Yun Wu PhD
Yun Wu
PhD
Associate Professor of Biomedical Engineering
Department of Biomedical Engineering
Jacobs School of Medicine & Biomedical Sciences
Professional Summary:
My research applies engineering pricinples and design concepts to develop novel therapeutics and diagnostics (theranostics) for the diagnosis and treatment of cancer and other deadly diseases.
Education and Training:
- PhD, Chemical and Biomolecular Engineering, The Ohio State University (2009)
Employment:
- Associate Professor, Biomedical Engineering, University at Buffalo, State University of New York (2019-present)
- Assistant Professor, Biomedical Engineering, University at Buffalo, State University of New York School of Engineering and Applied Sciences (2013–2019)
- Postdoctoral Research Associate, Nanoscale Science and Engineering Center, The Ohio State University (2009–2013)
Research Expertise:
- Research Expertise: cancer theranostics, biosensor, cancer biomarkers
Journal Articles:
- Huang WC, Deng B, Mabrouk MT, Seffouh A, Ortega J, Long C, Miura K, Wu Y, Lovell JF. (2020) Particle-based, Pfs230 and Pfs25 immunization is effective, but not improved by duplexing at fixed total antigen dose. Malar J (Aug), 19(1): 309-309.
- Huang WC, Deng B, Seffouh A, Ortega J, Long CA, Suresh RV, He X, Miura K, Lee SM, Wu Y, Lovell JF. (2020) Antibody response of a particle-inducing, liposome vaccine adjuvant admixed with a Pfs230 fragment. NPJ Vaccines (Mar), 5: 23-23.
- Sun H, Yan L, Chang MYZ, Carter KA, Zhang R, Slyker L, Lovell JF, Wu Y, Cheng C. (2019) A multifunctional biodegradable brush polymer-drug conjugate for paclitaxel/gemcitabine co-delivery and tumor imaging. Nanoscale Adv (May), 1(7): 2761-2771.
- Sun H, Yan L, Carter KA, Zhang J, Caserto JS, Lovell JF, Wu Y, Cheng C. (2019) Zwitterionic Cross-Linked Biodegradable Nanocapsules for Cancer Imaging. Langmuir (Feb), 35(5): 1440-1449.
- Horti AG, Naik R, Foss CA, Minn I, Misheneva V, Du Y, Wang Y, Mathews WB, Wu Y, Hall A, LaCourse C, Ahn HH, Nam H, Lesniak WG, Valentine H, Pletnikova O, Troncoso JC, Smith MD, Calabresi PA, Savonenko AV, Dannals RF, Pletnikov MV, Pomper MG. (2019) PET imaging of microglia by targeting macrophage colony-stimulating factor 1 receptor (CSF1R). Proc Natl Acad Sci U S A (Jan), 116(5): 1686-1691.
- Sun H, Yan L, Carter KA, Zhang J, Caserto J, Lovell JF, Wu Y, Cheng C. (2018) Zwitterionic Crosslinked Biodegradable Nanocapsules for Cancer Imaging. Langmuir (Aug).
- Cook SF, Fiandalo MV, Watt DS, Wu Y, Mohler JL, Bies RR. (2018) Mathematical modeling of intracrine androgen metabolism in prostate cancer: Methodological aspects. Prostate (Jun).
- Zhang H, Qiao A, Yang D, Yang L, Dai A, de Graaf C, Reedtz-Runge S, Dharmarajan V, Zhang H, Han GW, Grant TD, Sierra RG, Weierstall U, Nelson G, Liu W, Wu Y, Ma L, Cai X, Lin G, Wu X, Geng Z, Dong Y, Song G, Griffin PR, Lau J, Cherezov V, Yang H, Hanson MA, Stevens RC, Zhao Q, Jiang H, Wang MW, Wu B. (2017) Structure of the full-length glucagon class B G-protein-coupled receptor. Nature (Jun), 546(7657): 259-264.
- Zhu Y, Peng X, Wu Y, Wu EX, Ying L, Liu X, Zheng H, Liang D, Ying LL. (2017) Direct diffusion tensor estimation using a model-based method with spatial and parametric constraints. Med Phys (Feb), 44(2): 570-580.
