John C. Hu M.D., Ph.D.
John C. Hu
M.D., Ph.D.
Clinical Assistant Professor
Jacobs School of Medicine & Biomedical Sciences
Specialty/Research Focus
Immunology; Infectious Diseases; Internal Medicine; Microbiology; Translational Research
Education and Training:
- Fellowship, Infectious Diseases, University at Buffalo, Jacobs School of Medicine and Biomedical Sciences (2022)
- Residency, Internal Medicine, University at Buffalo, Jacobs School of Medicine and Biomedical Sciences (2020)
- MD, University at Buffalo, Jacobs School of Medicine and Biomedical Sciences (2017)
- PhD, Microbiology and Immunology, University at Buffalo, Jacobs School of Medicine and Biomedical Sciences (2017)
- BS, Biomedical Sciences, University at Buffalo, Summa Cum Laude (2008)
- Certificate, Board Certified - American Board of Internal Medicine
- Certificate, Board Certified - American Board of Internal Medicine, Infectious Disease
Employment:
- Clinical Assistant Professor, Department of Medicine, Division of Infectious Diseases, University at Buffalo, Jacobs School of Medicine and Biomedical Sciences (2022-present)
- Research Assistant Professor, Department of Microbiology and Immunology, University at Buffalo, Jacobs School of Medicine and Biomedical Sciences (2022-present)
- Staff Physician, Department of Medicine, Division of Infectious Diseases, Veterans Affairs Western New York Medical Center (2022-present)
Awards and Honors:
- F. Carter Panill Award (Teaching) (2024)
- William M. and Stanley A. Bukowski Award (Resident of the Year Award) (2020)
- Resident Physician Award, Erie County Medical Society (2020)
- Dr. Norman Chassin Award for Outstanding Intern in Internal Medicine (2018)
- Gilbert D. Moore Fellowship (2009)
- Panasci Technology Entrepreneurship Competition 1st Place Winner (2007)
- Gregory B. Jarvis Engineering Scholarship (2005)
Research Centers:
- Witebsky Center for Microbial Pathogenesis and Immunology
UB 2020 Strategic Strengths:
- Health and Wellness Across the Lifespan
Grants and Sponsored Research:
- July 2022–June 2024
Immunoregulatory Properties of Exosomes in the Lung Microenvironment of Chronic Obstructive Pulmonary Disease.
KL2 Mentored Career Development Award
Role: Principal Investigator
$314,466 - January 2025
Optimizing Real-Time Screening and Enrollment Strategies for Time-Sensitive Clinical and Translational Studies in Pneumonia
CTSI Translational Pilot
Role: Principal Investigator
$50,000 - October 2024
The role of the extracellular adenosine pathway in the age-driven susceptibility to pulmonary infections
UB VPHS Aging-Related Pilot
Role: Co-Principal Investigator
$50,000
Journal Articles:
- Hu JC, Sethi S. (2024) New methods to detect bacterial or viral infections in patients with chronic obstructive pulmonary disease. Expert review of respiratory medicine (Aug).
- King-Lyons ND, Bhati AS, Hu JC, Mandell LM, Shenoy GN, Willison HJ, Connell TD. (2024) A Novel Cytotoxic Mechanism for Triple-Negative Breast Cancer Cells Induced by the Type II Heat-Labile Enterotoxin LT-IIc through Ganglioside Ligation. Toxins (Jul), 16(7). doi:10.3390/toxins16070311
- El-Atoum M, Hargarten JC, Park YD, Ssebambulidde K, Ding L, Chittiboina P, Hammoud DA, Anjum SH, Glassman SR, Merchant S, Williamson PR, Hu JC. (2023) Persistent neurological symptoms and elevated intracranial pressures in a previously healthy host with cryptococcal meningitis. BMC infectious diseases (Jun), 23(1): 407. doi:10.1186/s12879-023-08349-y
- Masso-Welch P, Girald Berlingeri S, King-Lyons ND, Mandell L, Hu J, Greene CJ, Federowicz M, Cao P, Connell TD, Heakal Y. (2018) LT-IIc, A Bacterial Type II Heat-Labile Enterotoxin, Induces Specific Lethality in Triple Negative Breast Cancer Cells by Modulation of Autophagy and Induction of Apoptosis and Necroptosis. International journal of molecular sciences (Dec), 20(1) doi:10.3390/ijms20010085
- Greene CJ, Hu JC, Vance DJ, Rong Y, Mandell L, King-Lyons N, Masso-Welch P, Mantis NJ, Connell TD. (2016) Enhancement of humoral immunity by the type II heat-labile enterotoxin LT-IIb is dependent upon IL-6 and neutrophils. Journal of leukocyte biology (Aug), 100(2): 361-9. doi:10.1189/jlb.3A0415-153RR
- Greene CJ, Marks LR, Hu JC, Reddinger R, Mandell L, Roche-Hakansson H, King-Lyons ND, Connell TD, Hakansson AP. (2016) Novel Strategy To Protect against Influenza Virus-Induced Pneumococcal Disease without Interfering with Commensal Colonization. Infection and immunity (Jun), 84(6): 1693-1703. doi:10.1128/IAI.01478-15
- Hu JC, Greene CJ, King-Lyons ND, Connell TD. (2015) The Divergent CD8+ T Cell Adjuvant Properties of LT-IIb and LT-IIc, Two Type II Heat-Labile Enterotoxins, Are Conferred by Their Ganglioside-Binding B Subunits. PloS one (Jan), 10(11): e0142942. doi:10.1371/journal.pone.0142942
- Hu W, Hu J. (2014) Prediction of siRNA potency using sparse logistic regression. Journal of computational biology : a journal of computational molecular cell biology (Jun), 21(6): 420-7.
