Husam A. Ghanim PhD
Husam A. Ghanim
PhD
Education and Training:
- PhD, State University of New York at Buffalo (2004)
- BS, University of Jordan
Employment:
- Research Associate Professor, Endocrinology, State University of New York at Buffalo Jacobs School of Medicine & Biomedical Sciences (2014-present)
Awards and Honors:
- Internal Medicine Training Program Teaching appreciation award (2013)
- The Pharmacia Corporation International Award for Excellence in Published Clinical Research (2001)
Grants and Sponsored Research:
- August 2012–July 2017
Liraglutide as an Additional treatment in Type 1 diabetes
NIH/NIDDK
Role: Co-Investigator - December 2012–November 2016
Effects of liraglutide treatment in overweight or obese patients with type 1 diabetes
JDRF
Role: Co-Investigator
Journal Articles:
- Garg M, Ghanim H, Kuhadiya ND, Green K, Hejna J, Abuaysheh S, Torre B, Batra M, Makdissi A, Chaudhuri A, Dandona P. (2017) Liraglutide acutely suppresses glucagon, lipolysis and ketogenesis in type 1 diabetes. Diabetes Obes Metab (Sep), 19(9): 1306-1311.
- Ghanim H, Batra M, Abuaysheh S, Green K, Makdissi A, Kuhadiya ND, Chaudhuri A, Dandona P. (2017) Antiinflammatory and ROS Suppressive Effects of the Addition of Fiber to a High-Fat High-Calorie Meal. J Clin Endocrinol Metab (Mar), 102(3): 858-869.
- Kuhadiya ND, Ghanim H, Mehta A, Garg M, Khan S, Hejna J, Torre B, Makdissi A, Chaudhuri A, Batra M, Dandona P. (2016) Dapagliflozin as Additional Treatment to Liraglutide and Insulin in Patients With Type 1 Diabetes. J Clin Endocrinol Metab (Sep), 101(9): 3506-3515.
- Kuhadiya ND, Dhindsa S, Ghanim H, Mehta A, Makdissi A, Batra M, Sandhu S, Hejna J, Green K, Bellini N, Yang M, Chaudhuri A, Dandona P. (2016) Addition of Liraglutide to Insulin in Patients With Type 1 Diabetes: A Randomized Placebo-Controlled Clinical Trial of 12 Weeks. Diabetes Care (Jun), 39(6): 1027-1035.
- Dhindsa S, Ghanim H, Batra M, Kuhadiya ND, Abuaysheh S, Green K, Makdissi A, Chaudhuri A, Dandona P. (2016) Effect of testosterone on hepcidin, ferroportin, ferritin and iron binding capacity in patients with hypogonadotropic hypogonadism and type 2 diabetes. Clin Endocrinol (Oxf) (Jun).
- Dandona P, Kuhadiya ND, Ghanim H, Chaudhuri A. (2016) ADJUNCT THERAPIES IN TYPE 1 DIABETES. Endocr Pract (Feb), 22(2): 277-280.
- Dhindsa S, Ghanim H, Batra M, Kuhadiya ND, Abuaysheh S, Sandhu S, Green K, Makdissi A, Hejna J, Chaudhuri A, Punyanitya M, Dandona P. (2016) Insulin Resistance and Inflammation in Hypogonadotropic Hypogonadism and Their Reduction After Testosterone Replacement in Men With Type 2 Diabetes. Diabetes Care (Jan), 39(1): 82-91.
- Caruana JA, Monte SV, Jacobs DM, Voytovich C, Ghanim H, Dandona P. (2015) Distal small bowel bypass for weight regain after gastric bypass: safety and efficacy threshold occurs at <70% bypass. Surg Obes Relat Dis (Nov), 11(6): 1248-1255.
