Steven N. Hochwald MD, FACS
Steven N. Hochwald
MD, FACS
Professor of Surgery, Roswell Park Chief of Gastrointestinal Surgery, Vice Chair of Department of Surgical Oncology (Roswell Park)
Jacobs School of Medicine & Biomedical Sciences
Professional Summary:
I have been Chief of Gastrointestinal Surgery and Professor of Oncology at Roswell Park Cancer Institute since April 2012. I did my residency at the NYU Medical Center Department of Surgery and both research and clinical fellowships at Memorial Sloan Kettering Cancer Center and I am a graduate of Johns Hopkins University with a MD from New York University School of Medicine.
My research focuses on technical advances in minimally invasive esophageal and GI surgeries and developing new targets and agents for treatment of pancreatic and other GI cancers. I lead a funded laboratory program which focuses on glucose promotion of histidine signaling to drive cancer progression in the absence of growth factor stimulation. The goal is to target histidine signaling as novel therapy in GI cancer.
Education and Training:
- Business, University at Buffalo (2017)
- Residency, New York University Medical Center (1997)
- Residency, New York University Medical Center (1996)
- Fellowship, Surgical Oncology, Memorial Sloan-Kettering Cancer Center (1995)
- Internship, Categorical General Surgery, New York University Medical Center (1991)
- MD, Medicine, New York University School of Medicine (1990)
- BA, John Hopkins University (1986)
Awards and Honors:
- 2016 Top Oncologist, International Association of Oncologists (2017)
- Best Doctors in America (2017)
- Buffalo Spree Best Docs (2017)
- International Business Honor Society:Beta Gamma Sigma (2017)
- US News Top Doctor (2017)
- Surgical Oncology Fellows Teaching Award (2014)
- Comission on Cancer (2008)
- Cancer Liaison Physician Outstanding Performance Award (2007)
- Dept. of Surgery Research Career Development Award (2005)
- Lester Dragstedt Physician-Scientist Award (2002)
- Lester Dragstedt Physician-Scientist Award (2001)
- SSAT/Ross Laboratory presentation (1999)
- SSAT/Ross Laboratory presentation (1997)
- New York University Housestaff award for Scholarship (1996)
- NCI National Research Service Award (1995)
- Alpha Epsilon Delta Premedical Honor Society (1985)
- National Westinghouse Science Competition (1981)
Grants and Sponsored Research:
- February 2013–January 2017
Esophageal Cancer Research Fund
Roswell Park Cancer Institute
Role: Principal Investigator
$400,000 - January 2006–December 2016
Phosphohistidine signaling in glycolytic metabolite control of gastric tumorigenesis
Roswell Park Alliance Foundation
Role: Principal Investigator
$50,000 - July 2010–May 2015
Design, synthesis and evaluation of novel selective inhibitors of FAK and IGF-1R function in pancreatic cancer.
Bankhead Coley Cancer Research Program
Role: Principal Investigator
$1,200,000 - January 2012–December 2012
Novel therapeutic targets and approaches in pancreatic cancer
University of Florida Shands Cancer Center
Role: Principal Investigator
$100,000 - July 2006–June 2011
FAK and IGF-1R interactions in pancreatic cancer survival
NCI-5K08
Role: Principal Investigator
$593,925 - March 2009–February 2010
Modulating radiation response in pancreatic cancer through targeting the FAK/IGF-1R pathways.
Moffitt-UF Collaborative grant
Role: Principal Investigator
$75,000 - March 2009–February 2010
Novel agents that target FAK and IGF-1R binding in pancreatic cancer
Moffitt-UF Collaborative grant
Role: Principal Investigator
$100,000 - February 2009–January 2010
Targeting FAK and VEGFR-3 in melanoma
Bankhead Coley Research Foundation
Role: Principal Investigator
$75,000 - November 2005–November 2006
A single center prospective randomized trial of Epoetin alpha in patients undergoing major abdominal operation for malignancy.
