Husam A. Ghanim PhD
Husam A. Ghanim
PhD
Professional Summary:
My research has been focused on conducted basic and clinical research for over last 20 years. My lab is mainly Interested in understanding molecular mechanisms of insulin resistance, diabetes, obesity and weight loss focusing on the role of inflammation and oxidative stress in metabolic diseases and the micro- and Macro-nutrients intake and the inflammatory response.
Education and Training:
- PhD, State University of New York at Buffalo (2004)
- BS, University of Jordan
Employment:
- UB-IRB Committee member, University at Buffalo (2018-present)
- Research Director, Medicine, Division of Endocrinology, Diabetes and Metabolism (2005-present)
- Research Associate Professor, Endocrinology, State University of New York at Buffalo Jacobs School of Medicine & Biomedical Sciences (2014-present)
Awards and Honors:
- Internal Medicine Training Program Teaching appreciation award (2013)
- The Pharmacia Corporation International Award for Excellence in Published Clinical Research (2001)
Research Expertise:
- Mechanisms of insulin resistance: Research focused on understanding role of inflammation and oxidative stress in developing insulin resistance
- Weight loss quality and quantity: As weight loss drugs are commonly used now, our lab is focused on investigating mechanisms of preserving lean mass we patients are losing weight. We are also interested in understanding best practices for weight loss maintenance.
Research Centers:
- Clinical and Translational Research Center (CTRC)
- Diabetes-Endocrinology Center of Western New York
UB 2020 Strategic Strengths:
- Health and Wellness Across the Lifespan
- Molecular Recognition in Biological Systems and Bioinformatics
Grants and Sponsored Research:
- January 2018–December 2025
An Investigation into the effects of Dapagliflozin on Ketogensis in Type 1 Diabetes
AstraZeneca Pharmaceuticals LP
Role: Co-Investigator
$735,000 - January 2019–December 2024
Triple therapy for T1DM with insulin, semaglutide and dapagliflozin
JDRF
Role: Co-Principal Investigator
$1,641,000 - September 2022–June 2024
3- Phase 3, Multicenter, Randomized, Parallel-Design, Open Label Study to Evaluate the Efficacy and Safety of LY3209590 as a Weekly Basal Insulin Compared with Insulin Degludec in Participants with Type 1 Diabetes treated with Multiple Daily Injection Therapy
Lilly
Role: Co-Investigator
$258,000 - September 2022–April 2024
2- A Phase 3, Parallel-Design, Open-Label, Randomized Controlled Study to Evaluate the Efficacy and Safety of LY3209590 as a Weekly Basal Insulin Compared to Insulin Glargine in Adults with Type 2 Diabetes on Multiple Display Injections
Lilly
Role: Co-Investigator
$283,500 - December 2021–December 2022
Preserving Lean Body Mass During Weight Loss In Elderly Obese Patients With GLP-1 Receptor Agonist Treatment
CTSI
Role: Principal Investigator
$50,000 - July 2021–July 2022
LIGHT-UP Study service contract
Gelesis Inc
Role: Contributor
$371,000 - December 2012–November 2019
Effects of liraglutide treatment in overweight or obese patients with type 1 diabetes
JDRF
Role: Co-Investigator
$600,000 - August 2012–July 2017
Liraglutide as an Additional treatment in Type 1 diabetes
NIH/NIDDK
Role: Co-Investigator
$1,580,000 - May 2025
A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study Evaluating the Efficacy and Safety of Tirzepatide Once Weekly Compared to Placebo in Adult Participants with Type 1 Diabetes and Obesity or Overweigh
Lilly USA LLC
Role: Co-Investigator
$343,200 - May 2025
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Safety and Efficacy of Efruxifermin in Subjects with Compensated Cirrhosis Due to Nonalcoholic Steatohepatitis (NASH)/Metabolic Dysfunction Associated STEATOHEPATITIS (MASH)
Akero Therapeutics Incorporated
Role: Contributor
$252,000 - May 2024
A Phase 3, Randomized, Multicenter, Double-Blind Study to Investigate the Efficacy and Safety of Retatrutide Once Weekly Compared with Placebo in Adult Participants with Type 2 Diabetes, Moderate or Severe Renal Impairment with Inadequate Glycemic Control on Basal Insulin with or without Metformin and/or SGLT2 inhibitor (TRANSCEND-T2D-3)
Lilly
Role: Co-Investigator
$315,000 - May 2024
1- Phase 2/3 multicenter, double blinded, randomized, dose-conversion, active control study examining the efficacy and safety of Armour Thyroid compared to synthetic T4 for the treatment of adults with primary hypothyroidism
AbbVie
Role: Co-Investigator
$340,200 - January 2023
3- NATiV3: A randomized, double blind, placebo-controled, multicentre, Phase 3 study evaluating long term efficacy and safety of lanifibranor in adult patients with non-cirrhotic non-alcoholic steatohepatitis (NASH) and fibrosis 2 (F2)/fibrosis.
