Frank Chen
Frank Chen
Clinical Associate Professor Hs
Jacobs School of Medicine & Biomedical Sciences
Specialty/Research Focus
Anatomic Pathology; Cytopathology; Molecular diagnostics; Oncology; Translational Research
Education and Training:
- Certificate, Certifications for GYN Cytology (Sure-Path), BD diagnostics (2014)
- MBA, George Washington University, School of Business (2012)
- Certificate, Medical Coding Training, Medical Coding Training, Kaleida Health, Buffalo, NY (2008)
- Certificate, Royal College of Physicians (RCP) Educator course held by UB, Royal College of Physicians (RCP) (2008)
- Fellowship, Oncologic Pathology Fellowship, Roswell Park Cancer Institute (2006)
- Certificate, Certifications for GYN Cytology (Thin-Prep), Johns Hopkins University, Division of Cytopatholgy (2005)
- Fellowship, Cytopathology Fellowship, The Johns Hopkins Hospital (2005)
- Residency, Pathology Residency 07/1999-06/2003, New England Medical Center, Tufts Univ. (2003)
- Fellowship, Postdoc Research Training, Harvard University, School of Public Health (1999)
- PhD, Biomedical Sciences/Molecular Endocrinology, Mt. Sinai Medical Center, City Univ of New York (1996)
- Other, Graduate Student, East Tennessee State University, Department of Physiology (1991)
- MD, Beijing Medical University (1989)
Employment:
- Chief of Pathology, Department of Pathology, Erie County Medical Center (2025-present)
- Clinical Associate Professor, Department of Pathology and Anatomical Sciences, Jacobs School of Medicine and Biomedical Sciences (2025-present)
- Cytopathology Director, Pathology, Kaleida Health (2024-present)
- Assistant Medical Director, ECMC Clinical Lab, Department of Pathology, Erie County Medical Center (2023-present)
- Medical Director, Clinical Lab in Buffalo, Quest Diagnostics (2020-present)
- Medical Director, Clinical Lab at Syracuse, Quest Diagnostics (2015-present)
- Treasurer and board member, Western New York Society of Pathologists (WNYSP) (2014-present)
- Co-acting Chief Editor, North American Journal of Medicine and Science (2010-present)
- Associate Editor and Managing Editor, North American Journal of Medicine and Science (2008-present)
- Medical Director of Clinical Lab, Department of Pathology, Gates Hospital
- Member, resident interviewing committee, Department of Pathology, University at Buffalo (2025–2026)
- Member, Pathology Chairman searching committee, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo (2025)
- Assistant Medical Director, Quest Diagnostics (2017–2020)
- Medical Director, Sexually Transmitted Disease (STD) Lab, Onondaga County, NY (2015–2018)
- Medical Director, Clinical Lab, Quest Diagnostics, Medina Hospital, Medina, NY (2014–2016)
- Assistant Medical Director of Clinical Laboratory, Department of Pathology, Buffalo General Medical Center (2013–2014)
- President, Western New York Society of Pathologists (WNYSP) (2013–2014)
- Co-chair, office for faculty development, Department of Pathology, State Univ. of New York at Buffalo (2012–2014)
- Clinical Associate Professor, Department of Pathology, State Univ. of New York at Buffalo (2011–2014)
- Director of Cytopathology, Department of Pathology, Kaleida Health Hospitals (2010–2014)
- Member, Quality Assurance and Process Improvement Committee, Department of Pathology, Kaleida Health/Univ at Buffalo (2010–2014)
- Director of Cytopathology Education, Department of Pathology, State Univ. of New York at Buffalo (2006–2014)
- Board Member (Elected), Department of Pathology, University at Buffalo Pathologists (2011–2013)
- Clinical Assistant Professor, Department of Pathology, State Univ. of New York at Buffalo (2006–2011)
- Associate Editor, Online Journal of American Chinese Medical Association, American Chinese Medical Association (1998–2003)
- Chairman, Association of Chinese Students, Mt. Sinai Med Center, New York, NY (1993–1996)
- Class President, Basic Medicine sciences, B83, Beijing Medical University (1985–1989)
Awards and Honors:
- Top Doctor (2026)
- Service award (2025)
- Certificate of Achievement During COVID-19 Pandemic (2020)
- Service award (2016)
- Recognition award for outstanding achievement (2010)
- Seed Award on Translational Research (2004)
- NIH National Research Service Award. Award Number: 5 T32 CA 67751-07 (2003)
- NIH National Research Service Award. Award Number: 5 T32 ES 07155-12 (1996)
Journal Articles:
- Chen F, Hicks DG, D’Angelis CA, Chen H, Sait S, Zhang S. (2010) The Epithelioid Variant of Angiomyolipoma in Kidney Expresses a Higher Level of Epidermal Growth Factor Receptor than Its Conventional Type. North American Journal of Medicine and Science. (Oct), 3(3): 117-122.
