Marilou I. Ching MD, MPH, FACP

Marilou Ching

Marilou I. Ching
MD, MPH, FACP

Associate Professor of Neurology, Program Director, Vascular Neurology Fellowship Program

Department of Neurology

Jacobs School of Medicine & Biomedical Sciences


Specialty/Research Focus

Cerebrovascular (Stroke); Internal Medicine; Neurology; Neuroscience; Stroke

Contact Information
UB Department of Neurology
1010 Main Street, 2nd floor
Buffalo, New York 14202
Phone: (716) 932-6080, ext. 102
Fax: (716) 829-4001
mching@buffalo.edu


Patient Care

This faculty member is affiliated with UBMD, practicing physicians who are also professors in the Jacobs School.

View this physician on UBMD


Professional Summary:

I am a neurologist who specializes in the care of patients with stroke and other neurovascular disorders. I am board-certified in internal medicine, neurology and vascular neurology. I care for inpatients at Buffalo General Medical Center, the busiest stroke service in New York State, and for outpatients after their discharge from the hospital. I serve as the neurology medical director at the Gates Vascular Institute, a state-of-the-art facility adjoining Buffalo General Medical Center that specializes in the care of vascular disorders. As a member of several committees, I help develop admission and treatment guidelines for the medical center. Of note, we continue to improve our door-to-tissue plasminogen activator time for those patients who are eligible for this treatment for acute stroke. Our stroke center has been recognized as a Comprehensive Stroke Center by the Joint Commission and received a “Get With The Guidelines Gold Plus” award from the American Heart Association.

I am very involved in stroke research and serve as principal investigator on several cutting-edge National Institutes of Health (NIH) and industry-funded clinical trials. My research and publications in this domain include clinical investigation into the diagnosis, treatment and prevention of cerebrovascular disease.

In addition to my clinical and research role, I am very involved with the education of medical students, residents and fellows on the neurovascular service. I serve as the program director for the Vascular Neurology Fellowship Program approved by the Accreditation Council for Graduate Medical Education (ACGME) which trains one to two fellows each year. I give several didactic lectures every year to various audiences at different levels of training.

Education and Training:

  • Fellowship, Vascular Neurology, Cleveland Clinic Foundation (2007)
  • Residency, Combined Residency in Internal Medicine and Neurology, University at Buffalo School of Medicine and Biomedical Sciences (2005)
  • Fellowship, Research Fellow, Food and Drug Administration Fellow in Clinical Pharmacology (1996)
  • MPH, Master of Public Health, Columbia University (1994)
  • MD, Far Eastern University - Dr. Nicanor Medical Foundation (1985)
  • BS, Ateneo de Manila University (1981)

Employment:

  • Associate Professor, Neurology, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (2015-present)
  • Fellow, American College of Physicians (2012-present)
  • Program Director, Vascular Neurology Fellowship Program, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (2009-present)
  • Assistant Professor, Neurology, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (2007–2015)

Awards and Honors:

  • Louis A. and Ruth Siegel Award for Excellence in Teaching (2013)
  • Outstanding Accreditation Award (2012)
  • Michael E. Cohen Resident’s Research Day Award for Outstanding Resident Research Presentation (2005)
  • American Academy of Neurology Resident Scholarship Award (2005)
  • Michael E. Cohen Resident’s Research Day Award for Outstanding Resident Presentation (2004)
  • Best Resident (1997)

Research Expertise:

  • Cerebrovascular disease
  • Stroke

Research Centers:

  • Jacobs Neurological Institute

Grants and Sponsored Research:

