Timothy F. Murphy MD
Timothy F. Murphy
MD
SUNY Distinguished Professor; Senior Associate Dean for Clinical and Translational Research; Director, Clinical and Translational Science Institute; Director, Community Health Equity Research Institute
Jacobs School of Medicine & Biomedical Sciences
Specialty/Research Focus
Infectious Disease
Professional Summary:
As a physician scientist, research in my laboratory focuses on the respiratory tract bacterial pathogens, nontypeable Haemophilus influenzae and Moraxella catarrhalis. Both are important causes of otitis media (ear infections) in children and lower respiratory tract infections in adults with chronic obstructive pulmonary disease (COPD). Funded by the NIH, work is focusing on identifying how these bacteria cause disease in the human respiratory tract and developing vaccines and novel interventions to prevent and treat these infections. My work has resulted in ~220 publications, 13 patents, and chapters on Haemophilus and Moraxella in the major textbooks of medicine and infectious diseases.
I am also Director of the UB Clinical and Translational Science Institute (CTSI), founded in 2015. The CTSI provides support and expertise to perform clinical and translational research throughout UB and partner institutions with a vision to improve health and reduce health disparities in our community and the nation. The CTSI has catalyzed a transformation of the clinical and translational research environment with a tripling of actively recruiting clinical trials since 2015 at UB.
In response to a national shortage of physician scientists, I direct an NIH training grant entitled Training the Next Generation of Physician Scientists. The program introduces medical students to careers as physician scientists through mentored research projects and professional development training. The goal is to increase the shrinking number of physician scientists in the U.S. biomedical research workforce.
One of the most pressing problems facing the City of Buffalo is health disparities among African Americans who live in neighborhoods on the East Side. In 2019, UB launched the UB Community Health Equity Research Institute that will conduct research that addresses the root causes of these health disparities, while developing and testing innovative solutions to the social determinants of health to eliminate health inequities in the region. I am privileged to serve as Director of the Institute, which includes faculty from ten UB schools and works closely with community partners.
Education and Training:
- Infectious Diseases, Tufts University (1981)
- Medicine, New York Hospital Cornell Medical Center (1979)
- MD, Tufts University (1976)
Employment:
- Director, Clinical and Translational Research Center, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (2012-present)
- SUNY Distinguished Profesor, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (2011-present)
- Senior Associate Dean for Clinical and Translational Research, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (2009-present)
- Professor, Department of Medicine, Medicine, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (1992-present)
- UB Distinguished Professor, Medicine, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (2004–2011)
- Chief, Medicine, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (1993–2009)
- Chief, Infectious Diseases, VA WNY Healthcare System (1990–2009)
- Consultant, Erie County Medical Center (1990–2000)
- Consultant, Buffalo General Hospital (1981–2000)
- Visiting Professor, University of Canberra, Australia Faculty of Applied Science (1995–1996)
- Adjunct Associate Professor, Microbiology and Immunology, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (1987–1994)
- Associate Professor, Medicine, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (1987–1992)
- Chief, Infectious Diseases, Erie County Medical Center (1988–1990)
- Internist, Erie County Medical Center (1981–1990)
- Assistant Professor, Medicine, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (1981–1987)
Awards and Honors:
- UB President’s Medal (2024)
- Office of Inclusion and Cultural Enhancement's 2020 Community Award of Excellence for Promoting Inclusion and Cultural Diversity (2020)
- Outstanding Mentorship in Research, UB Department of Medicine (2015)
- Spark Arts Integration Award for Clinical and Translational Research Center Arts Services Initiative of Western New York (2015)
- Outstanding Mentorship in Research, University at Buffalo Department of Medicine (2015)
- Outstanding Research Award, University at Buffalo Department of Medicine (2013)
- SUNY Distinguished Professor (2011)
- Visionary Innovator Award, University at Buffalo (2009)
- Empire Clinical Research Investigator Program Award (2008)
- Top 5% Reviewers, Journal of Infectious Diseases (2005)
- UB Distinguished Professor (2004)
- Outstanding Inventor Award, State University of New York (2002)
- Stockton Kimball Ward, University at Buffalo School of Medicine (2000)
- Who's Who in the World (2000)
- Niagara Frontier Inventor of the Year (1998)
- Niagara Frontier Inventor of the Year, semi-finalist (1996)
- American Society for Clinical Investigation (1995)
- Senior International Fellowship, Fogarty Center, NIH (1995)
- Eastern Regional Young Investigator Award (1994)
- Niagara Frontier Inventor of the Year (1992)
- American Men and Women of Science (1991)
- Who's Who in Science and Engineering (1990)
- Sinsheimer Scholar Award (1982)
- Teaching Excellence Citation, Tufts University School of Medicine (1980)
- Alpha Omega Alpha, Tufts University School of Medicine (1975)
Research Expertise:
- Bacterial infection in chronic obstructive pulmonary disease (COPD)
- Haemophilus influenzae pathogenesis
- Microbial pathogenesis within the respiratory tract
- Moraxella catarrhalis pathogenesis
- Vaccine development
Research Centers:
- Clinical and Translational Research Center (CTRC)
Grants and Sponsored Research:
- September 2022–August 2027
Training the Next Generation of Physician Scientists T35 Training Grant
NIAID
Role: Principal Investigator
$293,309 - August 2019–December 2024
Clinical and Translational Science Award: Buffalo Clinical and Translational Research Center
National Center for Advancing Translational Sciences
Role: Principal Investigator
$19,101,902 - July 2019–June 2024
Genome Evolution During Bacterial Persistence in the Human Airways in COPD
NIAID
Role: Principal Investigator
$2,653,298 - July 2020–June 2023
Igniting Hope: Mobilizing Community Resources to Achieve Health Equity
NCATS
Role: Principal Investigator
$24,711 - September 2015–June 2020
National Center for Advancing Translational Sciences
NIH
Role: Principal Investigator - September 2014–August 2018
Persistent H.influenzae in COPD: virulence, vaccines, and antibiotic resistance
NIAID
Role: Principal Investigator
$2,456,267 - September 2013–August 2018
Persistent H. influenzae in COPD – virulence, vaccines and antibiotic resistance
National Institute of Allergy and Infectious Diseases
Role: Principal Investigator
$2,400,000 - July 2012–June 2017
Moraxella catarrhalis: virulence-based prevention
NIDC
Role: Principal Investigator
$1,605,805 - September 2011–August 2016
Research in Infectious Diseases, Microbiology and Immunology for Medical Students. T35 Training grant.
NIH, National Institute of Allergy and Infectious Diseases
Role: Co-Principal Investigator
$177,065 - December 2013–November 2015
Selective eradication of nasopharyngeal colonization to prevent otitis media
NIDCD
Role: Principal Investigator
$448,061 - January 1993–March 2014
Bacterial infection in COPD
Department of Veterans Affairs/Merit Review
Role: Co-Investigator
$750,000 - January 2007–December 2012
Pathogenesis of Haemophilus influenzae Infections in COPD
NIH
Role: Principal Investigator
$1,225,125 - January 1983–December 2012
Development of a vaccine for nontypeable H. influenzae and Pathogenesis of nontypeable Haemophilus influenzae (2RO1AI019641)
NIH
Role: Principal Investigator
$1,250,000 - January 1987–June 2012
Development of a vaccine for Moraxella catarrhalis (RO1AI28304)Pathogenesis of Moraxella catarrhalis in chronic obstructive pulmonary disease (2R56AI1028304)
NIH
Role: Principal Investigator
$1,250,000 - May 2007–December 2007
Genotyping Analysis of Streptococcus pneumoniae strains isolated from the PERSPECTIVE study.
Sanofi-Aventis Pharmaceuticals
Role: Principal Investigator
$60,000 - September 2002–August 2007
Development of a vaccine for H. influenzae
NIH
Role: Principal Investigator
$1,200,000 - January 2001–January 2006
Research in infectious diseases, microbiology and immunology for medical students (T32AI49838)
NIH
Role: Principal Investigator
$214,000 - January 2001–January 2006
Recurrent otitis media and COPD: immunity and vaccines. Program Project(PO1AI46422). Project 2: Defining a protective immune response to Moraxella catarrhalis in humans
NIH
Role: Principal Investigator
$2,000,000
Patents:
- Methods for Stimulating Immune Response against Moraxella catarrhalis (2010)
- Vaccine for nontypeable Haemophilus influenzae infection (2008)
- Method for detecting bacterial exacerbations of chronic lung disease (2004)
- Peptide expression and delivery system (2000)
- Gene encoding outer membrane protein B1 of Moraxella catarrhalis (1999)
- Vaccine for Branhamella catarrhalis (1999)
- Vaccine for Branhamella catarrhalis (1998)
- Vaccine for Branhamella catarrhalis (1998)
- Vaccine for Moraxella catarrhalis (1997)
- Method for detecting Branhamella catarrhalis (1996)
- Method for purifying an outer membrane protein of Haemophilus influenzae (1994)
- DNA probe for the identification of Haemophilus influenzae (1992)
Journal Articles:
- Hawk LW, Murphy TF, Hartmann KE, Burnett A, Maguin E. (2024) A randomized controlled trial of a team science intervention to enhance collaboration readiness and behavior among early career scholars in the Clinical and Translational Science Award network. Journal of clinical and translational science (Jan), 8(1): e6. doi:10.1017/cts.2023.692
- Murphy TF, Kirkham C, D'Mello A, Sethi S, Pettigrew MM, Tettelin H. (2023) Adaptation of Nontypeable Haemophilus influenzae in Human Airways in COPD: Genome Rearrangements and Modulation of Expression of HMW1 and HMW2. mBio (Mar)e0014023.
- Dissanayake E, Brockman-Schneider RA, Stubbendieck RM, Helling BA, Zhang Z, Bochkov YA, Kirkham C, Murphy TF, Ober C, Currie CR, Gern JE. (2022) Rhinovirus increases Moraxella catarrhalis adhesion to the respiratory epithelium. Frontiers in cellular and infection microbiology (Jan), 12: 1060748. doi:10.3389/fcimb.2022.1060748
- Bengert E, Towle-Miller L, Boccardo J, Mercene G, Ohtake PJ, Balkundi P, Elkin PL, Balthasar J, Murphy TF, Noyes K. (2022) Novel approach for tracking interdisciplinary research productivity using institutional databases. Journal of clinical and translational science (Jan), 6(1): e119. doi:10.1017/cts.2022.455
- Murphy TF, Robinson RH, Wofford KM, Lesse AJ, Grinslade S, Taylor HL, Pointer KM, Nicholas GF, Orom H. (2022) A community-university run conference as a catalyst for addressing health disparities in an urban community. Journal of clinical and translational science (Jan), 6(1): e67. doi:10.1017/cts.2022.398
- Ren D, Bajorski P, Murphy TF, Lafontaine ER, Pichichero ME. (2020) Synchrony in serum antibody response to conserved proteins of Moraxella catarrhalis in young children. Human vaccines & immunotherapeutics (Dec), 16(12): 3194-3200.
