John C. Hu M.D., Ph.D.
John C. Hu
M.D., Ph.D.
Clinical Assistant Professor
Jacobs School of Medicine & Biomedical Sciences
Specialty/Research Focus
Emergent Pathogens; Immunology; Infectious Disease; Infectious Diseases; Inflammation; Microbial Pathogenesis; Microbiology; Models - cell and animal; Molecular and Cellular Biology; Translational Research; Vaccine Development
Education and Training:
- Fellowship, Infectious Diseases, University at Buffalo, Jacobs School of Medicine and Biomedical Sciences (2022)
- Residency, Internal Medicine, University at Buffalo, Jacobs School of Medicine and Biomedical Sciences (2020)
- MD, University at Buffalo, Jacobs School of Medicine and Biomedical Sciences (2017)
- PhD, Microbiology and Immunology, University at Buffalo, Jacobs School of Medicine and Biomedical Sciences (2017)
- BS, Biomedical Sciences, University at Buffalo, Summa Cum Laude (2008)
- Certificate, Board Certified - American Board of Internal Medicine
- Certificate, Board Certified - American Board of Internal Medicine, Infectious Disease
Employment:
- Clinical Assistant Professor, Department of Medicine, Division of Infectious Diseases, University at Buffalo, Jacobs School of Medicine and Biomedical Sciences (2022-present)
- Research Assistant Professor, Department of Microbiology and Immunology, University at Buffalo, Jacobs School of Medicine and Biomedical Sciences (2022-present)
- Staff Physician, Department of Medicine, Division of Infectious Diseases, Veterans Affairs Western New York Medical Center (2022-present)
Awards and Honors:
- William M. and Stanley A. Bukowski Award (Resident of the Year Award) (2020)
- Resident Physician Award, Erie County Medical Society (2020)
- Dr. Norman Chassin Award for Outstanding Intern in Internal Medicine (2018)
- Gilbert D. Moore Fellowship (2009)
- Panasci Technology Entrepreneurship Competition 1st Place Winner (2007)
- Gregory B. Jarvis Engineering Scholarship (2005)
Grants and Sponsored Research:
- July 2022
Immunoregulatory Properties of Exosomes in the Lung Microenvironment of Chronic Obstructive Pulmonary Disease.
KL2 Mentored Career Development Award
Role: Principal Investigator
$314,466
Journal Articles:
- Masso-Welch P, Girald Berlingeri S, King-Lyons ND, Mandell L, Hu J, Greene CJ, Federowicz M, Cao P, Connell TD, Heakal Y. (2018) LT-IIc, A Bacterial Type II Heat-Labile Enterotoxin, Induces Specific Lethality in Triple Negative Breast Cancer Cells by Modulation of Autophagy and Induction of Apoptosis and Necroptosis. International journal of molecular sciences (Dec), 20(1) doi:10.3390/ijms20010085
- Greene CJ, Hu JC, Vance DJ, Rong Y, Mandell L, King-Lyons N, Masso-Welch P, Mantis NJ, Connell TD. (2016) Enhancement of humoral immunity by the type II heat-labile enterotoxin LT-IIb is dependent upon IL-6 and neutrophils. Journal of leukocyte biology (Aug), 100(2): 361-9. doi:10.1189/jlb.3A0415-153RR
- Greene CJ, Marks LR, Hu JC, Reddinger R, Mandell L, Roche-Hakansson H, King-Lyons ND, Connell TD, Hakansson AP. (2016) Novel Strategy To Protect against Influenza Virus-Induced Pneumococcal Disease without Interfering with Commensal Colonization. Infection and immunity (Jun), 84(6): 1693-1703. doi:10.1128/IAI.01478-15
- Hu JC, Greene CJ, King-Lyons ND, Connell TD. (2015) The Divergent CD8+ T Cell Adjuvant Properties of LT-IIb and LT-IIc, Two Type II Heat-Labile Enterotoxins, Are Conferred by Their Ganglioside-Binding B Subunits. PloS one (Jan), 10(11): e0142942. doi:10.1371/journal.pone.0142942
- Hu W, Hu J. (2014) Prediction of siRNA potency using sparse logistic regression. Journal of computational biology : a journal of computational molecular cell biology (Jun), 21(6): 420-7.
- Hu JC, Mathias-Santos C, Greene CJ, King-Lyons ND, Rodrigues JF, Hajishengallis G, Ferreira LC, Connell TD. (2014) Intradermal administration of the Type II heat-labile enterotoxins LT-IIb and LT-IIc of enterotoxigenic Escherichia coli enhances humoral and CD8+ T cell immunity to a co-administered antigen. PloS one (Jan), 9(12): e113978. doi:10.1371/journal.pone.0113978
- Greene CJ, Chadwick CM, Mandell LM, Hu JC, O'Hara JM, Brey RN, Mantis NJ, Connell TD. (2013) LT-IIb(T13I), a non-toxic type II heat-labile enterotoxin, augments the capacity of a ricin toxin subunit vaccine to evoke neutralizing antibodies and protective immunity. PloS one (Jan), 8(8): e69678. doi:10.1371/journal.pone.0069678
- Nawar HF, King-Lyons ND, Hu JC, Pasek RC, Connell TD. (2010) LT-IIc, a new member of the type II heat-labile enterotoxin family encoded by an Escherichia coli strain obtained from a nonmammalian host. Infection and immunity (Nov), 78(11): 4705-13. doi:10.1128/IAI.00730-10
- Hu JC, Bengrine A, Lis A, Awayda MS. (2009) Alternative mechanism of activation of the epithelial na+ channel by cleavage. The Journal of biological chemistry (Dec), 284(52): 36334-36345. doi:10.1074/jbc.M109.032870
- Perry MJ, Tait J, Hu J, White SC, Medler S. (2009) Skeletal muscle fiber types in the ghost crab, Ocypode quadrata: implications for running performance. The Journal of experimental biology (Mar), 212(Pt 5): 673-83.
- Aletta JM, Hu JC. (2008) Protein arginine methylation in health and disease. Biotechnology annual review (Jan), 14: 203-24.
Professional Memberships:
- University at Buffalo Witebsky Center for Microbial Pathogenesis and Immunology (2022–present)
- Infectious Diseases Society of America (2019–present)
- American College of Physicians (2017–present)
Presentations:
- "Immunomodulation by extracellular vesicles" Department of Oral Biology Seminar Series (2022)
- "Infectious Diseases in the Veteran Population" Western New York VA Medical Center, Buffalo NY Nurse Residency Program, Interdisciplinary Series (2022)
Service Activities:
- Global Health Medical Trip with University at Buffalo Medical Students Gold Coast Medical Foundation Accra, Ghana; Physician Leader (2022)
- Western New York VA Health Care System (WNYHS) IRB Buffalo VA Medical Center, Buffalo, New York; Full Committee Member, Voting and Review (2022–present)
- Infectious Disease Fellowship, Buffalo VA Medical Center; Site Director (2022–present)
- Doctoral Candidate Qualifying Exam; Committee Member (2022–present)
- Infection Control & Hospital Epidemiology (Cambridge Press); Reviewer (2022–present)
- Medical Mycology (Oxford Academic Journal); Reviewer (2020–present)