Ortho Biotech
Role: Co-Principal Investigator
$100,000 - July 2005–June 2006
Anti-neoplastic efficacy of FAK and/or IGF-1R tyrosine kinase inhibition in human pancreatic cancer xenografts
University of Florida Department of Surgery Career Development Award
Role: Principal Investigator
$25,000 - July 2003–June 2005
Alternative estrogen therapy for colon cancer prevention
NCI R21CA098741-01
Role: Co-Investigator
$362,500 - September 2001–December 2004
A phase II trial of neoadjuvant irinotecan and docetaxel chemotherapy followed by surgery in patients with gastric cancer
Aventis Pharmaceuticals
Role: Principal Investigator
$37,467 - July 2001–December 2004
Role of Nuclear Factor kB in the chemotherapy and radioresistance of gastrointestinal cancer.
Florida Biomedical Research Program
Role: Principal Investigator
$470,419
Patents:
- "Jejunostomy tube and method" (2015)
- "Kinase protein binding inhibitors" Licensed in 2010 (2009)
Journal Articles:
- Peng JS, Kukar M, Hochwald SN. (2020) ASO Author Reflections: Overcoming the Learning Curve for Minimally Invasive Esophagectomy. Ann Surg Oncol (Aug), 27(8): 3039-3040.
- Kukar M, Ben-David K, Peng JS, Attwood K, Thomas RM, Hennon M, Nwogu C, Hochwald SN. (2020) Minimally Invasive Ivor Lewis Esophagectomy with Linear Stapled Anastomosis Associated with Low Leak and Stricture Rates. J Gastrointest Surg (Aug), 24(8): 1729-1735.
- Peng JS, Joyce D, Brady M, Groman A, Attwood K, Kuvshinoff B, Hochwald SN, Kukar M. (2020) Risk-stratified analysis of pasireotide for patients undergoing pancreatectomy. J Surg Oncol (Aug), 122(2): 195-203.
- Peng JS, Kukar M, Hochwald SN. (2020) Technique for Robotic Transhiatal Esophagectomy. Ann Surg Oncol (Aug), 27(8): 3037-3038.
- Peng JS, Hochwald SN, Kukar M. (2020) ASO Author Reflections: Robotic Oncologic Surgery. Ann Surg Oncol (Jul).
- Peng JS, Nurkin SJ, Hochwald SN, Kukar M. (2020) Technique for Robotic Ivor Lewis Esophagectomy with 6-cm Linear Stapled Side-to-Side Anastomosis. Ann Surg Oncol (Mar), 27(3): 824-824.
- Liang Y, Jiang L, Zhong X, Hochwald SN, Wang Y, Huang L, Nie Q, Huang H, Xu JF. (2019) Discovery of Aberrant Alteration of Genome in Colorectal Cancer by Exome Sequencing. Am J Med Sci (Nov), 358(5): 340-349.
- Xu Y, Wan B, Chen X, Zhan P, Zhao Y, Zhang T, Liu H, Afzal MZ, Dermime S, Hochwald SN, Hofman P, Borghaei H, Lin D, Lv T, Song Y. (2019) The association of PD-L1 expression with the efficacy of anti-PD-1/PD-L1 immunotherapy and survival of non-small cell lung cancer patients: a meta-analysis of randomized controlled trials. Transl Lung Cancer Res (Aug), 8(4): 413-428.
- Katsuta E, Qi Q, Peng X, Hochwald SN, Yan L, Takabe K. (2019) Pancreatic adenocarcinomas with mature blood vessels have better overall survival. Sci Rep (Jan), 9(1): 1310-1310.
- Peng JS, Kukar M, Mann GN, Hochwald SN. (2019) Minimally Invasive Esophageal Cancer Surgery. Surg Oncol Clin N Am (Jan), 28(2): 177-200.
- Kukar M, Gabriel E, Ben-David K, Hochwald SN. (2018) Laparoscopic proximal gastrectomy for gastric neoplasms. J Surg Oncol (Jul), 118(1): 95-100.
- Gabriel E, Kim J, Ostapoff KT, Attwood K, Kurenov S, Kuvshinoff B, Hochwald SN, Nurkin SJ. (2018) Preoperative survival calculator for resectable hepatocellular carcinoma. J Gastrointest Oncol (Apr), 9(2): 316-325.
- Singla S, Gabriel E, Alnaji R, Du W, Attwood K, Nava H, Hochwald SN, Kukar M. (2018) Complete pathologic response is independent of the timing of esophagectomy following neoadjuvant chemoradiation for esophageal cancer. J Gastrointest Oncol (Feb), 9(1): 73-79.