- Jacobs DM, Ochs-Balcom HM, Noyes K, Zhao J, Leung WY, Pu CY, Murphy TF, Sethi S. (2020) Impact of Pseudomonas aeruginosa Isolation on Mortality and Outcomes in an Outpatient Chronic Obstructive Pulmonary Disease Cohort. Open Forum Infect Dis (Jan), 7(1): 546-546.
- D. (2019) ReVac: a reverse vaccinology computational pipeline for prioritization of prokaryotic protein vaccine candidates. BMC genomics (Dec), 20(1): 981. doi:10.1186/s12864-019-6195-y
- Ahearn CP, Kirkham C, Chaves LD, Kong Y, Pettigrew MM, Murphy TF. (2019) Discovery and Contribution of Nontypeable Haemophilus influenzae NTHI1441 to Human Respiratory Epithelial Cell Invasion. Infect Immun (Nov), 87(11).
- Atack JM, Murphy TF, Pettigrew MM, Seib KL, Jennings MP. (2019) Non-typeable Haemophilus influenzae isolates from patients with chronic obstructive pulmonary disease contain new phase-variable modA methyltransferase alleles controlling phasevarions. Sci Rep (Nov), 9(1): 15963-15963.
- Perez AC, Murphy TF. (2019) Potential impact of a Moraxella catarrhalis vaccine in COPD. Vaccine (Sep), 37(37): 5551-5558.
- Su YC, Mattsson E, Singh B, Jalalvand F, Murphy TF, Riesbeck K. (2019) The Laminin Interactome: A Multifactorial Laminin-Binding Strategy by Nontypeable Haemophilus influenzae for Effective Adherence and Colonization. J Infect Dis (Aug), 220(6): 1049-1060.
- Shehaj L, Choudary SK, Makwana KM, Gallo MC, Murphy TF, Kritzer JA. (2019) Small-Molecule Inhibitors of Haemophilus influenzae IgA1 Protease. ACS Infect Dis (Jul), 5(7): 1129-1138.
- Atack JM, Murphy TF, Pettigrew MM, Seib KL, Jennings MP. (2019) Transcriptome Sequencing Data Sets for Determining Gene Expression Changes Mediated by Phase-Variable DNA Methyltransferases in Nontypeable Haemophilus influenzae Strains Isolated from Patients with Chronic Obstructive Pulmonary Disease. Microbiol Resour Announc (Jul), 8(29).
- Murphy TF, Brauer AL, Pettigrew MM, LaFontaine ER, Tettelin H. (2019) Persistence of Moraxella catarrhalis in Chronic Obstructive Pulmonary Disease and Regulation of the Hag/MID Adhesin. J Infect Dis (Apr), 219(9): 1448-1455.
- Blakeway LV, Tan A, Lappan R, Ariff A, Pickering JL, Peacock CS, Blyth CC, Kahler CM, Chang BJ, Lehmann D, Kirkham LS, Murphy TF, Jennings MP, Bakaletz LO, Atack JM, Peak IR, Seib KL. (2018) Moraxella catarrhalis Restriction-Modification Systems Are Associated with Phylogenetic Lineage and Disease. Genome Biol Evol (Nov), 10(11): 2932-2946.
- Resman F, Manat G, Lindh V, Murphy TF, Riesbeck K. (2018) Differential distribution of IgA-protease genotypes in mucosal and invasive isolates of Haemophilus influenzae in Sweden. BMC Infect Dis (Nov), 18(1): 592-592.
- Jacobs DM, Ochs-Balcom HM, Zhao J, Murphy TF, Sethi S. (2018) Lower Airway Bacterial Colonization Patterns and Species-specific Interactions in Chronic Obstructive Pulmonary Disease. J Clin Microbiol (Jul).
- Atack JM, Murphy TF, Bakaletz LO, Seib KL, Jennings MP. (2018) Closed Complete Genome Sequences of Two Nontypeable Haemophilus influenzae Strains Containing Novel modA Alleles from the Sputum of Patients with Chronic Obstructive Pulmonary Disease. Microbiol Resour Announc (Jul), 7(2).
- Jacobs DM, Noyes K, Zhao J, Gibson W, Murphy TF, Sethi S, Ochs-Balcom HM. (2018) Early Hospital Readmissions Following an Acute Exacerbation of COPD in the Nationwide Readmissions Database. Ann Am Thorac Soc (Apr).
- Tsuji BT, Fisher J, Boadi-Yeboah R, Holden PN, Sethi S, Pettigrew MM, Murphy TF. (2018) Azithromycin Pharmacodynamics against Persistent Haemophilus influenzae in Chronic Obstructive Pulmonary Disease. Antimicrob Agents Chemother (Feb), 62(2).
- Gallo MC, Kirkham C, Eng S, Bebawee RS, Kong Y, Pettigrew MM, Tettelin H, Murphy TF. (2018) Changes in IgA Protease Expression Are Conferred by Changes in Genomes during Persistent Infection by Nontypeable Haemophilus influenzae in Chronic Obstructive Pulmonary Disease. Infect Immun (Jan), 86(8).
- Jacobs DM, Noyes K, Zhao J, Gibson W, Murphy TF, Sethi S, Ochs-Balcom HM. (2018) Early Hospital Readmissions after an Acute Exacerbation of Chronic Obstructive Pulmonary Disease in the Nationwide Readmissions Database. Ann Am Thorac Soc (Jan), 15(7): 837-845.
- Pettigrew MM, Ahearn CP, Gent JF, Kong Y, Gallo MC, Munro JB, D'Mello A, Sethi S, Tettelin H, Murphy TF. (2018) Haemophilus influenzae genome evolution during persistence in the human airways in chronic obstructive pulmonary disease. Proc Natl Acad Sci U S A (Jan), 115(14): 3256-3265.
- Perez AC, Johnson A, Chen Z, Wilding GE, Malkowski MG, Murphy TF. (2017) Mapping protective regions on a three-dimensional model of the Moraxella catarrhalis vaccine antigen, Oligopeptide Permease A. Infect Immun (Dec).
- Murphy TF, Kirkham C, Gallo MC, Yang Y, Wilding GE, Pettigrew MM. (2017) Immunoglobulin A Protease Variants Facilitate Intracellular Survival in Epithelial Cells By Nontypeable Haemophilus influenzae That Persist in the Human Respiratory Tract in Chronic Obstructive Pulmonary Disease. J Infect Dis (Dec), 216(10): 1295-1302.
- Perez AC, Murphy TF. (2017) A Moraxella catarrhalis vaccine to protect against otitis media and exacerbations of COPD: An update on current progress and challenges. Hum Vaccin Immunother (Oct), 13(10): 2322-2331.
- Ren D, Murphy TF, Lafontaine ER, Pichichero ME. (2017) Stringently Defined Otitis Prone Children Demonstrate Deficient Naturally Induced Mucosal Antibody Response to Moraxella catarrhalis Proteins. Front Immunol (Aug), 8: 953-953.
- Ren D, Almudevar AL, Murphy TF, Lafontaine ER, Campagnari AA, Luke-Marshall NR, Pichichero ME. (2017) Serum antibody response to Moraxella catarrhalis proteins in stringently defined otitis prone children. Vaccine (Jul).
- Murphy TF, Brauer AL, Johnson A, Wilding GE, Koszelak-Rosenblum M, Malkowski MG. (2017) A Cation-binding Surface Protein as a Vaccine Antigen to Prevent Moraxella catarrhalis Otitis Media and Infections in Chronic Obstructive Pulmonary Disease. Clin Vaccine Immunol (Jun).
- Ahearn CP, Gallo MC, Murphy TF. (2017) Insights on persistent airway infection by non-typeable Haemophilus influenzae in chronic obstructive pulmonary disease. Pathog Dis (Jun), 75(4).
- Pettigrew MM, Alderson MR, Bakaletz LO, Barenkamp SJ, Hakansson AP, Mason KM, Nokso-Koivisto J, Patel J, Pelton SI, Murphy TF. (2017) Panel 6: Vaccines. Otolaryngol Head Neck Surg (Apr), 156(4_sup): 76-87.
- Perez AC, Murphy TF. (2017) Potential impact of a Moraxella catarrhalis vaccine in COPD. Vaccine (Feb).
- Sinha S, Burstein GR, Leonard KE, Murphy TF, Elkin PL. (2017) Prescription Opioid Dependence in Western New York: Using Data Analytics to Find an Answer to the Opioid Epidemic. Stud Health Technol Inform (Jan), 245: 594-598.
- Murphy TF, Kirkham C, Johnson A, Brauer AL, Koszelak-Rosenblum M, Malkowski MG. (2016) Sulfate-binding protein, CysP, is a candidate vaccine antigen of Moraxella catarrhalis. Vaccine (Jul), 34(33): 3855-3861.
- Pettigrew MM, Tsuji BT, Gent JF, Kong Y, Holden PN, Sethi S, Murphy TF. (2016) Effect of Fluoroquinolones and Macrolides on Eradication and Resistance of Haemophilus influenzae in Chronic Obstructive Pulmonary Disease. Antimicrob Agents Chemother (Jul), 60(7): 4151-4158.
- Sethi S. (2016) Effect of Fluoroquinolones and Macrolides on Eradication and Resistance of Haemophilus influenzae in Chronic Obstructive Pulmonary Disease. Antimicrobial Agents and Chemotherapy (Jun), 60(7): 4151-4158.
- Dy R., Wrona C., Murphy TF, Sethi S. (2016) Airway Inflammatory Mediator Determinants of COPD Exacerbation Severity and Resolution. ATS International Conference, San Francisco, CA (May).
- Mustafa B., Wrona C., Murphy TF, Sethi S. (2016) Change in Titer of Serum Antibodies Directed at the Bacterial Surface Reflect the Frequency of Lower Airway Bacterial Carriage and Infection in COPD. ATS International Conference, San Francisco, CA (May).
- Otsuka T, Kirkham C, Brauer A, Koszelak-Rosenblum M, Malkowski MG, Murphy TF. (2016) The Vaccine Candidate Substrate Binding Protein SBP2 Plays a Key Role in Arginine Uptake, Which Is Required for Growth of Moraxella catarrhalis. Infect Immun (Feb), 84(2): 432-438.
- Otsuka T, Kirkham C, Brauer A, Koszelak-Rosenblum M, Malkowski MG, Murphy TF. (2015) The Vaccine Candidate, Substrate Binding Protein SBP2, Plays a Key Role in Arginine Uptake, which is Required for Growth of Moraxella catarrhalis. Infect Immun (Nov).
- Ren D, Almudevar AL, Murphy TF, Lafontaine ER, Campagnari AA, Luke-Marshall N, Casey JR, Pichichero ME. (2015) Serum antibody response to Moraxella catarrhalis proteins OMP CD, OppA, Msp22, Hag, and PilA2 after nasopharyngeal colonization and acute otitis media in children. Vaccine (Oct), 33(43): 5809-5814.
- Jones MM, Murphy TF. (2015) Expression of the Oligopeptide Permease Operon of Moraxella catarrhalis Is Regulated by Temperature and Nutrient Availability. Infection and immunity (Sep), 83(9): 3497-505. doi:10.1128/IAI.00597-15
- Murphy TF, Kirkham C, Jones MM, Sethi S, Kong Y, Pettigrew MM. (2015) Expression of IgA Proteases by Haemophilus influenzae in the Respiratory Tract of Adults With Chronic Obstructive Pulmonary Disease. J Infect Dis (May), 212(11).