- Thethi TK, Bajwa MA, Ghanim H, Jo C, Weir M, Goldfine AB, Umpierrez G, Desouza C, Dandona P, Fang-Hollingsworth Y, Raghavan V, Fonseca VA. (2015) Effect of paricalcitol on endothelial function and inflammation in type 2 diabetes and chronic kidney disease. J Diabetes Complications (Apr), 29(3): 433-437.
- Dandona P, Ghanim H, Abuaysheh S, Green K, Batra M, Dhindsa S, Makdissi A, Patel R, Chaudhuri A. (2015) Decreased insulin secretion and incretin concentrations and increased glucagon concentrations after a high-fat meal when compared with a high-fruit and -fiber meal. Am J Physiol Endocrinol Metab (Feb), 308(3): 185-191.
- Ghanim H, Green K, Abuaysheh S, Batra M, Kuhadiya ND, Patel R, Makdissi A, Dhindsa S, Chaudhuri A, Dandona P. (2015) Suppressive effect of insulin on the gene expression and plasma concentrations of mediators of asthmatic inflammation. J Diabetes Res (Jan), 2015: 202406-202406.
- Dandona P, Ghanim H, Monte SV, Caruana JA, Green K, Abuaysheh S, Lohano T, Schentag J, Dhindsa S, Chaudhuri A. (2014) Increase in the mediators of asthma in obesity and obesity with type 2 diabetes: reduction with weight loss. Obesity (Silver Spring) (Feb), 22(2): 356-362.
- Dandona P, Ghanim H, Sia CL, Green K, Abuaysheh S, Dhindsa S, Chaudhuri A, Makdissi A. (2014) A mixed anti-inflammatory and pro-inflammatory response associated with a high dose of corticosteroids. Curr Mol Med (Jan), 14(6): 793-801.
- Mogri M, Dhindsa S, Quattrin T, Ghanim H, Dandona P. (2013) Testosterone concentrations in young pubertal and post-pubertal obese males. Clin Endocrinol (Oxf) (Apr), 78(4): 593-599.
- Makdissi A, Ghanim H, Vora M, Green K, Abuaysheh S, Chaudhuri A, Dhindsa S, Dandona P. (2012) Sitagliptin exerts an antinflammatory action. J Clin Endocrinol Metab (Sep), 97(9): 3333-3341.
- Breen DM, Dolinsky VW, Zhang H, Ghanim H, Guo J, Mroziewicz M, Tsiani EL, Bendeck MP, Dandona P, Dyck JR, Heximer SP, Giacca A. (2012) Resveratrol inhibits neointimal formation after arterial injury through an endothelial nitric oxide synthase-dependent mechanism. Atherosclerosis (Jun), 222(2): 375-381.
- Chaudhuri A, Ghanim H, Vora M, Sia CL, Korzeniewski K, Dhindsa S, Makdissi A, Dandona P. (2012) Exenatide exerts a potent antiinflammatory effect. J Clin Endocrinol Metab (Jan), 97(1): 198-207.
- Dhindsa S, Furlanetto R, Vora M, Ghanim H, Chaudhuri A, Dandona P. (2011) Low estradiol concentrations in men with subnormal testosterone concentrations and type 2 diabetes. Diabetes Care (Aug), 34(8): 1854-1859.
- Dandona P, Ghanim H, Bandyopadhyay A, Korzeniewski K, Ling Sia C, Dhindsa S, Chaudhuri A. (2010) Insulin suppresses endotoxin-induced oxidative, nitrosative, and inflammatory stress in humans. Diabetes Care (Nov), 33(11): 2416-2423.
- Ghanim H, Sia CL, Abuaysheh S, Korzeniewski K, Patnaik P, Marumganti A, Chaudhuri A, Dandona P. (2010) An antiinflammatory and reactive oxygen species suppressive effects of an extract of Polygonum cuspidatum containing resveratrol. J Clin Endocrinol Metab (Sep), 95(9): 1-8.
- Dandona P, Chaudhuri A, Ghanim H. (2010) Rosiglitazone, thiazolidinediones and atherosclerosis. Atherosclerosis (Aug), 211(2): 384-385.
