Samir Haj-Dahmane PhD

Samir Haj-Dahmane

Samir Haj-Dahmane
PhD

Senior Research Scientist

Department of Pharmacology and Toxicology

Jacobs School of Medicine & Biomedical Sciences


Specialty/Research Focus

Ion channel kinetics and structure; Membrane Transport (Ion Transport); Molecular and Cellular Biology; Neurobiology; Neuropharmacology; Signal Transduction

Contact Information
507 Research Institute On Addiction
1021 Main Street
Buffalo, NY 14203
Phone: (716) 887-2231
sh38@buffalo.edu



Professional Summary:

Synaptic transmission is a fundamental mechanism that mediates communication between neurons in the brain. My Laboratory is interested in delineating the mechanisms and regulation of synaptic transmission in the central nervous system. In particular, we investigate the mechanisms by which G-protein coupled receptors, including endocannabinoid receptors, gate synaptic transmission and plasticity. We are also interested in the mechanisms of synaptic homeostasis induced by prenatal and postnatal exposure to stress and drugs of abuse. We use a electrophysiological, genetic, optogenetic and behavioral approaches the delineate the synaptic mechanisms underlying addiction and other mental disorders.

Education and Training:

  • Postdoctoral Fellow, Cellular Neuroscience, Wayne State University Medical School (1998)
  • Postdoctoral Fellow, Pharmacological Sciences, Saint Louis University (1996)
  • PhD, Neuroscience, University Piere et Marie Curie, With honor (1993)
  • MS, Neuroscience, Univerrsity Piere et Marie Curie, With honor (1990)
  • BS, Biology, University of Orsay, Paris Sud, With honor (1988)

Awards and Honors:

  • NARSAD Young Investigator Award (1999)
  • International Brain Research Organization (IBRO) (1992)
  • Servier Pharmaceutical Company Research Fellowship (1991)
  • Bayer Pharmaceutical Company Research Fellowship (1990)

Grants and Sponsored Research:

  • September 2018–August 2023
    Prenatal ethanol exposure and nitric oxide signaling in serotonin neurons
    NIH
    Role: Principal Investigator
    $1,794,375
  • June 2018–March 2023
    Prenatal ethanol exposure on executive function
    NIH
    Role: Co-Investigator
    $1,794,375
  • March 2018–February 2020
    Fatty acid binding protein-mediated control of endocannabinoid signaling and addiction
    NIH
    Role: Principal Investigator
    $426,635
  • December 2010–November 2017
    Addiction propensity after prenatal ethanol exposure
    NIH
    Role: Co-Investigator
    $1,641,925
  • December 2010–November 2017
    Addiction Propensity After Prenatal Ethanol Exposure.
    NIH
    Role: Co-Investigator
    $1,651,617
  • May 2016–April 2017
    Developing wireless optical approaches to dissect the neuronal circuit underlying cognitive function
    Research Institute on Addictions
    Role: Principal Investigator
    $23,500
  • October 2014–September 2015
    Fatty acid binding proteins and the regulation of synaptic transmission and plasticity in monoaminergic neurons
    SUNY REACH
    Role: Principal Investigator
    $20,000
  • March 2014–August 2015
    Regulation of social reward in rat valproic acid model of autism
    Research Institute on Addictions
    Role: Co-Investigator
    $22,500
  • October 2012–September 2014
    Fatty acid binding proteins and the regulation and the regulation of VTA DA neurons
    SUNY REACH
    Role: Principal Investigator
    $15,000
  • April 2007–September 2014
    Stress and endocannabinoids in serotonin neurons
    NIH
    Role: Principal Investigator
    $1,688,465
  • April 2007–March 2011
    Dopamine function after prenatal ethanol exposure
    NIH
    Role: Co-Investigator
    $701,924
  • December 2001–November 2005
    Dopamine mechanisms and receptor in raphe serotonin neurons
    NIH
    Role: Principal Investigator
    $881,208
  • January 1999–January 2005
    NIH/NIAAA 12435
    NIH/NIAAA
    Role: Co-Investigator
  • January 1999–December 2001
    Muscarinic receptors in the prefrontal cortex and schizophrenia
    NARSAD
    Role: Principal Investigator
    $60,000
See all (4 more)

Journal Articles:

See all (32 more)

Presentations:

  • "Constitutive endocannabinoid signaling gates hebbian plasticity of glutamte synapses of dorsal raphe neurons" International Society for Research in Serotonin (2017)
  • "Optogenetic dissection of endocannabinoid signaling at central synapses" UB Pharmacology and Toxicology seminar series, University at Buffalo (2014)
  • "Mechanisms of endocannabinoid signaling at central synapses" SUNY Reach Addiction Research Day, SUNY Reach (2013)
  • "Stress and dugs of abuse converge on serotoninergic system" Winter Conference in Brain Research (2011)
  • "Stress and the modulation of endocannbinoid signaling in dorsal raphe serotonin neurons" Serotonin Club Meeting (2010)
  • "Endocannabinoid signaling and the modulation of synaptic plasticity in monoaminergic neurons" Department of Cellular and Molecular Medicine, University of Ottawa Medical Center (2010)
  • "Retrograde endocannabinoid signaling and the regulation of glutamte synapses of monoaminergic neurons" UB Neuroscience program seminar series, Unversity at Buffalo School of Medicine and Biomedical Sciences (2009)
  • "Endocannbinoid system and the regulation of stress related mood disorders" Department of Psychiatry and Human Genetic, Virginia Commonwealth University (2008)
  • "Stress and the regulation of endocannabinoid signaling in the central nervous system" Department of Pharmacology, Uniformed Services University, Naval medical Center (2008)
  • "Retrograde modulation of synaptic transmission and plasticity: Role of endocannabinoids" Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center (2008)

Service Activities:

  • International Cannabinoid Research Society (ICRS); Affiliate Member (2016–present)
  • American Society for Pharmacology and Experimental Therapeutics; Affiliate Member (2011–present)
  • International Brain Research Organization (IBRO); Affiliate Member (1999–present)
  • Society for Neuroscience; Affiliate Member (1993–present)
  • European Neuroscience association; Affiliate Member (1989–present)

School News:

In the Media:


Clinical Specialties:

Clinical Offices:

Insurance Accepted:



Contact Information

507 Research Institute On Addiction
1021 Main Street
Buffalo, NY 14203
Phone: (716) 887-2231
sh38@buffalo.edu