- Shah R, Ostapoff KT, Kuvshinoff B, Hochwald SN. (2018) Ablative Therapies for Locally Advanced Pancreatic Cancer. Pancreas (Jan), 47(1): 6-11.
- Ostapoff KT, Gabriel E, Attwood K, Kuvshinoff BW, Nurkin SJ, Hochwald SN. (2017) Does adjuvant therapy improve overall survival for stage IA/B pancreatic adenocarcinoma?. HPB (Oxford) (Jan), 19(7): 587-594.
- Baldwin S, Kukar M, Gabriel E, Attwood K, Wilkinson N, Hochwald SN, Kuvshinoff B. (2016) Pancreatic cancer metastatic to a limited number of lymph nodes has no impact on outcome. HPB (Oxford) (Jan), 18(6): 523-528.
- Oyasiji T, Zhang J, Kuvshinoff B, Iyer R, Hochwald SN. (2015) Molecular Targets in Biliary Carcinogenesis and Implications for Therapy. Oncologist (Jul), 20(7): 742-751.
- Singla S, Hochwald SN, Kuvshinoff B. (2014) Evolving ablative therapies for hepatic malignancy. Biomed Res Int (Apr), 2014: 230174-230174.
- Nurkin SJ, Nava HR, Yendamuri S, LeVea CM, Nwogu CE, Groman A, Wilding G, Bain AJ, Hochwald SN, Khushalani NI. (2014) Outcomes of endoscopic resection for high-grade dysplasia and esophageal cancer. Surg Endosc (Apr), 28(4): 1090-1095.
- Waterman AL, Grobmyer SR, Cance WG, Hochwald SN. (2008) Is endoscopic resection of gastric gastrointestinal stromal tumors safe?. Am Surg (Dec), 74(12): 1186-1189.
- Garces CA, Reith JD, Grobmyer SR, Hochwald SN. (2008) Isolated metastatic extremity liposarcoma to the liver, an uncommon and transient finding. World J Surg Oncol (Oct), 6: 108-108.
- Kim T, Grobmyer SR, Dixon LR, Allan RW, Hochwald SN. (2008) Autoimmune pancreatitis and concurrent small lymphocytic lymphoma: not just a coincidence?. J Gastrointest Surg (Sep), 12(9): 1566-1570.
- Mortellaro VE, Marshall J, Harms SE, Hochwald SN, Copeland EM, Grobmyer SR. (2008) Breast MR for the evaluation of occult nipple discharge. Am Surg (Aug), 74(8): 739-742.
- Winfield RD, Parr AG, Ang DN, Martin TD, Chen MK, Seagle MB, Hochwald SN, Reed AI, Lottenberg L. (2008) A case of dual thoracoabdominal impalement in vehicular trauma. Am Surg (Aug), 74(8): 757-760.
- Kim T, Grobmyer SR, Dixon LR, Hochwald SN. (2008) Isolated lymphoplasmacytic sclerosing pancreatitis involving the pancreatic tail. Am Surg (Jul), 74(7): 654-658.
- Liu W, Bloom DA, Cance WG, Kurenova EV, Golubovskaya VM, Hochwald SN. (2008) FAK and IGF-IR interact to provide survival signals in human pancreatic adenocarcinoma cells. Carcinogenesis (Jun), 29(6): 1096-1107.
- Grobmyer SR, Mortellaro VE, Marshall J, Higgs GM, Hochwald SN, Mendenhall NP, Copeland EM, Cance WG. (2008) Is there a role for routine use of MRI in selection of patients for breast-conserving cancer therapy?. J Am Coll Surg (May), 206(5): 1045-1050.
- Hochwald SN, Hemming AW, Draganov P, Vogel SB, Dixon LR, Grobmyer SR. (2008) Elevation of serum IgG4 in Western patients with autoimmune sclerosing pancreatocholangitis: a word of caution. Ann Surg Oncol (Apr), 15(4): 1147-1154.
- Mendenhall WM, Amdur RJ, Grobmyer SR, George TJ, Werning JW, Hochwald SN, Mendenhall NP. (2008) Adjuvant radiotherapy for cutaneous melanoma. Cancer (Mar), 112(6): 1189-1196.
