Joshua Jianxin Wang MD
Joshua Jianxin Wang
MD
Professional Summary:
Synopsis Of Research:
My research focuses on studying the diabetic related vascular complications, including diabetic retinopathy, diabetic vascular disease, insulin resistance and diabetic nephropathy. In addition to addressing mechanisms, our cellular and biochemical studies are meant to develop cures for diseases that affect the retina, peripheral vessel and kidney.
1.Diabetic retinopathy: Focusing on endoplasmic reticulum (ER) stress activation and interactions among ER stress, oxidative stress and inflammation in retina.
2.Peripheral vascular disease (PVD): Endothelial cells in the vascular system are especially vulnerable to hyperglycemic conditions. Exploring endothelial dysfunction in diabetic setting, would aid in the search for novel approaches in the prevention of diabetes vascular disease.
3.Diabetic nephropathy: Glomerular endothelial cells and podocytes are primary sites of injury resulting in chronic kidney disease in diabetes. We investigate the function of endogenous angiogenic inhibitors in regulation of renal cells in diabetic kidney.
4.Adipocyte and insulin resistance: Studying the function of PEDF in adipogenesis, provide pivotal information for understanding the mechanisms underlying the association of PEDF,obesity and insulin resistance.
Selected Publications:
1.Yang J, Chen C, McLaughlin T, Wang Y-Q, Le YZ, Wang JJ, and Zhang SX*. Loss of X-box Binding Protein 1 in Müller Cells Augments Retinal Inflammation in Diabetes. Diabetologia. 2019 doi: 10.1007/s00125-018-4776-y
2.McLaughlin T, Manhal Siddiqi, Wang JJ, and Zhang SX*. Loss of XBP1 Leads to Early-Onset Retinal Neurodegeneration in a Mouse Model of Type I Diabetes. J. Clin. Med. 2019; 8, 906; doi:10.3390/jcm8060906
3.McLaughlin T, Falkowski M, Wang JJ, and Zhang SX*. Molecular chaperone ERp29: a potential target for cellular protection in retinal and neurodegenerative diseases. Adv Exp Med Biol. 2018; 1074:421-427. doi: 10.1007/978-3-319-75402-4_52.
4.McLaughlin T, Falkowski M, Park JW, Keegan S, Elliott MH, Wang JJ, and Zhang SX. Loss of XBP1 accelerates age-related decline in retinal function and neurodegeneration. Mol Neurodegeneration, 2018; 13(1):16. doi: 10.1186/s13024-018-0250-z.
5.Bhatta M, Chatpar K, Wang JJ, and Zhang SX*. Reduction of Endoplasmic Reticulum Stress Improves Angiogenic Progenitor Cell function in a Mouse Model of Type 1 Diabetes. Cell Death Dis. 2018; 9(5):467. doi: 10.1038/s41419-018-0501-5.
6.McLaughlin T, Dhimal N, Li J, Wang JJ, Zhang SX. p58IPK Is an Endogenous Neuroprotectant for Retinal Ganglion Cells. Front Aging Neurosci. 2018 Sep 7;10:267. doi: 10.3389/fnagi.2018.00267.
7.Kelly K, Wang JJ, Zhang SX. The unfolded protein response signaling and retinal Müller cell metabolism. Neural Regen Res. 2018 Nov;13(11):1861-1870. doi: 10.4103/1673-5374.239431.
8.Chen C, Zhong Y, Wang JJ, Yu Q, Plafker K, Plafker S, and Zhang SX*. Regulation of Nrf2 by X Box-Binding Protein 1 in Retinal Pigment Epithelium. Front. Genet., 2018; doi.org/10.3389/fgene.2018.00658.
9.Ma JH, Shen S, Wang JJ, He Z, Poon A, Li J, Qu J, and Zhang SX. Proteomic characterization of the Mitochondria-associated ER Membrane (MAM) in a Mouse Model of Type 2 Diabetes Scientific Reports. 2017;7(1):2062. doi: 10.1038/s41598-017-02213-1.
10.Boriushkin E, Wang JJ, Li J, Bhatta M, Zhang SX. p58(IPK) suppresses NLRP3 inflammasome activation and IL-1β production via inhibition of PKR in macrophages. Sci Rep. 2016 Apr 26;6:25013. doi: 10.1038/srep25013. PubMed PMID: 27113095; PubMed Central PMCID: PMC4845006.
