Clinical Associate Professor
Neonatal-Perinatal Medicine; Neonatology; Pathophysiology; Pediatrics
The focus of my research in the clinical arena has been delivery room resuscitation and stabilization of preterm infants. I have been involved in both clinical and basic science research to this end. Thermal support during delivery room resuscitation and stabilization is a cornerstone in the management of the extremely preterm infant. Hypothermia occurs frequently during resuscitation and has been shown to be associated with increased incidence of morbidities and mortality in extremely low birth weight infants. During my fellowship training, I introduced the use of vinyl bags for the prevention of hypothermia in extremely preterm infants in the NICU at the Women and Children’s Hospital of Buffalo. Following the acceptance of the practice I performed a retrospective study of change of practice and published the results in the Indian Journal of Pediatrics peer reviewed journal. As a junior faculty member, I conducted a randomized controlled trial of comparing two different methods of thermal management in the delivery room [thermal mattress vs Vinyl bags] the results of that study were published in 2013 in the American Journal of Perinatology.
Simulation has been used extensively both in teaching and research in neonatal resuscitation. I along with my mentee, Dr. Vinay Sharma, undertook a study to evaluate the perception of neonatal care providers and their adherence to an updated algorithm of additional airway corrective maneuvers in the 2015 resuscitation guidelines. The result of this study was published in the journal, Resuscitation.
I have been involved in building a collaborative research team with the three regional perinatal centers –Albany, Rochester and Buffalo – to facilitate clinical research and quality improvement projects across the thruway. I am the principal investigator at the Buffalo Regional Perinatal Center and we have completed a prospective study on the utility of a clinical examination score for predicting the need for and the optimal timing of surgery for preterm infants with necrotizing enterocolitis. [Necrotizing Enterocolitis is a gastrointestinal condition affecting 6-12 % of extremely preterm low birth weight infants and is associated with high mortality and severe long term morbidity among survivors.] The results of this study were published in the Journal of Perinatology.
Basic science research - Optimizing techniques in neonatal resuscitation has been a focus of my research. Much of neonatal cardiopulmonary resuscitation techniques and protocols have been extrapolated from adult and pediatric practice. There is very little evidence for even the most fundamental aspects of neonatal resuscitation such as compression to ventilation ratio during cardiopulmonary resuscitation in newborns. Our laboratory’s basic science research has focused on these areas and is providing the much needed evidence for modification of guidelines for the neonatal resuscitation program. I have been the principal investigator on an American Academy of Pediatrics Neonatal resuscitation program grant comparing three different compressions to ventilation ratios in a newborn porcine model of cardiac arrest and resuscitation. I have presented the results of this study at the Eastern Society for Pediatric Research (ESPR) and at the Pediatric Academic Society’s (PAS) meetings and was Faculty Young Investigator of the Year finalist at the ESPR in 2012. In 2013 I presented the results of a study comparing two different depths of compression during cardiopulmonary resuscitation in newborn piglets at the PAS and the ESPR meetings and was the finalist at the Faculty Young Investigator of the Year at the ESPR.