Inventiva
Role: Contributor
$245,700
Journal Articles:
- Ghanim H, Batra M, Green K, Hejna J, Abuaysheh S, Makdissi A, Chaudhuri A, Dandona P. (2021) Dapagliflozin reduces systolic blood pressure and modulates vasoactive factors. Diabetes Obes Metab (Jul), 23(7): 1614-1623. doi:10.1111/dom.14377
- Ghanim H, Batra M, Green K, Abuaysheh S, Hejna J, Makdissi A, Borowski R, Kuhadiya ND, Chaudhuri A, Dandona P. (2020) Liraglutide treatment in overweight and obese patients with type 1 diabetes: A 26-week randomized controlled trial; mechanisms of weight loss. Diabetes Obes Metab (Oct), 22(10): 1742-1752. doi:10.1111/dom.14090
- Ghanim H, Abuaysheh S, Hejna J, Green K, Batra M, Makdissi A, Chaudhuri A, Dandona P. (2020) Dapagliflozin Suppresses Hepcidin And Increases Erythropoiesis. The Journal of clinical endocrinology and metabolism (Apr), 105(4)
- Ghanim H, Dhindsa S, Batra M, Green K, Abuaysheh S, Kuhadiya ND, Makdissi A, Chaudhuri A, Sandhu S, Dandona P. (2020) Testosterone Increases the Expression and Phosphorylation of AMP Kinase a in Men With Hypogonadism and Type 2 Diabetes. The Journal of clinical endocrinology and metabolism (Apr), 105(4) doi:10.1210/clinem/dgz288
- Nassar M, Abosheaishaa H, Misra A, Dandona P, Ghanim H, Chaudhuri A. (2025) Use of glucagon-like peptide-1 receptor agonists in people with history of acute pancreatitis: TriNetX analysis. Diabetes & metabolism (Mar), 51(2): 101613.
- Dhindsa S, Ghanim H, McPhaul MJ, Ghoshal AK, Dandona P. (2024) Glucose ingestion does not lower testosterone concentrations in men on testosterone therapy. Journal of investigative medicine : the official publication of the American Federation for Clinical Research (Jun), 72(5): 487-491.
- Epstein LH, Rizwan A, Rashid S, Bickel WK, Ghanim H. (2024) Glucose response to sugar challenge moderates the effect of insulin resistance on reinforcing value of sugar-sweetened yogurt. Appetite (Feb), 193: 107160.
- Ghanim H, Thethi TK, Abuaysheh S, Fonseca V, Dandona P. (2023) Vasoactive mediators of hypertension in obesity. American journal of physiology. Endocrinology and metabolism (Oct), 325(4): E406-E411. doi:10.1152/ajpendo.00209.2022
- Epstein LH, Biondolillo MJ, Rizwan A, Ghanim H, Dandona P, Bickel WK, Paluch RA. (2023) Insulin Resistance and Glycated Hemoglobin in Obesity Are Associated With Preference for Sugar-Sweetened Yogurt: A Pilot Study. Psychosomatic medicine (Apr), 85(3): 289-293. doi:10.1097/PSY.0000000000001171
- Dhindsa S, Ghanim H, Jenkins T, Inge TH, Harmon CM, Ghoshal A, Wu Z, McPhaul MJ, Saad F, Dandona P. (2022) High prevalence of subnormal testosterone in obese adolescent males: reversal with bariatric surgery. Eur J Endocrinol (Feb), 3(186): 319-327. doi:10.1530/EJE-21-0545
- Pereira S, Moore J, Li JX, Yu WQ, Ghanim H, Vlavcheski F, Joseph YD, Dandona P, Volchuk A, Cummins CL, Tsiani E, Giacca A. (2021) 4-Phenylbutyric acid improves free fatty acid-induced hepatic insulin resistance in vivo. Endocr Connect (Jul), 8(10): 861-872. doi:0.1530/EC-21-0248
- Al-Sofiani M, MacLeod S, Ghanim H, Stecker N, Hall J, Lippes H. (2020) Type 1 diabetes and hearing loss: Audiometric assessment and measurement of circulating levels of soluble receptor for advanced glycation end products. Diabetes/metabolism research and reviews (Sep), 36(6): e3312.
- Biobaku F, Ghanim H, Batra M, Dandona P. (2019) Macronutrient-Mediated Inflammation and Oxidative Stress: Relevance to Insulin Resistance, Obesity, and Atherogenesis. The Journal of clinical endocrinology and metabolism (Dec), 104(12): 6118-6128.
- Dhindsa S, Ghanim H, Green K, Abuaysheh S, Batra M, Makdissi A, Chaudhuri A, Sandhu S, Dandona P. (2019) Acute effects of insulin on skeletal muscle growth and differentiation genes in men with type 2 diabetes. European journal of endocrinology (Dec), 181(6): K55-K59.
- Ghanim H, Dhindsa S, Green K, Abuaysheh S, Batra M, Makdissi A, Chaudhuri A, Dandona P. (2019) Increase in Osteocalcin Following Testosterone Therapy in Men With Type 2 Diabetes and Subnormal Free Testosterone. Journal of the Endocrine Society (Aug), 3(8): 1617-1630. doi:10.1210/js.2018-00426
- Ghanim H, Dhindsa S, Batra M, Green K, Abuaysheh S, Kuhadiya ND, Makdissi A, Chaudhuri A, Dandona P. (2019) Effect of Testosterone on FGF2, MRF4, and Myostatin in Hypogonadotropic Hypogonadism: Relevance to Muscle Growth. The Journal of clinical endocrinology and metabolism (Jun), 104(6): 2094-2102. doi:10.1210/jc.2018-01832
- Kuhadiya ND, Prohaska B, Ghanim H, Dandona P. (2019) Addition of glucagon-like peptide-1 receptor agonist therapy to insulin in C-peptide-positive patients with type 1 diabetes. Diabetes, obesity & metabolism (Apr), 21(4): 1054-1057.
- Dandona P, Ghanim H, Chaudhuri A. (2019) Liraglutide and systolic blood pressure. Journal of clinical hypertension (Greenwich, Conn.) (Jan), 21(1): 116-117. doi:10.1111/jch.13443
- Ghanim H, Monte S, Caruana J, Green K, Abuaysheh S, Dandona P. (2018) Decreases in neprilysin and vasoconstrictors and increases in vasodilators following bariatric surgery. Diabetes, obesity & metabolism (Aug), 20(8): 2029-2033.