11.Bhatta M, Ma JH, Wang JJ, Sakowski J, Zhang SX. Enhanced endoplasmic reticulum stress in bone marrow angiogenic progenitor cells in a mouse model of long-term experimental type 2 diabetes. Diabetologia. 2015 Sep;58(9):2181-90. doi: 10.1007/s00125-015-3643-3. Epub 2015 Jun 11. PubMed PMID: 26063198; PubMed Central PMCID: PMC4529381.
12.Gardner AW, Parker DE, Montgomery PS, Sosnowska D, Casanegra AI, Ungvari Z, Csiszar A, Zhang SX, Wang JJ, Sonntag WE. INFLUENCE OF DIABETES ON AMBULATION AND INFLAMMATION IN MEN AND WOMEN WITH SYMPTOMATIC PERIPHERAL ARTERY DISEASE. J Clin Transl Endocrinol. 2015 Dec 1;2(4):137-143. PubMed PMID: 26835254; PubMed Central PMCID: PMC4730895.
13.Zhang SX, Ma JH, Bhatta M, Fliesler SJ, Wang JJ. The unfolded protein response in retinal vascular diseases: implications and therapeutic potential beyond protein folding. Prog Retin Eye Res. 2015 Mar;45:111-31. doi: 10.1016/j.preteyeres.2014.12.001. Epub 2014 Dec 18. Review. PubMed PMID: 25529848; PubMed Central PMCID: PMC4339403.
14.Chen C, Cano M, Wang JJ, Li J, Huang C, Yu Q, Herbert TP, Handa JT, Zhang SX. Role of unfolded protein response dysregulation in oxidative injury of retinal pigment epithelial cells. Antioxid Redox Signal. 2014 May 10;20(14):2091-106. doi: 10.1089/ars.2013.5240. Epub 2013 Dec 17. PubMed PMID: 24053669; PubMed Central PMCID: PMC3995121
15.Zhang SX, Sanders E, Wang JJ. Endoplasmic reticulum stress and inflammation: mechanisms and implications in diabetic retinopathy. J Ocul Biol Dis Infor. 2011 Jun;4(1-2):51-61. doi: 10.1007/s12177-011-9075-5. Epub 2012 Jan 18. PubMed PMID: 23330021; PubMed Central PMCID: PMC3342410.
16.Wang M, Wang JJ, Li J, Park K, Qian X, Ma JX, Zhang SX. Pigment epithelium-derived factor suppresses adipogenesis via inhibition of the MAPK/ERK pathway in 3T3-L1 preadipocytes. Am J Physiol Endocrinol Metab. 2009 Dec;297(6):E1378-87. doi: 10.1152/ajpendo.00252.2009. Epub 2009 Oct PubMed PMID: 19808909; PubMed Central PMCID: PMC2793046.
17.Wang JJ, Zhang SX, Mott R, Knapp RR, Cao W, Lau K, Ma JX. Salutary effect of pigment epithelium-derived factor in diabetic nephropathy: evidence for antifibrogenic activities. Diabetes. 2006 Jun;55(6):1678-85. PubMed PMID: 16731830.
See more publications on http://www.ncbi.nlm.nih.gov/sites/myncbi/1heXcsvGDSdAl/bibliography/41170057/public/?sort=date&direction=ascending.
