Ekrem Maloku MD., M.M.S.
Ekrem Maloku
MD., M.M.S.
Clinical Assistant Professor
Jacobs School of Medicine & Biomedical Sciences
Specialty/Research Focus
Anatomic Pathology; Autopsy; Brain Tumor; Education; Neuropathology; Pathophysiology; Surgical Pathology
Professional Summary:
As a Clinical Neuropathologist I provide diagnostic services for different neurological diseases and in a close collaboration with other team members I help to choose the best available therapy for the patients. I spent several years doing Neuroscience research followed by a Residency clinical training in Pathology and Clinical Fellowship in Neuropathology. The majority of my work is focused on central and peripheral nervous system tumors. In addition to clinical responsibilities, I am very interested in further research and elucidate mechanisms in tumorigenesis and further improve patient care. I am also involved in autopsy service and also teaching Pathology to medical students at Jacobs School of Medicine, as well as serving as an Attending Physician and training of Pathology residents at Buffalo General Medical Center.
I am a Diplomate of the American Board of Pathology (ABPath).
Education and Training:
- Fellowship, Clinical Neuropathology, New York University Langone and Grossman School of Medicine (2019)
- Residency, Anatomic Pathology Clinical Residency, Dartmouth Hitchcock Medical Center and Geisel School of Medicine (2016)
- MS, Medicine, University of Prishtina/University of Illinois at Chicago (2011)
- Certificate, Education Commission of Foreign Medical Graduates (2008)
- MD, Medical Doctor, University of Prishtina, School of Medicine, Magna Cum Laude (2001)
Employment:
- Clinical Assistant Professor, Pathology, University at Buffalo and Jacobs School of Medicine and Biomedical Sciences (2022-present)
- Lecturer, Masters in Management of Health Institutions, German-Kosovan Heimerer College of Health Sciences (2016–2022)
- Neuropathology Consultant, "Nucleus" Pathology laboratory, Prishtine, Kosovo (2020–2021)
- Instructor of Pathology and Laboratory Medicine, Pathology, Geisel School of Medicine at Dartmouth (2019–2020)
- Research Associate, Neurology, Dartmouth Hitchcock Medical Center and Geisel School of Medicine (2011–2013)
- Post-doctoral Research Associate, Psychiatry, University of Illinois at Chicago Institute of Psychiatry (2004–2010)
- Teaching Assistant, Physical medicine and Rehabilation, University of Prishtina, School of Medicine (2002–2004)
Awards and Honors:
- "Teacher of the Year", German-Kosovan Heimerer College of Health Sciences (2021)
- "Distinguished Student" Magna Cum Laude, University Of Prishtina, School of Medicine (2000)
Research Expertise:
- Brain tumors
- Epigenetics
- Neuropathology
Journal Articles:
- Kristyn Galbraith, Varshini Vasudevaraja, Jonathan Serrano, Guomiao Shen, Ivy Tran, Nancy Abdallat, Mandisa Wen, Seema Patel, Misha Movahed-Ezazi, Arline Faustin, Marissa Spino-Keeton, Leah Geiser Roberts, Ekrem Maloku, Steven A Drexler, Benjamin L Liechty, David Pisapia, Olga Krasnozhen-Ratush, Marc Rosenblum, Seema Shroff, Daniel R Boué, Christian Davidson, Qinwen Mao, Mariko Suchi, Paula North, Amanda Hopp, Annette Segura, Jason A Jarzembowski, Lauren Parsons, Mahlon D Johnson, Bret Mobley, Wesley Samore, Declan McGuone, Pallavi P Gopal, Peter D Canoll, Craig Horbinski, Joseph M Fullmer, Midhat S Farooqui, Murat Gokden, Nitin R Wadhwani, Timothy E Richardson, Melissa Umphlett, Nadejda M Tsankova, John C DeWitt, Chandra Sen, Dimitris G Placantonakis, Donato Pacione, Jeffrey H Wisoff, Eveline Teresa Hidalgo, David Harter, Christopher M William, Christine Cordova, Sylvia C Kurz, Marissa Barbaro, Daniel A Orringer, Matthias A Karajannis, Erik P Sulman, Sharon L Gardner, David Zagzag, Aristotelis Tsirigos, Jeffrey C Allen, John G Golfinos, Matija Snuderl. (2023) Clinical utility of whole genome DNA methylation profiling as a primary molecular diagnostic assay for central nervous system tumors – a prospective study and guidelines for clinical testing. Neuro-Oncology advances (Jun) doi:https://doi.org/10.1093/noajnl/vdad076