- Murphy TF. (2015) Vaccines for Nontypeable Haemophilus influenzae: the Future Is Now. Clin Vaccine Immunol (May), 22(5): 459-466.
- Jones MM, Johnson A, Koszelak-Rosenblum M, Kirkham C, Brauer AL, Malkowski MG, Murphy TF. (2014) Role of the oligopeptide permease ABC Transporter of Moraxella catarrhalis in nutrient acquisition and persistence in the respiratory tract. Infect Immun (Nov), 82(11): 4758-4766.
- Huang Y.J., Sethi S, Murphy TF, Nariya S., Boushey H.A., Lynch S.V. (2014) Airway Microbiome dynamics in exacerbations of chronic obstructive pulmonary disease. Journal of Clinical Microbiology (Aug), 52(8): 2813-2823.
- Otsuka T, Kirkham C, Johnson A, Jones MM, Murphy TF. (2014) Substrate binding protein SBP2 of a putative ABC transporter as a novel vaccine antigen of Moraxella catarrhalis. Infect Immun (Jun), 82(8).
- Desai H., Eschberger K., Wrona C., Grove L., Agrawal A., Grant B., Yin J., Parameswaran GI, Murphy TF, Sethi S. (2014) Bacterial Colonization of the Lower Respiratory Tract Increases Daily Symptoms in Patients with Chronic Obstructive Pulmonary Disease. Annals of the American Thoracic Society (Mar), 11(3): 303-309.
- Clementi CF, Håkansson AP, Murphy TF. (2014) Internalization and trafficking of nontypeable Haemophilus influenzae in human respiratory epithelial cells and roles of IgA1 proteases for optimal invasion and persistence. Infect Immun (Jan), 82(1): 433-444.
- Bertelle-Ibrahim LA, Murphy TF, Kirkham C, Parameswaran GI, Berenson CS. (2013) Non-typeable Haemophilus influenzae infective endocarditis in a renal transplant recipient: compromised host or virulent strain?. BMJ case reports (Sep), 2013. doi:10.1136/bcr-2013-200377
- Murphy TF, Brauer AL, Kirkham C, Johnson A, Koszelak-Rosenblum M, Malkowski MG. (2013) Role of the Zinc Uptake ABC Transporter of Moraxella catarrhalis in Persistence in the Respiratory Tract. Infect Immun (Sep), 81(9): 3406-3413.
- Eutsey R.A., Hiller N.L., Earl J.P., Janto B.A., Dahlgren M.E., Ahmed A., Powell E., Schultz M.P., Gilsdorf J.R., Zhang L., Smith A., Murphy TF, Sethi S, Shen K., Post J.C., Hu F.Z., Ehrlich G.D. (2013) Design and validation of a supragenome array for determination of the genomic content of Haemophilus influenzae isolates. BMC Genomics (Jul), 14: 484.
- Murphy TF, Chonmaitree T, Barenkamp S, Kyd J, Nokso-Koivisto J, Patel JA, Heikkinen T, Yamanaka N, Ogra P, Swords WE, Sih T, Pettigrew MM. (2013) Panel 5: Microbiology and immunology panel. Otolaryngol Head Neck Surg (Apr), 148(4 Sup): 64-89.
- Pelton SI, Pettigrew MM, Barenkamp SJ, Godfroid F, Grijalva CG, Leach A, Patel J, Murphy TF, Selak S, Bakaletz LO. (2013) Panel 6: Vaccines. Otolaryngol Head Neck Surg (Apr), 148(4 Sup): 90-101.
- Zhang L, Xie J, Patel M, Bakhtyar A, Ehrlich GD, Ahmed A, Earl J, Marrs CF, Clemans D, Murphy TF, Gilsdorf JR. (2012) Nontypeable Haemophilus influenzae genetic islands associated with chronic pulmonary infection. PLoS One (Sep), 7(9): 44730-44730.
- Verhaegh SJ, Stol K, de Vogel CP, Riesbeck K, Lafontaine ER, Murphy TF, van Belkum A, Hermans PW, Hays JP. (2012) Comparative analysis of the humoral immune response to Moraxella catarrhalis and Streptococcus pneumoniae surface antigens in children suffering from recurrent acute otitis media and chronic otitis media with effusion. Clin Vaccine Immunol (Jun), 19(6): 914-918.
- Agrawal A, Murphy TF. (2011) Haemophilus influenzae Infections in the H. influenzae Type b Conjugate Vaccine Era. J Clin Microbiol (Nov), 49(11): 3728-3732.
- Murphy TF, Lesse AJ, Kirkham C, Zhong H, Sethi S, Munson RS. (2011) A Clonal Group of Nontypeable Haemophilus influenzae with Two IgA Proteases Is Adapted to Infection in Chronic Obstructive Pulmonary Disease. PLoS One (Oct), 6(10): 25923-25923.
- Parameswaran GI, Sethi S, Murphy TF. (2011) Effects of bacterial infection on airway antimicrobial peptides and proteins in COPD. Chest (Sep), 140(3): 611-617.
- Murphy TF, Brauer AL. (2011) Expression of urease by Haemophilus influenzae during human respiratory tract infection and role in survival in an acid environment. BMC Microbiol (Aug), 11: 183-183.
- Verhaegh SJ, de Vogel CP, Riesbeck K, Lafontaine ER, Murphy TF, Verbrugh HA, Jaddoe VW, Hofman A, Moll HA, van Belkum A, Hays JP. (2011) Temporal development of the humoral immune response to surface antigens of Moraxella catarrhalis in young infants. Vaccine (Aug), 29(34): 5603-5610.
- Lugade AA, Bianchi-Smiraglia A, Pradhan V, Elkin G, Murphy TF, Thanavala Y. (2011) Lipid motif of a bacterial antigen mediates immune responses via TLR2 signaling. PLoS One (May), 6(5): 19781-19781.
- Parameswaran GI, Sethi S, Murphy TF, Parameswaran G. (2011) Effects of bacterial infection on airway antimicrobial peptides and proteins in chronic obstructive pulmonary disease. Chest (Feb).
- Yang M, Johnson A, Murphy TF. (2011) Characterization and evaluation of the Moraxella catarrhalis oligopeptide permease A as a mucosal vaccine antigen. Infect Immun (Feb), 79(2): 846-857.
- Nakamura S, Shchepetov M, Dalia AB, Clark SE, Murphy TF, Sethi S, Gilsdorf JR, Smith AL, Weiser JN. (2011) Molecular basis of increased serum resistance among pulmonary isolates of non-typeable Haemophilus influenzae. PLoS Pathog (Jan), 7(1): 1001247-1001247.
- Döring G, Parameswaran IG, Murphy TF. (2011) Differential adaptation of microbial pathogens to airways of patients with cystic fibrosis and chronic obstructive pulmonary disease. FEMS Microbiol Rev (Jan), 35(1): 124-146.
- Murphy TF, Lesse AJ, Kirkham C., Zhong H., Sethi S, Munson Jr. R.S. (2011) A Clonally Related Group of Nontypeable Haemophilus influenzae Adapted to Infection in Chronic Obstructive Pulmonary Disease. PLoS ONE (Jan), 6(10): e2592.
- Lugade AA, Bogner PN, Murphy TF, Thanavala Y. (2011) The role of TLR2 and bacterial lipoprotein in enhancing airway inflammation and immunity. Frontiers in immunology (Jan), 2: 10. doi:10.3389/fimmu.2011.00010
- Clementi CF, Murphy TF. (2011) Non-typeable Haemophilus influenzae invasion and persistence in the human respiratory tract. Frontiers in cellular and infection microbiology (Jan), 1: 1. doi:10.3389/fcimb.2011.00001
- Desai H., Richter S., Doern G., Heilmann K., Dohrn C., Johnson A., Brauer A., Murphy TF, Sethi S. (2010) Antibiotic resistance in Sputum Isolates of Streptococcus pneumoniae in Chronic Obstructive Pulmonary Disease is related to antibiotic exposure. Journal of COPD. (Oct), 7(5): 337-344.
- Hotomi M, Kono M, Togawa A, Arai J, Takei S, Ikeda Y, Ogami M, Murphy TF, Yamanaka N. (2010) Haemophilus influenzae and Haemophilus haemolyticus in tonsillar cultures of adults with acute pharyngotonsillitis. Auris Nasus Larynx (Oct), 37(5): 594-600.
- Qu J, Lesse AJ, Brauer AL, Cao J, Gill SR, Murphy TF. (2010) Proteomic expression profiling of Haemophilus influenzae grown in pooled human sputum from adults with chronic obstructive pulmonary disease reveal antioxidant and stress responses. BMC Microbiol (Jun), 10: 162-162.
- Parameswaran GI, Wrona CT, Murphy TF, Sethi S, Parameswaran G. (2009) Moraxella catarrhalis acquisition, airway inflammation and protease-antiprotease balance in chronic obstructive pulmonary disease. BMC Infect Dis (Nov), 9: 178-178.
- Ruckdeschel EA, Brauer AL, Johnson A, Murphy TF. (2009) Characterization of proteins Msp22 and Msp75 as vaccine antigens of Moraxella catarrhalis. Vaccine (Nov), 27(50): 7065-7072.
- Sabirov A, Casey JR, Murphy TF, Pichichero ME. (2009) Breast-feeding is associated with a reduced frequency of acute otitis media and high serum antibody levels against NTHi and outer membrane protein vaccine antigen candidate P6. Pediatr Res (Nov), 66(5): 565-570.
- Murphy TF, Bakaletz LO, Smeesters PR. (2009) Microbial interactions in the respiratory tract. The Pediatric infectious disease journal (Oct), 28(10 Suppl): S121-6.
- Schwingel JM, Edwards KJ, Cox AD, Masoud H, Richards JC, St Michael F, Tekwe CD, Sethi S, Murphy TF, Campagnari AA. (2009) Use of Moraxella catarrhalis lipooligosaccharide mutants to identify specific oligosaccharide epitopes recognized by human serum antibodies. Infect Immun (Oct), 77(10): 4548-4558.
- Novotny LA, Adams LD, Kang DR, Wiet GJ, Cai X, Sethi S, Murphy TF, Bakaletz LO. (2009) Epitope mapping immunodominant regions of the PilA protein of nontypeable Haemophilus influenzae (NTHI) to facilitate the design of two novel chimeric vaccine candidates. Vaccine (Aug).
- Murphy TF, Parameswaran GI. (2009) Moraxella catarrhalis, a human respiratory tract pathogen. Clin Infect Dis (Jul), 49(1): 124-131.
- LaFontaine ER, Snipes LE, Bullard B, Brauer AL, Sethi S, Murphy TF. (2009) Identification of domains of the Hag/MID surface protein recognized by systemic and mucosal antibodies in adults with chronic obstructive pulmonary disease following clearance of Moraxella catarrhalis. Clin Vaccine Immunol (May), 16(5): 653-659.
