Buffalo Business First Most Powerful 200 Women #23 (2021)
City and State's 2021 Life Sciences Power Fifty New York #10 (2021)
Research Centers:
Center of Excellence in Bioinformatics and Life Sciences
UB 2020 Strategic Strengths:
Molecular Recognition in Biological Systems and Bioinformatics
Grants and Sponsored Research:
July 2017–June 2027 Center for Advanced Technology in Big Data and Health Sciences New York State Department of Empire State Development Role: Principal Investigator $9,200,000
June 2020–April 2025 The Metagenomics Education Partnership NIH/NIGMS Role: Co-Investigator $1,288,542
January 2014–December 2024 The NYS Genomic Medicine and Big Data Center Empire State Development Role: Co-Principal Investigator $41,500,000
September 2019–July 2024 A UB-Buffalo Public School Partnership to improve student achievement in Biological Sciences Cullen Foundation Role: Co-Principal Investigator $94,700
October 2021–April 2023 Genomic surveillance of SARS-CoV-2 in Western New York NYSDOH Role: Co-Investigator $2,000,000
January 2021–December 2022 New York State Center of Excellence in Bioinformatics and Life Sciences Empire State Development Role: Principal Investigator $1,762,067
December 2020–December 2021 Personalizing Head and Neck Squamous Cell Carcinoma (HNSCC) Community Foundation of Greater Buffalo Role: Principal Investigator $22,380
April 2020–March 2021 Bioinformatic Approaches for understanding macrophage plasticity NIDCR Role: Co-Investigator $94,393
June 2014–May 2019 Western New York Genetics in Research and Healthcare Partnership NIH Role: Co-Principal Investigator $1,249,995
April 2006–March 2010 Biomarkers for the Progression of Head and Neck Squamous Cell Carcinoma NCI Role: Principal Investigator $1,270,914
December 2005–December 2009 Genomic and Bioinformatic Approaches to Understanding Animal Development NASA Role: Co-Investigator $330,667
November 2005–October 2009 NYS Center of Excellence in Bioinformatics & Life Sciences: Structural Biology NASA Role: Co-Investigator $3,968,000
September 2005–September 2009 Systems Biology and Bioinformatics in Medical Applications Army Role: Co-Investigator $4,872,680
August 2005–July 2009 NYS Center of Excellence in Bioinformatics & Life Sciences: Functional Genomics NASA Role: Co-Investigator $5,606,724
July 2004–June 2009 Center of Excellence in Bioinformatics DOE Role: Co-Investigator $2,655,000
March 2007–February 2009 Empirical Assessment of Analysis Methods for DNA Microarrays NIH/NLM Role: Co-Investigator $79,250
July 2003–June 2008 Restriction landmark genomic analysis of cancer NIH/NCI Role: Co-Investigator $250,000
January 2004–May 2007 Buffalo Center of Excellence in Bioinformatics: Astrobiology NASA Role: Co-Investigator $4,471,000
December 2005–December 2006 Genomic and Bioinformatic approaches to understanding animal development NASA Role: Co-Investigator $992,000
May 2003–April 2006 Pilot and Feasibility Program Related to the Kidney Array Based CGH for Genome Wide Analysis of Wilm's Tumor NCI/NIH Role: Principal Investigator $200,000
April 2005–March 2006 Determination of copy number changes using BAC array-CGH and RLS Technology Invitrogen, Inc. Role: Principal Investigator $120,000
April 2003–March 2006 Pharmacogenetics: Breast Cancer Treatment and Prognosis NCI Role: Co-Investigator $225,000
February 1998–March 2006 Genomic Instability in Human Colorectal Cancer NCI Role: Co-Investigator $166,250
March 2005–February 2006 Biomarkers for the Progression of Head and Neck Squamous Cell Carcinoma The Charlotte Geyer Foundation Role: Principal Investigator $83,000
October 2000–February 2004 High Throughput Analysis of Gene Expression Patterns in the Nervous System Rochefeller University - Subcontract NINDS Role: Co-Investigator $1,854,259
September 1998–September 2003 A Resource of arrayed BAC Clones for FISH Mapping of the Human Genome NCI Role: Principal Investigator $1,084,188
April 2002–April 2003 Affymetrix 437 Arrayer NCI - National Center for Research Resources Role: Principal Investigator $125,000
April 2000–March 2001 DNA Microarray Infrastructure for Model Organism Research Roswell Park Alliance Foundation Role: Principal Investigator $98,000
Traffic Air Pollution, Genetic Variation and Autism Spectrum Disorder RENEW Institute and the Office of the Vice President for Research and Economic Development Role: Co-Investigator $32,990
Gluck C, Tsompana M, Nowak N, Garrett-Sinha L, Buck M and Sinha S. (2019) Molecular Dissection of the Oncogenic Role of ETS1 in the Mesenchymal Subtypes of Head and Neck Squamous Cell Carcinoma. (Jul), 15 doi:10.1371/journal.pgen.1008250
Tsompana M, Valiyaparambil S, Bard J, Marzullo B, Nowak N, Buck MJ. (2015) An automated method for efficient, accurate and reproducible construction of RNA-seq libraries. BMC Res Notes (Apr), 8: 124. doi:10.1186/s13104-015-1089-9
de Gaetano M, Quacquaruccio G, Di Castelnuovo A, Nowak N, Dorn J, Donati MB, Freudenheim JL, Trevisan M, Iacoviello L. (2011) Haplotypes and haplotype-pairs of IL-1 beta and IL-6 genes and risk of non fatal myocardial infarction in the Western New York Acute MI Study. Thromb Haemost (Nov), 106(6): 1231-1233.