- Grobmyer SR, Stasik CN, Draganov P, Hemming AW, Dixon LR, Vogel SB, Hochwald SN. (2008) Contemporary results with ampullectomy for 29 "benign" neoplasms of the ampulla. J Am Coll Surg (Mar), 206(3): 466-471.
- Ferrone CR, Tang LH, Tomlinson J, Gonen M, Hochwald SN, Brennan MF, Klimstra DS, Allen PJ. (2007) Determining prognosis in patients with pancreatic endocrine neoplasms: can the WHO classification system be simplified?. J Clin Oncol (Dec), 25(35): 5609-5615.
- Kim T, Grobmyer SR, Liu C, Hochwald SN. (2007) Primary presacral neuroendocrine tumor associated with imperforate anus. World J Surg Oncol (Oct), 5: 115-115.
- Meadows K, Morris CG, Rout WR, Zlotecki RA, Hochwald SN, Marsh RD, Copeland EM, Mendenhall WM. (2006) Preoperative radiotherapy alone or combined with chemotherapy followed by transanal excision for rectal adenocarcinoma. Am J Clin Oncol (Oct), 29(5): 430-434.
- Winfield RD, Hochwald SN, Vogel SB, Hemming AW, Liu C, Cance WG, Grobmyer SR. (2006) Presentation and management of gastrointestinal stromal tumors of the duodenum. Am Surg (Aug), 72(8): 719-722.
- Li J, Minnich DJ, Camp ER, Brank A, Mackay SL, Hochwald SN. (2006) Enhanced sensitivity to chemotherapy in esophageal cancer through inhibition of NF-kappaB. J Surg Res (May), 132(1): 112-120.
- Zee SY, Hochwald SN, Conlon KC, Brennan MF, Klimstra DS. (2005) Pleomorphic pancreatic endocrine neoplasms: a variant commonly confused with adenocarcinoma. Am J Surg Pathol (Sep), 29(9): 1194-1200.
- Mendenhall WM, Zlotecki RA, Hochwald SN, Hemming AW, Grobmyer SR, Cance WG. (2005) Retroperitoneal soft tissue sarcoma. Cancer (Aug), 104(4): 669-675.
- Zlotecki RA, Katz TS, Morris CG, Lind DS, Hochwald SN. (2005) Adjuvant radiation therapy for resectable retroperitoneal soft tissue sarcoma: the University of Florida experience. Am J Clin Oncol (Jun), 28(3): 310-316.
- Mendenhall WM, Zlotecki RA, Morris CG, Hochwald SN, Scarborough MT. (2005) Aggressive fibromatosis. Am J Clin Oncol (Apr), 28(2): 211-215.
- Mendenhall WM, Amos EH, Rout WR, Zlotecki RA, Hochwald SN, Cance WG. (2004) Adjuvant postoperative radiotherapy for colon carcinoma. Cancer (Sep), 101(6): 1338-1344.
- Camp ER, Hochwald SN, Liu C. (2004) FAP with concurrent duodenal adenomatous polyposis and carcinoid tumor. J Surg Oncol (Sep), 87(4): 187-190.
- Camp ER, Li J, Minnich DJ, Brank A, Moldawer LL, MacKay SL, Hochwald SN. (2004) Inducible nuclear factor-kappaB activation contributes to chemotherapy resistance in gastric cancer. J Am Coll Surg (Aug), 199(2): 249-258.
- Newlin HE, Zlotecki RA, Morris CG, Hochwald SN, Riggs CE, Mendenhall WM. (2004) Squamous cell carcinoma of the anal margin. J Surg Oncol (May), 86(2): 55-62.
- Hemming AW, Reed AI, Howard RJ, Fujita S, Hochwald SN, Caridi JG, Hawkins IF, Vauthey JN. (2003) Preoperative portal vein embolization for extended hepatectomy. Ann Surg (May), 237(5): 686-691.
- Minter RM, Reith JD, Hochwald SN. (2003) Metastatic potential of dermatofibrosarcoma protuberans with fibrosarcomatous change. J Surg Oncol (Mar), 82(3): 201-208.
