Ding Xu PhD
Ding Xu
PhD
Associate Professor
Specialty/Research Focus
Drug Development; Inflammation; Monoclonal Antibodies; Oral Biology; Pathophysiology; Protein Function and Structure; Structural Biology; Transgenic organisms
Education and Training:
- Fellowship, Vascular Biology, Inflammation, University of California, San Diego (2011)
- PhD, University of North Carolina (2007)
- BS, Biochemistry, Central China Normal Universtiy (1999)
Employment:
- Associate Professor, Oral Biology, University at Buffalo (2020-present)
- Assistant Professor, Oral Biology, University at Buffalo (2014–2019)
- Scientist, Assistant Project Scientist, Cellular and Molecular Medicine, University of California, San Diego School of Medicine (2011–2014)
Awards and Honors:
- ASBMR 2019 Annual Meeting Research Team Travel Award (2019)
- JBC/Herbert Tabor Young Investigator Award (2012)
- Outstanding Poster Award at the Gordon Research Conference, Proteoglycans (2012)
- The ASBMB 2012 Thematic Best Poster in Glycobiology, 2012 ASBMB Annual Meeting (2012)
- American Heart Association postdoctoral Fellowship (2008)
- American Heart Association Predoctoral Fellowship (2005)
Research Expertise:
- Bone biology
- Glycobiology
- Heparan Sulfate
- Inflammation
- Structural Biology
- www.xulab-heparan.org: Lab website
Patents:
- Sulfated oligosaccharides decrease sterile inflammation damage in the live A new sulfated heparin sulfate oligosaccharide displays protective effect on drug-induced liver damage. The compound likely inhibits the function of HMGB1, a common protein in regulating immune responses. This discovery can be applied for a wide range of diseases that are caused by over reaction of inflammation responses.
Professional Memberships:
- International Association for Dental Research (2023–present)
- The American Society for Bone and Mineral Research (2015–present)
- American Society for Biochemistry and Molecular Biology (2012–present)
- Society for Glycobiology (2009–present)
- American Society for Matrix Biology (2008–present)
- American Heart Association (2004–present)
Presentations:
- "Heparan sulfate is a master regulator of bone remodeling" National Institute of Environmental Health Sciences (2024)
- "Heparan sulfate is a master regulator of bone remodeling" Emory School of Medicine (2024)
- "Deciphering Heparan sulfate-protein interactions in Bone remodeling and inflammation" (2018)
- "Deciphering Heparan sulfate-protein interactions in Bone remodeling" (2017)
- "Deciphering Heparan sulfate-protein interactions in Bone remodeling" (2017)
- "Heparan sulfate in bone remodeling" (AADR) Buffalo Section, Lunch and Learn Seminar Series; University at Buffalo (2015)
- "Heparan sulfate in inflammation and bone remodeling" Inviated talk; Roswell Park Cancer Institute (2015)
- "Heparan Sulfate–Dependent Oligomerization of RAGE is essential for signal transduction" Vasculata 2013; North American Vascular Biology Organization (2013)
- "Heparan Sulfate–Dependent Oligomerization of RAGE is essential for signal transduction" Gordon Research Conference, Glycobiology; Gordon Research Conference (2013)
- "Heparan Sulfate–Dependent Oligomerization of RAGE–a novel target for therapeutic intervention" Invited presentation; School of Pharmacy, University of Arizona (2013)
- "Inactivation of heparan sulfate 2-O-sulfotransferase accentuates neutrophil infiltration during acute inflammation in mice" 2012 ASBMB Annual Meeting; ASBMB (2012)
- "Heparan Sulfate as a regulator of VEGF-induced vascular permeability" Gordon Research Conference, Vascular Cell Biology; ; Vascular Cell Biology (2009)
Service Activities:
- Oral Biology Faculty Search committee (2023–2024)
- School of Dental Medicine, Student Research and Honors Committee; Co-Chair (2022–2024)
- Musculoskeletal, Oral and Skin Sciences IRG;; Ad Hoc Reviewer (2019)
- Jacobs School of Medicine & Biomedical Sciences, Admissions Committee; Member (2017–2019)
- NIH; Intercellular Interactions; Ad Hoc reviewer for R01 and R21 grants;; Ad Hoc Reviewer (2017)
- School of Dental Medicine, Graduate Committee, Thesis; Member (2017–2020)
- School of Dental Medicine, Graduate Committee, Admissions; Member (2017–2019)
- School of Dental Medicine, Graduate Committee, Preliminary Exams; Fellow (2017–2018)
- School of Dental Medicine, Student Research and Honors Committee; Member (2017–2022)
- School of Dental Medicine, Graduate Committee, Preliminary Exams; Advisor (2016)
- School of Dental Medicine, Graduate Committee, Preliminary Exams; Member (2015–2018)