University at Buffalo (UB)
Junghun Cho
Junghun Cho
Professional Summary:
My research focuses on developing novel magnetic resonance imaging techniques for the quantification of clinically relevant tissue properties, including cerebral oxygenation, and its clinical application in neurologic disorders. We perform research in biophysics modeling, data processing, validation, and clinical application.
Education and Training:
- PhD, Biomedical Engineering, Cornell University (2019)
- MS, Physics, University of Wisconsin Madison (2010)
- BS, Physics, University of Michigan Ann Arbor (2008)
Employment:
- Assistant Professor, Biomedical Engineering, SUNY Buffalo (2022-present)
- Postdoctoral Associate, Radiology, Weill Cornell Medicine (2020–2022)
- Researcher (military duty), Ulsan National Institute of Science and Technology (2013–2014)
- Researcher (military duty), Korea Basic Science Institute (2011–2012)
Awards and Honors:
- BME faculty award: Rookie of the Year Award (2024)
- ISMRM "Summa cum laude" merit award (2022)
- National Institute of Health Pathway to Independence Award (K99/R00) (2021)
- Best Abstract Award - 1st place in ISMRM PET/MRI Study Group Meeting (2021)
- Best Abstract Award - 3rd place in ISMRM Electro-Magnetic Study Group meeting (2021)
- ISMRM "Summa cum laude" merit award (2021)
- ISMRM "Magna cum laude" merit award (2020)
- Editor's Pick for MRM publication (2020)
- ISMRM "Summa cum laude" merit award (2018)
Research Expertise:
- Biophysics modeling and data processing in magnetic resonance imaging
- Quantitative mapping of cerebral oxygenation
Grants and Sponsored Research:
- April 2024–March 2029
MRI-based quantitative mapping of oxygen extraction fraction in MS
NIH, R01
Role: Principal Investigator
$1,773,282 - July 2023–July 2026
Development and validation of MRI mapping of brain oxygen metabolism for clinical use
NIH, R00
Role: Principal Investigator
$746,999 - July 2021–June 2022
Development and validation of MRI mapping of brain oxygen metabolism for clinical use
NIH, K99
Role: Principal Investigator
$183,107
Journal Articles:
- Xie, Y., Zhang, S., Wu, D., Yao, Y., Cho, J., Lu, J., Zhu, H., Wang, Y., Zhang, Y., and Zhu, W. (2024) The changes of oxygen extraction fraction in different types of lesions in relapsing-remitting multiple sclerosis: A cross-sectional and longitudinal study. Neurol Sci (May) doi:10.1007/s10072-024-07463-2
- Cho, J., Zhang, J., Spincemaille, P., Zhang, H., Nguyen T.D., Zhang, S., Gupta, A., and Wang, Y. (2024) Multi-echo complex quantitative susceptibility mapping and quantitative blood oxygen level-dependent magnitude (mcQSM+qBOLD or mcQQ) for oxygen extraction fraction (OEF) mapping. Bioengineering (Jan), 2(11): 131. doi:10.3390/bioengineering11020131
- Yan, S., Lu, J., Li, Y., Cho, J., Zhang, S., Zhu, W., Wang, Y. (2023) Spatiotemporal pattern of brain iron-oxygen metabolism in patients with Parkinson’s disease. Eur Radiol (Oct)0-10. doi:10.1007/s00330-023-10283-1
- Biondetti, E., Cho, J., Lee, Y. (2023) Cerebral oxygen metabolism from MRI susceptibility. Neuroimage (Aug), 276: ID 120189. doi:10.1016/j.neuroimage.2023.120189
- Van Grinsven, E.E., De Leeuw, J., Siero, J.C.W., Verhoeff, J.J.C., Van Zandvoort, M.J.E., Cho, J., Philippens, M.E.P., and Bhogal, A.A. (2023) Evaluating physiological MRI parameters in patients with brain metastases undergoing stereotactic radiosurgery – a preliminary analysis and case report. Cancers (Aug), 15: 4298. doi:10.3390/cancers15174298
- Zhuang, H., Cho, J., Chiang, G.C.Y, Kovanlikaya, I., Heier L.A., Dyke J.P., Wang,Y. (2023) Cerebral oxygen extraction fraction declines with ventricular enlargement in patients with normal pressure hydrocephalus. Clin Imaging (May), 97: 22-27. doi:10.1016/j.clinimag.2023.02.001
- Zhang, Q., Sui, C., Cho, J., Yang, L., Chen, T., Guo, B., Gillen, K.M.C., Li, J., Guo, L., Wang, Y. (2023) Assessing cerebral oxygen metabolism changes in patients with preeclampsia using voxel-based morphometry of oxygen extraction fraction maps in magnetic resonance imaging. Korean J Radiol (Apr), 24: 324-327. doi:10.3348/kjr.2022.0652
- Yang L, Cho J, Chen T, Gillen KM, Li J, Zhang Q, Guo L, Wang Y. (2022) Oxygen extraction fraction (OEF) assesses cerebral oxygen metabolism of deep gray matter in patients with pre-eclampsia. European radiology (Sep), 32(9): 6058-6069.
