Brian R. Weil PhD
Brian R. Weil
PhD
Research Assistant Professor
Department of Physiology and Biophysics
Jacobs School of Medicine & Biomedical Sciences
Specialty/Research Focus
Cardiology; Cardiovascular Disease; Stem Cells
Professional Summary:
My research program is focused on the investigation of mechanisms underlying functional and structural cardiac remodeling in heart disease, as well as novel therapeutic interventions to prevent or reverse left ventricular dysfunction caused by myocardial ischemia and hemodynamic overload. These studies generally utilize non-invasive advanced cardiovascular imaging techniques and invasive hemodynamic assessment to assess cardiac performance in vivo, along with ex vivo analysis of myocardial tissue to examine cellular and molecular mechanisms underlying observed changes in physiological function.
Education and Training:
- PhD, Integrative Physiology, University of Colorado - Boulder (2011)
- MS, Exercise Science, Syracuse University (2007)
- BS, Clinical Exercise Science, Ithaca College (2005)
Employment:
- Research Assistant Professor, Physiology and Biophysics, University at Buffalo (2016-present)
- Post Doctoral Fellow, Medicine, University at Buffalo (2011–2016)
Research Centers:
- Center for Research in Cardiovascular Medicine
Grants and Sponsored Research:
- Pathophysiology of Myocardial Remodeling in Heart Failure With Preserved Ejection Fraction
American Heart Association
Role: Principal Investigator
Journal Articles:
- Wang J, Seo MJ, Deci MB, Weil BR, Canty JM, Nguyen J. Effect of CCR2 inhibitor-loaded lipid micelles on inflammatory cell migration and cardiac function after myocardial infarction. Int J Nanomedicine. 2018; 13.
- Techiryan G, Weil BR, Palka BA, Canty JM. Effect of Intracoronary Metformin on Myocardial Infarct Size in Swine. Circ Res. 2018; 123(8).
- Weil BR, Suzuki G, Young RF, Iyer V, Canty JM. Troponin Release and Reversible Left Ventricular Dysfunction After Transient Pressure Overload. J Am Coll Cardiol. 2018; 71(25).
- Bain AR, Weil BR, Diehl KJ, Greiner JJ, Stauffer BL, DeSouza CA. Insufficient sleep is associated with impaired nitric oxide-mediated endothelium-dependent vasodilation. Atherosclerosis. 2017; 265.
- Sharma UC, W Mosleh, MR Chaudhari, R Katkar, B Weil, C Evelo, TR Cimato, S Pokharel, WM Blenkesteijn, G Suzuki.. Myocardial and serum galectin-3 expression dynamics marks post-myocardial infarction cardiac remodeling.. Heart Lung Circulation. 2017; 26(7).
- Weil BR, RF Young, X Shen, G Suzuki, JK Qu, S Malhotra and JM Canty, Jr.. Brief myocardial ischemia produces cardiac troponin I release and focal myocyte apoptosis in the absence of pathological infarction in swine. J Am Coll Cardiol Basic Trans Sci. 2017; 2(2).
- Canty, Jr. JM and BR Weil.. Cortical Bone Stem Cells Administered at Reperfusion Attenuate Adverse Post-Infarction Left Ventricular Remodeling and Prevent Myocyte Loss at a Distance.. Circulation Research. 2017; 121.
- Weil BR, Konecny F, Suzuki G, Iyer V, Canty JM. Comparative Hemodynamic Effects of Contemporary Percutaneous Mechanical Circulatory Support Devices in a Porcine Model of Acute Myocardial Infarction.. JACC Cardiovasc Interv. 2016; 9(22).
- Canty, Jr, JM, Weil BR, Suzuki G. Widespread Intracoronary Cardiopoietic Cell Infusion: Treating at the Time of Myocardial Reperfusion to Prevent Rather Than Reverse Established Left Ventricular Dysfunction Moves Us Closer to Practical Clinical Translation. Circ Res. 2016; 118(7).
- Lo CY, Weil BR, Palka BA, Momeni A, Canty JM Jr. and Neelamegham S. Cell Surface Glycoengineering Improves Selectin-mediated Adhesion of Mesenchymal Stem Cells (MSCs) and Cardiosphere-derived Cells (CDCs); Pilot Validation in Porcine Ischemia-Reperfusion Model. Biomaterials. 2016; 74.
- Weil BR, Suzuki G, Leiker MM, Fallavollita JA, Canty, Jr., JM. Comparative Efficacy of Intracoronary Allogeneic Mesenchymal Stem Cells and Cardiosphere-Derived Cells in Swine with Hibernating Myocardium. Circ Res. 2015; 117(7).
