University at Buffalo (UB)
Sergio Dominguez-Lopez Ph.D.
Sergio Dominguez-Lopez
Ph.D.
Assistant Professor
Department of Pharmacology and Toxicology
Jacobs School of Medicine & Biomedical Sciences
Specialty/Research Focus
Addictions; Ageing; Behavioral Neuroscience; Behavioral pharmacology; Brain Research; Drug Abuse; Image Processing and Analysis; Mitochondria; Neurobiology; Neuroimaging Analysis; Neuropharmacology; Neuropsychiatric Disorders; Neuroscience; Pain; Pathophysiology; Toxicology; Transcriptomics; Translational Research
Education and Training:
- PhD, Neuroscience, McGill University (2014)
- MS, Neuroethology, University of Veracruz (2006)
- BS, Chemical-Pharmaceutical-Biology, University of Veracruz (2003)
Employment:
- Assistant Professor, Pharmacology and Toxicology, State University of New York at Buffalo (2023-present)
- Assistant Professor, Anatomy and Neurobiology, University of Maryland School of Medicine (2021–2023)
- Research Assistant Member, Aging and Metabolism, Oklahoma Medical Research Foundation (2020–2021)
- Postdoctoral Research Fellow, Aging and Metabolism, Oklahoma Medical Research Foundation (2017–2020)
- Postdoctoral Research Fellow, Cellular and Integrative Physiology, University of Texas Health Science Center (2014–2017)
- PhD Visiting Researcher, University of Montreal (2013–2014)
Awards and Honors:
- ACNP Travel Award (2023)
- Center for Underrepresented Research in Addiction (CURA) Fellow (2023)
- Postdoctoral Quebec Merit Scholarship (2013)
- Robert C Paterson Graduate Research Award (2009)
- CONACYT PhD Scholarship (2007)
- CONACYT MSc Scholarship (2005)
Journal Articles:
- Dominguez-Lopez S, Ahn B, Sataranatarajan K, Ranjit R, Premkumar P, Van Remmen H, Beckstead MJ. (2023) Long-term methamphetamine self-administration increases mesolimbic mitochondrial oxygen consumption and decreases striatal glutathione. Neuropharmacology (Apr), 227: 109436. doi:10.1016/j.neuropharm.2023.109436
- Bhaskaran S, Kumar G, Thadathil N, Piekarz KM, Mohammed S, Lopez SD, Qaisar R, Walton D, Brown JL, Murphy A, Smith N, Saunders D, Beckstead MJ, Plafker S, Lewis TL, Towner R, Deepa SS, Richardson A, Axtell RC, Van Remmen H. (2023) Neuronal deletion of MnSOD in mice leads to demyelination, inflammation and progressive paralysis that mimics phenotypes associated with progressive multiple sclerosis. Redox biology (Feb), 59: 102550. doi:10.1016/j.redox.2022.102550
- Dominguez-Lopez S, Sharma R, Beckstead MJ. (2021) Neurotensin receptor 1 deletion decreases methamphetamine self-administration and the associated reduction in dopamine cell firing. Addiction biology (Jan), 26(1): e12854. doi:10.1111/adb.12854
- Howell RD, Dominguez-Lopez S, Ocañas SR, Freeman WM, Beckstead MJ. (2020) Female mice are resilient to age-related decline of substantia nigra dopamine neuron firing parameters. Neurobiology of aging (Nov), 95: 195-204. doi:10.1016/j.neurobiolaging.2020.07.025
- Posa L, Lopez-Canul M, Rullo L, De Gregorio D, Dominguez-Lopez S, Kaba Aboud M, Caputi FF, Candeletti S, Romualdi P, Gobbi G. (2020) Nociceptive responses in melatonin MT2 receptor knockout mice compared to MT1 and double MT1 /MT2 receptor knockout mice. Journal of pineal research (Oct), 69(3): e12671.
- Dominguez-Lopez S, Piccart E, Lynch WB, Wollet MB, Sharpe AL, Beckstead MJ. (2018) Antagonism of Neurotensin Receptors in the Ventral Tegmental Area Decreases Methamphetamine Self-Administration and Methamphetamine Seeking in Mice. The international journal of neuropsychopharmacology (Apr), 21(4): 361-370. doi:10.1093/ijnp/pyx117
- McCall NM, Kotecki L, Dominguez-Lopez S, Marron Fernandez de Velasco E, Carlblom N, Sharpe AL, Beckstead MJ, Wickman K. (2017) Selective Ablation of GIRK Channels in Dopamine Neurons Alters Behavioral Effects of Cocaine in Mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology (Feb), 42(3): 707-715. doi:10.1038/npp.2016.138
- López-Canul M, Comai S, Domínguez-López S, Granados-Soto V, Gobbi G. (2015) Antinociceptive properties of selective MT(2) melatonin receptor partial agonists. European journal of pharmacology (Oct), 764: 424-432.
