Christine E. Schaner Tooley PhD

Christine Schaner Tooley

Christine E. Schaner Tooley
PhD

Associate Professor

Department of Biochemistry

Jacobs School of Medicine & Biomedical Sciences


Specialty/Research Focus

Ageing; Cell growth, differentiation and development; DNA Replication, Recombination and Repair; Gene Expression; Molecular and Cellular Biology; Signal Transduction; Stem Cells; Transcription Factors

Contact Information
955 Main Street
Office 4214
Lab 4220
Buffalo, New York 14203
Phone: (716) 829-2978
Fax: (716) 829-2725
ceschane@buffalo.edu



Professional Summary:

The main goal of my research group is to understand the role of N-terminal methylation in human development and disease. I identified the first eukaryotic N-terminal methyltransferases, NRMT1 and NRMT2, and am now working to identify how these enzymes affect cancer development and ageing. Our laboratory has shown that NRMT1 functions as a tumor suppressor in mammary glands, and its loss sensitizes breast cancer cells to DNA damaging chemotherapeutics. We have also created the first NRMT1 knockout mouse and shown it to have developmental defects, as well as exhibit phenotypes of premature ageing, including neurodegeneration and cognitive impairment. We hypothesize that these premature ageing phenotypes may result from misregulation of different stem cell populations, as we have recently shown that loss of NRMT1 alters both muscle and neural stem cell differentiation. Currently, we are working to understand the exact biochemical pathways that lead from loss of N-terminal methylation to these phenotypes. We are also studying how post-translational modifications on the N-terminus of proteins may interact and dictate protein function, similar to the post-translational modifications found on histone tails.

Education and Training:

  • Fellowship, Biochemistry, University of Virginia (2011)
  • PhD, Biochemistry, Cell, & Developmental Biology, Emory University (2005)
  • BS, Biochemistry, University of Rochester, Magna Cum Laude (2000)

Employment:

  • Associate Professor, Biochemistry, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (2019-present)
  • Assistant Professor, Biochemistry, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (2016–2019)
  • Assistant Professor, Biochemistry & Molecular Genetics, University of Louisville (2011–2016)

Grants and Sponsored Research:

  • September 2015–June 2022
    Deciphering the Code of N-terminal Post-translational Modification
    NIGMS
    Role: Principal Investigator
    $1,504,140
  • April 2018–March 2020
    HNRNPA2B1 as a reader of RNA methylation in breast cancer
    NCI
    Role: Co-Principal Investigator
    $356,370
  • September 2013–August 2015
    The Role of the First Mammalian N-terminal Methyltransferase, NRMT1, in tumorigenesis
    NCI
    Role: Principal Investigator
    $454,074
  • September 2011–August 2013
    The Role of the First Mammalian N-term. Methyltransferase, NRMT, in tumorigenesis
    NCI
    Role: Principal Investigator
    $176,934
  • September 2006–December 2008
    Regulation of RCC1 through N-terminal serine methylation
    NIGMS
    Role: Principal Investigator

Journal Articles:

See all (11 more)

Books and Book Chapters:


Professional Memberships:

  • American Society for Cell Biology; Member
  • Association of Biochemistry Educators; Member
  • International Society of Protein Termini; Member

Presentations:

  • "Panel Discussion I: Tenure Track" Moffitt Cancer Center Junior Scientist Retreat (2021)

Service Activities:

  • Poster judge for the 15th annual CSTEP Summer Research Poster Symposium; Poster Judge (2021)
  • Served on NIH Special Interest Panel ZRG1 F05 U20 for Feb. and June study sections; Grant reviewer (2021)
  • Reviewed manuscripts for several journals, including Biochemical Journal, Bioscience Reports, Cell Biology and Toxicology, and Immunity, Imflammation, & Disease; Manuscript Reviewer (2021)
  • UB School of Dental Medicine Executive Council; Committee Member (2020–present)
  • Ad Hoc Committee on Promotions to Academic (Tenurial) Ranks; Committee Member (2019–2022)
  • Natural Sciences Interdisciplinary Masters Program Admission Committee; Committee Member (2019–present)
  • MD/PhD Admissions Committee; Metric Reviewer and Interviewer (2019–present)
  • Dept. of Biochemistry representative to the PPBS Steering/Curriculum Committee; Committee Member (2018–present)
  • Served as a JSMBS representative to the Faculty Senate; Faculty Senator (2017–2021)

School News:

In the Media:


Clinical Specialties:

Clinical Offices:

Insurance Accepted:



Contact Information

955 Main Street
Office 4214
Lab 4220
Buffalo, New York 14203
Phone: (716) 829-2978
Fax: (716) 829-2725
ceschane@buffalo.edu