Biophysical Modeling; Chemistry - Inorganic and Physical Chemistry; Drug Discovery; Electrophysiology; Ion channel kinetics and structure; Membrane Biophysics; Membrane Transport (Ion Transport); Molecular and Cellular Biology; Neuroscience; Protein Engineering; Protein Function and Structure
Synapses are the primary points of communication between cells of the nervous system. Our laboratory is interested in synaptic receptors and ion channels. We study the molecular events that constitute agonist binding, channel activation and receptor desensitization. Our research bridges physiology pharmacology, biochemistry and structural biology, and our experimental approaches include electrophysiology, computational chemistry (MD simulations) and molecular biology. We seek to to understand the molecular operation of receptors and other allosteric membrane proteins in the context of their physiological roles.
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