  • –September 2021
    Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Multicenter, Phase 3 Study to Evaluate the Efficacy and Safety of Intravenous BIIB093 (Glibenclamide) for Severe Cerebral Edema following Large Hemispheric Infarction CHARM Study: GlibenClamide for large Hemispheric infarction Analyzing mRS and Mortality
    Biogen
    Role: Principal Investigator
  • –September 2021
    Stroke AF
    Medtronic
    Role: Principal Investigator
  • –September 2021
    AtRial Cardiopathy and Antithrombotic Drugs In prevention After cryptogenic stroke (ARCADIA)
    NIH StrokeNet
    Role: Co-Investigator
  • –September 2021
    ARCADIA CSI (Cognitive function and Silent Infarcts)
    NIH
    Role: Co-Investigator
  • –September 2021
    Anticoagulation in Intracerebral Hemorrhage (ICH) Survivors for Stroke Prevention and Recovery (ASPIRE)
    NIH
    Role: Co-Investigator
  • –September 2021
    StATins Use in intRacereberal hemorrhage patieNts (SATURN)
    NIH
    Role: Co-Investigator
  • –September 2021
    Sleep for Stroke Management and Recovery Trial - SLEEP SMART
    StrokeNet
    Role: Co-Investigator
  • September 2021
    Secondary Prevention of Small Subcortical Strokes
    National Institutes of Health
    Role: Principal Investigator
  • DIAS4: A randomized, double blind, parallel-group placebo- controlled phase III study to evaluate the efficacy and safety of desmoteplase in subjects with acute ischemic stroke
    Lundbeck A/S
    Role: Principal Investigator
  • IRIS: Insulin Resistance after Ischemic Stroke
    National Institute of Neurological Disorders and Stroke (NINDS)
    Role: Principal Investigator
  • POINT: Platelet Oriented Inhibition in New TIA and minor ischemic stroke Trial.
    National Institute of Neurological Disorders and Stroke (NINDS)
    Role: Principal Investigator
  • SHINE: Stroke Hyperglycemia Insulin Network Effort (SHINE) Trial.
    National Institutes of Health
    Role: Principal Investigator
  • A Randomized, Double-Blind, Multinational Study to Prevent Major Vascular Events with Ticagrelor Compared to Aspirin (ASA) in Patients with Acute Ischemic Stroke or TIA [SOCRATES –Acute Stroke Or Transient IsChemic Attack TReated with Aspirin or Ticagrelor and Patient OutcomES]
    Astra Zeneca
    Role: Principal Investigator
  • Modified Matrix Study of Vanlev® with Hydrochlorothiazide in Mild-to-Moderate Hypertension
    Bristol-Myers Squibb Pharmaceutical Research Institute
    Role: Co-Investigator
  • A prospective, double-blind, randomized, parallel efficacy study of a losartan treatment regimen versus placebo in the treatment of patients with isolated systolic hypertension.
    Merck & Co., Inc
    Role: Co-Investigator
  • Desmoteplase in Acute Ischemic Stroke: Phase III
    Paion and Forest Research Institute.
    Role: Principal Investigator
  • CLOSURE 1 Trial: A Prospective, Multicenter, Randomized, Controlled Trial to Evaluate the Safety and Efficacy of the Starflex septl Closure System Versus Best Medical Therapy In Patients with a Stroke and/or Transient Ischemic Attack Due to Presumed Paradoxical Embolism Through a Patient Foramen Ovale
    NMT Medical, Inc.
    Role: Co-Principal Investigator
  • WARCEF Trial: Warfarin vs. Aspirin in Reduced Cardiac Ejection Fraction,
    National Institutes of Health.
    Role: Co-Principal Investigator
  • PRoFESS: Prevention Regimen for Effectively Avoiding Secondary Strokes: A Double-Blind, Active and Placebo Controlled Study of Aggrenox vs. Clopidogrel With and Without Micardis
    Boehringer Ingelheim
    Role: Co-Principal Investigator