- Dhindsa S, Ghanim H, Batra M, Dandona P. (2018) Hypogonadotropic Hypogonadism in Men With Diabesity. Diabetes care (Jul), 41(7): 1516-1525. doi:10.2337/dc17-2510
- Dandona P, Ghanim H, Abuaysheh S, Green K, Dhindsa S, Makdissi A, Batra M, Kuhadiya ND, Chaudhuri A. (2018) Exenatide Increases IL-1RA Concentration and Induces Nrf-2?Keap-1?Regulated Antioxidant Enzymes: Relevance to ß-Cell Function. The Journal of clinical endocrinology and metabolism (Mar), 103(3): 1180-1187.
- Ghanim H, Dhindsa S, Abuaysheh S, Batra M, Kuhadiya ND, Makdissi A, Chaudhuri A, Dandona P. (2018) Diminished androgen and estrogen receptors and aromatase levels in hypogonadal diabetic men: reversal with testosterone. European journal of endocrinology (Mar), 178(3): 277-283.
- Dandona P, Ghanim H, Chaudhuri A. (2018) Incretins: Beyond type 2 diabetes. Diabetes, obesity & metabolism (Feb), 20 Suppl 1: 59-67.
- Dhindsa S, Chemitiganti R, Ghanim H, Santiago E, Haider A, Chaar N, Mok M, McKee A, Dandona P. (2018) Intranasal Insulin Administration Does Not Affect LH Concentrations in Men with Diabetes. International journal of endocrinology (Jan), 2018: 6170154. doi:10.1155/2018/6170154
- Garg M, Ghanim H, Kuhadiya ND, Green K, Hejna J, Abuaysheh S, Torre B, Batra M, Makdissi A, Chaudhuri A, Dandona P. (2017) Liraglutide acutely suppresses glucagon, lipolysis and ketogenesis in type 1 diabetes. Diabetes Obes Metab (Sep), 19(9): 1306-1311.
- Ghanim H, Green K, Abuaysheh S, Patel R, Batra M, Chaudhuri A, Makdissi A, Kuhadiya ND, Dandona P. (2017) Ezetimibe and simvastatin combination inhibits and reverses the pro-inflammatory and pro-atherogenic effects of cream in obese patients. Atherosclerosis (Aug), 263: 278-286.
- Chaudhuri A, Ghanim H, Makdissi A, Green K, Abuaysheh S, Batra M, D Kuhadiya N, Dandona P. (2017) Exenatide induces an increase in vasodilatory and a decrease in vasoconstrictive mediators. Diabetes, obesity & metabolism (May), 19(5): 729-733.
- Ghanim H, Batra M, Abuaysheh S, Green K, Makdissi A, Kuhadiya ND, Chaudhuri A, Dandona P. (2017) Antiinflammatory and ROS Suppressive Effects of the Addition of Fiber to a High-Fat High-Calorie Meal. J Clin Endocrinol Metab (Mar), 102(3): 858-869.
- Kuhadiya ND, Ghanim H, Mehta A, Garg M, Khan S, Hejna J, Torre B, Makdissi A, Chaudhuri A, Batra M, Dandona P. (2016) Dapagliflozin as Additional Treatment to Liraglutide and Insulin in Patients With Type 1 Diabetes. J Clin Endocrinol Metab (Sep), 101(9): 3506-3515.
- Kuhadiya ND, Dhindsa S, Ghanim H, Mehta A, Makdissi A, Batra M, Sandhu S, Hejna J, Green K, Bellini N, Yang M, Chaudhuri A, Dandona P. (2016) Addition of Liraglutide to Insulin in Patients With Type 1 Diabetes: A Randomized Placebo-Controlled Clinical Trial of 12 Weeks. Diabetes Care (Jun), 39(6): 1027-1035.
- Dhindsa S, Ghanim H, Batra M, Kuhadiya ND, Abuaysheh S, Green K, Makdissi A, Chaudhuri A, Dandona P. (2016) Effect of testosterone on hepcidin, ferroportin, ferritin and iron binding capacity in patients with hypogonadotropic hypogonadism and type 2 diabetes. Clin Endocrinol (Oxf) (Jun).
- Chaudhuri A, Ghanim H, Dandona P. (2016) Targeting AMP Kinase in Myeloid Cells to Reduce Atherosclerosis. Diabetes (Jun), 65(6): 1493-5.
- Dandona P, Kuhadiya ND, Ghanim H, Chaudhuri A. (2016) ADJUNCT THERAPIES IN TYPE 1 DIABETES. Endocr Pract (Feb), 22(2): 277-280.
- Dhindsa S, Ghanim H, Batra M, Kuhadiya ND, Abuaysheh S, Sandhu S, Green K, Makdissi A, Hejna J, Chaudhuri A, Punyanitya M, Dandona P. (2016) Insulin Resistance and Inflammation in Hypogonadotropic Hypogonadism and Their Reduction After Testosterone Replacement in Men With Type 2 Diabetes. Diabetes Care (Jan), 39(1): 82-91.
- Caruana JA, Monte SV, Jacobs DM, Voytovich C, Ghanim H, Dandona P. (2015) Distal small bowel bypass for weight regain after gastric bypass: safety and efficacy threshold occurs at <70% bypass. Surg Obes Relat Dis (Nov), 11(6): 1248-1255.
- Guo J, Breen DM, Pereira TJ, Dalvi PS, Zhang H, Mori Y, Ghanim H, Tumiati L, Fantus IG, Bendeck MP, Dandona P, Rao V, Dolinsky VW, Heximer SP, Giacca A. (2015) The effect of insulin to decrease neointimal growth after arterial injury is endothelial nitric oxide synthase-dependent. Atherosclerosis (Jul), 241(1): 111-20.