Gaile D, Hutson A, Java J, Conroy J, McQuaid D, Rossi M, Nowak N. (2007) Errors in Centering of array data can induce biases in correlation estimates. J Stat Plan Inference Stat Appl Genet Mol Biol (Nov)
Swede H, Bartos JD, Chen N, Shaukat A, Dutt SS, McQuaid DA, Natarajan N, Rodriguez-Bigas MA, Nowak NJ, Wiseman SM, Alrawi S, Brenner BM, Petrelli NJ, Cummings KM, Stoler DL, Anderson GR. (2006) Genomic profiles of colorectal cancers differ based on patient smoking status. Cancer Genet Cytogenet (Jul), 168(2): 98-104.
Hodgson G, Hager JH, Volik S, Hariono S, Wernick M, Moore D, Nowak N, Albertson AG, Pinkel D., Collins, C., Hanahan, D., Gray, J.W. (2001) Genome scanning with array CGH delineates regional alterations in murine islet carcinomas. Nat Genet (Nov), 29: 459-464.
Snijders, A., Nowak, N., Seagraves, R., Blackwood, S., Brown, N., Conroy, J., Hamilton, G., Hindle, A, Huey B, Kimura K, Law S, Myambo K, Palmer J, Ylstra B, Yue J, Gray J, Jain A, Pinkel D, Albertson D. (2001) Assembly of microarrays for genome-wide measurement of DNA copy number by CGH. Nat Genet (Nov), 29: 263-264. doi:https://doi.org/10.1038/ng754
The International Human Genome Mapping Consortium. (2001) A physical map of the human genome suitable for systematic sequencing. Nature (Jan), 409: 934-941.
The International Human Genome Sequencing Consortium. (2001) Initial sequencing and analysis of the human genome. (Jan), 409: 860-921.
Cheung V,*Nowak N,*, Kirsch L, Wonhee J, Kim U-J, Conroy J, Massa H, Raluca DY, Thoreen C, Carter N Chen XN, Collins S, Friedman C, Gray J, Korenberg J, Kuo WL, Lee J, McPherson J, Pinkel D, Olivier Sorotkin K, Ried T, Shen G, Strausberg B, Zhao S, Albertson D, Morton C, Schuler G, de Jong P, Trask B. (2001) Integration of the cytogenetic landmarks into the draft sequence of the human genome. Nature 409 (Jan), 409: 953-958.
Guru SC, Olufemi SE, Manickam P, Cummings C, Gieser LM, Pike BL, Bittner ML, Jiang Y, Chinault AC, Nowak NJ, Brzozowska A, Crabtree JS, Wang Y, Roe BA, Weisemann JM, Boguski MS, Agarwal SK, Burns AL, Spiegel AM, Marx SJ, Flejter WL, de Jong PJ, Collins FS, Chandrasekharappa SC. (1997) A 2.8-Mb clone contig of the multiple endocrine neoplasia type 1 (MEN1) region at 11q13. Genomics (Jun), 42(3): 436-445.
Shows TB, Alders M, Bennett S, Burbee D, Cartwright P, Chandrasekharappa S, Cooper P, Courseaux A, Davies C, Devignes M-D, Devilee P, Elliott R, Evans G, Fantes J, Garner H, Gaudray P, Gerhard DS, Gessler M, Higgins M, Hummerich H, James M, Lagercrantz J, Litt M, Little P, Mannens M, Munroe D, Nowak N, O'Brien S, Parker N, Perlin M, Reid L, Richard C, Sawicki M, Swallow D, Thakker R, van Heyningen V, van Schothorst E, Vorechovsky I, Wadelius C, Weber B, Zabel B. (1996) Report of the fifth international workshop on human chromosome 11 mapping. 74:, 1996. PMID:. Cytogenet Cell Genet (Nov), 74: 1-56.
Wuyts W, Van Hul W, Wauters J, Nemtsova M, Reyniers E, Van Hul EV, De Boulle K, de Vries BB, Hendrickx J, Herrygers I, Bossuyt P, Balemans W, Fransen E, Vits L, Coucke P, Nowak NJ, Shows TB, Mallet L, van den Ouweland AM, McGaughran J, Halley DJ, Willems PJ. (1996) Positional cloning of a gene involved in hereditary multiple exostoses. Hum Mol Genet (Oct), 5(10): 1547-1557.