- Hu JC, Mathias-Santos C, Greene CJ, King-Lyons ND, Rodrigues JF, Hajishengallis G, Ferreira LC, Connell TD. (2014) Intradermal administration of the Type II heat-labile enterotoxins LT-IIb and LT-IIc of enterotoxigenic Escherichia coli enhances humoral and CD8+ T cell immunity to a co-administered antigen. PloS one (Jan), 9(12): e113978. doi:10.1371/journal.pone.0113978
- Greene CJ, Chadwick CM, Mandell LM, Hu JC, O'Hara JM, Brey RN, Mantis NJ, Connell TD. (2013) LT-IIb(T13I), a non-toxic type II heat-labile enterotoxin, augments the capacity of a ricin toxin subunit vaccine to evoke neutralizing antibodies and protective immunity. PloS one (Jan), 8(8): e69678. doi:10.1371/journal.pone.0069678
- Nawar HF, King-Lyons ND, Hu JC, Pasek RC, Connell TD. (2010) LT-IIc, a new member of the type II heat-labile enterotoxin family encoded by an Escherichia coli strain obtained from a nonmammalian host. Infection and immunity (Nov), 78(11): 4705-13. doi:10.1128/IAI.00730-10
- Hu JC, Bengrine A, Lis A, Awayda MS. (2009) Alternative mechanism of activation of the epithelial na+ channel by cleavage. The Journal of biological chemistry (Dec), 284(52): 36334-36345. doi:10.1074/jbc.M109.032870
- Perry MJ, Tait J, Hu J, White SC, Medler S. (2009) Skeletal muscle fiber types in the ghost crab, Ocypode quadrata: implications for running performance. The Journal of experimental biology (Mar), 212(Pt 5): 673-83.
- Aletta JM, Hu JC. (2008) Protein arginine methylation in health and disease. Biotechnology annual review (Jan), 14: 203-24.
Professional Memberships:
- University at Buffalo Witebsky Center for Microbial Pathogenesis and Immunology (2022–present)
- Infectious Diseases Society of America (2019–present)
- American College of Physicians (2017–present)
Presentations:
- "Immune Dysfunction in Chronic Obstructive Pulmonary Disease" Infectious Disease Conference, Kwame Nkrumah University of Science and Technology (2024)
- "Immunomodulation by extracellular vesicles" Department of Oral Biology Seminar Series (2022)
- "Infectious Diseases in the Veteran Population" Western New York VA Medical Center, Buffalo NY Nurse Residency Program, Interdisciplinary Series (2022)
Service Activities:
- Microbes and Infection (Elsevier); ad hoc Reviewer (2024–present)
- Journal of COPD; ad hoc Reviewer (2024–present)
- BMC Pulmonary Medicine; ad hoc Reviewer (2024–present)
- MD/PhD Program; Committee Member (2023–present)
- Leading annual global health trip with to Ghana and in collaboration with local allied health professionals.; Physician Leader (2022–present)
- Western New York VA Health Care System (WNYHS) IRB Buffalo VA Medical Center, Buffalo, New York; Full Committee Member, Voting and Review (2022–present)
- Infectious Disease Fellowship, Buffalo VA Medical Center; Site Director (2022–present)
- Doctoral Candidate Qualifying Exam; Committee Member (2022–present)
- Infection Control & Hospital Epidemiology (Cambridge Press); ad hoc Reviewer (2022–present)
- Medical Mycology (Oxford Academic Journal); ad hoc Reviewer (2020–present)