- Thethi TK, Bajwa MA, Ghanim H, Jo C, Weir M, Goldfine AB, Umpierrez G, Desouza C, Dandona P, Fang-Hollingsworth Y, Raghavan V, Fonseca VA. (2015) Effect of paricalcitol on endothelial function and inflammation in type 2 diabetes and chronic kidney disease. J Diabetes Complications (Apr), 29(3): 433-437.
- Dandona P, Ghanim H, Abuaysheh S, Green K, Batra M, Dhindsa S, Makdissi A, Patel R, Chaudhuri A. (2015) Decreased insulin secretion and incretin concentrations and increased glucagon concentrations after a high-fat meal when compared with a high-fruit and -fiber meal. Am J Physiol Endocrinol Metab (Feb), 308(3): 185-191.
- Ghanim H, Green K, Abuaysheh S, Batra M, Kuhadiya ND, Patel R, Makdissi A, Dhindsa S, Chaudhuri A, Dandona P. (2015) Suppressive effect of insulin on the gene expression and plasma concentrations of mediators of asthmatic inflammation. J Diabetes Res (Jan), 2015: 202406-202406.
- Dandona P, Ghanim H, Monte SV, Caruana JA, Green K, Abuaysheh S, Lohano T, Schentag J, Dhindsa S, Chaudhuri A. (2014) Increase in the mediators of asthma in obesity and obesity with type 2 diabetes: reduction with weight loss. Obesity (Silver Spring) (Feb), 22(2): 356-362.
- Dandona P, Ghanim H, Sia CL, Green K, Abuaysheh S, Dhindsa S, Chaudhuri A, Makdissi A. (2014) A mixed anti-inflammatory and pro-inflammatory response associated with a high dose of corticosteroids. Curr Mol Med (Jan), 14(6): 793-801.
- Sternberg Z, Ghanim H, Gillotti KM, Tario JD, Munschauer F, Curl R, Noor S, Yu J, Ambrus JL, Wallace P, Dandona P. (2013) Flow cytometry and gene expression profiling of immune cells of the carotid plaque and peripheral blood. Atherosclerosis (Aug), 229(2): 338-47.
- Dandona P, Ghanim H, Green K, Sia CL, Abuaysheh S, Kuhadiya N, Batra M, Dhindsa S, Chaudhuri A. (2013) Insulin infusion suppresses while glucose infusion induces Toll-like receptors and high-mobility group-B1 protein expression in mononuclear cells of type 1 diabetes patients. American journal of physiology. Endocrinology and metabolism (Apr), 304(8): E810-8.
- Mogri M, Dhindsa S, Quattrin T, Ghanim H, Dandona P. (2013) Testosterone concentrations in young pubertal and post-pubertal obese males. Clin Endocrinol (Oxf) (Apr), 78(4): 593-599.
- Tang C, Naassan AE, Chamson-Reig A, Koulajian K, Goh TT, Yoon F, Oprescu AI, Ghanim H, Lewis GF, Dandona P, Donath MY, Ehses JA, Arany E, Giacca A. (2013) Susceptibility to fatty acid-induced ß-cell dysfunction is enhanced in prediabetic diabetes-prone biobreeding rats: a potential link between ß-cell lipotoxicity and islet inflammation. Endocrinology (Jan), 154(1): 89-101.
- Guo J, Dhaliwall JK, Chan KK, Ghanim H, Al Koudsi N, Lam L, Madadi G, Dandona P, Giacca A, Bendeck MP. (2013) In vivo effect of insulin to decrease matrix metalloproteinase-2 and -9 activity after arterial injury. Journal of vascular research (Jan), 50(4): 279-88.
- Makdissi A, Ghanim H, Vora M, Green K, Abuaysheh S, Chaudhuri A, Dhindsa S, Dandona P. (2012) Sitagliptin exerts an antinflammatory action. J Clin Endocrinol Metab (Sep), 97(9): 3333-3341.
- Ghanim H, Monte SV, Sia CL, Abuaysheh S, Green K, Caruana JA, Dandona P. (2012) Reduction in inflammation and the expression of amyloid precursor protein and other proteins related to Alzheimer's disease following gastric bypass surgery. The Journal of clinical endocrinology and metabolism (Jul), 97(7): E1197-201. doi:10.1210/jc.2011-3284
- Breen DM, Dolinsky VW, Zhang H, Ghanim H, Guo J, Mroziewicz M, Tsiani EL, Bendeck MP, Dandona P, Dyck JR, Heximer SP, Giacca A. (2012) Resveratrol inhibits neointimal formation after arterial injury through an endothelial nitric oxide synthase-dependent mechanism. Atherosclerosis (Jun), 222(2): 375-381.
- Monte SV, Caruana JA, Ghanim H, Sia CL, Korzeniewski K, Schentag JJ, Dandona P. (2012) Reduction in endotoxemia, oxidative and inflammatory stress, and insulin resistance after Roux-en-Y gastric bypass surgery in patients with morbid obesity and type 2 diabetes mellitus. Surgery (Apr), 151(4): 587-93.
- Chaudhuri A, Ghanim H, Vora M, Sia CL, Korzeniewski K, Dhindsa S, Makdissi A, Dandona P. (2012) Exenatide exerts a potent antiinflammatory effect. J Clin Endocrinol Metab (Jan), 97(1): 198-207.
- Dhindsa S, Furlanetto R, Vora M, Ghanim H, Chaudhuri A, Dandona P. (2011) Low estradiol concentrations in men with subnormal testosterone concentrations and type 2 diabetes. Diabetes Care (Aug), 34(8): 1854-1859.
