Duncan B. Johnstone MD, PhD

Duncan Johnstone

Duncan B. Johnstone
MD, PhD

Clinical Associate Professor

Department of Medicine

Jacobs School of Medicine & Biomedical Sciences


Specialty/Research Focus

Nephrology

Contact Information
462 Grider Street, 11th Floor Kidney clinic
Buffalo, New York 14215
Phone: (716) 898-4803
Fax: (716) 898-3928
duncanjo@buffalo.edu


Patient Care

This faculty member is affiliated with UBMD, practicing physicians who are also professors in the Jacobs School.

View this physician on UBMD


Professional Summary:

I provide clinical care for a diverse group of patients with kidney disease. My research and primary clinical interest are people who have glomerular diseases that cause nephrotic syndrome, nephritic syndrome, or arise from systemic vasculitis. I am also happy to see patients with CKD of unclear cause, with the aim that I might find a reversible cause of kidney disease to prevent the need for dialysis, or delay dialysis as long as possible.
In addition, I provide care for patients with malignant hypertension, renal artery stenosis, recurrent kidney stones, genetic kidney diseases such as polycystic kidney disease, rare kidney diseases such as idiopathic retroperitoneal fibrosis, and disorders of electrolytes or acid-base status.
I have received funding from the NIH, the American Heart Association and the NephCure foundation to study the basic science of glomerular disease. This work started in cultured cells and transgenic mice, then evolved to study patients with rare mutations in APOL1 in India, and then clinical studies of Nephrotic and Nephritic Syndrome as part of the NEPTUNE and CureGN consortium.
Lastly, I provide care to patients on hemodialysis and peritoneal dialysis, with a goal of making the quality of life as good as possible while undergoing dialysis. Among dialysis patients, I have been involved with clinical studies of uremic itching, which involves opiod and capsaicin pathways instead of histamine.
As a member of the Jacobs School faculty, my goals are to remain on the forefront of clinical and translational care to provide the best care for my patients with kidney disease, and to share what I have learned over the years with medical students, resident doctors, nephrology fellows, students in NP or PA training, and more. For my teaching, I have received awards from internal medicine residents and nephrology fellows at the University of Pennsylvania, Temple University and the University of Pittsburgh.
I enjoy discussing complex kidney disease topics at all levels of medical expertise, including “lunch and learn” lectures to patients and families with nephrotic syndrome, talks with colleagues in primary care, or colleagues from Urology, cardiology and critical care who have shared interests.

Education and Training:

  • Fellowship, Nephrology, University of Michigan Hospitals (2007)
  • Residency, Internal Medicine, Northwestern University Hospital (2004)
  • MD, Medicine, University of Washington (2001)
  • PhD, Molecular and Cellular Biology, University of Washington (2001)
  • BA, History and Science, Harvard College, Magna Cum Laude (1990)

Employment:

  • Associate Professor, Internal Medicine, University of Buffalo (2022-present)
  • Course Director, Medical School Renal Block, University of Pittsburgh School of Medicine Renal Block (2020–2021)
  • Dialysis Unit Director, Fresenius, FMC Western Pennsylvania (2020–2021)
  • Medical Advisory Board, National Kidney Foundation of Western Pennsylvania (2020–2021)
  • Associate Professor, Clinical Director, and Associate Chief in Renal-Electrolyte, Internal Medicine, University of Pittsburgh (2019–2021)
  • Dialysis Physician, DCI Oakland (2019–2021)
  • Associate Professor and Fellowship Program Director, Nephrology, Internal Medicine, Temple University Health System (2015–2019)
  • Chair, Medication Safety and Practices subcommittee, Temple University Hospital (2013–2019)
  • Pharmacy and Therapeutics Committee, Temple University Hospital (2013–2019)
  • Dialysis Physician, DCI Philadelphia (2012–2019)
  • Dialysis Physician, FMC Episcopal (2012–2019)
  • Clinical Competency Committee for Internal Medicine Residency, Internal Medicine, Temple University (2015–2017)
  • Chair, Clinical Competency Committee for Nephrology, Internal Medicine, Division of Nephrology, Temple University (2014–2015)
  • Assistant Professor in Nephrology, Internal Medicine, Temple University Health System (2011–2015)
  • Instructor in Nephrology, Internal Medicine, University of Pennsylvania (2009–2011)
  • Lecturer in Nephrology, Internal Medicine, University of Michigan (2007–2009)
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Awards and Honors:

