Robert H. Blessing PhD
Robert H. Blessing
PhD
Professional Summary:
Professional Interests and Activities:
Teaching and research in structural molecular biology, biochemistry, and biophysics. Experimental, computational, and theoretical methods of biocrystallography.
Education and Training:
- PhD, Chemistry, Ohio University (1970)
- BS, Chemistry, King‘s College (1962)
Employment:
- Professor of Structural Biology, Structural Biology, University at Buffalo (2001-present)
- Reserach Professor of Chemistry, Chemistry, University at Buffalo (1991-present)
- Senior Research Scientist, Structural Biology, Hauptman-Woodward Biomedical Research Institute, Inc. (1978-present)
- Associate Professor of Chemistry, Department of Chemistry and Physics, Mercyhurst College, Mercyhurst College (1974–1978)
- Postdoctoral Research Associate in Crystallography, Chemistry, University at Buffalo (1972–1974)
- Postdoctoral Research Associate in Biocrystallography, Crystallography, University of Pittsburgh, University Of Pittsburgh (1970–1972)
- Postdoctoral Fellow, Chemical Institute, University of Lund, University of Lund, Sweden (1969–1970)
Research Expertise:
- Crystallography
Journal Articles:
- Smith GD, Pangborn WA, Blessing RH. The structure of T6 bovine insulin. Acta Crystallogr D Biol Crystallogr. 2005; 61(Pt 11).
- Smith GD, Blessing RH. Lessons from an aged, dried crystal of T(6) human insulin. Acta Crystallogr D Biol Crystallogr. 2003; 59(Pt 8).
- Smith GD, Pangborn WA, Blessing RH. The structure of T6 human insulin at 1.0 A resolution. Acta Crystallogr D Biol Crystallogr. 2003; 59(Pt 3).
- Hauptman HA, Guo DY, Xu H, Blessing RH. Algebraic direct methods for few-atoms structure models. Acta Crystallogr A. 2002; 58(Pt 4).
- Langs DA, Blessing RH, Guo D. Map self-validation: improved criteria to resolve the SIR or SAS phase ambiguity. Acta Crystallogr D Biol Crystallogr. 2001; 57(Pt 9).
- Smith GD, Pangborn WA, Blessing RH. Phase changes in T(3)R(3)(f) human insulin: temperature or pressure induced? Acta Crystallogr D Biol Crystallogr. 2001; 57(Pt 8).
- Langs DA, Blessing RH, Guo D. Improvement of SAS triple invariant estimates for macromolecular direct-methods phasing. Acta Crystallogr A. 2001; 57(Pt 3).
- Langs DA, Blessing RH, Guo D. Map self-validation: a useful discriminator of phase correctness at low resolution. Acta Crystallogr D Biol Crystallogr. 2001; 57(Pt 4).
- Von Dreele RB, Stephens PW, Smith GD, Blessing RH. The first protein crystal structure determined from high-resolution X-ray powder diffraction data: a variant of T3R3 human insulin-zinc complex produced by grinding. Acta Crystallogr D Biol Crystallogr. 2000; 56(Pt 12).
- Smith GD, Ciszak E, Magrum LA, Pangborn WA, Blessing RH. R6 hexameric insulin complexed with m-cresol or resorcinol. Acta Crystallogr D Biol Crystallogr. 2000; 56(Pt 12).
- Guo DY, Blessing RH, Langs DA. Globbic approximation in low-resolution direct-methods phasing. Acta Crystallogr D Biol Crystallogr. 2000; 56(Pt 9).
- Howell PL, Blessing RH, Smith GD, Weeks CM. Optimizing DREAR and SnB parameters for determining Se-atom substructures. Acta Crystallogr D Biol Crystallogr. 2000; 56(Pt 5).
- Guo DY, Blessing RH, Langs DA. Bulk-solvent correction in direct-methods phasing. Acta Crystallogr D Biol Crystallogr. 2000; 56(Pt 4).
- Jelsch C, Teeter MM, Lamzin V, Pichon-Pesme V, Blessing RH, Lecomte C. Accurate protein crystallography at ultra-high resolution: valence electron distribution in crambin. Proc Natl Acad Sci U S A. 2000; 97(7).
- Langs DA, Blessing RH, Guo D. Progress on the direct-methods solution of macromolecular structures using single-wavelength anomalous-dispersion (SAS) data. Acta Crystallogr A. 1999; 55 (.