- Dhindsa S, Miller MG, McWhirter CL, Mager DE, Ghanim H, Chaudhuri A, Dandona P. (2010) Testosterone concentrations in diabetic and nondiabetic obese men. Diabetes Care (Jun), 33(6): 1186-1192.
- Ghanim H, Korzeniewski K, Sia CL, Abuaysheh S, Lohano T, Chaudhuri A, Dandona P. (2010) Suppressive effect of insulin infusion on chemokines and chemokine receptors. Diabetes Care (May), 33(5): 1103-1108.
- Deopurkar R, Ghanim H, Friedman J, Abuaysheh S, Sia CL, Mohanty P, Viswanathan P, Chaudhuri A, Dandona P. (2010) Differential effects of cream, glucose, and orange juice on inflammation, endotoxin, and the expression of Toll-like receptor-4 and suppressor of cytokine signaling-3. Diabetes Care (May), 33(5): 991-997.
- Dandona P, Ghanim H, Chaudhuri A, Dhindsa S, Kim SS. (2010) Macronutrient intake induces oxidative and inflammatory stress: potential relevance to atherosclerosis and insulin resistance. Exp Mol Med (Apr), 42(4): 245-253.
- Ghanim H, Sia CL, Upadhyay M, Upadhyay M, Korzeniewski K, Viswanathan P, Abuaysheh S, Mohanty P, Dandona P. (2010) Orange juice neutralizes the proinflammatory effect of a high-fat, high-carbohydrate meal and prevents endotoxin increase and Toll-like receptor expression. Am J Clin Nutr (Apr), 91(4): 940-949.
- Ghanim H, Abuaysheh S, Sia CL, Korzeniewski K, Chaudhuri A, Fernandez-Real JM, Dandona P. (2009) Increase in plasma endotoxin concentrations and the expression of Toll-like receptors and suppressor of cytokine signaling-3 in mononuclear cells after a high-fat, high-carbohydrate meal: implications for insulin resistance. Diabetes Care (Dec), 32(12): 2281-2287.
- Breen DM, Chan KK, Dhaliwall JK, Ward MR, Al Koudsi N, Lam L, De Souza M, Ghanim H, Dandona P, Stewart DJ, Bendeck MP, Giacca A. (2009) Insulin increases reendothelialization and inhibits cell migration and neointimal growth after arterial injury. Arterioscler Thromb Vasc Biol (Jul), 29(7): 1060-1066.
- Dandona P, Chaudhuri A, Ghanim H, Mohanty P. (2009) Insulin as an anti-inflammatory and antiatherogenic modulator. J Am Coll Cardiol (Feb), 53(5 Sup): 14-20.
- Srinivasan M, Dodds C, Ghanim H, Gao T, Ross PJ, Browne RW, Dandona P, Patel MS. (2008) Maternal obesity and fetal programming: effects of a high-carbohydrate nutritional modification in the immediate postnatal life of female rats. Am J Physiol Endocrinol Metab (Oct), 295(4): 895-903.
- Ghanim H, Mohanty P, Deopurkar R, Sia CL, Korzeniewski K, Abuaysheh S, Chaudhuri A, Dandona P. (2008) Acute modulation of toll-like receptors by insulin. Diabetes Care (Sep), 31(9): 1827-1831.
- Srinivasan M, Mitrani P, Sadhanandan G, Dodds C, Shbeir-ElDika S, Thamotharan S, Ghanim H, Dandona P, Devaskar SU, Patel MS. (2008) A high-carbohydrate diet in the immediate postnatal life of rats induces adaptations predisposing to adult-onset obesity. J Endocrinol (Jun), 197(3): 565-574.
- Dandona P, Chaudhuri A, Ghanim H, Mohanty P. (2008) Use of insulin to improve glycemic control in diabetes mellitus. Cardiovasc Drugs Ther (Jun), 22(3): 241-251.