- Sun J, Sands A, Chen F, Mojica W. (2009) Secretory Leukocyte Protease Inhibitor: Immunohistochemical Evidence Supporting a Fallopian Tube Origin for Serous Papillary Carcinoma. North America Journal of Medicine and Science. (Apr), 2(2): 42-43.
- Murphy KM, Chen F, Clark DP. (2008) Identification of immunohistochemical biomarkers for papillary thyroid carcinoma using gene expression profiling. Hum Pathol. (Mar), 39(3): 420-6. doi:10.1016/j.humpath.2007.07.015
- Chen F, Clark DP, Hawkins AL, Morsberger LA, Griffin CA. (2007) A break-apart fluorescence in situ hybridization assay for detecting RET translocations in papillary thyroid carcinoma. Cancer Genet Cytogenet. (Oct), 2(178): 128-34. doi:10.1016/j.cancergencyto.2007.07.006
- Chen F, Selinger Z, Marks P, Belinsky G, Tashjian AH Jr. (2001) Production and characterization of an antiserum which recognizes the native receptor for thyrotropin-releasing hormone. Biochem Biophys Res Commun. (Jul), 285(3): 742-50. doi:10.1006/bbrc.2001.5140
- Chen X, Tang S, Tashjian AH Jr. (2000) Novel action of pituitary adenylate cyclase-activating polypeptide. Stimulation of extracellular acidification in rat pituitary GH4C1 cells. Cell Signal. (Apr), 12(4): 255-63. doi:10.1016/s0898-6568(00)00067-x
- Coleman DT, Chen X, Sassaroli M, Bancroft C. (1996) Pituitary adenylate cyclase-activating polypeptide regulates prolactin promoter activity via a protein kinase A-mediated pathway that is independent of the transcriptional pathway employed by thyrotropin-releasing hormone. Endocrinology (Apr), 137(4): 1276-85. doi:10.1210/endo.137.4.8625900.
- D J Fischberg, X H Chen, C Bancroft. (1994) A Pit-1 phosphorylation mutant can mediate both basal and induced prolactin and growth hormone promoter activity. Mol Endocrinol. (Nov), 8(11): 1566-73. doi:10.1210/mend.8.11.7877625
- Yan G, Chen X, Bancroft C. (1994) A Constitutively Active Form of CREB can Activate Expression of the Rat Prolactin Promoter in Non-Pituitary Cells. Molecular and Cellular Endocrinology (May), 101(1-2): R25-R30. doi:10.1016/0303-7207(94)90255-0
Abstracts:
- Dinh T, Hoang V, Chen F. (2025) A Rare Case of Lingual Cryptococcosis Presented as a Tongue Nodule in a HIV-Positive Patient. Canadian Journal of Medical Specialties. 2025;1(Suppl 1)., Poster presentation at The 2025 Canadian Association of Pathologists Annual Scientific Meeting. Saskatoon, Saskatchewan, Canada (Jul) Poster
- Chen A, Zhang A; Krabill K, Chen F. (2025) Sclerosing mucoepidermoid carcinoma with eosinophilia of the parotid gland: a case report and review of the literature. Canadian Journal of Medical Specialties. 2025;1(Suppl 1)., Poster presentation at The 2025 Canadian Association of Pathologists Annual Scientific Meeting on July 4-6, 2025.. Saskatoon, Saskatchewan, Canada (Jul) Poster
Evaluative Studies and Case Reports:
- Guo, L, Zhang, E, Chen, F. (2025) Fumarate Hydratase-deficient Uterine Leiomyoma in a 25-Year-Old Woman. N A J Med Sci. 2025;18(1):028-031. (Sep), 18(1): 028-031. doi:10.7156/najms.2025.1801028