- Chen Z, Wang Q, Asmani M, Li Y, Liu C, Li C, Lippmann JM, Wu Y, Zhao R. (2016) Lung Microtissue Array to Screen the Fibrogenic Potential of Carbon Nanotubes. Sci Rep (Jan), 6: 31304-31304.
- Wei ZW, Xia GK, Wu Y, Chen W, Xiang Z, Schwarz RE, Brekken RA, Awasthi N, He YL, Zhang CH. (2015) CXCL1 promotes tumor growth through VEGF pathway activation and is associated with inferior survival in gastric cancer. Cancer Lett (Apr), 359(2): 335-343.
- Wei ZW, Li JL, Wu Y, Xia GK, Schwarz RE, He YL, Zhang CH. (2014) Impact of pre-existing type-2 diabetes on patient outcomes after radical resection for gastric cancer: a retrospective cohort study. Dig Dis Sci (May), 59(5): 1017-1024.
- Wei ZW, Xia GK, Wu Y, Schwarz RE, Smith DD, He YL, Zhang CH. (2013) Evaluation of skeletonization of the hepatoduodenal ligament for the lower third gastric cancer by propensity score analysis. Hepatogastroenterology (Oct), 60(127): 1789-1796.
- Chhipa RR, Halim D, Cheng J, Zhang HY, Mohler JL, Ip C, Wu Y. (2013) The direct inhibitory effect of dutasteride or finasteride on androgen receptor activity is cell line specific. Prostate (Oct), 73(14): 1483-1494.
- Wu Y, Godoy A, Azzouni F, Wilton JH, Ip C, Mohler JL. (2013) Prostate cancer cells differ in testosterone accumulation, dihydrotestosterone conversion, and androgen receptor signaling response to steroid 5a-reductase inhibitors. Prostate (Sep), 73(13): 1470-1482.
- Wu Y, Wei ZW, He YL, Schwarz RE, Smith DD, Xia GK, Zhang CH. (2013) Efficacy of adjuvant XELOX and FOLFOX6 chemotherapy after D2 dissection for gastric cancer. World J Gastroenterol (Jun), 19(21): 3309-3315.
- Wu Y, Zhu YJ, Tang QY, Zou C, Liu W, Dai RB, Liu X, Wu EX, Ying L, Liang D, Ying LL. (2013) Accelerated MR diffusion tensor imaging using distributed compressed sensing. Magn Reson Med (Mar).
- Wu Y, Chhipa RR, Cheng J, Zhang H, Mohler JL, Ip C. (2010) Androgen receptor-mTOR crosstalk is regulated by testosterone availability: implication for prostate cancer cell survival. Anticancer Res (Oct), 30(10): 3895-3901.
- Chhipa RR, Wu Y, Mohler JL, Ip C. (2010) Survival advantage of AMPK activation to androgen-independent prostate cancer cells during energy stress. Cell Signal (Oct), 22(10): 1554-1561.
- Cheng J, Wu Y, Mohler JL, Ip C. (2010) The transcriptomics of de novo androgen biosynthesis in prostate cancer cells following androgen reduction. Cancer Biol Ther (Jun), 9(12): 1033-1042.
- Zeremski M, Shu MA, Brown Q, Wu Y, Des Jarlais DC, Busch MP, Talal AH, Edlin BR. (2009) Hepatitis C virus-specific T-cell immune responses in seronegative injection drug users. J Viral Hepat (Jan), 16(1): 10-20.
- Wu Y, Rudin S, Bednarek DR. (2005) A Prototype Micro-Angiographic Fluoroscope and Its Application in Animal Studies. Proc SPIE Int Soc Opt Eng (Jan), 5745: 1066-1077.
- Wang ES, Teruya-Feldstein J, Wu Y, Zhu Z, Hicklin DJ, Moore MA. (2004) Targeting autocrine and paracrine VEGF receptor pathways inhibits human lymphoma xenografts in vivo. Blood (Nov), 104(9): 2893-2902.
Abstracts:
- Rudin S, Kuhls AT, Yadava GK, Josan GC, Wu Y, Chityala RN, Rangwala HS, Ciprian Ionita N, Hoffmann KR, Bednarek DR. (2006) New light-amplifier-based detector designs for high spatial resolution and high sensitivity CBCT mammography and fluoroscopy. (Dec)