  • IMS III: Interventional Management of Stroke Trial: A Phase III, Randomized, Multi-center, open label, 900 subject clinical trial that will examine whether a Combined intravenous and intra-arterial approach to recanalization is superior to standard IV rt-PA (Activase) alone when initiated within three hours of Acute ischemic stroke
    NIH/HINDS
    Role: Co-Principal Investigator
  • Effects of Omapatrilat or Enalapril on Conduit Vessel Hemodynamics in Subjects with Systolic Hypertension
    Bristol-Myers Squibb Pharmaceutical Research Institute
    Role: Co-Investigator
  • Hypertension Optimal Treatment
    Astra/Merck Inc.
    Role: Co-Investigator
  • Losartan Intervention for Endpoint Reduction in Hypertension: A Triple-Blind, Parallel Study to Investigate the Effect of Losartan Versus Atenolol o the Reduction of Morbidity and Mortality in Hypertnesive Patients with Left Ventricular Hypertrophy
    Merck and Company
    Role: Co-Investigator
  • Effects of Omapatrilat or Enalapril on Conduit Vessel Hemodynamics in Subjects with Systolic Hypertension
    Bristol-Myers Squibb Pharmaceutical Research Institute
    Role: Co-Investigator
  • A Phase IIIb, double blind, multicenter study to evaluate the efficacy and safety of alteplase in patients with mild stroke: rapidly improving symptoms and minor neurological deficits (PRISMS)
    National Institute of Neurological Disorders and Stroke (NINDS)
    Role: Co-Investigator
  • NAVIGATE ESUS - Multicenter, randomized, double-blind, double-dummy, active-comparator, event-driven, superiority phase III study of secondary prevention of stroke and prevention of systemic embolism in patients with a recent Embolic Stroke of Undetermined Source (ESUS), comparing rivaroxaban 15 mg once daily with aspirin 100 mg
    Role: Co-Investigator
  • Evaluation of the Efficacy and Safety of Candesartan Cilexetil in the Treatment of Patients with Hypertension: A Multicenter, Randomized, Double Blind, Placebo-Controlled Dose Response Study
    Astra Merck Inc.
    Role: Co-Investigator
  • A Multicenter, Double-Blind, Placebo-Controlled, Parallel Study to Determine the LDL-C Lowering Efficacy of Pravastatin Administered Once Daily Over the Dosage Range of 40 mg Through 60 mg
    Bristol-Myers Squibb Pharmaceutical Research Institute
    Role: Co-Investigator
  • Preliminary Characteristics of the OPERA (Omapatrilat in Persons with Enhanced Risk of Atherosclerotic Events) Mortality and Morbidity Protocol.
    Bristol-Myers Squibb Pharmaceutical Research Institute
    Role: Co-Investigator
  • COSS: Carotid Occlusion Surgery Study National Institute of Neurological Disorders and Stroke
    NINDS
    Role: Principal Investigator
  • Comprehensive Rimonabant Evaluation Study of Cardiovascular Endpoints and Outcomes
    Sanofi Aventis.
    Role: Co-Investigator
  • SWISS: Siblings with Ischemic Stroke Study
    National Institutes of Health.
    Role: Co-Investigator
  • Warfarin vs. Aspirin in Reduced Cardiac Ejection Fraction
    National Institutes of Health
    Role: Co-Investigator
  • A Phase III Randomized Multicenter Clinical Trial of High-Dose Human Albumin Therapy for Neuroprotection in Acute Ischemic Stroke
    The National Institute of Neurological Disorders and Stroke (NINDS)
    Role: Co-Investigator
  • GORE Reduce Study: Gore Helix Septal Occluder and Antiplatelet Medical Management for Reduction of Recurrent Stroke or Imaging-Confirmed TIA in Patients with Patent Foramen
    W.L. Gore and Associates, Inc.
    Role: Co-Investigator
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Journal Articles:

  • Meschia JF, Walton RL, Farrugia LP, Ross OA, Elm JJ, Farrant M, Meurer WJ, Lindblad AS, Barsan W, Ching M, Gentile N, Ross M, Nahab F, Easton JD, Kim AS, Zurita KG, Cucchiara B, Johnston SC. (2020) Efficacy of Clopidogrel for Prevention of Stroke Based on CYP2C19 Allele Status in the POINT Trial. Stroke (Jul), 51(7): 2058-2065.
  • Mowla A, Kamal H, Lail NS, Vaughn C, Shirani P, Mehla S, Rajabzadeh-Oghaz H, Deline C, Ching M, Crumlish A, Sawyer RN. (2017) Intravenous Thrombolysis for Acute Ischemic Stroke in Patients with Thrombocytopenia. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association (Jul), 26(7): 1414-1418.
  • Mowla A, Doyle J, Lail NS, Rajabzadeh-Oghaz H, Deline C, Shirani P, Ching M, Crumlish A, Steck DA, Janicke D, Levy EI, Sawyer RN. (2017) Delays in door-to-needle time for acute ischemic stroke in the emergency department: A comprehensive stroke center experience. Journal of the neurological sciences (May), 376: 102-105.
  • Sternberg Z, Chichelli T, Sternberg D, Sawyer R, Ching M, Janicke D, Ambrus JL, Yu J, Munschauer F. (2016) Relationship between Inflammation and Aspirin and Clopidogrel Antiplatelet Responses in Acute Ischemic Stroke. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association (Feb), 25(2): 327-34.
  • Mowla A, Singh K, Mehla S, Ahmed MK, Shirani P, Kamal H, Krishna C, Sawyer RN, Ching M, Siddiqui AH, Levy EI, Snyder KV, Crumlish A, Hopkins LN. (2015) Is acute reperfusion therapy safe in acute ischemic stroke patients who harbor unruptured intracranial aneurysm?. International journal of stroke : official journal of the International Stroke Society (Oct), 10 Suppl A100: 113-8.
  • AbdelRazek MA, Mowla A, Hojnacki D, Zimmer W, Elsadek R, Abdelhamid N, Elsadek L, Farooq S, Kamal H, Crumlish A, Shirani P, Ching M, Sawyer R. (2015) Prior Asymptomatic Parenchymal Hemorrhage Does Not Increase the Risk for Intracranial Hemorrhage after Intravenous Thrombolysis. Cerebrovascular diseases (Basel, Switzerland) (Jan), 40(5-6): 201-4.
  • Sternberg Z, Ching M, Sawyer RN, Chichelli T, Li F, Janicke D, Radovic V, Mehta B, Farooq O, Munschauer FE. (2013) Clopidogrel responsiveness in stroke patients on a chronic aspirin regimen. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association (Aug), 22(6): 725-32.
  • Baker JG, Williams AJ, Ionita CC, Lee-Kwen P, Ching M, Miletich RS. (2012) Cerebral small vessel disease: cognition, mood, daily functioning, and imaging findings from a small pilot sample. Dementia and geriatric cognitive disorders extra (Jan), 2: 169-79. doi:10.1159/000333482
  • Patel D, Bailey SM, Furlan AJ, Ching M, Zachaib J, Di Biase L, Mohanty P, Horton RP, Burkhardt JD, Sanchez JE, Zagrodzky JD, Gallinghouse GJ, Schweikert R, Saliba W, Natale A. (2010) Long-term functional and neurocognitive recovery in patients who had an acute cerebrovascular event secondary to catheter ablation for atrial fibrillation. Journal of cardiovascular electrophysiology (Apr), 21(4): 412-7.
  • Bong Hee Sung, Marilou Ching, Joseph Izzo, Jr., Paresh Dandona, Michael F. Wilson. (1900) Insulin-Mediated Venodilation is Impaired in Patients with High Cholesterol. Hypertension (Jan), 31(1998): 1266-1271.
  • Johnston SC, Amarenco P, Albers GW, Denison H, Easton JD, Evans SR, Held P, Jonasson J, Minematsu K, Molina CA, Wang Y, Wong KS; SOCRATES Steering Committee and Investigators. (1900) Ticagrelor versus Aspirin in Acute Stroke or Transient Ischemic Attack. N Engl J Med (Jan), 375(1)(2016): 35-43.