- Chen, A, Zhang, E, Krabill K, Chen F. (2025) Sclerosing Mucoepidermoid Carcinoma with Eosinophilia of the Parotid Gland: A Case Report and Review of the Literature. N A J Med Sci. (Aug), 18(1): 021-023. doi:10.7156/najms.2025.1801021
- Dinh, T, Hoang, V, Chen F. (2025) A Rare Case of Lingual Cryptococcosis Presented as a Tongue Nodule in A HIV-Positive Patient. N A J Med Sci. (Aug), 18(1): 024-027. doi:10.7156/najms.2025.1801024
- Chavez M, Chen F, Desouki M. (2025) Clear Cell Carcinoma Arising from Endometriosis in a C-section Scar: A Case Report with Literature Review. N A J Med Sci. (Jul), 18(1): 018-020. doi:10.7156/najms.2025.1801018
- Wong T, Hussain N, Chen F. (2025) An unusual case of invasive carcinoma with squamous and low-grade glandular features arising in a giant condyloma acuminatum. North American Journal of Medicine and Science. (May), 18(1): 013-017. doi:10.7156/najms.2025.1801013
- Guo L, Andea A, Chen F, Goldenberg A. (2025) A Case Report of BAP1-inactivated Melanocytoma with Discussion of Possible Dual Roles of BAP1 Loss in Tumorigenesis. North American Journal of Medicine and Science. (May), 18(1): 009-012. doi:DOI: 10.7156/najms.2025.1801009
- Dinh T, Zhu M, Chen F. (2025) Establishing the First Diagnosis of Hepatocellular Carcinoma in Lung Biopsy in a 47-Year-Old Man: A Case Report. North American Journal of Medicine and Science. (Jan), 18(1): 005-008. doi:DOI: 10.7156/najms.2025.1801005
- Huang Y, Kumarapeli A, Chen F, Paczos T. (2012) Primary Mucinous Carcinoid of Ovary: A Case Report with Review of the Literature. North American Journal of Medicine and Science. (Oct), 5(4): 239-242.
- Huang H, Balos L, Chen F. (2012) Case Report: Pulmonary Benign Metastasizing Leiomyoma Appears 26 Years after Resection of Uterine Leiomyoma. North American Journal of Medicine and Science. (Jan), 5(1): 55-57.
- Gill S, Chen F. (2011) Left atrial pseudotumor caused by caseous calcification of the mitral annulus, case report with review of literature. North American Journal of Medicine and Science. (Apr), 4(2): 242-244.
- Liang Y, Mojica W, Chen F. (2010) Water-Clear Cell Adenoma of Parathyroid, a Case Report and Literature Review. North American Journal of Medicine and Science. (Oct), 3(4): 194-198.
- Yu G, Goodloe S Jr, D'Angelis CA, McGrath BE, Chen F. (2010) Giant clear cell hidradenoma of the knee. J Cutan Pathol. (Sep), 37(9): e37-41. doi:10.1111/j.1600-0560.2009.01354.x.
- Ganapathi KA, Paczos T, George MD, Goodloe S, Balos LL, Chen F. (2010) Incidental finding of placental choriocarcinoma after an uncomplicated term pregnancy: a case report with review of the literature. Int J Gynecol Pathol. (Sep), 29(5): 476-8. doi:10.1097/PGP.0b013e3181d81cc2
- Nwizu NN, George MD, Chen F. (2010) An Aggressive Psammomatoid Ossifying Fibroma Presenting as a Sphenoethmoidal Mass. North American Journal of Medicine and Science. (Jan), 3(1): 24-27.
- Guo R, Chen F, Heffner R. (2009) A Giant Atypical Neurofibroma in the Right Thoracic Cavity of a 57-year-old Man: A Case Report with Review of the Literature. North American Journal of Medicine and Science. (Oct), 2(4): 135-138.