Qin S, Nowak NJ, Zhang J, Sait SN, Mayers PG, Higgins MJ, Cheng Y, Li L, Munroe DJ, Gerhard DS, Weber BH, Bric E, Housman DE, Evans GA, Shows TB. (1996) A high-resolution physical map of human chromosome 11. Proc Natl Acad Sci U S A (Apr), 93(7): 3149-3154.
Higgins MJ, Smilinich NJ, Sait S, Koenig A, Pongratz J, Gessler M, Richard CW III, James MR, Sanford JP, Kim B-W, Cattelane J, Nowak NJ, Winterpacht A, Zabel BU, Munroe DJ, Bric E, Housman DE, Jones C, Nakamura Y, Gerhard DS, Shows TB. (1994) An ordered NotI fragment map of human chromosome band 11p15. Genomics (Nov), 23: 211-222.
American Society of Human Genetics and Genomics; Member
Presentations:
"Biotechnology, Medical Technology, & Personalized Medicine" NYS Innovation Summit (2021)
"The Future Is Upon Us: How Genomics Is Tackling The Pandemic And Healthcare Challenges Of Our Times" JSMBS Medical Emeritus Faculty Speaker Event UB Virtual (2021)
"The Role of Small Biotech in Innovation" NY Bio Patient Engagement Summit (2021)
Service Activities:
Med Tech Association; Board Member (2021–2022)
As a Board member I support the 434North mission to grow and support the entrepreneurial ecosystem in WNY. This organization holds a business competition resulting in $1mil for the top company and $500k for the runners up. These young companies in addition to the funds are incubated at Seneca One and must take up residency in western NY for at least 1 year. Life science company successes include 2 companies focused on democratizing clinical trials in communities outside of large academic medical centers as well as enrolling individuals from non white populations. The portfolio companies include founders of color, women and as an organization 43North strongly supports inclusive companies that will leverage the talent across our community for their growth.; Board Member
As a board member for the Buffalo Center for the Arts and Technology I support the vision and mission of the organization which serves both youth and adults from economically marginalized and disadvantaged areas of Buffalo. The youth program supports high school children at risk of not graduating high school through an arts program (performing and visual) while at the same time provides support to lift them up academically to graduate from high school. Many then attend 2 year and 4 year colleges or continue on with one of the adult training programs. Similarly the adult program provides educational training in medical coding, IT Help desk, pharmacy technician, phlebotomy, and landscape design along with 13 other programs.; Board member
Empire State Stem Cell Advisory Board; Board Member
Governor's Life Science Advisory Board; Board Member
As Co Chair of the CBLS Core Advisory Committee provide guidance to the Genomics and Bioinformatics Core and the Protein and Bioanalysis Core at CBLS. Advocate with the University for support such as technology upgrades, operations as well as scientific experts in the cores.; Co Chair of CBLS Core Advisory Committee
As a Co Director of GEM work with Jennifer Surtees (Co-Director GEM) to achieve GEM's goals.; Co Director of GEM (Genome, Environment, Microenvironment)
As the Executive Director of the NYS CENter of Excellence in Bioinformatics and Life Sciences I serve on the CTSI board with other members of the Buffalo Translational Consortium to enable the CTSI goals and mission.; CTSI Board Member
The CTSI Steering Committee enables the members of the Buffalo Translational Consortium in their translational research programs goals as part of the mission funded by the CTSA. The CTSA provides experts in team science, funding for pilot projects, cores (ie. BNAC Imaging Core, Informatics), community engagement and outreach and training for the next generation of translational scientists with an emphasis on diversity, equity, and inclusion.; CTSI Steering Committee
As Director of the Genomics and Bioinformatics Core I lead the scientific direction of the core focusing on leading edge genomic technologies (ie. Next Generation Sequencing platforms) as well as the bioinformatic tools and experts required to fully leverage these datasets.; Director of the Genomics and Bioinformatics Core
As the Executive Director of New York State Center of Excellence in Bioinformatics I provide the vision and direction for the CBLS in its mission to enable scientific discoveries and their commercialization. This includes providing state of the art infrastructure in our laboratory and core resources. These resources include cores in genomics, bioinformatics, and proteomics, a clean room facility as well shared equipment. As part of the portfolio, the Executive Director serves as the Principal Investigator for the UB Center for Advanced Technology (CAT) in Big Data and health sciences a grant matching program serving to fund industry partner projects with UB faculty and students. The CBLS and CAT also fund student internships with Life Science companies through our Career Experience Program with a focus on diversity, equity and inclusion.; Executive Director of New York State Center of Excellence in Bioinformatics and Life Sciences
As the Executive Director of the UB Biorepository I oversee its operations and programmatic direction. The biorepository was established to create an enterprise wide collection of human and model system biomaterial for biomedical research. The biorepository is a regulatory compliant, automated, and technology forward infrastructure that meets all of the demands for government, academic and commercial projects.; Executive Director of the UB Biorepository
Represent the Biochemistry Department at Faculty Council meetings; Faculty council representative