- Chiang GC, Cho J, Dyke J, Zhang H, Zhang Q, Tokov M, Nguyen T, Kovanlikaya I, Amoashiy M, de Leon M, Wang Y. (2022) Brain oxygen extraction and neural tissue susceptibility are associated with cognitive impairment in older individuals. Journal of neuroimaging : official journal of the American Society of Neuroimaging (Jul), 32(4): 697-709. doi:10.1111/jon.12990
- Kim J, Nguyen TD, Zhang J, Gauthier SA, Marcille M, Zhang H, Cho J, Spincemaille P, Wang Y. (2022) Subsecond accurate myelin water fraction reconstruction from FAST-T2 data with 3D UNET. Magnetic resonance in medicine (Jun), 87(6): 2979-2988.
- Cho J, Zhang J, Spincemaille P, Zhang H, Hubertus S, Wen Y, Jafari R, Zhang S, Nguyen TD, Dimov AV, Gupta A, Wang Y. (2022) QQ-NET - using deep learning to solve quantitative susceptibility mapping and quantitative blood oxygen level dependent magnitude (QSM+qBOLD or QQ) based oxygen extraction fraction (OEF) mapping. Magnetic resonance in medicine (Mar), 87(3): 1583-1594. doi:10.1002/mrm.29057
- Cho H, Lee H, Gong Y, Kim YR, Cho J, Cho HJ. (2022) Quantitative susceptibility mapping and R1 measurement: Determination of the myelin volume fraction in the aging ex vivo rat corpus callosum. NMR in biomedicine (Mar), 35(3): e4645.
- Cho J, Nguyen TD, Huang W, Sweeney EM, Luo X, Kovanlikaya I, Zhang S, Gillen KM, Spincemaille P, Gupta A, Gauthier SA, Wang Y. (2022) Brain oxygen extraction fraction mapping in patients with multiple sclerosis. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (Feb), 42(2): 338-348. doi:10.1177/0271678X211048031
- Li J, Huang W, Luo X, Wen Y, Cho J, Kovanlikaya I, Gauthier SA, Nguyen TD, Spincemaille P, Wang Y. (2022) The central vein sign in multiple sclerosis lesions: Susceptibility relaxation optimization from a routine MRI multiecho gradient echo sequence. Journal of neuroimaging : official journal of the American Society of Neuroimaging (Jan), 32(1): 48-56.
- Cho J, Spincemaille P, Nguyen TD, Gupta A, Wang Y. (2021) Temporal clustering, tissue composition, and total variation for mapping oxygen extraction fraction using QSM and quantitative BOLD. Magnetic resonance in medicine (Nov), 86(5): 2635-2646.
- Wen Y, Spincemaille P, Nguyen T, Cho J, Kovanlikaya I, Anderson J, Wu G, Yang B, Fung M, Li K, Kelley D, Benhamo N, Wang Y. (2021) Multiecho complex total field inversion method (mcTFI) for improved signal modeling in quantitative susceptibility mapping. Magnetic resonance in medicine (Oct), 86(4): 2165-2178.