- Hochwald SN, Lind DS, Malaty J, Copeland EM, Moldawer LL, MacKay SL. (2003) Antineoplastic therapy in colorectal cancer through proteasome inhibition. Am Surg (Jan), 69(1): 15-23.
- Hernandez LV, Mishra G, Forsmark C, Draganov PV, Petersen JM, Hochwald SN, Vogel SB, Bhutani MS. (2002) Role of endoscopic ultrasound (EUS) and EUS-guided fine needle aspiration in the diagnosis and treatment of cystic lesions of the pancreas. Pancreas (Oct), 25(3): 222-228.
- Feezor RJ, Kasraeian A, Copeland EM, Schell SR, Hochwald SN, Cendan J, Drane W, Mastin S, Wilkinson E, Lind DS. (2002) Sequential dermal-peritumoral radiocolloid injection for sentinel node biopsy for breast cancer: the University of Florida experience. Am Surg (Aug), 68(8): 684-687.
- Hochwald SN, Zee S, Conlon KC, Colleoni R, Louie O, Brennan MF, Klimstra DS. (2002) Prognostic factors in pancreatic endocrine neoplasms: an analysis of 136 cases with a proposal for low-grade and intermediate-grade groups. J Clin Oncol (Jun), 20(11): 2633-2642.
- Mendenhall WM, Rout WR, Lind DS, Zlotecki RA, Hochwald SN, Schell SR, Copeland EM. (2002) Role of radiation therapy in the treatment of resectable rectal adenocarcinoma. J Surg Oncol (Feb), 79(2): 107-117.
- Lind DS, Hochwald SN, Malaty J, Rekkas S, Hebig P, Mishra G, Moldawer LL, Copeland EM, Mackay S. (2001) Nuclear factor-kappa B is upregulated in colorectal cancer. Surgery (Aug), 130(2): 363-369.
- Hochwald SN, Weiser MR, Colleoni R, Brennan MF, Conlon KC. (2001) Laparoscopy predicts metastatic disease and spares laparotomy in selected patients with pancreatic nonfunctioning islet cell tumors. Ann Surg Oncol (Apr), 8(3): 249-253.
- Mendenhall WM, Morris CG, Rout WR, Zlotecki RA, Lind DS, Hochwald SN, Schell SR, Copeland EM. (2001) Local excision and postoperative radiation therapy for rectal adenocarcinoma. Int J Cancer (Jan), 96 Su: 89-96.
- Hochwald SN, Kim S, Klimstra DS, Brennan MF, Karpeh MS. (2000) Analysis of 154 actual five-year survivors of gastric cancer. J Gastrointest Surg (Sep), 4(5): 520-525.
- Hochwald SN, Blumgart LH. (2000) Giant hepatic hemangioma with Kasabach-Merritt syndrome: is the appropriate treatment enucleation or liver transplantation?. HPB Surg (Aug), 11(6): 413-419.
- Hochwald SN, Brennan MF, Klimstra DS, Kim S, Karpeh MS. (1999) Is lymphadenectomy necessary for early gastric cancer?. Ann Surg Oncol (Oct), 6(7): 664-670.
- Hochwald SN, Rofsky NM, Dobryansky M, Shamamian P, Marcus SG. (1999) Magnetic resonance imaging with magnetic resonance cholangiopancreatography accurately predicts resectability of pancreatic carcinoma. J Gastrointest Surg (Sep), 3(5): 506-511.
- Brooks AD, Hochwald SN, Heslin MJ, Harrison LE, Burt M, Brennan MF. (1999) Intestinal permeability after early postoperative enteral nutrition in patients with upper gastrointestinal malignancy. JPEN J Parenter Enteral Nutr (Mar), 23(2): 75-79.
- Burke EC, Jarnagin WR, Hochwald SN, Pisters PW, Fong Y, Blumgart LH. (1998) Hilar Cholangiocarcinoma: patterns of spread, the importance of hepatic resection for curative operation, and a presurgical clinical staging system. Ann Surg (Sep), 228(3): 385-394.
- Heslin MJ, Harrison LE, Brooks AD, Hochwald SN, Coit DG, Brennan MF. (1998) Is intra-abdominal drainage necessary after pancreaticoduodenectomy?. J Gastrointest Surg (Jul), 2(4): 373-378.