- Dandona P, Mohamed I, Ghanim H, Sia CL, Dhindsa S, Dandona S, Makdissi A, Chaudhuri A. (2011) Insulin suppresses the expression of amyloid precursor protein, presenilins, and glycogen synthase kinase-3beta in peripheral blood mononuclear cells. The Journal of clinical endocrinology and metabolism (Jun), 96(6): 1783-8. doi:10.1210/jc.2010-2961
- Ghanim H, Sia CL, Korzeniewski K, Lohano T, Abuaysheh S, Marumganti A, Chaudhuri A, Dandona P. (2011) A resveratrol and polyphenol preparation suppresses oxidative and inflammatory stress response to a high-fat, high-carbohydrate meal. The Journal of clinical endocrinology and metabolism (May), 96(5): 1409-14. doi:10.1210/jc.2010-1812
- Dandona P, Ghanim H, Bandyopadhyay A, Korzeniewski K, Ling Sia C, Dhindsa S, Chaudhuri A. (2010) Insulin suppresses endotoxin-induced oxidative, nitrosative, and inflammatory stress in humans. Diabetes Care (Nov), 33(11): 2416-2423.
- Ghanim H, Sia CL, Abuaysheh S, Korzeniewski K, Patnaik P, Marumganti A, Chaudhuri A, Dandona P. (2010) An antiinflammatory and reactive oxygen species suppressive effects of an extract of Polygonum cuspidatum containing resveratrol. J Clin Endocrinol Metab (Sep), 95(9): 1-8.
- Dandona P, Chaudhuri A, Ghanim H. (2010) Rosiglitazone, thiazolidinediones and atherosclerosis. Atherosclerosis (Aug), 211(2): 384-385.
- Dhindsa S, Miller MG, McWhirter CL, Mager DE, Ghanim H, Chaudhuri A, Dandona P. (2010) Testosterone concentrations in diabetic and nondiabetic obese men. Diabetes Care (Jun), 33(6): 1186-1192.
- Ghanim H, Korzeniewski K, Sia CL, Abuaysheh S, Lohano T, Chaudhuri A, Dandona P. (2010) Suppressive effect of insulin infusion on chemokines and chemokine receptors. Diabetes Care (May), 33(5): 1103-1108.
- Deopurkar R, Ghanim H, Friedman J, Abuaysheh S, Sia CL, Mohanty P, Viswanathan P, Chaudhuri A, Dandona P. (2010) Differential effects of cream, glucose, and orange juice on inflammation, endotoxin, and the expression of Toll-like receptor-4 and suppressor of cytokine signaling-3. Diabetes Care (May), 33(5): 991-997.
- Dandona P, Ghanim H, Chaudhuri A, Dhindsa S, Kim SS. (2010) Macronutrient intake induces oxidative and inflammatory stress: potential relevance to atherosclerosis and insulin resistance. Exp Mol Med (Apr), 42(4): 245-253.
- Ghanim H, Sia CL, Upadhyay M, Upadhyay M, Korzeniewski K, Viswanathan P, Abuaysheh S, Mohanty P, Dandona P. (2010) Orange juice neutralizes the proinflammatory effect of a high-fat, high-carbohydrate meal and prevents endotoxin increase and Toll-like receptor expression. Am J Clin Nutr (Apr), 91(4): 940-949.
- Ghanim H, Abuaysheh S, Sia CL, Korzeniewski K, Chaudhuri A, Fernandez-Real JM, Dandona P. (2009) Increase in plasma endotoxin concentrations and the expression of Toll-like receptors and suppressor of cytokine signaling-3 in mononuclear cells after a high-fat, high-carbohydrate meal: implications for insulin resistance. Diabetes Care (Dec), 32(12): 2281-2287.
- Breen DM, Chan KK, Dhaliwall JK, Ward MR, Al Koudsi N, Lam L, De Souza M, Ghanim H, Dandona P, Stewart DJ, Bendeck MP, Giacca A. (2009) Insulin increases reendothelialization and inhibits cell migration and neointimal growth after arterial injury. Arterioscler Thromb Vasc Biol (Jul), 29(7): 1060-1066.
- Dandona P, Chaudhuri A, Ghanim H, Mohanty P. (2009) Insulin as an anti-inflammatory and antiatherogenic modulator. J Am Coll Cardiol (Feb), 53(5 Sup): 14-20.
- Srinivasan M, Dodds C, Ghanim H, Gao T, Ross PJ, Browne RW, Dandona P, Patel MS. (2008) Maternal obesity and fetal programming: effects of a high-carbohydrate nutritional modification in the immediate postnatal life of female rats. Am J Physiol Endocrinol Metab (Oct), 295(4): 895-903.
- Ghanim H, Mohanty P, Deopurkar R, Sia CL, Korzeniewski K, Abuaysheh S, Chaudhuri A, Dandona P. (2008) Acute modulation of toll-like receptors by insulin. Diabetes Care (Sep), 31(9): 1827-1831.
- Srinivasan M, Mitrani P, Sadhanandan G, Dodds C, Shbeir-ElDika S, Thamotharan S, Ghanim H, Dandona P, Devaskar SU, Patel MS. (2008) A high-carbohydrate diet in the immediate postnatal life of rats induces adaptations predisposing to adult-onset obesity. J Endocrinol (Jun), 197(3): 565-574.
- Dandona P, Chaudhuri A, Ghanim H, Mohanty P. (2008) Use of insulin to improve glycemic control in diabetes mellitus. Cardiovasc Drugs Ther (Jun), 22(3): 241-251.
- Dandona P, Ghanim H, Chaudhuri A, Mohanty P. (2008) Thiazolidinediones-improving endothelial function and potential long-term benefits on cardiovascular disease in subjects with type 2 diabetes. J Diabetes Complications (Jan), 22(1): 62-75.