- Murphy TF. (2009) Current and Future Prospects for a Vaccine for Nontypeable Haemophilus influenzae. Curr Infect Dis Rep (May), 11(3): 177-182.
- Gaschler GJ, Skrtic M, Zavitz CC, Lindahl M, Onnervik PO, Murphy TF, Sethi S, Stämpfli MR. (2009) Bacteria challenge in smoke-exposed mice exacerbates inflammation and skews the inflammatory profile. Am J Respir Crit Care Med (Apr), 179(8): 666-675.
- Murphy TF. (2009) Pseudomonas aeruginosa in adults with chronic obstructive pulmonary disease. Curr Opin Pulm Med (Mar), 15(2): 138-142.
- Ostberg KL, Russell MW, Murphy TF. (2009) Mucosal immunization of mice with recombinant OMP P2 induces antibodies that bind to surface epitopes of multiple strains of nontypeable Haemophilus influenzae. Mucosal Immunol (Jan), 2: 63-73.
- Murphy TF, Faden H, Bakaletz LO, Kyd JM, Forsgren A, Campos J, Virji M, Pelton SI. (2009) Nontypeable Haemophilus influenzae as a pathogen in children. Pediatr Infect Dis J (Jan), 28(1): 43-48.
- Iyer Parameswaran G, Murphy TF, Parameswaran G. (2009) Chronic obstructive pulmonary disease: role of bacteria and updated guide to antibacterial selection in the older patient. Drugs Aging (Jan), 26(12): 985-995.
- Ostberg KL, Russell MW, Murphy TF. (2009) Mucosal immunization of mice with recombinant OMP P2 induces antibodies that bind to surface epitopes of multiple strains of nontypeable Haemophilus influenzae. Mucosal immunology (Jan), 2(1): 63-73. doi:10.1038/mi.2008.70
- Murphy TF. (2008) Placebo-controlled trials of treatments for community-acquired pneumonia: review of the literature and discussion of feasibility and potential value. Clin Infect Dis (Dec), 47 Su: 145-149.
- Sethi S, Murphy TF. (2008) Infection in the pathogenesis and course of chronic obstructive pulmonary disease. N Engl J Med (Nov), 359(22): 2355-2365.
- Cholon DM, Cutter D, Richardson SK, Sethi S, Murphy TF, Look DC, St Geme JW. (2008) Serial isolates of persistent Haemophilus influenzae in patients with chronic obstructive pulmonary disease express diminishing quantities of the HMW1 and HMW2 adhesins. Infect Immun (Aug).
- Ruckdeschel EA, Kirkham C, Lesse AJ, Hu Z, Murphy TF. (2008) Mining the Moraxella catarrhalis genome: identification of potential vaccine antigens expressed during human infection. Infect Immun (Apr), 76(4): 1599-1607.
- Sethi S, Wrona C, Eschberger K, Lobbins P, Cai X, Murphy TF. (2008) Inflammatory profile of new bacterial strain exacerbations of chronic obstructive pulmonary disease. Am J Respir Crit Care Med (Mar), 177(5): 491-497.
- McCrea KW, Xie J, LaCross N, Patel M, Mukundan D, Murphy TF, Marrs CF, Gilsdorf JR. (2008) Relationships of nontypeable Haemophilus influenzae strains to hemolytic and nonhemolytic Haemophilus haemolyticus strains. J Clin Microbiol (Feb), 46(2): 406-416.
- Murphy TF, Brauer AL, Eschberger K, Lobbins P, Grove L, Cai X, Sethi S. (2008) Pseudomonas aeruginosa in Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med (Jan).
- Sethi S, Wrona C, Eschberger K, Lobbins P, Cai X, Murphy TF. (2007) Inflammatory Profile of New Bacterial Strain Exacerbations of Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med (Dec).
- Parameswaran GI, Murphy TF. (2007) Infections in chronic lung diseases. Infect Dis Clin North Am (Sep), 21(3): 673-695.
- Malley R, Lipsitch M, Bogaert D, Thompson CM, Hermans P, Watkins AC, Sethi S, Murphy TF. (2007) Serum antipneumococcal antibodies and pneumococcal colonization in adults with chronic obstructive pulmonary disease. J Infect Dis (Sep), 196(6): 928-935.
- Sethi S, Sethi R, Eschberger K, Lobbins P, Cai X, Grant BJ, Murphy TF. (2007) Airway bacterial concentrations and exacerbations of chronic obstructive pulmonary disease. Am J Respir Crit Care Med (Aug), 176(4): 356-361.
- Murphy TF, Brauer AL, Sethi S, Kilian M, Cai X, Lesse AJ. (2007) Haemophilus haemolyticus: a human respiratory tract commensal to be distinguished from Haemophilus influenzae. J Infect Dis (Jan), 195(1): 81-89.
- Fung WW, O'Dwyer CA, Sinha S, Brauer AL, Murphy TF, Kroll JS, Langford PR. (2006) Presence of copper- and zinc-containing superoxide dismutase in commensal Haemophilus haemolyticus isolates can be used as a marker to discriminate them from nontypeable H. influenzae isolates. J Clin Microbiol (Nov), 44(11): 4222-4226.
- Fernaays MM, Lesse AJ, Cai X, Murphy TF. (2006) Characterization of igaB, a second immunoglobulin A1 protease gene in nontypeable Haemophilus influenzae. Infect Immun (Oct), 74(10): 5860-5870.
- Murphy TF, Kirkham C, Lesse AJ. (2006) Construction of a mutant and characterization of the role of the vaccine antigen P6 in outer membrane integrity of nontypeable Haemophilus influenzae. Infect Immun (Sep), 74(9): 5169-5176.
- Look DC, Chin CL, Manzel LJ, Lehman EE, Humlicek AL, Shi L, Starner TD, Denning GM, Murphy TF, Sethi S. (2006) Modulation of airway inflammation by Haemophilus influenzae isolates associated with chronic obstructive pulmonary disease exacerbation. Proceedings of the American Thoracic Society (Aug), 3(6): 482-3. doi:10.1513/pats.200603-060MS
- Kurita S, Koyama J, Onizuka S, Motomura K, Watanabe H, Watanabe K, Senba M, Apicella MA, Murphy TF, Yoneyama H, Matsushima K, Nagatake T, Oishi K. (2006) Dynamics of dendritic cell migration and the subsequent induction of protective immunity in the lung after repeated airway challenges by nontypeable Haemophilus influenzae outer membrane protein. Vaccine (Jul), 24(31-32): 5896-5903.
- Fernaays MM, Lesse AJ, Sethi S, Cai X, Murphy TF. (2006) Differential genome contents of nontypeable Haemophilus influenzae strains from adults with chronic obstructive pulmonary disease. Infect Immun (Jun), 74(6): 3366-3374.
- Murphy TF. (2006) The role of bacteria in airway inflammation in exacerbations of chronic obstructive pulmonary disease. Curr Opin Infect Dis (Jun), 19(3): 225-230.
- Neary JM, Murphy TF. (2006) Antibodies directed at a conserved motif in loop 6 of outer membrane protein P2 of nontypeable Haemophilus influenzae recognize multiple strains in immunoassays. FEMS Immunol Med Microbiol (Mar), 46(2): 251-261.
- Adlowitz DG, Kirkham C, Sethi S, Murphy TF. (2006) Human serum and mucosal antibody responses to outer membrane protein G1b of Moraxella catarrhalis in chronic obstructive pulmonary disease. FEMS immunology and medical microbiology (Feb), 46(1): 139-46.
- Murphy TF, Brauer A., Sethi S, Kilian M., Cai X., Lesse A. (2006) Haemophilus hemolyticus: a human respiratory tract commensal to be distinguished from Haemophilus influenzae. Journal of Infectious Disease (Jan), 195(1): 81-89.
- Adlowitz D., Kirkham, C., Sethi S, Murphy TF. (2006) Human Serum and Mucosal Antibody Responses to Outer Membrane Protein G1b of Moraxella catarrhalis in Chronic Obstructive Pulmonary Disease. FEMS Immunology (Jan), 46(1): 139-146.
- Look D.C., Chin C.L., Manzel L.J., Lehman E.E., Humlicek A.L., Shi L., Starner T.D., Denning G.M., Murphy TF, Sethi S. (2006) Modulation of airway inflammation by Haemophilus influenzae isolates associated with chronic obstructive pulmonary disease exacerbation. Proceedings of the American Thoracic Society (Jan), 3(6): 482-483.
- Murphy TF, Brauer AL, Aebi C, Sethi S. (2005) Antigenic specificity of the mucosal antibody response to Moraxella catarrhalis in chronic obstructive pulmonary disease. Infection and immunity (Dec), 73(12): 8161-6. doi:10.1128/IAI.73.12.8161-8166.2005
- Murphy TF. (2005) Vaccine development for non-typeable Haemophilus influenzae and Moraxella catarrhalis: progress and challenges. Expert Rev Vaccines (Dec), 4(6): 843-853.
- Adlowitz DG, Sethi S, Cullen P, Adler B, Murphy TF. (2005) Human antibody response to outer membrane protein G1a, a lipoprotein of Moraxella catarrhalis. Infection and immunity (Oct), 73(10): 6601-7. doi:10.1128/IAI.73.10.6601-6607.2005
- Wu T, Chen J, Murphy TF, Green BA, Gu XX. (2005) Investigation of non-typeable Haemophilus influenzae outer membrane protein P6 as a new carrier for lipooligosaccharide conjugate vaccines. Vaccine (Oct), 23(44): 5177-5185.
- Chin CL, Manzel LJ, Lehman EE, Humlicek AL, Shi L, Starner TD, Denning GM, Murphy TF, Sethi S, Look DC. (2005) Haemophilus influenzae from patients with chronic obstructive pulmonary disease exacerbation induce more inflammation than colonizers. Am J Respir Crit Care Med (Jul), 172(1): 85-91.
- Murphy TF, Brauer AL, Grant BJ, Sethi S. (2005) Moraxella catarrhalis in chronic obstructive pulmonary disease: burden of disease and immune response. Am J Respir Crit Care Med (Jul), 172(2): 195-199.
- Murphy TF, Brauer A., Grant BJ, Sethi S. (2005) Moraxella catarrhalis in chronic obstructive pulmonary disease: burden of disease, dynamics of carriage and immune responses. American Journal of Respiratory and Critical Care Medicine (Jul), 172(2): 195-199.
- Murphy TF, Brauer AL, Aebi C, Sethi S. (2005) Identification of surface antigens of Moraxella catarrhalis as targets of human serum antibody responses in chronic obstructive pulmonary disease. Infection and immunity (Jun), 73(6): 3471-8. doi:10.1128/IAI.73.6.3471-3478.2005
- McMahon M, Murphy TF, Kyd J, Thanavala Y. (2005) Role of an immunodominant T cell epitope of the P6 protein of nontypeable Haemophilus influenzae in murine protective immunity. Vaccine (May), 23(27): 3590-3596.