- Cho J, Lee J, An H, Goyal MS, Su Y, Wang Y. (2021) Cerebral oxygen extraction fraction (OEF): Comparison of challenge-free gradient echo QSM+qBOLD (QQ) with 15O PET in healthy adults. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (Jul), 41(7): 1658-1668. doi:10.1177/0271678X20973951
- Jafari R, Spincemaille P, Zhang J, Nguyen TD, Luo X, Cho J, Margolis D, Prince MR, Wang Y. (2021) Deep neural network for water/fat separation: Supervised training, unsupervised training, and no training. Magnetic resonance in medicine (Apr), 85(4): 2263-2277. doi:10.1002/mrm.28546
- Cho J, Ma Y, Spincemaille P, Pike GB, Wang Y. (2021) Cerebral oxygen extraction fraction: Comparison of dual-gas challenge calibrated BOLD with CBF and challenge-free gradient echo QSM+qBOLD. Magnetic resonance in medicine (Feb), 85(2): 953-961. doi:10.1002/mrm.28447
- Shen N, Zhang S, Cho J, Li S, Zhang J, Xie Y, Wang Y, Zhu W. (2021) Application of Cluster Analysis of Time Evolution for Magnetic Resonance Imaging -Derived Oxygen Extraction Fraction Mapping: A Promising Strategy for the Genetic Profile Prediction and Grading of Glioma. Frontiers in neuroscience (Jan), 15: 736891. doi:10.3389/fnins.2021.736891
- Wu D, Zhou Y, Cho J, Shen N, Li S, Qin Y, Zhang G, Yan S, Xie Y, Zhang S, Zhu W, Wang Y. (2021) The Spatiotemporal Evolution of MRI-Derived Oxygen Extraction Fraction and Perfusion in Ischemic Stroke. Frontiers in neuroscience (Jan), 15: 716031. doi:10.3389/fnins.2021.716031
- Ma Y, Mazerolle EL, Cho J, Sun H, Wang Y, Pike GB. (2020) Quantification of brain oxygen extraction fraction using QSM and a hyperoxic challenge. Magnetic resonance in medicine (Dec), 84(6): 3271-3285.
- Eskreis-Winkler S, Simon K, Reichman M, Spincemaille P, Nguyen T, Kee Y, Cho J, Christos PJ, Drotman M, Prince MR, Morris EA, Wang Y. (2020) Dipole modeling of multispectral signal for detecting metallic biopsy markers during MRI-guided breast biopsy: a pilot study. Magnetic resonance in medicine (Apr), 83(4): 1380-1389. doi:10.1002/mrm.28017
- Cho J, Zhang S, Kee Y, Spincemaille P, Nguyen TD, Hubertus S, Gupta A, Wang Y. (2020) Cluster analysis of time evolution (CAT) for quantitative susceptibility mapping (QSM) and quantitative blood oxygen level-dependent magnitude (qBOLD)-based oxygen extraction fraction (OEF) and cerebral metabolic rate of oxygen (CMRO2 ) mapping. Magnetic resonance in medicine (Mar), 83(3): 844-857. doi:10.1002/mrm.27967
- Zhang S, Cho J, Nguyen TD, Spincemaille P, Gupta A, Zhu W, Wang Y. (2020) Initial Experience of Challenge-Free MRI-Based Oxygen Extraction Fraction Mapping of Ischemic Stroke at Various Stages: Comparison With Perfusion and Diffusion Mapping. Frontiers in neuroscience (Jan), 14: 535441. doi:10.3389/fnins.2020.535441
- Ma Y, Sun H, Cho J, Mazerolle EL, Wang Y, Pike GB. (2020) Cerebral OEF quantification: A comparison study between quantitative susceptibility mapping and dual-gas calibrated BOLD imaging. Magnetic resonance in medicine (Jan), 83(1): 68-82.
- Hubertus S, Thomas S, Cho J, Zhang S, Wang Y, Schad LR. (2019) Using an artificial neural network for fast mapping of the oxygen extraction fraction with combined QSM and quantitative BOLD. Magnetic resonance in medicine (Dec), 82(6): 2199-2211.