- Chaudhuri A, Janicke D, Wilson M, Ghanim H, Wilding GE, Aljada A, Dandona P. (2007) Effect of modified glucose-insulin-potassium on free fatty acids, matrix metalloproteinase, and myoglobin in ST-elevation myocardial infarction. Am J Cardiol (Dec), 100(11): 1614-1618.
- Patel C, Ghanim H, Ravishankar S, Sia CL, Viswanathan P, Mohanty P, Dandona P. (2007) Prolonged reactive oxygen species generation and nuclear factor-kappaB activation after a high-fat, high-carbohydrate meal in the obese. J Clin Endocrinol Metab (Nov), 92(11): 4476-4479.
- Dandona P, Chaudhuri A, Mohanty P, Ghanim H. (2007) Anti-inflammatory effects of insulin. Curr Opin Clin Nutr Metab Care (Jul), 10(4): 511-517.
- Dandona P, Chaudhuri A, Ghanim H, Mohanty P. (2007) Effect of hyperglycemia and insulin in acute coronary syndromes. Am J Cardiol (Jun), 99(11A): 12-18.
- Ghanim H, Mohanty P, Pathak R, Chaudhuri A, Sia CL, Dandona P. (2007) Orange juice or fructose intake does not induce oxidative and inflammatory response. Diabetes Care (Jun), 30(6): 1406-1411.
- Dandona P, Ghanim H, Brooks DP. (2007) Antioxidant activity of carvedilol in cardiovascular disease. J Hypertens (Apr), 25(4): 731-741.
- Dandona P, Chaudhuri A, Ghanim H, Mohanty P. (2007) Proinflammatory effects of glucose and anti-inflammatory effect of insulin: relevance to cardiovascular disease. Am J Cardiol (Feb), 99(4A): 15-26.
- Ghanim H, Aljada A, Daoud N, Deopurkar R, Chaudhuri A, Dandona P. (2007) Role of inflammatory mediators in the suppression of insulin receptor phosphorylation in circulating mononuclear cells of obese subjects. Diabetologia (Feb), 50(2): 278-285.
- Dandona P, Dhindsa S, Ghanim H, Chaudhuri A. (2007) Angiotensin II and inflammation: the effect of angiotensin-converting enzyme inhibition and angiotensin II receptor blockade. J Hum Hypertens (Jan), 21(1): 20-27.
- Bhatia V, Chaudhuri A, Tomar R, Dhindsa S, Ghanim H, Dandona P. (2006) Low testosterone and high C-reactive protein concentrations predict low hematocrit in type 2 diabetes. Diabetes care (Oct), 29(10): 2289-94.
- Aljada A, Friedman J, Ghanim H, Mohanty P, Hofmeyer D, Chaudhuri A, Dandona P. (2006) Glucose ingestion induces an increase in intranuclear nuclear factor kappaB, a fall in cellular inhibitor kappaB, and an increase in tumor necrosis factor alpha messenger RNA by mononuclear cells in healthy human subjects. Metabolism: clinical and experimental (Sep), 55(9): 1177-85.
- Ghanim H, Dhindsa S, Aljada A, Chaudhuri A, Viswanathan P, Dandona P. (2006) Low-dose rosiglitazone exerts an antiinflammatory effect with an increase in adiponectin independently of free fatty acid fall and insulin sensitization in obese type 2 diabetics. The Journal of clinical endocrinology and metabolism (Sep), 91(9): 3553-8.
- Dandona P, Chaudhuri A, Ghanim H, Mohanty P. (2006) Anti-inflammatory effects of insulin and pro-inflammatory effects of glucose: relevance to the management of acute myocardial infarction and other acute coronary syndromes. Reviews in cardiovascular medicine (Jan), 7 Suppl 2: S25-34.
- Dandona P, Chaudhuri A, Ghanim H, Mohanty P. (2006) Anti-inflammatory effects of insulin and the pro-inflammatory effects of glucose. Seminars in thoracic and cardiovascular surgery (Jan), 18(4): 293-301.
- Dhindsa S, Tripathy D, Sanalkumar N, Ravishankar S, Ghanim H, Aljada A, Dandona P. (2005) Free fatty acid-induced insulin resistance in the obese is not prevented by rosiglitazone treatment. The Journal of clinical endocrinology and metabolism (Sep), 90(9): 5058-63.
- Dandona P, Aljada A, Ghanim H, Mohanty P, Tripathy C, Hofmeyer D, Chaudhuri A. (2004) Increased plasma concentration of macrophage migration inhibitory factor (MIF) and MIF mRNA in mononuclear cells in the obese and the suppressive action of metformin. The Journal of clinical endocrinology and metabolism (Oct), 89(10): 5043-7.
- Ghanim H, Aljada A, Hofmeyer D, Syed T, Mohanty P, Dandona P. (2004) Circulating mononuclear cells in the obese are in a proinflammatory state. Circulation (Sep), 110(12): 1564-71.
- Aljada A, Ghanim H, Mohanty P, Syed T, Bandyopadhyay A, Dandona P. (2004) Glucose intake induces an increase in activator protein 1 and early growth response 1 binding activities, in the expression of tissue factor and matrix metalloproteinase in mononuclear cells, and in plasma tissue factor and matrix metalloproteinase concentrations. The American journal of clinical nutrition (Jul), 80(1): 51-7.
- Mohanty P, Aljada A, Ghanim H, Hofmeyer D, Tripathy D, Syed T, Al-Haddad W, Dhindsa S, Dandona P. (2004) Evidence for a potent antiinflammatory effect of rosiglitazone. The Journal of clinical endocrinology and metabolism (Jun), 89(6): 2728-35.