- Berenson CS, Murphy TF, Wrona CT, Sethi S. (2005) Outer membrane protein P6 of nontypeable Haemophilus influenzae is a potent and selective inducer of human macrophage proinflammatory cytokines. Infection and immunity (May), 73(5): 2728-35. doi:10.1128/IAI.73.5.2728-2735.2005
- Murphy TF, Bakaletz LO, Kyd JM, Watson B, Klein DL. (2005) Vaccines for otitis media: proposals for overcoming obstacles to progress. Vaccine (Apr), 23(21): 2696-2702.
- Murphy TF, Kirkham C, Sethi S, Lesse AJ. (2005) Expression of a peroxiredoxin-glutaredoxin by Haemophilus influenzae in biofilms and during human respiratory tract infection. FEMS Immunol Med Microbiol (Apr), 44(1): 81-89.
- Chin C.L., Manzel L.J., Lehman E.E., Humlicek, A.L., Shi L., Starner T.D., Denning G.M., Murphy TF, Sethi S, Look D.C. (2005) Haemophilus influenzae from patients with COPD exacerbation induce more inflammation than colonizers. American Journal of Respiratory and Critical Care Medicine (Jan), 172: 85-91.
- Adlowitz D., Sethi S, Adler B., Cullen, P., Murphy TF. (2005) Human Antibody Response to Outer Membrane Protein G1a, a Lipoprotein of Moraxella catarrhalis. Infection and Immunity (Jan), 73(10): 6601-6607.
- Murphy TF, Brauer A.L., Aebi C., Sethi S. (2005) Identification of surface antigens of Moraxella catarrhalis as targets of human serum antibody responses in chronic obstructive pulmonary disease. Infection and Immunity (Jan), 73(6): 3471-3478.
- Murphy TF, Brauer, A.L., Adler, B., Sethi S. (2005) Antigenic specificity of the mucosal antibody response to Moraxella catarrhalis in chronic obstructive pulmonary disease. Infection and Immunity (Jan), 73(12): 8161-8166.
- Sethi S, Murphy TF. (2005) RSV infection: not for kids only. New England Journal of Medicine (Jan), 352(17): 1810-1812.
- Barenkamp SJ, Kurono Y, Ogra PL, Leiberman A, Bakaletz LO, Murphy TF, Chonmaitree T, Patel JA, Heikkinen T, Sih TM, Hurst DS, St Geme JW, Kawauchi H, Stenfors LE. (2005) Recent advances in otitis media. 5. Microbiology and immunology. Ann Otol Rhinol Laryngol Suppl (Jan), 194: 60-85.
- Giebink GS, Kurono Y, Bakaletz LO, Kyd JM, Barenkamp SJ, Murphy TF, Green B, Ogra PL, Gu XX, Patel JA, Heikkinen T, Pelton SI, Hotomi M, Karma P. (2005) Recent advances in otitis media. 6. Vaccine. Ann Otol Rhinol Laryngol Suppl (Jan), 194: 86-103.
- Berenson CS, Murphy TF, Wrona, C.T., Sethi S. (2005) Outer membrane protein P6 of nontypeable Haemophilus influenzae is a potent and selective inducer of human macrophage cytokines. Infection and Immunity (Jan), 73(5): 2728-2735.
- Sethi S, Murphy TF. (2004) Acute exacerbations of chronic bronchitis: new developments concerning microbiology and pathophysiology--impact on approaches to risk stratification and therapy. Infect Dis Clin North Am (Dec), 18(4): 861-882.
- Chen R, Lim JH, Jono H, Gu XX, Kim YS, Basbaum CB, Murphy TF, Li JD. (2004) Nontypeable Haemophilus influenzae lipoprotein P6 induces MUC5AC mucin transcription via TLR2-TAK1-dependent p38 MAPK-AP1 and IKKbeta-IkappaBalpha-NF-kappaB signaling pathways. Biochem Biophys Res Commun (Nov), 324(3): 1087-1094.
- Murphy TF, Brauer AL, Schiffmacher AT, Sethi S. (2004) Persistent colonization by Haemophilus influenzae in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (Aug), 170(3): 266-272.
- Adlowitz DG, Hiltke T, Lesse AJ, Murphy TF. (2004) Identification and characterization of outer membrane proteins G1a and G1b of Moraxella catarrhalis. Vaccine (Jun), 22(20): 2533-2540.
- Sethi S, Wrona C, Grant BJ, Murphy TF. (2004) Strain-specific immune response to Haemophilus influenzae in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (Feb), 169(4): 448-453.
- Bandi V, Jakubowycz M, Kinyon C, Mason EO, Atmar RL, Greenberg SB, Murphy TF. (2003) Infectious exacerbations of chronic obstructive pulmonary disease associated with respiratory viruses and non-typeable Haemophilus influenzae. FEMS Immunol Med Microbiol (Jun), 37(1): 69-75.
- Murphy TF. (2003) Respiratory infections caused by non-typeable Haemophilus influenzae. Curr Opin Infect Dis (Apr), 16(2): 129-134.
- MURPHY TF. (2003) Horizontal transfer of the gene encoding outer membrane protein P2 of nontypeable Haemophilus influenzae in a patient with chronic obstructive pulmonary disease. Journal of Infectious Diseases (Jan), 188: 114-117.
- MURPHY TF. (2003) Human immune response to outer membrane protein CD of Moraxella catarrhalis in adults with chronic obstructive pulmonary disease. Infection and Immunity (Jan), 71: 1288-1294.
- Abe Y, Murphy TF, Sethi S, Faden HS, Dmochowski J, Harabuchi Y, Thanavala YM. (2002) Lymphocyte proliferative response to P6 of Haemophilus influenzae is associated with relative protection from exacerbations of chronic obstructive pulmonary disease. Am J Respir Crit Care Med (Apr), 165(7): 967-971.
- Murphy TF, Kirkham C. (2002) Biofilm formation by nontypeable Haemophilus influenzae: strain variability, outer membrane antigen expression and role of pili. BMC Microbiol (Apr), 2: 7-7.
- Bakaletz LO, Barenkamp SJ, Eskola J, Green B, Gu XX, Harada T, Heikkinen T, Karma P, Klein JO, Kurono Y, Mogi G, Murphy TF, Ogra PL, Patel JA, Suzuki M, Yamanaka N. (2002) Recent advances in otitis media. 7. Vaccine. Ann Otol Rhinol Laryngol Suppl (Mar), 188: 82-94.
- Hiltke TJ, Sethi S, Murphy TF. (2002) Sequence stability of the gene encoding outer membrane protein P2 of nontypeableHaemophilus influenzae in the human respiratory tract. J Infect Dis (Mar), 185(5): 627-631.
- Bakri F, Brauer AL, Sethi S, Murphy TF. (2002) Systemic and mucosal antibody response to Moraxella catarrhalis after exacerbationsof chronic obstructive pulmonary disease. J Infect Dis (Mar), 185(5): 632-640.
- Sethi S, Evans N, Grant BJ, Murphy TF. (2002) New strains of bacteria and exacerbations of chronic obstructive pulmonary disease. New England Journal of Medicine (Jan), 347(7): 465-471.
- Murphy TF, Sethi S. (2002) Chronic obstructive pulmonary disease: Role of bacteria and guide to antibacterial selection in the older patient. Drugs and Aging (Jan), 19: 761-775.
- Bernstein JM, Dryja D, Murphy TF. (2001) Molecular typing of paired bacterial isolates from the adenoid and lateral wall of the nose in children undergoing adenoidectomy: implications in acute rhinosinusitis. Otolaryngol Head Neck Surg (Dec), 125(6): 593-597.
- Bandi V, Apicella MA, Mason E, Murphy TF, Siddiqi A, Atmar RL, Greenberg SB. (2001) Nontypeable Haemophilus influenzae in the lower respiratory tract of patients with chronic bronchitis. Am J Respir Crit Care Med (Dec), 164(11): 2114-2119.
- Murphy TF, Brauer AL, Yuskiw N, McNamara ER, Kirkham C. (2001) Conservation of outer membrane protein E among strains of Moraxella catarrhalis. Infect Immun (Jun), 69(6): 3576-3580.
- Sethi S, Murphy TF. (2001) Bacterial infection in chronic obstructive pulmonary disease in 2000: a state-of-the-art review. Clin Microbiol Rev (Apr), 14(2): 336-363.
- Neary JM, Yi K, Karalus RJ, Murphy TF. (2001) Antibodies to loop 6 of the P2 porin protein of nontypeable Haemophilus influenzae are bactericidal against multiple strains. Infect Immun (Feb), 69(2): 773-778.
- Sethi S, Muscarella K, Evans N, Klingman KL, Grant BJ, Murphy TF. (2000) Airway inflammation and etiology of acute exacerbations of chronic bronchitis. Chest (Dec), 118(6): 1557-1565.
- Murphy TF, Brauer AL, Yuskiw N, Hiltke TJ. (2000) Antigenic structure of outer membrane protein E of Moraxella catarrhalis and construction and characterization of mutants. Infect Immun (Nov), 68(11): 6250-6256.
- Barton BE, Murphy TF. (2000) Constitutive expression of IL-6-LIKE cytokines in normal bone marrow: implications for pathophysiology of myeloma. Cytokine (Oct), 12(10): 1537-1545.
- Murphy TF, Sethi S, Niederman MS. (2000) The role of bacteria in exacerbations of COPD. A constructive view. Chest (Jul), 118(1): 204-209.
- Murphy TF. (2000) Bacterial otitis media: pathogenetic considerations. Pediatr Infect Dis J (May), 19(5 Sup): 9-15.
- Samukawa T, Yamanaka N, Hollingshead S, Murphy TF, Faden H. (2000) Immune response to surface protein A of Streptococcus pneumoniae and to high-molecular-weight outer membrane protein A of Moraxella catarrhalis in children with acute otitis media. J Infect Dis (May), 181(5): 1842-1845.
- Samukawa T, Yamanaka S, Hollingshead S, Murphy TF, Faden HS. (2000) Immune response to surface protein A of Streptococcus pneumoniae and to high-molecular-weight outer membrane protein A of Moraxella catarrhalis in children with acute otitis media. J Infect Dis (May), 181(5): 1842-1845.
- Murphy TF. (2000) Haemophilus influenzae in chronic bronchitis. Semin Respir Infect (Mar), 15(1): 41-51.
- Sethi S., Muscarella, K.A., Evans, N., Klingman, K.L., & Murphy, T.F. (2000) Acute bacterial exacerbations of COPD are associated with greater airway inflammation than non-bacterial exacerbations. Chest (Jan), 118: 1557-1565.
- Karalus RJ, Murphy TF. (1999) Purification and characterization of outer membrane protein P6, a vaccine antigen of non-typeable Haemophilus influenzae. FEMS Immunol Med Microbiol (Nov), 26(2): 159-166.
- Kyd J, John A, Cripps A, Murphy TF. (1999) Investigation of mucosal immunisation in pulmonary clearance of Moraxella (Branhamella) catarrhalis. Vaccine (Oct), 18(5-6): 398-406.
- Murphy TF, Kirkham C, DeNardin E, Sethi S. (1999) Analysis of antigenic structure and human immune response to outer membraneprotein CD of Moraxella catarrhalis. Infect Immun (Sep), 67(9): 4578-4585.