- Diehl KJ, Weil BR, Greiner JJ, Wright KP, Stauffer BL, DeSouza CA. Impaired endogenous fibrinolytic capacity in prehypertensive men. J Hum Hypertens. 2015; 29(8).
- Weil BR, Ozcan C. Cardiomyocyte Remodeling in Atrial Fibrillation and Hibernating Myocardium: Shared Pathophysiologic Traits Identify Novel Treatment Strategies? Biomed Res Int. 2015; 2015.
- Page BJ, Banas MD, Suzuki G, Weil BR, Young RF, Fallavollita JA, Palka BA and Canty JM Jr. Revascularization of chronic hibernating myocardium stimulates myocyte proliferation and partially reverses chronic adaptations to ischemia. J Am College Card. 2015; 65(7).
- Suzuki G, Weil BR, Leiker MM, Ribbeck AE, Young RF, Cimato TR, Canty JM. Global intracoronary infusion of allogeneic cardiosphere-derived cells improves ventricular function and stimulates endogenous myocyte regeneration throughout the heart in swine with hibernating myocardium. PLoS One. 2014; 9(11).
- Weil BR and Canty, Jr. JM. Ceramide signaling in the coronary microcirculation: A double-edged sword?. Circulation Research. 2014; 115.
- Weil BR, Canty JM. Stem cell stimulation of endogenous myocyte regeneration. Clin Sci (Lond). 2013; 125(3).
- Weil BR, Greiner JJ, Stauffer BL, Desouza CA. Self-reported habitual short sleep duration is associated with endothelial fibrinolytic dysfunction in men: a preliminary report. Sleep. 2013; 36(2).
- Weil BR, Canty JM Jr. Stem cell stimulation of endogenous myocyte regeneration. Clinical Science (London). 2013; 125.
- Diehl KJ, Weil BR, Greiner JJ, Stauffer BL, Desouza CA. White blood cell count and endothelin-1 vasoconstrictor tone in middle-aged and older adults. Artery Res. 2012; 6(2).
- Diehl KJ, Weil BR, Westby CM, MacEneaney OJ, Kushner EJ, Greiner JJ, DeSouza CA. Effects of endothelin-1 on endothelial progenitor cell function. Clin Chem Lab Med. 2012; 50(6).
- Diehl KJ, Stauffer BL, Greiner JJ, Weil BR, DeSouza CA. Nitric oxide-mediated endothlium-dependent vasodilation is impaired with borderline high-LDL cholesterol. Clin Transl Sci. 2012; 5(1).
- Cameron SJ, Goulopoulou S, Weil BR, Kanaley JA. Regulation of blood flow by aspirin following muscle ischemia. Eur Rev Med Pharmacol Sci. 2012; 16(2).
- Weil BR, Kushner EJ, Diehl KJ, Greiner JJ, Stauffer BL, Desouza CA. CD31+ T cells, endothelial function and cardiovascular risk. Heart Lung Circ. 2011; 20(10).
- Weil BR, Stauffer BL, Greiner JJ, DeSouza CA. Prehypertension is associated with impaired nitric oxide-mediated endothelium-dependent vasodilation in sedentary adults. Am J Hypertens. 2011; 24(9).
- Weil BR, Westby CM, Van Guilder GP, Greiner JJ, Stauffer BL, DeSouza CA. Enhanced endothelin-1 system activity with overweight and obesity. Am J Physiol Heart Circ Physiol. 2011; 301(3).
- Westby CM, Weil BR, Greiner JJ, Stauffer BL, DeSouza CA. Endothelin-1 vasoconstriction and the age-related decline in endothelium-dependent vasodilatation in men. Clin Sci (Lond). 2011; 120(11).
- Weil BR, Maceneaney OJ, Stauffer BL, Desouza CA. Habitual short sleep duration and circulating endothelial progenitor cells. J Cardiovasc Dis Res. 2011; 2(2).
- MacEneaney OJ, DeSouza CA, Weil BR, Kushner EJ, Van Guilder GP, Mestek ML, Greiner JJ, Stauffer BL. Prehypertension and endothelial progenitor cell function. J Hum Hypertens. 2011; 25(1).
- Mestek ML, Weil BR, Greiner JJ, Westby CM, DeSouza CA, Stauffer BL. Osteopenia and endothelin-1-mediated vasconstrictor tone in postmenopausal women. Bone. 2010; 47(3).
- Weil BR, Mestek ML, Westby CM, Van Guilder GP, Greiner JJ, Stauffer BL, DeSouza CA. Short sleep duration is associated with enhanced endothelin-1 vasoconstrictor tone. Can J Physiol Pharmacol. 2010; 88(8).
Professional Memberships:
- American Physiological Society (2017–present)
- American Heart Association (2011–present)