  • Søndergaard L, Kasner SE, Rhodes JF, Andersen G, Iversen HK, Nielsen-Kudsk JE, Settergren M, Sjöstrand C, Roine RO, Hildick-Smith D, Spence JD, Thomassen L; Gore REDUCE Clinical Study Investigators. (1900) Patent Foramen Ovale Closure or Antiplatelet Therapy for Cryptogenic Stroke. N Engl J Med (Jan), 377(11)(2017): 1033-1042.
  • Ching M, Sung BH, Forrest A, Wilson MF, Izzo JL Jr. (1900) Vasoreactivity in Pre and Postmenopausal Women: Evaluation by Pharmacodynamic Modelling. J of Clin Pharmacol (Jan), 38(1998): 151-159.
  • Elkind MS1, Luna JM, McClure LA, Zhang Y, Coffey CS, Roldan A, Del Brutto OH, Pretell EJ, Pettigrew LC, Meyer BC, Tapia J, White C, Benavente OR; LIMITS Investigators. (1900) C-reactive protein as a prognostic marker after lacunar stroke: levels of inflammatory markers in the treatment of stroke study. Stroke (Jan), 45(3)(2014): 707-16.
  • Amit Kandel, MBBS; Marilou Ching, MD, MPH; Osman Farooq, MD; Rohit Gokhale, MBBS; Carina Alfaro-Franco, MD, MS, FACC; Ping Li, MD. (1900) Takotsubo Cardiomyopathy in a Patient with Chronic Inflammatory Demyelinating Polyneuropathy. N A J Med Sci (Jan), 8(2)(2015): 100-104.
  • Johnston SC, Easton JD, Farrant M, Barsan W, Conwit RA, Elm JJ, Kim AS, Lindblad AS, Palesch YY; Clinical Research Collaboration, Neurological Emergencies Treatment Trials Network, and the POINT Investigators. (1900) Clopidogrel and Aspirin in Acute Ischemic Stroke and High-Risk TIA. N Engl J Med (Jan), 379(3)(2018): 215-225.
  • Allen K, Golden L, Izzo JL, Jr., Ching M, Forrest A, Niles C, Niswander P, Barlow J. (1900) Normalization of Hypertensive Responses During Ambulatory Surgical Stress by Perioperative Music. Psychosomatic Medicine (Jan), 63(2001): 487-492.
  • COSS Investigators. (1900) Extracranial-Intracranial Bypass Surgery for Stroke Prevention in Hemodynamic Cerebral IschemiaL the Carotid Occlusion Surgery Study Randomized Trial. JAMA (Jan), 306(18)(2011): 412-417.
  • Epstein KA, Viscoli CM, Spence JD, Young LH, Inzucchi SE, Gorman M, Gerstenhaber B, Guarino PD, Dixit A, Furie KL, Kernan WN; IRIS Trial Investigators. (1900) Smoking cessation and outcome after ischemic stroke or TIA. Neurology (Jan), 89(16)(2017): 1723-1729.
  • Marilou Ching, MD. MPH, FACP. (1900) Anticoagulation for Atrial Fibrillation: Current Strategies. UH Neurological Institute Journal (Jan), 6(1)(2013)
  • Easton JD, Aunes M, Albers GW, Amarenco P, Bokelund-Singh S, Denison H, Evans SR, Held P, Jahreskog M, Jonasson J, Minematsu K, Molina CA, Wang Y, Wong KSL, Johnston SC; SOCRATES Steering Committee and Investigators. (1900) Risk for Major Bleeding in Patients Receiving Ticagrelor Compared With Aspirin After Transient Ischemic Attack or Acute Ischemic Stroke in the SOCRATES Study (Acute Stroke or Transient Ischemic Attack Treated With Aspirin or Ticagrelor and Patient Outcomes). Circulation (Jan), 136(10)(2017): 907-916.
  • Karen C Johnston , Askiel Bruno , Qi Pauls , Christiana E Hall, Kevin M Barrett , William Barsan , Amy Fansler , Katrina Van de Bruinhorst , Scott Janis , Valerie L Durkalski-Mauldin , Neurological Emergencies Treatment Trials Network and the SHINE Trial Investigators. (1900) Intensive vs Standard Treatment of Hyperglycemia and Functional Outcome in Patients With Acute Ischemic Stroke: The SHINE Randomized Clinical Trial. JAMA (Jan), 322(4)(2019): 326-335.
  • BH Sung, M Ching, JL Izzo, Jr., P Dandona, MF Wilson. (1900) Estrogen Improves Abnormal Norepinephrine-induced Vasoconstriction in Postmenopausal Women. Journal of Hypertension (Jan), 17(4)(1999): 523-528.
  • The SPS3 Investigators. (1900) Effects of Clopidogrel Added to Aspirin in Patients with Recent Lacunar Stroke. N Engl J Med (Jan), 367(2012): 817-25.
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Professional Memberships:

  • European Stroke Organization (2019–present)
  • Ontario Medical Association (2015–present)
  • College of Physicians and Surgeons of Ontario (2014–present)
  • American Heart Association/American Stroke Association (2006–present)
  • American Academy of Neurology (2003–present)
  • American College of Physician-American Society of Internal Medicine (2002–present)
  • American Medical Association (2001–present)
  • American College of Clinical Pharmacy (1997–present)
  • Council on Geriatric Cardiology (1996–present)
  • American Society of Hypertension (1995–present)
  • Public Health Association of New York City (1993–present)
  • American Hospital Association (1993–present)
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Presentations:

  • "Aortic Thrombus In The Setting of COVID-19" European Stroke Organization Conference (2021)
  • "Body Mass Index, Creatinine and Triglycerides are Independent Predictors of Occurrence of Stroke in Patients Adherent with Direct Oral Anticoagulant for Non-Valvular Atrial Fibrillation." European Stroke Organization Conference (2021)
  • "Weight is a Predictor of Mortality in Patients with Active Cancer and Stroke." European Stroke Organization Conference (2021)
  • "Ischemic and Hemorrhagic Stroke" Lecture for Cardiology Fellows (2021)
  • "Stroke and Covid (via Zoom)" Invitation from Far Eastern University (2021)
  • "Age, Left Atrial Volume Inex and PR Interval are Independent Predictors of Atrial Fibrillation in Embolic Stroke Patients with Insertable Cardiac Monitors." European Stroke Organization Conference (2020)
  • "Stroke in Cancer Patients" Society for Neuro-Oncology Annual Meeting (2019)
  • "Triglycerides, Creatinine and Body Mass Index are Independent Predictors of Occurrence of Stroke in patients Adherent with Direct oral Anticogulant." American Academy of Neurology (2019)
  • "Triglycerides, Creatinine and Body Mass Index are Independent Predictors of Occurrence of Stroke in patients Adherent with Direct oral Anticogulant." European Stroke Organization Conference (2019)
  • "Stroke for the Cardiologist" Lecture for Cardiology Fellows (2018)
  • "Left Atrial Volume Index and PR Interval are Independent Predictors of Atiral Fibrillation in Embolic Stroke Patients with Insertable Cardiac Monitor." International Stroke Conference 2018 (2018)
  • "Delays in Door to Needle Time for Acute Ischemnic Stroke in the Emergency Department-A Comprehensive Stroke Center Experience." European Stroke Conference 2017 (2017)
  • "Man-in-the-Barrel syndrome with delayed diffusion-weighted MRI findings." European Stroke Conference 2017 (2017)
  • "Predictors of Parosysmal Atrial Fibrillation in Embolic Stroke Patients with insertable cardiac monitor: A Comprehensive Stroke Center Experience." European Stroke Conference 2017 (2017)
  • "Safety of Intravenous Thrombolysis in Acute ischemic Stroke Patients Older than 80 Years of Age within the 3-4.5 hour Period after Symptom Onset." European Stroke Conference 2017. (2017)
  • "Safety of Intravenous Thrombolysis in Acute ischemic Stroke Patients taking Oral Anricoagulants" European Stroke Conference 2017 (2017)
  • "The Heart Brain Connection" Stroke Care Seminar 2016 (2016)
  • "Analytic Study of Neurology Residents’ Clinical Assessment of Potential Stroke Patients Prior to MRI Results" 2016 International Stroke Conference (2016)
  • ". Ischemic Stroke in Patients with Elevated Body Mass Index while on Novel Anticoagulants: A case series report." 2015 American Academy of Neurology (2015)
  • "Rate, Clinical features, Safety profile and Outcome of Intravenous Thrombolysis for Acute Ischemic Stroke in Patients with Negative Brain Imaging." 2015 International Stroke Conference (2015)
  • "Is Acute Reperfusion Therapy Safe in Acute Ischemic Stroke Patients Who Harbor Unruptured Intracranial Aneurysm?" 12th Annual Neurocritical Care Society Meeting (2014)
  • "Case-based Correlative Neuroanatomy" Stroke Care Seminar 2014 (2014)
  • "Serum Albumin Is Associated with Cerebral Hemorrhage in Post-Intravenous Thrombolytic Therapy for Acute Stroke –: A Retrospective Chart Review" 2014 American Academy of Neurology (2014)
  • "A Practicum in the Management of Acute Stroke" Stroke Care Seminar 2013 (2013)
  • "Anticoagulation in Atrial Fibrillation: Current Strategies" 10th Annual Cleveland Neurocritical Care and Stroke Conference (2013)
  • "Truths and Myths Surrounding Vascular Risk Factors" 2012 Stroke Care Seminar (2012)
  • "Timing of Mobile Cardiac Outpatient Telemetry May Increase Diagnostic Yield of Atrial Fibrillation in Select Patients with Cryptogenic Strokes." International Stroke Conference (2012)
  • "Patent Foramen Ovale" Third Annual Holes in the Heart Symposium (2011)
  • "Comparison of Three “Point of Care” Laboratory Methods to Assess Clopidogrel Responsiveness in Stroke patients on Chronic Aspirin Regimen." 63rd AAN Annual Meeting (2011)