- Badr WH, Loghmanee D, Karalus RJ, Murphy TF, Thanavala Y. (1999) Immunization of mice with P6 of nontypeable Haemophilus influenzae: kinetics of the antibody response and IgG subclasses. Vaccine (Aug), 18(1-2): 29-37.
- Murphy TF, Sethi S, Klingman KL, Brueggemann AB, Doern GV. (1999) Simultaneous respiratory tract colonization by multiple strains of nontypeablehaemophilus influenzae in chronic obstructive pulmonary disease: implications for antibiotic therapy. J Infect Dis (Aug), 180(2): 404-409.
- Murphy TF, Kyd JM, John A, Kirkham C, Cripps AW. (1998) Enhancement of pulmonary clearance of Moraxella (Branhamella) catarrhalis following immunization with outer membrane protein CD in a mouse model. J Infect Dis (Dec), 178(6): 1667-1675.
- Harabuchi Y, Murakata H, Goh M, Kodama H, Kataura A, Faden HS, Murphy TF. (1998) Serum antibodies specific to CD outer membrane protein of Moraxella catarrhalis, P6 outer membrane protein of non-typeable Haemophilus influenzae and capsular polysaccharides of Streptococcus pneumoniae in children with otitis media with effusion. Acta Otolaryngol (Nov), 118(6): 826-832.
- Qiu J, Hendrixson DR, Baker EN, Murphy TF, St Geme JW, Plaut AG. (1998) Human milk lactoferrin inactivates two putative colonization factors expressed by Haemophilus influenzae. Proc Natl Acad Sci U S A (Oct), 95(21): 12641-12646.
- Murphy TF. (1998) Lung infections. 2. Branhamella catarrhalis: epidemiological and clinical aspects of a human respiratory tract pathogen. Thorax (Feb), 53(2): 124-128.
- Kyd JM, Cripps AW, Murphy TF. (1998) Outer-membrane antigen expression by Moraxella (Branhamella) catarrhalis influences pulmonary clearance. J Med Microbiol (Feb), 47(2): 159-168.
- Murphy TF, Yi K. (1997) Mechanisms of recurrent otitis media: importance of the immune response to bacterial surface antigens. Ann N Y Acad Sci (Dec), 830: 353-360.
- Yi K, Sethi S, Murphy TF. (1997) Human immune response to nontypeable Haemophilus influenzae in chronic bronchitis. J Infect Dis (Nov), 176(5): 1247-1252.
- Bernstein JM, Dryja D, Yuskiw N, Murphy TF. (1997) Analysis of isolates recovered from multiple sites of the nasopharynx of children colonized by nontypeable Haemophilus influenzae. Eur J Clin Microbiol Infect Dis (Oct), 16(10): 750-753.
- Sethi S, Surface JM, Murphy TF. (1997) Antigenic heterogeneity and molecular analysis of CopB of Moraxella (Branhamella)catarrhalis. Infect Immun (Sep), 65(9): 3666-3671.
- Bhushan R, Kirkham C, Sethi S, Murphy TF. (1997) Antigenic characterization and analysis of the human immune response to outermembrane protein E of Branhamella catarrhalis. Infect Immun (Jul), 65(7): 2668-2675.
- Fakih MG, Murphy TF, Pattoli MA, Berenson CS. (1997) Specific binding of Haemophilus influenzae to minor gangliosides of human respiratory epithelial cells. Infect Immun (May), 65(5): 1695-1700.
- Reddy M, Murphy TF, Faden HS, Bernstein JM. (1997) Middle ear mucin glycoprotein: purification and interaction with nontypable Haemophilus influenzae and Moraxella catarrhalis. Otolaryngol Head Neck Surg (Feb), 116(2): 175-180.
- Yi K, Murphy TF. (1997) Importance of an immunodominant surface-exposed loop on outer membrane protein P2 of nontypeable Haemophilus influenzae. Infect Immun (Jan), 65(1): 150-155.
- Sen K, Sikkema DJ, Murphy TF. (1996) Isolation and characterization of the Haemophilus influenzae tolQ, tolR, tolA and tolB genes. Gene (Oct), 178(1-2): 75-81.
- Murphy TF. (1996) Branhamella catarrhalis: epidemiology, surface antigenic structure, and immune response. Microbiol Rev (Jun), 60(2): 267-279.
- Reddy M, Bernstein JM, Murphy TF, Faden HS. (1996) Binding between outer membrane proteins of nontypeable Haemophilus influenzae and human nasopharyngeal mucin. Infect Immun (Apr), 64(4): 1477-1479.
- Berenson CS, Patterson MA, Pattoli MA, Murphy TF. (1996) A monoclonal antibody to human macrophage gangliosides inhibits macrophage migration. J Leukoc Biol (Mar), 59(3): 371-379.
- Sethi S, Murphy TF, Klingman KL. (1996) Diagnosis, epidemiology and pathogenesis of bacterial infections in the molecular era. Clin Mol Pathol (Feb), 49(1): 1-7.
- Sethi S., Murphy, T.F., & Klingman, K.L. (1996) Diagnosis, epidemiology & pathogenesis of bacterial infection in the molecular era. Clinical Pathology:Molecular Pathology (Jan), 49: M1-M7.
- Hsiao CB, Sethi S, Murphy TF. (1995) Outer membrane protein CD of Branhamella catarrhalis: sequence conservation in strains recovered from the human respiratory tract. Microb Pathog (Oct), 19(4): 215-225.
- Klingman KL, Pye A, Murphy TF, Hill SL. (1995) Dynamics of respiratory tract colonization by Branhamella catarrhalis in bronchiectasis. Am J Respir Crit Care Med (Sep), 152(3): 1072-1078.
- Sethi S, Hill SL, Murphy TF. (1995) Serum antibodies to outer membrane proteins (OMPs) of Moraxella (Branhamella)catarrhalis in patients with bronchiectasis: identification of OMP B1 as an important antigen. Infect Immun (Apr), 63(4): 1516-1520.
- Hsiao C, Sethi S, Murphy TF. (1995) Outer membrane protein CD of Branhamella catarrhalis: sequnce conservation in strains recovered from the human respiratory tract. Microbial Pathogenesis (Jan), 19: 215-225.
- Bhushan R, Craigie R, Murphy TF. (1994) Molecular cloning and characterization of outer membrane protein E of Moraxella (Branhamella) catarrhalis. J Bacteriol (Nov), 176(21): 6636-6643.
- Murphy TF. (1994) Antigenic variation of surface proteins as a survival strategy for bacterial pathogens. Trends Microbiol (Nov), 2(11): 427-428.
- Yi K, Murphy TF. (1994) Mapping of a strain-specific bactericidal epitope to the surface-exposed loop 5 on the P2 porin protein of non-typeable Haemophilus influenzae. Microb Pathog (Oct), 17(4): 277-282.
- Haase EM, Yi K, Morse GD, Murphy TF. (1994) Mapping of bactericidal epitopes on the P2 porin protein of nontypeable Haemophilus influenzae. Infect Immun (Sep), 62(9): 3712-3722.
- Haase EM, Yi K, Morse GD, Murphy TF, Morse ED. (1994) Mapping of bactericidal epitopes on the P2 porin protein of nontypeable Haemophilus influenzae. Infect Immun (Sep), 62(9): 3712-3722.
- Klingman KL, Murphy TF. (1994) Purification and characterization of a high-molecular-weight outer membrane protein of Moraxella (Branhamella) catarrhalis. Infect Immun (Apr), 62(4): 1150-1155.
- Murphy TF, Kirkham C, Lesse AJ. (1993) The major heat-modifiable outer membrane protein CD is highly conserved among strains of Branhamella catarrhalis. Mol Microbiol (Oct), 10(1): 87-97.
- Burnett D, Chamba A, Stockley RA, Murphy TF, Hill SL. (1993) Effects of recombinant GM-CSF and IgA opsonisation on neutrophil phagocytosis of latex beads coated with P6 outer membrane protein from Haemophilus influenzae. Thorax (Jun), 48(6): 638-642.
- Sikkema DJ, Murphy TF. (1992) Molecular analysis of the P2 porin protein of nontypeable Haemophilus influenzae. Infect Immun (Dec), 60(12): 5204-5211.
- Murphy TF, Sethi S. (1992) Bacterial infection in chronic obstructive pulmonary disease. Am Rev Respir Dis (Oct), 146(4): 1067-1083.
- Faden HS, Hong J, Murphy TF. (1992) Immune response to outer membrane antigens of Moraxella catarrhalis in children with otitis media. Infect Immun (Sep), 60(9): 3824-3829.
- Murphy TF, Nelson MB, Apicella MA. (1992) The P6 outer membrane protein of nontypeable Haemophilus influenzae as a vaccine antigen. J Infect Dis (Jun), 165 S: 203-205.
- Murphy TF, Kirkham C, Sikkema DJ. (1992) Neonatal, urogenital isolates of biotype 4 nontypeable Haemophilus influenzae express a variant P6 outer membrane protein molecule. Infect Immun (May), 60(5): 2016-2022.
- Sikkema DJ, Nelson MB, Apicella MA, Murphy TF. (1992) Outer membrane protein P6 of Haemophilus influenzae binds to its own gene. Mol Microbiol (Feb), 6(4): 547-554.
- Bernstein JM, Faden HS, Loos BG, Murphy TF, Ogra PL. (1992) Recurrent otitis media with non-typable Haemophilus influenzae: the role of serum bactericidal antibody. Int J Pediatr Otorhinolaryngol (Jan), 23(1): 1-13.
- Nelson MB, Munson RS, Apicella MA, Sikkema DJ, Molleston JP, Murphy TF. (1991) Molecular conservation of the P6 outer membrane protein among strains of Haemophilus influenzae: analysis of antigenic determinants, gene sequences, and restriction fragment length polymorphisms. Infect Immun (Aug), 59(8): 2658-2663.
- Moeser PJ, Costello PB, Gillikin S, Murphy TF. (1991) Haemophilus influenzae polyarthritis in an adult: an analysis of serotype b strains. Rev Infect Dis (Jan), 13(1): 61-63.
- Murphy TF. (1990) Molecular biology and respiratory disease. 6. Modern molecular biology and respiratory bacterial infections: a revolution on the horizon. Thorax (Jul), 45(7): 552-559.
- Murphy TF. (1990) Studies of the outer membrane proteins of Branhamella catarrhalis. Am J Med (May), 88(5A): 41-45.
- Murphy TF, Bartos LC. (1989) Surface-exposed and antigenically conserved determinants of outer membrane proteins of Branhamella catarrhalis. Infect Immun (Oct), 57(10): 2938-2941.
- Loos BG, Bernstein JM, Dryja DM, Murphy TF, Dickinson DP. (1989) Determination of the epidemiology and transmission of nontypable Haemophilus influenzae in children with otitis media by comparison of total genomic DNA restriction fingerprints. Infect Immun (Sep), 57(9): 2751-2757.
- Murphy TF, Loeb MR. (1989) Isolation of the outer membrane of Branhamella catarrhalis. Microb Pathog (Mar), 6(3): 159-174.
- Murphy TF. (1989) The surface of Branhamella catarrhalis: a systematic approach to the surface antigens of an emerging pathogen. Pediatr Infect Dis J (Jan), 8(1 Sup): 75-77.