- Dandona P, Ghanim H, Chaudhuri A, Mohanty P. (2008) Thiazolidinediones-improving endothelial function and potential long-term benefits on cardiovascular disease in subjects with type 2 diabetes. J Diabetes Complications (Jan), 22(1): 62-75.
- Chaudhuri A, Janicke D, Wilson M, Ghanim H, Wilding GE, Aljada A, Dandona P. (2007) Effect of modified glucose-insulin-potassium on free fatty acids, matrix metalloproteinase, and myoglobin in ST-elevation myocardial infarction. Am J Cardiol (Dec), 100(11): 1614-1618.
- Patel C, Ghanim H, Ravishankar S, Sia CL, Viswanathan P, Mohanty P, Dandona P. (2007) Prolonged reactive oxygen species generation and nuclear factor-kappaB activation after a high-fat, high-carbohydrate meal in the obese. J Clin Endocrinol Metab (Nov), 92(11): 4476-4479.
- Dandona P, Chaudhuri A, Mohanty P, Ghanim H. (2007) Anti-inflammatory effects of insulin. Curr Opin Clin Nutr Metab Care (Jul), 10(4): 511-517.
- Dandona P, Chaudhuri A, Ghanim H, Mohanty P. (2007) Effect of hyperglycemia and insulin in acute coronary syndromes. Am J Cardiol (Jun), 99(11A): 12-18.
- Ghanim H, Mohanty P, Pathak R, Chaudhuri A, Sia CL, Dandona P. (2007) Orange juice or fructose intake does not induce oxidative and inflammatory response. Diabetes Care (Jun), 30(6): 1406-1411.
- Dandona P, Ghanim H, Brooks DP. (2007) Antioxidant activity of carvedilol in cardiovascular disease. J Hypertens (Apr), 25(4): 731-741.
- Dandona P, Chaudhuri A, Ghanim H, Mohanty P. (2007) Proinflammatory effects of glucose and anti-inflammatory effect of insulin: relevance to cardiovascular disease. Am J Cardiol (Feb), 99(4A): 15-26.
- Ghanim H, Aljada A, Daoud N, Deopurkar R, Chaudhuri A, Dandona P. (2007) Role of inflammatory mediators in the suppression of insulin receptor phosphorylation in circulating mononuclear cells of obese subjects. Diabetologia (Feb), 50(2): 278-285.
- Dandona P, Dhindsa S, Ghanim H, Chaudhuri A. (2007) Angiotensin II and inflammation: the effect of angiotensin-converting enzyme inhibition and angiotensin II receptor blockade. J Hum Hypertens (Jan), 21(1): 20-27.
- Dandona P, Kumar V, Aljada A, Ghanim H, Syed T, Hofmayer D, Mohanty P, Tripathy D, Garg R, Ghanim HA. (2003) Angiotensin II receptor blocker valsartan suppresses reactive oxygen species generation in leukocytes, nuclear factor-kappa B, in mononuclear cells of normal subjects: evidence of an antiinflammatory action. J Clin Endocrinol Metab (Sep), 88(9): 4496-4501.
- Aljada A, Ghanim H, Dandona P, Ghanim HA. (2002) Activation of nuclear factor-kappa B (NF-kappa B) in mononuclear cells (MNC). Methods Mol Biol (Jan), 196: 105-110.
- Aljada A, Ghanim H, Dandona P, Ghanim HA. (2002) Translocation of p47phox and activation of NADPH oxidase in mononuclear cells. Methods Mol Biol (Jan), 196: 99-103.
- Dandona P, Mohanty P, Hamouda W, Ghanim H, Aljada A, Garg R, Kumar V, Ghanim HA. (2001) Inhibitory effect of a two day fast on reactive oxygen species (ROS) generation by leucocytes and plasma ortho-tyrosine and meta-tyrosine concentrations. J Clin Endocrinol Metab (Jun), 86(6): 2899-2902.