  • "Cerebrovascular Disease" (2011)
  • "Correlations between Stroke Severity and Different Types of Antihyperglycemic Medication." 62nd Annual Meeting of the American Academy of Neurology (2010)
  • "Vitamin D Deficiency and Acute Ischemic Stroke: Correlation Between Vitamin D Levels and Stroke Severity." International Stroke Conference (2010)
  • "Does a 320-Slice vs 64-Slice CT Scanner Change Ones Management of Acute Stroke?" American Society of Neuroimaging (2010)
  • "Evidenced Based Review of Stroke Risk Factors and Management" Grand Rounds at Erie County medical Center (2010)
  • "Stroke Following Percutaneous Radiofrequency Ablation for Atrial Fibrillation: The Cleveland Clinic Experience." Grand Rounds (2009)
  • "Stroke Following Percutaneous Radiofrequency Ablation for Atrial Fibrillation: The Cleveland Clinic Experience" 32nd Annual Neuroscience Resident’s Day (2007)
  • "Stroke Following Percutaneous Radiofrequency Ablation for Atrial Fibrillation: The Cleveland Clinic Experience." American Academy of Neurology (2007)
  • "Hospital Formulary Unavailability of tPA for Acute Stroke: The Ohio Community Hospital Survey." International Stroke Conference 2007 (2007)
  • "Assessment of Arterial Compliance in Obstructive Sleep Apnea" Nineteenth Annual Meeting, Association of Professional Sleep Society, Colorado Convention Center (2005)
  • "Arterial Compliance is Reduced in Sleep Apnea" Twentieth Annual Scientific Meeting, American Society of Hypertension (2005)
  • "Neurologic Complications of Cardiac Surgery" Neurology Grand Rounds (2005)
  • "Long Term Neurologic Outcomes in Acute Thromboembolic Events Associated with Ablation for Atrial Fibrillation." Heart Rhythm Society, AFIB Summit (2004)
  • "Assessment of Current Treatment Trends in the Management of High Risk Hypertension" Fifteenth Scientific Meeting of the American Society of Hypertension (2000)
  • "Role of Estrogen in Blood Pressure Regulation at Rest and During Stress. Institute for Research and Education on Women and Gender" Second Annual Celebration of Women’s Scholarship Across the Disciplines (1999)
  • "Development of a Pharmacodynamic Model for the Assessment of Vasoreactivity in Premenopausal and Postmenopausal Women" American Society of Clinical Pharmacy (1997)
  • "Subpopulation of Healthy Normotensive Blacks Show Abnormal Insulin-Mediated Vasodilation." Twelfth International Interdisciplinary Conference on Hypertension in Blacks (1997)
  • "Vasoreactivity in Pre and Postmenopausal Women: Evaluation by Pharmacodynamic Modelling." Conference at Food and Drug Administration (1997)
  • "Altered Reactivity to Norepinephrine and Insulin in Pre and Postmenopausal Women: Evaluation by Pharmacodynamic Modeling." The Canadian Hypertension Society Annual Spring Research Meeting (1997)
  • "Effects of Heavy Alcohol Consumption on Hemodynamic Response to Mental and Physical Stress" Twelfth Scientific Meeting of the American Society of Hypertension, (1997)
  • "Comparison of Blood Pressure Response to Mental and Physical Stress Between Heavy vs Mild Social Drinkers." Experimental Biology ‘97 (1997)
  • "Patient Stress and Ambulatory Ophthalmic Surgery: The Moderating Effects of Music." 1997 Annual Meeting of the American Psychosomatic Society (1997)
  • "Insulin Sensitivity and the Maintenance of Normotension in Postmenopausal Women." Vascular Reactivity Conference (1996)
  • "Alcohol Consumption Modifies Norepinephrine-Induced Vasoconstriction and Insulin-Mediated Vasodilation." American Heart Association (1996)
  • "Effects of Age and Gender on Cardiovascular Reactivity to Mental Stress in Hypercholesterolemic Patients" Council on Geriatric Cardiology (1996)
  • "Estrogen Modifies Cardiovascular Reactivity to Mental Stress in Hypercholesterolemic Subjects" The Fourth International Congress of Behavioral Medicine (1996)
  • "Modelled Venoactive Responses to Norepinephrine and Insulin are Abnormal in Postmenopausal Women" Council on Geriatric Cardiology (1996)
  • "Hypercholesterolemia impairs insulin-mediated but not nitroprusside-induced venodilation" American Heart Association 68th Scientific Sessions (1995)
  • "Effects of gender on venous reactivity to insulin." Tenth Scientific Meeting of the American Society of Hypertension (1995)
  • "Venous reactivity in postmenopausal women." Tenth Scientific Meeting of the American Society of Hypertension (1995)
  • "Effects of menopause on dorsal hand vein reactivity to norepinephrine in vivo." Federation of American Societies for Experimental Biology (FASEB) (1995)
  • "Does gender affect vascular response to norepinephrine? In vivo evaluation of dorsal hand vein." Federation of American Societies for Experimental Biology (FASEB) (1994)
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Service Activities:

  • Developed a dedicated stroke and telemetry unit at Millard Fillmore Gates Hospital. Developed admission guidelines and criteria for the stroke unit. Developed an algorithm for triaging and treatment of cardiac-related arrhythmias in the stroke unit. Mandated that all nurses in the stroke unit be NIH Stroke Scale certified - in collaboration with the Director of Nursing. Developed a tracking system to ensure that Get with the Guidelines was enforced. Millard Fillmore Hospital has been awarded the Stroke Gold Performance Achievement Award, Developed new hospital stroke admission orders. Attended regular meetings with architects and hospital administration regarding design and construction of the Buffalo Niagara Medical Campus’ Gates Vascular Institute, the new home of the Stroke Center, 2011. Developed guidelines for admission of TIA patients to the observation unit. (2021)
  • ; Member (2021–present)
  • Council on Epidemiology, American Heart Association; Consultant (2017–present)
  • Reviewer of Neurology section for American Board of Internal Medicine (MKSAP 18); Reviewer (2016)
  • Edited and wrote a 50-page stroke education brochure designed to help patients and their families understand the pathophysiology of stroke, interventional procedures and treatment options. It incorporates a multidisciplinary team approach and includes sections on rehabilitation, coping, nutrition and risk management. This handbook is revised periodically to meet current guidelines; Clinical Practice (2010–2021)
  • Revised Vascular Neurology Curriculum to comply with ACGME requirements. Program accredited by ACGME (2012-2020). (2009–present)
  • Director of Stroke Research Served as Principal Investigator of several state-of-the-art, NIH-funded, international Stroke Trials. Assisted and supervised residents and fellows in their research projects from inception (IRB submission) to publication. Grant funding sufficient to hire post-doctoral research associates. (2009–present)
  • Vascular Neurology Program Re-accreditation. Revised Vascular Neurology Curriculum to comply with ACGME requirements Revised Vascular Neurology's Program's Letter of Agreement and Goals and Objectives to conform to current ACGME requirements. Revised resident’s Vascular Neurology curriculum in accordance with ACGME guidelines. Developed stroke lecture series for residents and students. Preceptor for fellows, residents and students in inpatient and outpatient setting. Attending Physician on Stroke Service. Participated in residents’ and fellows’ clinical competency advisory meetings.; Program Director (2009–present)
  • Supervised medical students and residents in their research projects resulting in publications. (2007–present)
  • Preceptor for medical students on their Neurology rotation with Stroke Service at Buffalo General Medical Center Supervisor of residents requiring remediation. (prevented house staff from being terminated) Attending physician with Stroke Service (BGMC and Gates Vascular Institute) Participated in residents and fellows clinical competency advisory meetings Supervised medical students and residents in their research projects resulting in publications. (2007–present)

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Contact Information

UB Department of Neurology
1010 Main Street, 2nd floor
Buffalo, New York 14202
Phone: (716) 932-6080, ext. 102
Fax: (716) 829-4001
mching@buffalo.edu

This faculty member is affiliated with UBMD, practicing physicians who are also professors in the Jacobs School.

View this physician on UBMD