- Aljada A, Mohanty P, Ghanim H, Abdo T, Tripathy D, Chaudhuri A, Dandona P. (2004) Increase in intranuclear nuclear factor kappaB and decrease in inhibitor kappaB in mononuclear cells after a mixed meal: evidence for a proinflammatory effect. The American journal of clinical nutrition (Apr), 79(4): 682-90.
- Dhindsa S, Tripathy D, Mohanty P, Ghanim H, Syed T, Aljada A, Dandona P. (2004) Differential effects of glucose and alcohol on reactive oxygen species generation and intranuclear nuclear factor-kappaB in mononuclear cells. Metabolism: clinical and experimental (Mar), 53(3): 330-4.
- Chaudhuri A, Janicke D, Wilson MF, Tripathy D, Garg R, Bandyopadhyay A, Calieri J, Hoffmeyer D, Syed T, Ghanim H, Aljada A, Dandona P. (2004) Anti-inflammatory and profibrinolytic effect of insulin in acute ST-segment-elevation myocardial infarction. Circulation (Feb), 109(7): 849-54.
- Dandona P, Dhindsa S, Ghanim H, Aljada A. (2004) Do thiazolidinediones exert their insulin-sensitizing effect through the suppression of free Fatty acids?. Metabolic syndrome and related disorders (Jan), 2(4): 287-9.
- Tripathy D, Mohanty P, Dhindsa S, Syed T, Ghanim H, Aljada A, Dandona P. (2003) Elevation of free fatty acids induces inflammation and impairs vascular reactivity in healthy subjects. Diabetes (Dec), 52(12): 2882-7.
- Dandona P, Aljada A, Mohanty P, Ghanim H, Bandyopadhyay A, Chaudhuri A. (2003) Insulin suppresses plasma concentration of vascular endothelial growth factor and matrix metalloproteinase-9. Diabetes care (Dec), 26(12): 3310-4.
- Dandona P, Kumar V, Aljada A, Ghanim H, Syed T, Hofmayer D, Mohanty P, Tripathy D, Garg R, Ghanim HA. (2003) Angiotensin II receptor blocker valsartan suppresses reactive oxygen species generation in leukocytes, nuclear factor-kappa B, in mononuclear cells of normal subjects: evidence of an antiinflammatory action. J Clin Endocrinol Metab (Sep), 88(9): 4496-4501.
- Mohanty P, Ghanim H, Hamouda W, Aljada A, Garg R, Dandona P. (2002) Both lipid and protein intakes stimulate increased generation of reactive oxygen species by polymorphonuclear leukocytes and mononuclear cells. The American journal of clinical nutrition (Apr), 75(4): 767-72.
- Aljada A, Ghanim H, Assian E, Dandona P. (2002) Tumor necrosis factor-alpha inhibits insulin-induced increase in endothelial nitric oxide synthase and reduces insulin receptor content and phosphorylation in human aortic endothelial cells. Metabolism: clinical and experimental (Apr), 51(4): 487-91.
- Aljada A, Ghanim H, Mohanty P, Kapur N, Dandona P. (2002) Insulin inhibits the pro-inflammatory transcription factor early growth response gene-1 (Egr)-1 expression in mononuclear cells (MNC) and reduces plasma tissue factor (TF) and plasminogen activator inhibitor-1 (PAI-1) concentrations. The Journal of clinical endocrinology and metabolism (Mar), 87(3): 1419-22.
- Aljada A, Ghanim H, Dandona P, Ghanim HA. (2002) Activation of nuclear factor-kappa B (NF-kappa B) in mononuclear cells (MNC). Methods Mol Biol (Jan), 196: 105-110.
- Aljada A, Ghanim H, Dandona P, Ghanim HA. (2002) Translocation of p47phox and activation of NADPH oxidase in mononuclear cells. Methods Mol Biol (Jan), 196: 99-103.
- Dandona P, Mohanty P, Hamouda W, Ghanim H, Aljada A, Garg R, Kumar V, Ghanim HA. (2001) Inhibitory effect of a two day fast on reactive oxygen species (ROS) generation by leucocytes and plasma ortho-tyrosine and meta-tyrosine concentrations. J Clin Endocrinol Metab (Jun), 86(6): 2899-2902.
- Dandona P, Mohanty P, Ghanim H, Aljada A, Browne R, Hamouda W, Prabhala A, Afzal A, Garg R. (2001) The suppressive effect of dietary restriction and weight loss in the obese on the generation of reactive oxygen species by leukocytes, lipid peroxidation, and protein carbonylation. The Journal of clinical endocrinology and metabolism (Jan), 86(1): 355-62.
- Garg R, Kumbkarni Y, Aljada A, Mohanty P, Ghanim H, Hamouda W, Dandona P. (2000) Troglitazone reduces reactive oxygen species generation by leukocytes and lipid peroxidation and improves flow-mediated vasodilatation in obese subjects. Hypertension (Dallas, Tex. : 1979) (Sep), 36(3): 430-5.
- Mohanty P, Hamouda W, Garg R, Aljada A, Ghanim H, Dandona P. (2000) Glucose challenge stimulates reactive oxygen species (ROS) generation by leucocytes. The Journal of clinical endocrinology and metabolism (Aug), 85(8): 2970-3.
- Magsino CH, Hamouda W, Bapna V, Ghanim H, Abu-Reish IA, Aljada A, Dandona P. (2000) Nadolol inhibits reactive oxygen species generation by leukocytes and linoleic acid oxidation. The American journal of cardiology (Aug), 86(4): 443-8.
- Aljada A, Saadeh R, Assian E, Ghanim H, Dandona P. (2000) Insulin inhibits the expression of intercellular adhesion molecule-1 by human aortic endothelial cells through stimulation of nitric oxide. The Journal of clinical endocrinology and metabolism (Jul), 85(7): 2572-5.