- Lacoste B, Angeloni D, Dominguez-Lopez S, Calderoni S, Mauro A, Fraschini F, Descarries L, Gobbi G. (2015) Anatomical and cellular localization of melatonin MT1 and MT2 receptors in the adult rat brain. Journal of pineal research (May), 58(4): 397-417.
- Lopez-Canul M, Palazzo E, Dominguez-Lopez S, Luongo L, Lacoste B, Comai S, Angeloni D, Fraschini F, Boccella S, Spadoni G, Bedini A, Tarzia G, Maione S, Granados-Soto V, Gobbi G. (2015) Selective melatonin MT2 receptor ligands relieve neuropathic pain through modulation of brainstem descending antinociceptive pathways. Pain (Feb), 156(2): 305-317.
- Comai S, Ochoa-Sanchez R, Dominguez-Lopez S, Bambico FR, Gobbi G. (2015) Melancholic-Like behaviors and circadian neurobiological abnormalities in melatonin MT1 receptor knockout mice. The international journal of neuropsychopharmacology (Jan), 18(3). doi:10.1093/ijnp/pyu075
- Domínguez-López S, Howell RD, López-Canúl MG, Leyton M, Gobbi G. (2014) Electrophysiological characterization of dopamine neuronal activity in the ventral tegmental area across the light-dark cycle. Synapse (New York, N.Y.) (Oct), 68(10): 454-67.
- Rainer Q, Speziali S, Rubino T, Dominguez-Lopez S, Bambico FR, Gobbi G, Parolaro D. (2014) Chronic nandrolone decanoate exposure during adolescence affects emotional behavior and monoaminergic neurotransmission in adulthood. Neuropharmacology (Aug), 83: 79-88.
- Labonte B, McLaughlin RJ, Dominguez-Lopez S, Bambico FR, Lucchino I, Ochoa-Sanchez R, Leyton M, Gobbi G. (2012) Adolescent amphetamine exposure elicits dose-specific effects on monoaminergic neurotransmission and behaviour in adulthood. The international journal of neuropsychopharmacology (Oct), 15(9): 1319-30.
- Morales-Medina JC, Dominguez-Lopez S, Gobbi G, Beck-Sickinger AG, Quirion R. (2012) The selective neuropeptide Y Y5 agonist [cPP(1-7),NPY(19-23),Ala31,Aib32,Gln34]hPP differently modulates emotional processes and body weight in the rat. Behavioural brain research (Aug), 233(2): 298-304.
- Domínguez-López S, Mahar I, Bambico FR, Labonté B, Ochoa-Sánchez R, Leyton M, Gobbi G. (2012) Short-term effects of melatonin and pinealectomy on serotonergic neuronal activity across the light-dark cycle. Journal of psychopharmacology (Oxford, England) (Jun), 26(6): 830-44.
- Domínguez-López S, Howell R, Gobbi G. (2012) Characterization of serotonin neurotransmission in knockout mice: implications for major depression. Reviews in the neurosciences (Jan), 23(4): 429-43.
- Ochoa-Sanchez R, Comai S, Lacoste B, Bambico FR, Dominguez-Lopez S, Spadoni G, Rivara S, Bedini A, Angeloni D, Fraschini F, Mor M, Tarzia G, Descarries L, Gobbi G. (2011) Promotion of non-rapid eye movement sleep and activation of reticular thalamic neurons by a novel MT2 melatonin receptor ligand. The Journal of neuroscience : the official journal of the Society for Neuroscience (Dec), 31(50): 18439-52. doi:10.1523/JNEUROSCI.2676-11.2011
- Mahar I, Tan S, Davoli MA, Dominguez-Lopez S, Qiang C, Rachalski A, Turecki G, Mechawar N. (2011) Subchronic peripheral neuregulin-1 increases ventral hippocampal neurogenesis and induces antidepressant-like effects. PloS one (Jan), 6(10): e26610. doi:10.1371/journal.pone.0026610
- Bambico FR, Cassano T, Dominguez-Lopez S, Katz N, Walker CD, Piomelli D, Gobbi G. (2010) Genetic deletion of fatty acid amide hydrolase alters emotional behavior and serotonergic transmission in the dorsal raphe, prefrontal cortex, and hippocampus. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology (Sep), 35(10): 2083-100. doi:10.1038/npp.2010.80
Professional Memberships:
- American Aging Association (2018–2020)
- American Society for Pharmacology and Experimental Therapeutics (2018–2020)
- Society for Neuroscience (2017–present)
- American Association for the Advancement of Science (2013–2014)
- Canadian Society for Neuroscience (2009–2010)