- Chen H, Syriac S, Sands A, Salomon R, Chen F. (2009) Biliary Papillomatosis Coexisting with Hepatitis C: Report of a Rare Case with Review of the Literature. North American Journal of Medicine and Science. North American Journal of Medicine and Science. (Oct), 2(4): 131-134.
- Liu W, Nakhla H, Mojica W, Chen F. (2009) The Expression of TTF-1 in Small Cell Carcinoma of Urinary Bladder. North America Journal of Medicine and Science. (Jul), 2(3): 94-96.
- Syriac S, Mojica W, Chen F, Zhang S. (2009) Cystic Renal Oncocytoma: a Case Report with Review of the Literature. North America Journal of Medicine and Science. (Jul), 2(3): 97-99.
- Xu B, Balos L, Goodloe S, Krabill K, Chmiel R, Chen F. (2009) Studies of Cell Cycle-associated Proteins in a Case of Giant Cell Granuloma of Mandible. North America Journal of Medicine and Science. (Apr), 2(2): 48-50.
- Paczos T, McGrath B, Chen F. (2009) Primary Carcinosarcoma of Bone: a Case Report with Review of the Literature. North America Journal of Medicine and Science (Apr), 2(2): 51-54.
- Xu B, Lin L, Chen F. (2009) Desmoplastic Trichoepithelioma with Milia-like Structure. North America Journal of Medicine and Science. (Jan), 2(1): 23-24.
- Zhang S, Zhou J, Rizvi A, Chen F. (2009) Bronchial Carcinoid Tumor in a Young Man with Neurofibromatosis. Case Report and Review of the Literature. North America Journal of Medicine and Science. (Jan), 2(1): 17-20.
- Izevbaye I, Goodloe S, Chen F. (2008) Squamous Cell Carcinoma of Lung Metastatic to a Mediastinal Lymph Node Involved by Chronic Lymphocytic Leukaemia/Small Lymphocytic Lymphoma, a Case Report with Review of Literature. North American Journal of Medicine and Science (Oct), 1(1): 25-28.
Professional Memberships:
- Treasurer, Western New York Society of Pathologists (WNYSP) (2014–present)
- President, Western New York Society of Pathologists (WNYSP) (2013–2014)
- Member, American Chinese Medical Exchange Society (2008–present)
- Member, Western New York Society of Pathologists (WNYSP) (2005–present)
- Member, Chinese American Pathologists Association (2004–present)
- Member, American Society of Cytopathology (2003–present)
- Member, American Society for Clinical Pathology (2003–present)
- Member, College of American Pathologist (2003–present)
- Member, American Society for Clinical Pathology (1998–2003)
Presentations:
- "Fumarate Hydratase-deficient Uterine Leiomyoma: A Case Report and Review of Literature." Poster presentation at The New York State Society of Pathologists 2025 Annual Meeting on June 14, 2025. (2025)
- "Metastatic Melanoma with Thoracic Involvement: A Rare Case of Malignant Pleural Effusion." Poster presentation at The New York State Society of Pathologists 2025 Annual Meeting on June 14, 2025 (2025)
- "The Differences between Bethesda 2014 and Bethesda 2001 for Reporting Cervical Cytology" Western New York Society of Pathologists (WNYSP) Meeting (2015)
Service Activities:
- I created a "mini pathology rotation" at ECMC. The mini rotation is composed of observing gross/frozen section for 2 hours and double scoping with me reviewing teaching sets for 2 hours. Until January 2026, 3 medical students went thought this mini-rotation. Their feed back is very good.; Train medical student to learn basic pathology (2026–present)
- Train Dental residents about head and neck pathology and research; Train Dental residents (2025–present)
- The search committee was organized by dean of our medial school, and was composed of chiefs or chairmen from several departments. I participated in the interview process.; Served as search committee member to find a new Chairman for the Department of Pathology. (2025)
- Helped inviting CAP president Dr. Jim Zhai to come to our department, giving a lecture regarding thyroid pathology.; Helped to organize Grand Rounds in our department (2025)
- Working together with president, organized 4 meetings in 2025, invited 4 famous pathologists to Buffalo to give lectures. Taking care financial aspect of the WNYSP, including successfully getting company's sponsorship from several companies in 2025.; Serving as Board member and treasurer for Western New York Society of Pathologists (WNYSP) (2025)