Education and Training:
- Research Associate, University of Oklahoma HSC Diabetes/ Cell Biology (2007)
- Medical Univ. of South Carolina Ophthalmology/Molecular Biology (2003)
- California State University at Northridge, CA (2000)
- Fellowship, cardiology, Guangzhou Medical University, First Hospital, Guangzhou China (1993)
- Cardiology, Sun Yat-sen Univ. of Medical Sciences (1991)
- Residency (Internal Medicine) Hubei University of Medicine-University Hospital, Hubei China (1988)
- MD, Hubei University of Medicine, Hubei China(Graduated with highest honor) (1985)
Awards and Honors:
- Research Honors (2022)
- CSTEP-Summer Research Program fellowship award (2022)
- Dean’s Summer Research Fellowship (2022)
- AOA Honor Medical Society (2022)
Grants and Sponsored Research:
- February 2020–January 2024
Molecular Mechanisms of Severe Diabetic Retinopathy
NIH/NEI
Role: Co-Investigator
Journal Articles:
- Tang X, Wang J, Abboud HE, Chen Y, Wang JJ, and Zhang SX. (2022) Sustained Upregulation of Endothelial Nox4 Mediates Retinal Vascular Pathology in Type 1 Diabetes. Diabetes 2023 Jan 1;72(1):112-125. doi: 10.2337/db22-0194. PMID: 36321974 Peer Reviewed: Yes Type: Journal Article Date: October 2022 Role: Corresponding Author; Wrote / Edited Paper; Data Collection / Analysis. (2022) (Oct)
- Wang JJ, Park KS, Dhimal N, Shen S, Tang X, Qu J, and Zhang SX. (2022) Proteomic Analysis of Retinal Mitochondria-Associated ER Membranes Identified Novel Proteins of Retinal Degeneration in Long-Term Diabetes. Cells (Sep), 11(18): 2819. doi:doi:10.3390/cells11182819. (2022) (Sep)
- McLaughlin T., Medina M., Perkins J., Yera M., Wang J.J., and Zhang S.X. (2022) Cellular Stress Signaling in Retinal Degeneration: Mechanisms and Therapeutic Implications. Mol Neurodegenen (Mar), 1(17): 25. doi:doi: 10.1186/s13024-022-00528-w. (2022) (Mar)
- Tang X, Wang JJ, Wang J, Abboud HE, Chen Y, Zhang SX. (2021) Endothelium-specific deletion of Nox4 delays retinal vascular development and mitigates pathological angiogenesis. (Mar)(2021 May;24(2):363-377.) doi:10.1007/s10456-020-09757-3
- Xixiang Tang1,2,3,4, Jinli Wang1,2, Hanna E. Abboud5*, Yanming Chen3, Joshua J. Wang1,2, and Sarah X. Zhang1,2,6. (2021) Sustained Upregulation of Endothelial Nox4 Mediates Retinal Vascular Pathology in Type 1 Diabetes. Diabetologia (Jan)
- Hanineva A, Park KS, Wang JJ, DeAngelis MM, Farkas MH, Zhang SX. (2021) (2021)Emerging roles of circular RNAs in retinal diseases. (Jan)
- Wang J, Zhang J, Li R, Zheng H, Li J, Zhang Y, Li H, Ni P, Li S, Li S, Wang J, Liu D, McDermott J, Samudrala R, Liu S, Wang J, Yang H, Yu J, Wong GK. (2010) Evolutionary transients in the rice transcriptome. Genomics Proteomics Bioinformatics (Dec), 8(4): 211-228.
- Wang J, Zhang J, Li R, Zheng H, Li J, Zhang Y, Li H, Ni P, Li S, Li S, Wang J, Liu D, McDermott J, Samudrala R, Liu S, Wang J, Yang H, Yu J, Wong GK. (2010) Evolutionary transients in the rice transcriptome. Genomics Proteomics Bioinformatics (Dec), 8(4): 211-228.
- Wang J, Zhang J, Li R, Zheng H, Li J, Zhang Y, Li H, Ni P, Li S, Li S, Wang J, Liu D, McDermott J, Samudrala R, Liu S, Wang J, Yang H, Yu J, Wong GK. (2010) Evolutionary transients in the rice transcriptome. Genomics Proteomics Bioinformatics (Dec), 8(4): 211-228.
- Wang W, Zheng H, Yang S, Yu H, Li J, Jiang H, Su J, Yang L, Zhang J, McDermott J, Samudrala R, Wang J, Yang H, Yu J, Kristiansen K, Wong GK, Wang J. (2005) Origin and evolution of new exons in rodents. Genome Res (Sep), 15(9): 1258-1264.
