Immunology, Academic Pediatrics, Journal of Rheumatology, Rheumatology (Oxford), ACR Open, Nature Communications; Manuscript reviewer (2021)
  • M.D./Ph.D. Admissions Committee (2020–present)
  • Committee member; Admissions Committee: MD/PhD program (2020–present)
  • Diversity Inclusion and Learning Environment Subcommittee on Curriculum (2020–present)
  • Pediatric Academic Societies Annual Meeting: Allergy, Immunology and Rheumatology; Moderator (2019)
  • Pediatric Academic Societies: Annual Meeting "Genomics/Epigenomics" and "Allergy, Immunology & Rheumatology"; Moderator (2019)
  • University of Manchester: Centre for Genetics and Genomics (Manchester, UK); External Reviewer (2017)
  • Association of American Indian Physicians: Adverse Childhood Experiences Committee; Committee Member (2017–2018)
  • Canadian Institute for Health Research/Genome Canada; Grant Reviewer (2017)
  • Arthritis Society of Canada: Research Grants; Reviewer (2017)
  • Seminars in Arthritis and Rheumatism; Reviewer (2017)
  • Rush University Medical School/Amgen; Visiting Professor (2017)
  • American Pediatric Society: Committee on Diversity and Inclusion; Committee Member (2017–present)
  • Children’s Arthritis and Rheumatology Research Alliance: Grant Review Panel; Panel Member (2017–present)
  • Genetics, Genomics, & Bioinformatics Graduate Program; Steering Committee Member (2016–present)
  • Rheumatology Research Foundation: Resident Research Preceptorship Reviews; Reviewer (2016–2018)
  • UK Arthritis Research Program; Ad Hoc Reviewer (2016)
  • ZonMW: Translational Research Programme (Netherlands); Ad Hoc Reviewer (2016)
  • University of Alaska Center for Alaska Native Health Research: Clinical and Translational Science Award External Advisory Board; Board Member (2016)
  • Genetics, Genomics, & Bioinformatics Program; Steering Committee (2015–present)
  • Committee on Diversity and Inclusiveness (2014–present)
  • Children’s Arthritis and Rheumatology Research Alliance: Technology and Translational Research Committee; Vice-Chair (2014–2017)
  • WK Kellogg Foundation: Oral Health Needs of American Indians/Alaskan Natives (Aurora, CO); Invited Participant (2013)
  • Arthritis Connective Tissue & Skin Disorders (ACTS);; Panel Member (2013–present)
  • Rheumatology (Oxford); Reviewer (2013–2017)
  • NIH/National Institute of Arthritis and Musculoskeletal and Skin Diseases: Arthritis Connective Tissue and Skin Disorders Study Section; Ad Hoc Reviewer (2013–2016)
  • NIH/National Institute of General Medical Science: Native American Research Centers for Health Special Emphasis Panel; Chair (2013)
  • American Academy of Pediatrics: Committee on Native American Child Health; Chair (2012–2016)
  • Clinical and Experimental Immunology; Reviewer (2011)
  • American Association for the Advancement of Science/State of Washington Life Sciences Development Fund; Grant Reviewer (2009)
  • Colegio Mexicano Reumatologia; Visiting Professor (2008)
  • Bioinformatics and Biology Insights; Editorial Board Member (2008–present)
  • 2nd International American Indian/First Nations/Inuit Child Health Meeting: Planning Committee; Committee Member (2007)
  • BMC Genomics; Reviewer (2007–2018)
  • Pediatric Rheumatology Online Journal; Reviewer (2007–2015)
  • American Academy of Pediatrics: Section on Rheumatology Executive Committee; Chair (2007–2011)
  • NIH/National Institute of Child Health and Human Development: Pregnancy and Neonatology Study Section; Member (2007–2011)
  • BMC Immunology; Reviewer (2007)
  • Future Rheumatology Reports; Reviewer (2007)
  • American College of Rheumatology/Immunex: Monmouth Children‘s Medical Center; Visiting Professor (2007)
  • Journal of Medical Case Reports; Editorial Board Member (2007–present)
  • BMC Medical Genomics; Editorial Board Member (2007–present)
  • American College of Rheumatology: Research and Education Foundation - Study Section B; Grant Reviewer (2007–present)
  • Current Problems in Pediatric and Adolescent Health Care 36(3): Pediatric Rheumatology; Guest Editor (2006)
  • American Academy of Pediatrics: Section on Rheumatology Executive Committee; Chair-Elect (2006–2007)
  • BMC Musculoskeletal Disorders; Reviewer (2006)
  • American Academy of Pediatrics: University of Arizona Department of Pediatric Rheumatology; Visiting Professor (2006)
