Cell growth, differentiation and development; Developmental Biology; Epigenetics; Gene Expression; Genomics and proteomics; Models - cell and animal; Molecular and Cellular Biology; Transcription Factors; Transcriptomics; Vision science
My lab is interested in the fundamental mechanisms underlying cell specification and differentiation in the central nervous system during embryonic development. We use the neural retina as our model system to address this question. Our efforts have been on identifying key regulators and uncovering their roles in individual cell lineages. Our recent focus is on how transcription factors interact with the epigenome to promote the formation of retinal ganglion cells. We are also investigating how posttranscriptional control of gene expression affects retinal cell differentiation. We conduct our research with a combined approach of genetics, molecular biology, biochemistry, histology, transcriptomics, epigenomics, single-cell technologies, and bioinformatics.