- Heslin MJ, Brooks AD, Hochwald SN, Harrison LE, Blumgart LH, Brennan MF. (1998) A preoperative biliary stent is associated with increased complications after pancreatoduodenectomy. Arch Surg (Feb), 133(2): 149-154.
- Heslin MJ, Latkany L, Leung D, Brooks AD, Hochwald SN, Pisters PW, Shike M, Brennan MF. (1997) A prospective, randomized trial of early enteral feeding after resection of upper gastrointestinal malignancy. Ann Surg (Oct), 226(4): 567-577.
- Hochwald SN, Harrison LE, Heslin MJ, Burt ME, Brennan MF. (1997) Early postoperative enteral feeding improves whole body protein kinetics in upper gastrointestinal cancer patients. Am J Surg (Sep), 174(3): 325-330.
- Harrison LE, Hochwald SN, Heslin MJ, Berman R, Burt M, Brennan MF. (1997) Early postoperative enteral nutrition improves peripheral protein kinetics in upper gastrointestinal cancer patients undergoing complete resection: a randomized trial. JPEN J Parenter Enteral Nutr (Jul), 21(4): 202-207.
- Hochwald SN, Rose DM, Brennan MF, Burt ME. (1997) Elevation of glutathione and related enzyme activities in high-grade and metastatic extremity soft tissue sarcoma. Ann Surg Oncol (Jun), 4(4): 303-309.
- Newman E, Brennan MF, Hochwald SN, Harrison LE, Karpeh MS. (1997) Gastric remnant carcinoma: just another proximal gastric cancer or a unique entity?. Am J Surg (Apr), 173(4): 292-297.
- Hochwald SN, Harrison LE, Port JL, Blumberg D, Brennan MF, Burt M. (1996) Depletion of high energy phosphate compouds in the tumor-bearing state and reversal after tumor resection. Surgery (Sep), 120(3): 534-541.
- Rose DM, Hochwald SN, Klimstra DS, Brennan MF. (1996) Primary duodenal adenocarcinoma: a ten-year experience with 79 patients. J Am Coll Surg (Aug), 183(2): 89-96.
- Rose DM, Hochwald SN, Harrison LE, Burt M. (1996) Selective glutathione repletion with oral oxothiazolidine carboxylate (OTZ) in the radiated tumor-bearing rat. J Surg Res (May), 62(2): 224-228.
- Ng B, Hochwald SN, Burt ME. (1996) Isolated lung perfusion with doxorubicin reduces cardiac and host toxicities associated with systemic administration. Ann Thorac Surg (Mar), 61(3): 969-972.
- Hochwald SN, Harrison LE, Rose DM, Anderson M, Burt ME. (1996) gamma-Glutamyl transpeptidase mediation of tumor glutathione utilization in vivo. J Natl Cancer Inst (Feb), 88(3-4): 193-197.
- Wang HY, Ng B, Blumberg D, Port JL, Hochwald SN, Burt ME. (1995) Pulmonary artery perfusion of doxorubicin with blood flow occlusion: pharmacokinetics and treatment in a metastatic sarcoma model. Ann Thorac Surg (Nov), 60(5): 1390-1394.
- Port JL, Hochwald SN, Wang HY, Burt ME. (1995) Buthionine sulfoximine pretreatment potentiates the effect of isolated lung perfusion with doxorubicin. Ann Thorac Surg (Aug), 60(2): 239-243.
- Wang HY, Port JL, Hochwald SN, Burt ME. (1995) Revised technique of isolated lung perfusion in the rat. Ann Thorac Surg (Jul), 60(1): 211-212.
Professional Memberships:
- American Association of Cancer Research; Member
- American College of Surgeons; Fellow
- American Hepato-Pancreato-Biliary Association; Member
- American Society of Clinical Oncology; Member
- American Society of Clinical Oncology; Member
- American Surgical Association; Active Member
- Association for Academic Surgery; Member
- North America Neuroendocrine Tumor Society; Member
- Society for Surgery of the Alimentary Tract; Active Member
- Society of Surgical Oncology; Member
- Society of University Surgeons; Active Member
- Southern Surgical Association; Active Member
- Surgical Biology Club 1; Active Member