  • Annual Faculty Teaching Award (2021)
  • Annual Faculty Teaching Award (2020)
  • Annual Faculty Teaching Award (2019)
  • NephCure nominated “Nephrotic Syndrome Specialist” (2019)
  • Annual Faculty Teaching Award (2018)
  • 1 of the top 4 scores nationwide, ABIM nephrology exam (2017)
  • Outstanding Faculty Consultant Annual Award (2016)
  • Outstanding Faculty Consultant Annual Award (2014)
  • Fellow of the American College of Physicians (2013)
  • Faculty of 1000 Recommended Article, "http://f1000.com/prime/717970781?bd=1&ui=22087" (2013)
  • J. Russell Elkinton Faculty Teaching Award (2012)
  • Cover Illustration and "Spotlight article," Molecular and Cellular Biology, Vol 31(10) (2011)
  • 1st Prize, Nephrology Fellow Research Day, Midwest Chapter (2008)
  • Outstanding Teacher Award (2004)
  • Excellence in Teaching (2003)

Research Expertise:

  • Genetic approach to potassium channel biology in C. elegans: PhD thesis with 3 peer reviewed publications and multiple abstracts.
  • Molecular and cellular biology of podocytes; studies of Fat1, Myh9, and APOL1 in tissue culture, mice and humans.: Post doctoral basic research of glomerular disease at University of Michigan and University of Pennsylvania.
  • Multi-site clinical studies of glomerular disease (both NIH sponsored and industry sponsored). Clinical studies of uremic itch in dialysis patients. Clinical studies of anemia in chronic kidney disease.

Grants and Sponsored Research:

  • January 2019–August 2019
    Phase 2 study of CO22102 in FSGS
    Pfizer
    Role: Principal Investigator
  • June 2017–August 2019
    “A phase III, randomized, open-label, comparative safety and efficacy trial of intravenous iron isomaltoside (Monofer) and iron sucrose in subjects with iron deficiency anaemia and non-dialysis-dependent chronic kidney disease”
    Pharmacosmos, Parexel
    Role: Principal Investigator
  • January 2017–August 2019
    Cure Glomerulonephritis consortium "CureGN"
    NIH/NIDDK
    Role: Co-Investigator
  • January 2013–August 2019
    Neptune Consortium: multi-center study of the Nephrotic Syndrome
    NIH/NIDDK
    Role: Co-Investigator
  • January 2015–December 2017
    “Study of uremic pruritis, extension study”
    Trevi therapeutics
    Role: Co-Investigator
  • January 2015–December 2017
    “Efficacy and Safety of RE-021, a Dual Endothelin Receptor and Angiotensin Receptor Blocker, in Patients with FSGS: a Randomized, Double-Blind, Active-Control, Dose-Escalation Study”
    Retrophin
    Role: Principal Investigator
  • January 2013–December 2016
    “Losmapimod to Reduce Proteinuria in Steroid-Resistant Idiopathic Focal Segmental Glomerulosclerosis (FSGS) Patients”
    Glaxo Smith Kline
    Role: Principal Investigator
  • October 2009–June 2014
    “Fat1 and Conventional Kinesin In Lateral Polarity”
    NIH/NIDDK K-award K08-DK-082616
    Role: Principal Investigator
  • January 2011–December 2011
    “Utilizing Gene Delivery to Examine Inherited Kidney Disease Due to Variant Alleles of APOL1”
    NIH, via site grant to the University of Pennsylvania
    Role: Principal Investigator
  • May 2010–November 2011
    “Fat1 and Conventional Kinesin In Lateral Polarity”
    NIH/NIDDK KO8 supplementary grant
    Role: Principal Investigator
  • July 2008–June 2009
    “Interaction of Slit Diaphragm Protein Fat1 with Conventional Kinesin, Microtubules and the Actin Cytoskeleton”
    NephCure Young Investigator Grant
    Role: Principal Investigator
  • July 2006–June 2008
    “The Role of slit diaphragm protein Fat1 in cell polarity”
    American Heart Association 0625779Z
    Role: Principal Investigator
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Journal Articles:

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Professional Memberships:

  • Association of Specialty Professors (2015–present)
  • Fellow of the American College of Physicians (FACP) (2012–present)
  • American Society of Microbiology (2011–2014)
  • National Kidney Foundation (2010–present)
  • American Society of Nephrology (2005–present)

Presentations:

  • "“Nephrotoxins and Interstitial Nephritis”" Medicine Grand Rounds, UPMC Susquehana (2021)
  • "“Nephrolithiasis”" Medicine Grand Rounds, UPMC Susquehana (2021)
  • "“Race based algorithms for estimating GFR”" General Internal Medicine Grand Rounds, University of Pittsburgh (2020)
  • "“ESRD: No place like home”" Annual Update in Internal Medicine, University of Pittsburgh (2020)
  • "“Deciphering Race-Based eGFR”" University of Pittsburgh Global Health (2020)
  • "“Renal-Electrolyte Year in Review”" Medicine Grand Rounds, Shadyside hospital (2020)
  • "“Renal-Electrolyte Year in Review”" Medicine Grand Rounds, University of Pittsburgh (2019)
  • "“Round up the Usual Suspects: renal failure in HIV”" University of Pittsburgh, Renal-Electrolyte Division (2019)
  • "“Tough Beans and Tough Eggs”" SUNY Buffalo Nephrology Grand Rounds (2018)
  • "“Post-parathyroidectomy and The Hungry Bone Syndrome”" Department of Surgery Symposium, Temple University (2018)
  • "“Treating Hypertension in CKD and dialysis patients”" General Internal Medicine, Temple University (2016)
  • "“FSGS: the known, unknown and in-between,”" Nephrology Grand Rounds, Drexel University (2015)
  • "“Research Overview at Nephcure,”" The Nephcure Foundation Lunch and Learn Seminars, (2013)
  • "“Glomerular disease at the MYH9/APOL1 locus”" Temple University, Nephrology Grand Rounds (2012)
  • "Genetics and Kidney Disease" University of Pennsylvania, Renal-Electrolyte Division (2012)
  • "Kidney disease at the Myh9/APOL1 locus" SUNY Buffalo, Nephrology Grand Rounds (2012)
  • "“Glomerular disease at the Myh9/APOL1 locus" Grand Rounds, Institute for Microbial Technology (IMTEC) (2012)
  • "“Glomerulopathy at the Myh9/APOL1 locus in mouse and man" Yale University, Nephrology Grand Rounds (2011)
  • "“Of Mice and Men: Glomerulopathy and the MYH9/APOL1 locus" University of Iowa, Nephrology Grand Rounds (2011)
  • "“The Physiology of Renal Blood Flow and Glomerular Filtration Rate" Drexel School of Medicine (2011)
  • "“Glomerular disease at the MYH9/APOL1 locus”" Jefferson University School of Medicine (2011)
  • "Kidney disease in mouse and man: Myh9 and ApoL1" Physician-Scientist Series, University of Pennsylvania (2010)
  • "Myh9 and kidney disease in mouse and man" NIH symposium on MYH9 and Kidney Disease (2010)
  • "Introduction to ICU dialysis" Workshop for Renal fellow, Pulmonary fellows, and Critical Care fellows, 2020 and 2021
  • "Orientation to Fellowship in Nephrology" NKF of Delaware Valley, Renal Fellow Symposium (Eastern Pennsylvania, Southern New Jersey, Delaware and Eastern Maryland), 2016-2019
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Service Activities:

  • ; Assistant author (to Dr Palevsky), Dialysis to nursing home COVID-19 transfer form, Western Pennsylvania (2020)
  • ; Author, Dialysis to nursing home COVID-19 transfer proposal, Pennsylvania Dept of Heath (2020)
  • ; JASN (Journal of the American Society of Nephrology) (2020–present)
  • ; Judge for “Doctor’s dilemma,” American College of Physicians (2019)
  • ; Question Reviewer for “Doctor’s dilemma,” American College of Physicians (2019–present)
  • Free kidney and hypertension screening held at Enon Baptist Church, Philadelphia.; Physician Volunteer, NKF World Kidney Day (2016–2017)
  • ; American Journal of Kidney Disease (2016–present)
  • ; BMC Medical Genetics (2016–present)
  • ; BMC nephrology (2015–present)
  • ; At Temple University Hospital: Author of Anemia Protocol, 2014-2019 Author of Intravenous iron protocol, 2014-2019 EPIC eCare Physicians Group Nephrology Representative, 2014-2019 Co-Author of EPIC dialysis order sets (w Dr. Gerri Shulman), 2015-2019 Co-Author of iMed nephology consents (with Dr. Gerri Shulman), 2015- 2019 Co-Author of Hospital Guideline for DKA and HHNK (with Drs. Needleman, Rao, Gillespie, and Rubin), 2015 EPIC “champion” for Nephrology, 2015-2019 Author of SPAD Protocol (Single Pass Albumin Dialysis), 2018 Co-Author of Vancomycin dosing protocol (with PharmD Morita and Dr Mueller), 2018 Co-Author of Gentamicin dosing protocol (with PharmD group), 2018 Author of Protocol for parathyroidectomy / hungry bone syndrome, 2018 (2014–2019)
  • ; American Journal of Transplantation (2014–present)
  • ; Molecular Endocrinology (2014–present)
  • ; American Journal of Physiology Renal-Physiology (2012–present)
  • ; Moderator, ASN annual meeting, “Tubulo-interstitial fibrosis, starting and stopping” (2011)
  • ; NIH O'Brien Renal Center (2011)

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Contact Information

462 Grider Street, 11th Floor Kidney clinic
Buffalo, New York 14215
Phone: (716) 898-4803
Fax: (716) 898-3928
duncanjo@buffalo.edu

This faculty member is affiliated with UBMD, practicing physicians who are also professors in the Jacobs School.

View this physician on UBMD