- Karajannis MA, Mauguen A, Maloku E, Xu Q, Dunbar EM, Plotkin SR, Yaffee A, Wang S, Roland JT, Sen C, Placantonakis DG, Golfinos JG, Allen JC, Vitanza NA, Chiriboga LA, Schneider RJ, Deng J, Neubert TA, Goldberg JD, Zagzag D, Giancotti FG, Blakeley JO. (2021) Phase 0 Clinical Trial of Everolimus in Patients with Vestibular Schwannoma or Meningioma. Molecular cancer therapeutics (Sep), 20(9): 1584-1591. doi:10.1158/1535-7163.MCT-21-0143
- Ekrem Maloku, Eric Loo. (2020) Erdheim-Chester Disease: A review of molecular genetic and clinical features. (Nov), 3(1)
- Patel S, Pacione D, Fischer I, Maloku E, Agrawal N. (2019) FOLLICLE-STIMULATING HORMONE-PRODUCING PITUITARY ADENOMA: A CASE REPORT AND REVIEW OF THE LITERATURE. AACE clinical case reports (Jan), 5(3): e175-e180. doi:10.4158/ACCR-2018-0454
- Gavazaj FQ, Mikerezi II, Morina VH, Cakaj FA, Maloku EB, Gavazaj BB, Kastrati DS, Duriqi-Maloku BA. (2012) Optimization of DNA concentration to amplify short tandem repeats of human genomic DNA. Bosnian journal of basic medical sciences (Nov), 12(4): 236-9. doi:10.17305/bjbms.2012.2444
- Maloku E, Kadriu B, Zhubi A, Dong E, Pibiri F, Satta R, Guidotti A. (2011) Selective a4ß2 nicotinic acetylcholine receptor agonists target epigenetic mechanisms in cortical GABAergic neurons. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology (Jun), 36(7): 1366-74. doi:10.1038/npp.2011.21
- Maloku E, Covelo IR, Hanbauer I, Guidotti A, Kadriu B, Hu Q, Davis JM, Costa E. (2010) Lower number of cerebellar Purkinje neurons in psychosis is associated with reduced reelin expression. Proceedings of the National Academy of Sciences of the United States of America (Mar), 107(9): 4407-11. doi:10.1073/pnas.0914483107
- Hanbauer I, Rivero-Covelo I, Maloku E, Baca A, Hu Q, Hibbeln JR, Davis JM. (2009) The Decrease of n-3 Fatty Acid Energy Percentage in an Equicaloric Diet Fed to B6C3Fe Mice for Three Generations Elicits Obesity. Cardiovascular psychiatry and neurology (Jan), 2009: 867041. doi:10.1155/2009/867041
- Costa E, Chen Y, Dong E, Grayson DR, Kundakovic M, Maloku E, Ruzicka W, Satta R, Veldic M, Zhubi A, Guidotti A. (2009) GABAergic promoter hypermethylation as a model to study the neurochemistry of schizophrenia vulnerability. Expert review of neurotherapeutics (Jan), 9(1): 87-98.
- Veldic M, Kadriu B, Maloku E, Agis-Balboa RC, Guidotti A, Davis JM, Costa E. (2007) Epigenetic mechanisms expressed in basal ganglia GABAergic neurons differentiate schizophrenia from bipolar disorder. Schizophrenia research (Mar), 91(1-3): 51-61. doi:10.1016/j.schres.2006.11.029
- Agís-Balboa RC, Pinna G, Zhubi A, Maloku E, Veldic M, Costa E, Guidotti A. (2006) Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis. Proceedings of the National Academy of Sciences of the United States of America (Sep), 103(39): 14602-7. doi:10.1073/pnas.0606544103
- Veldic M, Guidotti A, Maloku E, Davis JM, Costa E. (2005) In psychosis, cortical interneurons overexpress DNA-methyltransferase 1. Proceedings of the National Academy of Sciences of the United States of America (Feb), 102(6): 2152-7. doi:10.1073/pnas.0409665102
Professional Memberships:
- New York Pathological Society (2022–present)
- Kosovo Chamber of Physicians (2021–present)
- United States and Canadian Association of Pathology (2015–present)
- American Medical Association (2013–present)
Service Activities:
- ; Attending Physician Neuropathology (2022–present)
- ; Clinical Assistant Professor University at Buffalo and Jacobs School of Medicine (2022–present)