- Magsino CH, Hamouda W, Ghanim H, Browne R, Aljada A, Dandona P. (2000) Effect of triiodothyronine on reactive oxygen species generation by leukocytes, indices of oxidative damage, and antioxidant reserve. Metabolism: clinical and experimental (Jun), 49(6): 799-803.
- Dandona P, Karne R, Ghanim H, Hamouda W, Aljada A, Magsino CH. (2000) Carvedilol inhibits reactive oxygen species generation by leukocytes and oxidative damage to amino acids. Circulation (Jan), 101(2): 122-4.
- Aljada A, Ghanim H, Assian E, Mohanty P, Hamouda W, Garg R, Dandona P. (1999) Increased IkappaB expression and diminished nuclear NF-kappaB in human mononuclear cells following hydrocortisone injection. The Journal of clinical endocrinology and metabolism (Sep), 84(9): 3386-9.
Abstracts:
- Husam Ghanim, Ajay Chaudhuri, Jeanne Hejna, Paresh Dandona. (2024) Preserving Lean Body Mass During Weight Loss In Elderly Obese Patients With Glp-1 Receptor Agonist Treatment. Journal of the Endocrine Society, Annual Meeting of the Endocrine Society – ENDO 2024. Boston, MassachusettsUnited States (Jun), (12608) Poster
- Archit Gupta, Mahmoud Nasdar, Husam Ghanim. (2024) Risk of Retinopathy in Patients with Type 2 Diabetes on Semaglutide. Journal of the Endocrine Society., ENDO 2024. Boston, MassachusettsUnited States (Jun), (12338) Poster
- William Jenkins, Mahmoud Nassar, Husam A. Ghanim. (2024) Gastroparesis Incidence Post-Initiation of Semaglutide Versus Sitagliptin in Type 2 Diabetes: A Retrospective TriNetX Database Analysis. AACE 2024 Annual Meeting. New Orleans, LouisianaUnited States (May) Poster
Professional Memberships:
- The Obesity Society; Member (2019–present)
- American Diabetes Association; Professional Membership
- Endocrine Society; Member
Presentations:
- "New Advancements in Weight Managment" CME/ Catholic Health Ground Rounds (2024)
- "Weight Loss Interventions: Quality vs. Quantity" GLSDE 2024 Annual Meeting: Pioneering Endocrine Frontiers: Advanced Practice and Innovative Research (2024)
- "Weight Loss Interventions: The Past and the Future" DOM City Wide Grand Rounds (2024)
- "How much can people with type 1 diabetes benefit from adjunct therapies?" 58th Annual European Association for the Study of Diabetes (2022)
- "Weight loss and body composition: Relevance to Weight Regain" Virtual CME Saturday (2022)
- "Weight Loss in Older Obese Patients: The Obesity Paradox" Grand Round (2022)
Service Activities:
- UB Resident & Fellow Research Day; Abstract and poster Judge (2025)
- 27th Annual UB Resident & Fellow Research Day; Facilitator/Poster Judge (2025)
- Health Sciences Scholarly Project: As a mentor to UB medical student, I designed and funded a research project for the student to complete before medical school graduation. Student name: Gianna Minnuto; Mentor: Health Sciences Scholarly Project (2025–2027)
- Medical Student Annual Research Forum; Poster/Abstract Judge (2025)
- Medical Student Annual Research Forum; Poster/Abstract Judge (2025)
- 14th Annual Postdoc Symposium; Postdoc Poster Session Judge (2024)
- 14th Annual Postdoc Symposium; Postdoc Poster Session Judge (2024)
- Strategic Grant reviewer for Breakthrough T1D; Grant Reviewer (2024–present)
- Endocrine Research; Assocaite Editor (2024–present)
- 26th Annual UB Resident & Fellow Research Day; Facilitator/poster judge (2024)
- Awards of Excellence for Promoting Inclusion and Cultural Diversity.; Reviewer (2024)
- Medical Students Annual Reseach Forum. Review, judge and rank posters of medical students; Reviewer and Judge (2024)
- Peace Center of WNY; Volunteer (2023–present)
- FY24 Training Awards Review, Breakthrough T1D; Reviewer (2023)
- Review, interview and rank applicants for fellowship position every year; reviewer (2023)
- Reivew applicant's CV's and patriciate in interviews and ranking; Chief of Nephrology search committee (2023–2024)
- JDRF FY22 Beta Improving Lives Training AWARD; REVIEWER (2021)
- Reviewer for Journal of Cellular and Molecular Medicine; Reviewer (2021–present)
- CTSI Translational Pilot Studies Program; Reviewer (2020)
- Reviewer for Diabetes, Obesity and Metabolism; Reviewer (2020–present)
- Discussion group to improve IRB function. Chair: Dr Sanjay Sethi; IRB working group (2019)
- DOM Research Day abstract reviewer and poster Judge. Research performed by residents, fellows and junior faculty; Abstract Reviewer (2019–present)
- Reviewer for The Journal of Clinical Endocrinology & Metabolism; Reviewer (2019–present)
- Islamic Society of Niagara Frontier Sunday School Board president; Sunday School Board president (2018–present)
- I have been a member of the review committee in UBIRB since 2018. Received excellent evaluation for my role and re-appointed for 3 more years till 2027; IRB review board member (2018–present)
- Research Staff and volunteer's supervisor. Signing time sheets, assign duties and allocating effort; Research Staff and volunteer's supervisor (2006–present)
- Provide general and specific research guidance for resident and fellows in the department and division; Endocrine Division Research Director (2005–present)
- Member of Network of Religious Communities. Supporting peace and understanding in the WNY area; Community Representative