- Hubertus S, Thomas S, Cho J, Zhang S, Wang Y, Schad LR. (2019) Comparison of gradient echo and gradient echo sampling of spin echo sequence for the quantification of the oxygen extraction fraction from a combined quantitative susceptibility mapping and quantitative BOLD (QSM+qBOLD) approach. Magnetic resonance in medicine (Oct), 82(4): 1491-1503.
- Cho, J; Zhou, D; Kee, Y; Spincemaille, P; Wang, Y. (2019) Quantitative susceptibility mapping of magnetic quadrupole moments. Concepts in MR Part A (Aug)Article ID 7174937. doi:https://doi.org/10.1155/2019/7174937
- Cho J, Kee Y, Spincemaille P, Nguyen TD, Zhang J, Gupta A, Zhang S, Wang Y. (2018) Cerebral metabolic rate of oxygen (CMRO2 ) mapping by combining quantitative susceptibility mapping (QSM) and quantitative blood oxygenation level-dependent imaging (qBOLD). Magnetic resonance in medicine (Oct), 80(4): 1595-1604. doi:10.1002/mrm.27135
- Kee Y, Cho J, Deh K, Liu Z, Spincemaille P, Wang Y. (2018) Coherence enhancement in quantitative susceptibility mapping by means of anisotropic weighting in morphology enabled dipole inversion. Magnetic resonance in medicine (Feb), 79(2): 1172-1180.
- Zhang J, Cho J, Zhou D, Nguyen TD, Spincemaille P, Gupta A, Wang Y. (2018) Quantitative susceptibility mapping-based cerebral metabolic rate of oxygen mapping with minimum local variance. Magnetic resonance in medicine (Jan), 79(1): 172-179.
- Kee Y, Liu Z, Zhou L, Dimov A, Cho J, de Rochefort L, Seo JK, Wang Y. (2017) Quantitative Susceptibility Mapping (QSM) Algorithms: Mathematical Rationale and Computational Implementations. IEEE transactions on bio-medical engineering (Nov), 64(11): 2531-2545.
- Zhou D, Cho J, Zhang J, Spincemaille P, Wang Y. (2017) Susceptibility underestimation in a high-susceptibility phantom: Dependence on imaging resolution, magnitude contrast, and other parameters. Magnetic resonance in medicine (Sep), 78(3): 1080-1086.
- H S Jung; S H Jin; J H Cho; S H Han; D K Lee; H Cho. (2016) UTE-?R2 -?R2 * combined MR whole-brain angiogram using dual-contrast superparamagnetic iron oxide nanoparticles. NMR in Biomedicine (Jun), 26(6): 690-701. doi:doi: 10.1002/nbm.3514
- S.H.Han; J.H.Cho; H.S.Jung; J.Y.Suh; J.K.Kim; Y.R.Kim; Cho H.Cho. (2015) Robust MR assessment of cerebral blood volume and mean vessel size using SPION-enhanced ultrashort echo acquisition. NeuroImage (May), 112: 382-389. doi:https://doi.org/10.1016/j.neuroimage.2015.03.042
- Jung H, Park B, Lee C, Cho J, Suh J, Park J, Kim Y, Kim J, Cho G, Cho H. (2014) Dual MRI T1 and T2(*) contrast with size-controlled iron oxide nanoparticles. Nanomedicine : nanotechnology, biology, and medicine (Nov), 10(8): 1679-89.
- Kim H, Cho J, Kim YR, Song Y, Chun SI, Suh JY, Kim JK, Ryu YH, Choi SM, Cho H, Cho G. (2014) Response of the primary auditory and non-auditory cortices to acoustic stimulation: a manganese-enhanced MRI study. PloS one (Jan), 9(3): e90427. doi:10.1371/journal.pone.0090427
Professional Memberships:
- Member; ISMRM (2015–present)
Service Activities:
- American Journal of Neuroradiology; Reviewer (2024)
- Phenomics; Reviewer (2022)
- Frontiers in Neuroscience; Topic Editor (2022–2023)
- Frontiers in Neuroscience; Reviewer (2022)
- Scientific Reports; Reviewer (2021)
- NMR in Biomedicine; Reviewer (2019)