- Neuronal p58IPK Protects Retinal Ganglion Cells Independent of Macrophage/Microglia Activation in Ocular Hypertension, Submitted to Cells 20221220. (1900) (Jan)
Abstracts:
- (2021) Abstract presentation: Title: The Neuroprotective Action of p58IPK is Independent of Macrophage Regulation in Retinal Disease Models May 2, 2021 from 9:00 AM to 10:45 AM EDT the 2021 ARVO Annual Meeting. (Jan) Poster
- (2021) Abstract Presentation Title: Impaired UPRER is associated with Chronic Endoplasmic Reticulum Stress in Aging Endothelial Cells May 6, 2021 from 11:15 AM to 1:00 PM EDT the 2021 ARVO Annual Meeting. (Jan) Poster
- (2021) abstract Presentation Title: Redox Regulation of Endothelial Progenitor Function and Senescence in Aging Retina Session Title: Retinal diseases: molecular and biochemical mechanisms Session Date/Times: May 2, 2021 from 9:00 AM to 10:45 AM EDT the 2021 ARVO Annual Meeting. (Jan)
- Nox4 Increases Endothelial Senescence by Activating ATF4 and Impairing Mitochondrial Biogenesis. (1900) Neuroscience Research Day 2022. (Jan) Poster
- The Role of X-box binding protein 1 (XBP1) in Photoreceptor Metabolism and Function. (1900) Neuroscience Research Day 2022. (Jan) Poster
- Characterization of Retinal Photoreceptor Synapse in Diabetic Retinopathy. (1900) Medical Annual Research Forum 2022. (Jan) Poster
Professional Memberships:
- member of The Association for Research in Vision and Ophthalmology
- member of The American Diabetes Association
- member of The American Heart Association
Presentations:
- "Characterization of Retinal Photoreceptor Synapse in Diabetic Retinopathy" Medical Annual Research Forum 2022 (2022)
- "Nox4 Increases Endothelial Senescence by Activating ATF4 and Impairing Mitochondrial Biogenesis" Neuroscience Research Day 2022 (2022)
- "Synaptic damage in diabetic retinopathy: quantitative characterization and mechanisms" Neuroscience Research Day 2022 (2022)
- "The Role of X-box binding protein 1 (XBP1) in Photoreceptor Metabolism and Function" Neuroscience Research Day 2022 (2022)
- "The Role of X-Box Binding Protein 1 in Photoreceptor Function and Diabetic Retinopathy" UB CSTEP RESEARCH DAY (2022)
- "Measurement of energy metabolism in dissociated mouse retinal rod photoreceptors" ARVO (2022)
- "Overexpression of NADPH Oxidase 4 Induces Endothelial Senescence by Impairing Mitochondrial Biogenesis and ATF4 Activation" ARVO (2022)
- "The Role of NOX4 in Retinal Endothelial Cell Damage and Diabetic Retinopathy" UB BIOCHEMISTRY RESEARCH DAY (2022)
Service Activities:
- invited grant reviewer for Macular Disease Foundation Australia (MDFA) grant peer review; reviewer (2022)
- cells-section: Cellular Metabolism; Academic editor (2022)
- EMBO Molecular Medicine (2022)
- Molecular Mechanisms of Angiogenesis and Inflammation in Retinal Diseases” in the journal Cells (2021–2022)
- Judge of 2021 Tri-County Science & Technology Fair (2021)
- Faculty Mentor for the June 2021 CSTEP (Collegiate Science and Technology Entry Program ) Summer Research Program (2021–present)
- The Council of Undergraduate Research Program Review Committee, 2016-present (2021–present)
- Co-director of UB--CMU (Capital Medical University, China) International Medical Students Exchange Program, 2016-present (2021–present)
- Metabolic Syndrome, Prediabetes and Diabetes (2021–present)
- Journal of Ophthalmology & Clinical Research (2021–present)
- Representative on UB’s Faculty Council for the period 6/1/21 – 5/31/23. (2021–present)
- Mentor of “undergraduate research and creative activity opportunities” , 2016-present (2021–present)
- Liaison of the Council of Undergraduate Research for SUNY at Buffalo, 2016-present (2021–present)
- Serve as JSMBS ( BAC)Building Area Coordinator, assisting in building evacuations in case of emergency. 2021 (2021–present)
- The Journal of Diabetes Research; reviewer (2021–present)
- Diabetes & Obesity; reviewer (2021–present)
- Member of UB’S the Institutional Biosafety Committee (IBC) (2020–present)
- OPH (Master Degree program) Steering Committee member since Feb. 2019.