- Guo DY, Blessing RH, Langs DA, Smith GD. On 'globbicity' of low-resolution protein structures. Acta Crystallogr D Biol Crystallogr. 1999; 55(Pt 1).
- Smith GD, Nagar B, Rini JM, Hauptman HA, Blessing RH. The use of SnB to determine an anomalous scattering substructure. Acta Crystallogr D Biol Crystallogr. 1998; 54(Pt 5).
- Smith GD, Blessing RH, Ealick SE, Fontecilla-Camps JC, Hauptman HA, Housset D, Langs DA, Miller R. Ab initio structure determination and refinement of a scorpion protein toxin. Acta Crystallogr D Biol Crystallogr. 1997; 53(Pt 5).
- Guo DY, Blessing RH, Langs DA, Hauptman HA. On integrating the techniques of direct methods with anomalous dispersion. IV. A simplified perturbation treatment for SAS phasing. Acta Crystallogr A. 1997; 53 (.
- Souhassou M, Schaber PM, Blessing RH. Structure of tris(cyclohexylammonium) phosphoenolpyruvate monohydrate and crystal chemistry of phosphoenolpyruvates. Acta Crystallogr B. 1996; 52 (.
- Maniukiewicz W, Kwiatkowski W, Blessing RH. O-phospho-DL-threonine and O-phospho-L-threonine compared with their serine analogs. Acta Crystallogr C. 1996; 52 (.
- Blessing RH, Guo DY, Langs DA. Statistical expectation value of the Debye-Waller factor and E(hkl) values for macromolecular crystals. Acta Crystallogr D Biol Crystallogr. 1996; 52(Pt 2).
- Souhassou M, Espinosa E, Lecomte C, Blessing RH. Experimental electron density in crystalline H3PO4. Acta Crystallogr B. 1995; 51 (.
- Moss GR, Souhassou M, Blessing RH, Espinosa E, Lecomte C. Computational studies of crystalline H3PO4. Acta Crystallogr B. 1995; 51 (.
- Blessing RH. On the differences between X-ray and neutron thermal vibration parameters. Acta Crystallogr B. 1995; 51 (.
- Weeks CM, Hauptman HA, Smith GD, Blessing RH, Teeter MM. Crambin: a direct solution for a 400-atom structure. Acta Crystallogr D Biol Crystallogr. 1995; 51(Pt 1).
- Blessing RH. An empirical correction for absorption anisotropy. Acta Crystallogr A. 1995; 51 (.
- Guo DY, Blessing RH, Hauptman HA. On integrating the techniques of direct methods with anomalous dispersion. III. Estimation of two-wavelength two-phase structure invariants. Acta Crystallogr A. 1994; 50 (.
- Wallet JC, Cody V, Wojtczak A, Blessing RH. Structural and conformational studies on bio-active flavonoids. Crystal and molecular structure of a complex formed between 2‘,6‘-dimethoxyflavone and orthophosphoric acid: a model for flavone-nucleotide interactions. Anticancer Drug Des. 1993; 8(5).
- Langs DA, Blessing RH, Duax WL. Crystal structure of valinomycin-monohydrate cage complexes crystallized from dioxane. Int J Pept Protein Res. 1992; 39(4).
- Guo DY, Blessing RH, Hauptman HA. On integrating the techniques of direct methods with anomalous dispersion. II. Statistical properties of the two-phase structure invariants. Acta Crystallogr A. 1991; 47 (.
- Souhassou M, Lecomte C, Blessing RH, Aubry A, Rohmer MM, Wiest R, Bénard M, Marraud M. Electron distributions in peptides and related molecules. 1. An experimental and theoretical study of N-acetyl-L-tryptophan methylamide. Acta Crystallogr B. 1991; 47 (.
- Blessing RH, Langs DA. A priori estimation of scale and overall anisotropic temperature factors from the Patterson origin peak. Acta Crystallogr A. 1988; 44 (.
- Blessing RH. New analysis of the neutron diffraction data for anhydrous orthophosphoric acid and the structure of H3PO4 molecules in crystals. Acta Crystallogr B. 1988; 44 (.
- DeTitta GT, Parthasarathy R, Blessing RH, Stallings W. Carboxybiotin translocation mechanisms suggested by diffraction studies of biotin and its vitamers. Proc Natl Acad Sci U S A. 1980; 77(1).