- Murphy TF, Bartos LC. (1988) Human bactericidal antibody response to outer membrane protein P2 of nontypeable Haemophilus influenzae. Infect Immun (Oct), 56(10): 2673-2679.
- Bartos LC, Murphy TF. (1988) Comparison of the outer membrane proteins of 50 strains of Branhamella catarrhalis. J Infect Dis (Oct), 158(4): 761-765.
- Nelson MB, Murphy TF, van Keulen H, Rekosh D, Apicella MA. (1988) Studies on P6, an important outer-membrane protein antigen of Haemophilus influenzae. Rev Infect Dis (Jul), 10 Su: 331-336.
- Murphy TF, Bartos LC. (1988) Purification and analysis with monoclonal antibodies of P2, the major outer membrane protein of nontypable Haemophilus influenzae. Infect Immun (May), 56(5): 1084-1089.
- Klingman KL, Jansen(Haase) EM, Murphy TF. (1988) Nearest Neighbor Analysis of Outer Membrane Proteins of Nontypeable Haemophilus influenzae. Infect Immun (Jan), 56: 3058-3063.
- Nelson MB, Apicella MA, Murphy TF, Vankeulen H, Spotila LD, Rekosh D. (1988) Cloning and sequencing of Haemophilus influenzae outer membrane protein P6. Infect Immun (Jan), 56(1): 128-134.
- Campagnari AA, Gupta MR, Dudas KC, Murphy TF, Apicella MA. (1987) Antigenic diversity of lipooligosaccharides of nontypable Haemophilus influenzae. Infect Immun (Apr), 55(4): 882-887.
- Murphy TF, Apicella MA. (1987) Nontypable Haemophilus influenzae: a review of clinical aspects, surface antigens, and the human immune response to infection. Rev Infect Dis (Jan), 9(1): 1-15.
- Murphy TF, Bartos LC, Rice PA, Nelson MB, Dudas KC, Apicella MA. (1986) Identification of a 16,600-dalton outer membrane protein on nontypeable Haemophilus influenzae as a target for human serum bactericidal antibody. J Clin Invest (Oct), 78(4): 1020-1027.
- Apicella MA, Dudas KC, Anthony Campagnari, Rice P, Joseph Mylotte, Murphy TF. (1985) Antigenic heterogeneity of lipid A of Haemophilus influenzae. Infect Immun (Oct), 50(1): 9-14.
- Murphy TF, Apicella MA. (1985) Antigenic heterogeneity of outer membrane proteins of nontypable Haemophilus influenzae is a basis for a serotyping system. Infect Immun (Oct), 50(1): 15-21.
- Amedei A, Della Bella C, Niccolai E, Stanflin N, Benagiano M, Duranti R, Del Prete G, Murphy TF, D. (1900) Moraxella catarrhalis-specific Th1 cells in BAL fluids of chronic obstructive pulmonary disease patients. International journal of immunopathology and pharmacology (Jan), 22(4): 979-90.
Books and Book Chapters:
- (2020) Moraxella catarrhalis. In: Nelson Textbook of Pediatrics. Elsevier Saunders
- (2020) Moraxella catarrhalis, Kingella and other gram negative cocci. In: Mandell, Douglas and Bennett’s Principles and Practice of Infectious Diseases Ninth Edition.
- (2020) Haemophilus species (Including H. influenzae and Chancroid). In: Mandell, Douglas and Bennett’s Principles and Practice of Infectious Diseases.
- (2018) Haemophilus and Moraxella infections. In: Harrison's Principles of Internal Medicine.
- Bernstein JM, Faden HS, Loos BG, Murphy TF, Ogra PL. (1991) In: "Recurrent Otitis Media with Nontypable Haemophilus Influenzae (NTHI)". Kugler Publications, 37-47.
Abstracts:
- Sethi S, Kim J., Wrona C., Eberhardt E., Grove L., Murphy TF. (2015) Distinguishing Infecting (New) from Colonizing (Pre-Existing) Nontypeable Haemophilus Influenzae and Moraxella Catarrhalis Strains at Exacerbation of COPD by Molecular and Immunological Assay. ATS International Conference, Denver, CO, (May)
- Huang Y.J., Sethi S, Murphy TF, Nariya S., Boushey H.A., Lynch S.V. (2014) Bacterial Airway Microbiome Dynamics In Exacerbations Of Chronic Obstructive Pulmonary Disease. ATS International Conference, San Diego, CA, (May)
- Mohan A., Eberhardt E., Grove L., Murphy TF, Parameswaran GI, Sethi S. (2014) Clinical Features Of Exacerbations Of Chronic Obstructive Pulmonary Disease Are Related To Sputum Microbiology. ATS International Conference, San Diego, CA, (May)
- Parameswaran GI, Murphy TF, Yin J., Grove L., Eberhardt E., Berenson CS, Sethi S. (2012) Species Specific Susceptibility To Bacterial Colonization And Exacerbation In COPD. ATS International Conference, San Francisco, CA, (May)
- Parameswaran GI, Sethi S, Murphy TF. (2012) Transcriptional And Cytokine Responses Of Airway Epithelial Cells To Infection In COPD. ATS International Conference, San Francisco, CA, (May)
- Jamil M.O., Yin J., Nag N., Eberhardt E., Grove L., Parameswaran GI, Murphy TF, Sethi S. (2012) Acquistion Of Pseudomonas Aeruginosa Is Associated With Adverse Clinical Outcomes In COPD. ATS International Conference, San Francisco, CA, (May)
- Sethi S, Wrona C., Eberhardt E., Grove L., Parameswaran GI, Murphy TF. (2012) Distinguishing Infecting (New) From Colonizing (Pre-Existing) Nontypeable Haemophilus Influenzae Strains At Exacerbation Of COPD By Molecular And Immunological Assays. ATS International Conference, San Francisco, CA, (May)
- Parameswaran GI, Sethi S, Murphy TF. (2011) Effects Of Bacterial Infection On Airway Antimicrobial Peptides And Proteins In Chronic Obstructive Pulmonary Disease. ATS International Conference, Denver, CO, (May)
- Desai H.D., Grant B.J.B., Eschberger K., Agrawal A., Murphy TF, Sethi S. (2011) Bacterial Colonization Of The Lower Respiratory Tract Increases Daily Symptoms In Patients With Chronic Obstructive Pulmonary Disease. ATS International Conference, Denver, CO, (May)
- Berim I.G., Lesse AJ, Eberhardt E., Grove L.J., Wrona C., Murphy TF, Sethi S. (2011) New Strain Acquisition Of Staphylococcus Aureus In Chronic Obstructive Pulmonary Disease Is Not Associated With Exacerbations. ATS International Conference, Denver, CO, (May)
- Sethi S, Parameswaran, G.I., Murphy TF. (2009) Antimicrobial Polypeptides and Moraxella Catarrhalis in COPD. ATS International Conference, San Diego, CA, (May)
- Reddy M, Murphy TF, Faden HS, Bernstein J. (1996) Middle Ear Mucin Glycoprotein: Purification and Interaction with Nontypable Haemophilus influenzae and Moraxella Catarrhalis. Proceedings of the 6th International Symposium on Recent Advances in Otitis Media, (Jan) 307-310
- Bernstein JM, Faden HS, Loos BG, Murphy TF, Ogra PL. (1992) Recurrent Otitis Media with Nontypable Haemophilus influenzae (NTHI): Role of Serum Bactericidal Antibody. Proceedings of International Journal of Pediatric Oto-Rhino-Laryngology, (Jan) 1-13
Professional Memberships:
- Association for Clinical and Translational Science (2015–present)
- American Society for Microbiology, Councilor at Large; Microbial pathogenesis (1996–1998)
- American Federation for Medical Research, Institutional Representative (1988–1993)
- American Society for Clinical Investigation
- Alpha Omega Alpha Honor Medical Society
- American Association for the Advancement of Science
- American College of Physicians, Fellow
- Buffalo Collegium of Immunology
- Infectious Diseases Society of America, Fellow
- Western New York American Society for Microbiology
Presentations:
- "State of Clinical and Translational Science Institute" CTSI Annual Forum (2024)
- "Community Health Equity Research Institute: Selected Equity Initiatives" Department of Psychiatry residency lecture series (2023)
- "COVID-19 Vaccination and Vaccine Hesitancy" Erie Niagara Area Health Education Center Invited Lecture (2023)
- "“Meaningful Community Partnerships: Establishing Trust and Sharing Power”" CDC Foundation Public Health Summit Panel. (2023)
- "“Haemophilus influenzae: Life is Good in Human COPD airways!”" Inauguration Ceremony of Professor Niels Nørskov-Lauritsen.University of Southern Denmark, Odense, Denmark. (2022)
- "Bacteria in the Human Respiratory Tract: How Microbial Genomes Reveal Their Secrets!" Nationwide Children’s Hospital and Ohio State University (2016)
- "Bacterial Infection in COPD: Microbial Genomics as a Powerful Research Approach" United States-Japan Cooperative Medical Sciences Program. 50th Anniversary Celebration.; National Institutes of Allergy and Infectious Diseases (2016)
- "Vaccine Development for Moraxella catarrhalis: Rationale, Challenges and Current Status" 18th International Symposium on Recent Advances in Otitis Media. (2015)
- "Bacterial Infection in COPD. Acute or chronic….or both?”" Drexel University (2014)
- "ABC Transporters of Moraxella catarrhalis as Vaccine Antigens and Virulence Factors" Wake Forest University (2014)
- "Prevention of bacterial otitis media: next generation approaches" 7th Extraordinary International Symposium on Recent Advances in Otitis Media (2013)
- "Dynamics of respiratory tract colonization in chronic obstructive pulmonary disease" Society for General Microbiology 2013 Spring Conference; Society for General Microbiology (2013)
- "Bacterial ABC transporters as vaccine antigens and antimicrobial targets" US Japan Cooperative Medical Science Program Acute Respiratory Tract Infection Panel Meeting (2011)
- "Oligopeptide permease A as a fitness virulence factor in Moraxella catarrhalis” HinMax 2011- 2nd International Workshop on Haemophilus influenzae and Moraxella catarrhalis" HinMax 2011- 2nd International Workshop on Haemophilus influenzae and Moraxella catarrhalis; HinMax (2011)
- "Urease operon of Haemophilus influenzae" HinMax 2011- 2nd International Workshop on Haemophilus influenzae and Moraxella catarrhalis; HinMax (2011)
- "Understanding Moraxella catarrhalis otitis media: challenges and progress" 10th International Symposium on Recent Advances in Otitis Media (2011)
- "Vaccine targets for nontypeable Haemophilus influenzae" 10th International Symposium on Recent Advances in Otitis Media (2011)
- "Vaccine development for Moraxella catarrhalis. Challenges and progress" University of Vienna, Intercell AG (2011)
- "Pseudomonas aeruginosa infection in chronic obstructive pulmonary disease" Interscience Conference on Antimicrobial Agents and Chemotherapy of the American Society for Microbiology; ASM (2010)
- "Mucosal immunity and bacterial infections of the upper airways. Are mucosal vaccines the answer?”" Seventh International Symposium on Tonsils and Mucosal Barriers of the Upper Airways.; ; Symposium (2010)
- "Bacterial infection in COPD. Novel approaches to pathogenesis" University of Texas Southwestern Medical Center Division of Pulmonary and Critical Care Medicine (2010)
- "Moraxella catarrhalis. Pathogenesis and vaccine development for an underestimated pathogen" University of Texas Southwestern Medical Center Department of Microbiology (2010)
- "Bacterial infection in the course of chronic obstructive pulmonary disease: bedside to bench and back" Grand Rounds Yale University of Public Health; Yale University of Public Health (2009)