  • Amgen/Immunex/American College of Rheumatology: Medical College of Georgia Department of Pediatric Rheumatology; Visiting Professor (2005)
  • Pediatric Academic Societies: Annual Meeting - Rheumatic Diseases in Children: Frontiers in Research and Clinical Care (Washington, DC); Chair (2005)
  • Arthritis Care and Research; Reviewer (2005–2017)
  • National Children‘s Study: Federal Advisory Committee; Committee Member (2005–2009)
  • National Institutes of Health: Pregnancy and Neonatology Study Section; Ad Hoc Reviewer (2005)
  • U.S. Department of Defense: Prostate Cancer Research Section - Immunological Sciences; Ad Hoc Reviewer (2005)
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases: Special Emphasis Panel; Grant Reviewer (2005)
  • The Lancet; Reviewer (2005)
  • BMC Musculoskeletal Disorders; Editorial Board Member (2005–present)
  • Arthritis Research and Therapy; Reviewer (2004–2018)
  • Journal of Pediatrics; Reviewer (2004)
  • Medical Science Monitor; Reviewer (2004)
  • Biotechnology and Applied Biochemistry; Reviewer (2004)
  • Pediatrics (Journal of the American Academy of Pediatrics); Reviewer (2004)
  • American College of Rheumatology/Immunex: University of Arizona Health Center; Visiting Professor (2004)
  • American Academy of Pediatrics: Indian Health Special Interest Group Steering Committee; Committee Member (2004–present)
  • Pediatric Nephrology; Reviewer (2003–2004)
  • American College of Rheumatology/Immunex: Henry Ford Hospital Department of Pediatric Rheumatology; Visiting Professor (2002)
  • Arthritis and Rheumatism; Reviewer (2002–2017)
  • Journal of Rheumatology; Reviewer (2002–2015)
  • National Arthritis Foundation: Inflammation Study Section; Grant Reviewer (2002–2010)
  • National Human Genome Research Institute: Developing a Haplotype Map of the Human Genome; Invited Participant (2001)
  • New York University: Intramural Research Program; Grant Reviewer (2001)
  • Archives of Diseases of Children and Adolescents; Reviewer (2001)
  • Wellcome Trust (London, UK); Grant Reviewer (2000)
  • Biology of the Neonate Journal; Reviewer (2000)
  • National Institute of General Medical Science: American Indian Research Training Needs; Invited Participant (1999)
  • American Academy of Pediatrics: Committee on Native American Child Health; Committee Member (1999–2005)
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases; Ad Hoc Reviewer (1999)
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases: T32 Training Grants and K-Awards; Grant Reviewer (1999)
  • Society for Pediatric Research: Annual Meeting - Rheumatology (New Orleans, LA); Chair (1998)
  • American Academy of Pediatrics: Section on Rheumatology Executive Committee; Committee Member (1998–2004)
  • Oklahoma University Health Science Center: American Indian Association; President (1998–2000)
  • American Society for Pediatric Research: Annual Meeting Abstract Selection Committee; Committee Member (1997)
  • Society for Pediatric Research: Annual Meeting - Neonatal Hematology/Immunology (Washington, DC); Chair (1996)
  • Institutional Biosafety Committee: Controlling the Complement System: Exploiting the Pathogenic Understanding for Novel Drug Development (Boston, MA); Chair (1995)
  • National Institutes of Health: Toxicology-1 Study Section; Grant Reviewer (1995)
  • Arthritis Foundation, Michigan Chapter; Grant Reviewer (1993–1996)
  • Grant reviewer; Children's Arthritis & Rheumatology Research Alliance (CARRA) Scientific Review Committee
  • American College of Rheumatology: Annual Meeting Abstract Selection Committee (1996, 2001, 2004, 2011); Committee Member
  • Pediatric Academic Societies: Meeting Abstract Selection Committee (2008, 2010, 2015, 2017); Committee Member
  • University at Buffalo: Committee of Diversity and Inclusiveness - Memorandum of Understanding with the Indian Health Service; Coordinator
  • National Human Genome Research Institute: Working Group (2001, 2004) Ethical, legal, and social implications of genetic research on medical conditions affecting Indian and Native People through a grant to Dr. Paul Spicer, University of Colorado; Member

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Clinical and Translational Research Center
875 Ellicott Street
Room 8026
Buffalo, New York 14203
Phone: (716) 888-4796
jamesjar@buffalo.edu
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