- "Pathogenesis of Haemophilus influenzae in COPD" University of Iowa Department of Microbiology (2009)
- "Clinical implications of nasopharyngeal bacterial colonization" 48th Annual Meeting of the Japan Rhinological Society; Japanese Rhinological Society (2009)
- "The many faces of Pseudomonas aeruginosa in chronic obstructive pulmonary disease" Pseudomonos 2009 XII International Conference; Hannover Medical School (2009)
- "IgA proteases of nontypeable Haemophilus influenzae. Characterization of new putative virulence factors" Acute Respiratory Tract Infection Panel Meeting; US Japan Cooperative Medical Science Program (2009)
- "Haemophilus influenzae in COPD: a uniquely adapted human pathogen" Center for Genomic Sciences; Allegheny General Hospital (2008)
- "Clinical implications of nasopharyngeal bacterial colonization" Symposium International Congress of Infectious Diseases (2008)
- "Mechanisms of recurrent bacterial infection in chronic obstructive pulmonary disease: a model of microbial evasion" Symposium General Meeting of the American Society for Microbiology (2008)
- "Streptococcus pneumoniae in community acquired pneumonia: the case against placebo-controlled trials" 4th International Symposium on Resistant Gram-positive Infections (2008)
- "Haemophilus influenzae and Moraxella catarrhalis in COPD: Pathogenesis and immunity" HinMax 2008-1st International Workshop on Haemophilus influenzae and Moraxella catarrhalis (2008)
- "Mining the Moraxella catarrhalis genome: identification of potential vaccine antigens expressed during human infection" HinMax 2008-1st International Workshop on Haemophilus influenzae and Moraxella catarrhalis (2008)
- "Upper and lower respiratory tract infections caused by Haemophilus influenzae and Moraxella catarrhalis" First Global Master Class on Childhood Bacterial Respiratory Diseases (2008)
- "Bacterial infection in COPD" Grand Rounds, Erie County Medical Center (2008)
- "Mining the Moraxella catarrhalis genome: Identification of potential vaccine antigens expressed during human infection" US Japan Cooperative Medical Science Program Acute Respiratory Tract Infection Panel Meeting (2008)
- "Community acquired pneumonia and placebo controlled trials: Review of the literature and discussion of feasibility and potential value" Workshop on Community-acquired Pneumonia sponsored by the Infectious Diseases Society of America and FDA (2008)
- "Pathogenesis of Haemophilus influenzae Infection, an Exclusively Human Pathogen" University of Rochester Department of Microbiology (2007)
- "Bacterial infection in chronic obstructive pulmonary disease" University of Rochester Division of Infectious Diseases (2007)
- "Pathogenesis of Haemophilus influenzae Infection, an Exclusively Human Pathogen" University of Texas at Austin Section of Molecular Genetics and Microbiology (2007)
- "Bacterial Infection of the Respiratory Tract. New Observations Using New Methods" Wakayama University Department of Otolaryngology (2007)
- "Pathogenesis of Haemophilus influenzae Infection, the Resurrection of IgA Protease" US Japan Cooperative Medical Science Program Acute Respiratory Tract Infection Panel Meeting (2007)
- "Respiratory Tract Infections: A View Through the Molecular Looking Glass" Annual Meeting of the University at Buffalo School of Dental Medicine Alumni Association (2006)
- "Bacterial Infection in Chronic Obstructive Pulmonary Disease: Is there a Role for Antibiotics and Vaccines?" Grand Rounds, Montefiore Medical Center (2006)
- "Respiratory Tract Infections: A View Through the Molecular Looking Glass" University at Buffalo Academy on the Road Harrington Lecture (2006)
- "Virulence Factors of Haemophilus influenzae in Chronic Obstructive Pulmonary Disease: A Genomics Approach" US Japan Cooperative Medical Science Program Acute Respiratory Tract Infection Panel Meeting (2006)
- "Nontypeable Haemophilus influenzae in Adults with Chronic Obstructive Pulmonary Disease, a Persistent Pathogen" Symposium at 45th Interscience Conference on Antimicrobial Agents and Chemotherapy of the American Society for Microbiology (2005)
- "Vaccine Development for Nontypeable Haemophilus influenzae: Feasibility of Prevention of Infection by a Persistent Pathogen" American Society for Microbiology Conference on Pasteurellaceae 2005 (2005)
- "Bacterial Infection in Chronic Lung Disease: What You See Depends on How You Look!" UB This Summer Lecture Series (2005)
- "An Ounce of Prevention: Vaccines Current and Future" Symposium American Thoracic Society International Conference (2005)
- "Community Acquired Pneumonia" Grand Rounds. Erie County Medical Center (2005)
- "Recent Developments in Vaccines" 27th Annual International Conference on Pediatric/Adult Allergy and Immunology (2004)
- "Bacterial Infection in COPD: Beyond Sputum Cultures" University of Iowa, Department of Microbiology (2004)
- "Update of Vaccines for Moraxella catarrhalis" NIH Workshop on Vaccines for Otitis Media: Overcoming Obstacles to Progress (2004)
- "Development of a Vaccine for Moraxella catarrhalis" Department of Medicine Research Conference. University at Buffalo, SUNY (2004)
- "Antibiotics for Upper Respiratory Tract Infections: When and When Not to Use Them" Upstate District Meeting of the American College of Physicians (2004)
- "Persistent Colonization of the Respiratory Tract by Haemophilus influenzae in Chronic Obstructive Pulmonary Disease in Spite of Negative Sputum Cultures" 8th Annual Meeting of the Acute Respiratory Infection Panel of the U.S.-Japan Cooperative Medical Science Program (2004)
Service Activities:
- Planning Committee for VPHS Symposium on Health Equity; Planning Committee for VPHS Symposium on Health Equity (2024)
- Planning Committee for VPHS Symposium on Artificial Intelligence; Planning Committee for VPHS Symposium on Artificial Intelligence (2024)
- Chair, Search Committee for Carl Granger Endowed Chair in Health Equity; Chair (2024)
- Co chair of Search Committee for Senior Associate Dean for Research and Director of the Research Office, Jacobs School of Medicine and Biomedical Sciences; Co Chair of Search Committee (2023–2022)
- Advise leaders of UCSF External Advisory Board; Member of External Advisory Board (2023–present)
- Co-Chair, Search Committee for Senior Associate Dean for Research and Executive Director of the Office of Research; Co-Chair, Search Committee for Senior Associate Dean for Research and Executive Director of the Office of Research (2023)
- UB Research Data Management Steering Committee; Chair, Medical Research Data Safety & Security Sub Committee (2023–present)
- Advise leaders of Case Western Research University CTSA; Member of External Advisory Board (2022–present)
- Director of Research Administration, Jacobs School of Medicine and Biomedical Sciences; Co Chair (2022)
- Regional Health Improvement Committee, HEALTHeLINK; Regional Health Improvement Committee, HEALTHeLINK (2022–present)
- Associate Vice President Business Operations Jacobs School of Medicine and Biomedical Sciences; Co Chair of Search Committee (2022)
- Co-Chair, Search Committee for VP for Health Sciences and Dean, Jacobs School of Medicine and Biomedical Sciences; Co-Chair (2021–2022)
- COVID-19 Vaccine Equity Task Force of the Western NY COVID-19 Vaccination Hub; Co Chair (2020–2022)
- Advise leaders of Penn State University CTSA; Member of External Advisory Board (2017–present)
- African American Health Equity Task Force; Member (2015–present)
- Review and advise leaders of University of Rochester CTSA; Member of External Advisory Board (2012–present)
- Department of Veterans Affairs; Study Section Infectious Disease B Committee; Member 2007;; Chair (2008–2011)
- NIH; Study Section-Clinical Research and Field Studies;; Grant Reviewer (2007–2011)
- Medical Research Board, Oishei Foundation Buffalo NY; Board Member (2007–present)
- Academic Medicine Services; Treasurer (2007–present)
- American College of Physicians - American Society of Internal Medicine; Committee Member (2006)
- Editorial Advisory Board, Journal of Infectious Diseases; Editorial Board Member (2006–present)
- Biosafety Committee, Buffalo VA Medical Center; Chair (2004–2009)
- Infectious Diseases Society of America Committee on Acute Exacerbations of Chronic Obstructive Pulmonary Disease with American Thoracic Society; Chair (2004–2005)
- NIH Worship on Vaccines for Otitis Media; Organizing Committee Member (2004)
- Leadership Council, American College of Physicians; Member (2004–present)
- Infectious Diseases Society of America, Publications; Chair (2001–2004)
- National Board of Medical Examiners United States Medical Licensing Examination; Committee Member (2000–2003)
- Infectious Diseases Society of America, Publications; Committee Member (1999–2004)
- Research Leadership Advisory Council; Member (1998–2009)
- NIAID-sponsored Symposium on CAP in adult and elderly populations; Co-Chair (1998)
- American College of Physicians - American Society of Internal Medicine; Committee Member (1998)
- US/Japan Co-operative Medical Science Program at NIH; Panel Member (1998–present)
- American Society for Microbiology; Councilor (1996–1998)
- NIH; Study Section;; Ad Hoc Reviewer (1994–present)
- Department of Veterans Affairs Merit Review; VA Multicenter Trials;; Ad Hoc Reviewer (1993)
- United Kingdom; United Birmingham Hospitals Endowment Fund;; Ad Hoc Reviewer (1993–present)
- NIH; Study Section Bacteriology and Mycology 2;; Chair (1992–1994)
- Budget, Space and Equipment Subcommittee Buffalo VAMC; Committee Member (1991–1994)
- Research and Development Committee Buffalo VAMC; Committee Member (1990–1993)
- NIH; Study Section Bacteriology and Mycology 2;; Grant Reviewer (1989–1991)
- Thrasher Foundation; Thrasher Research Fund;; Grant Reviewer (1989–present)
- American Federation for Clinical Research; University Representative (1988–1993)
- NIH; Study Section--Site Visits;; Panel Member (1988)
- Department of Veterans Affairs Merit Review; Study Section Infectious Disease B Committee;; Ad Hoc Reviewer (1987–present)
- Infection Control Committee, Erie County Medical Center; Committee Member (1981–1987)
- Medical Research Council of Canada;; Grant Reviewer
- United Kingdom; The Wellcome Trust;; Grant Reviewer
- National Health and Medical Research Council of Australia;; Grant Reviewer
- Medical Research Council, United Kingdom;; Grant Reviewer
- United Kingdom;; Grant Reviewer
- British Lung Foundation, United Kingdom;; Grant Reviewer