Jennifer K. Lang MD

Jennifer Lang

Jennifer K. Lang
MD

Assistant Professor

Department of Medicine

Jacobs School of Medicine & Biomedical Sciences


Specialty/Research Focus

Cardiology; Cardiovascular Disease; Cell growth, differentiation and development; Gene Expression; Molecular and Cellular Biology; Signal Transduction; Stem Cells

Contact Information
Clinical and Translational Research Center
875 Ellicott Street, Suite 7030
Buffalo, New York 14203
Phone: (716) 829-6118
Fax: 716-854-1840
jklang@buffalo.edu


Patient Care

This faculty member is affiliated with UBMD, practicing physicians who are also professors in the Jacobs School.

View this physician on UBMD


Professional Summary:

As a general cardiologist, I diagnose and treat a wide range of problems that affect the heart and blood vessels, including but not limited to coronary artery disease, valvular heart disease, heart failure, diseases of the myocardium and pericardium, cardiac arrhythmias, conduction disorders and syncope.

I care for patients at Buffalo General Medical Center (BGMC), the Gates Vascular Institute (GVI), the Buffalo VA Medical Center (VAMC) and am a member of the UBMD clinical practice. In addition to treating pre-existing cardiac conditions, I also believe in strong preventive care and addressing modifiable risk factors for coronary disease. I take time to get to know my patients, and I talk with them about measures they can take to reduce their risk for cardiovascular disease and improve their health.

As a clinician-scientist, I have a special interest in developing new stem cell based treatments for heart disease. My research is focused on understanding what stem cell secreted factors are responsible for improved heart function, what their targets are and how these can be modulated to develop new cell-free therapies that can help patients with a wide spectrum of coronary disease and heart failure. I welcome medical students, graduate students, residents and fellows to conduct research with me in my lab.

As a native Buffalonian, I am honored to partner with the patients in our community to help improve their heart health and cardiac knowledge base. I am equally excited to be involved in shaping the next generation of physicians through the teaching I conduct at the medical student, resident and fellow level.

Education and Training:

  • American Board of Internal Medicine (2016)
  • Fellowship, Cardiology, University at Buffalo (2015)
  • Residency, Internal Medicine, University at Buffalo (2012)
  • MD, University at Buffalo School of Medicine (2009)
  • BS, Dual Major in Molecular & Cellular Biology and Neurobiology, Cornell University (2003)

Employment:

  • Assistant Professor, Biomedical Engineering, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (2018-present)
  • Staff Cardiologist, VA Medical Center (2018-present)
  • Assistant Professor, Medicine, Jacobs School of Medicine and Biomedical Sciences (2017-present)
  • Assistant Professor, Pharmacology and Toxicology, Jacobs School of Medicine and Biomedical Sciences (2017-present)
  • Assistant Professor, Medicine, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (2017-present)
  • Assistant Professor, Pharmacology and Toxicology, University at Buffalo School of Pharmacy (2017-present)
  • Graduate Faculty, Graduate School of Education, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (2017-present)
  • Research Assistant Professor, Medicine, Jacobs School of Medicine and Biomedical Sciences Jacobs School of Medicine & Biomedical Sciences (2015–2017)

Awards and Honors:

  • UB Siegel Award Teaching, runner-up (2019)
  • CTSI Scholar (2016)
  • Department of Medicine Research Day, 1st Place (2015)
  • John C. Sable Memorial Heart Fund Grant Recipient (2014)
  • Northwestern Cardiovascular Young Investigators’ Forum, Basic Research 3rd Place (2013)
  • Department of Medicine Research Day, Basic Research 2nd Place (2013)
  • Frawley Fellowship Recipient, University at Buffalo (2012)
  • Excellence in Neurology Award, American Academy of Neurology (2009)
  • Thesis with Research Honors, University at Buffalo (2009)
  • University at Buffalo Medical Student Research Forum Honors (2007)
  • Cornell Presidential Research Scholar, Cornell University (2003)
  • cum laude with Research Distinction, Cornell University (2003)
  • Advanced Placement (AP) Scholar, City Honors (1999)
  • CHS Science Research Program Diploma, City Honors and RPCI (1999)
  • International Baccalaureate Diploma Recipient, City Honors (1999)

Research Expertise:

  • Cardiovascular stem cell therapy

Research Centers:

  • Center for Research in Cardiovascular Medicine

Grants and Sponsored Research:

  • October 2018–September 2023
    The Functional Role of Exosomes in Stem Cell-Mediated Cardiac Repair.
    Veteran‘s Administration
    Role: Principal Investigator
    $1,389,635
  • December 2017–November 2022
    The Functional Role of Exosomes in Stem Cell Mediated Cardiac Repair.
    NIH/NHLBI
    Role: Principal Investigator
    $1,006,430
  • June 2014–June 2015
    The Functional Role of Exosomes in Stem Cell-Mediated Cardiac Repair
    John C. Sable Memorial Heart Fund
    Role: Principal Investigator
    $15,000

Journal Articles:

See all (8 more)

Books and Book Chapters:

  • Varjabedian L, JK Lang, A Kamouh, SJ Horn, T Kemaloglu, KA Sungur, KJ Mehta, K Bhagatwala, N Karia, MGA Escanuela, RP Gatewood and NC NANDA. (2013) Echocardiographic assessment of tumors and masses. In: Echocardiographic assessment of tumors and masses. , 1-62.

Abstracts:

  • Lang JK. (2019) A Transcriptomic Analysis of Cardiac Myofibroblasts Reveals Novel Anti-Fibrotic and Immunomodulatory Genes Modulated by CDC-derived Exosomes. (Jan)
  • Lang JK. (2018) Association of CBR3 Polymorphisms With an Early Change in Cardiac Function as Assessed by Left Ventricular Global Longitudinal Strain in Breast Cancer Patients Treated with Doxorubicin. (Dec)
  • Lang JK, Mentkowski, K. (2018) Development of a Cardiomyocyte Targeting Delivery System Utilizing Cardiosphere-Derived Cell Exosomes. (Jul)
  • Mursleen, A, Mentkowski, K, Lang JK. (2017) CDC-Derived Exosomes Polarize Macrophages to a Distinct Arg1-High Phenotype. (Nov)
  • Lang JK. (2015) Exploring the Functional Role of Exosomes in Stem Cell-Mediated Cardiac Repair. (Jan)
  • Lang JK. (2012) Ciliary Neurotrophic Factor Increases the Angiogenic Properties of Human Pluripotent Stem Cell Derived Neuropilin-1 CD34 Nascent Endothelial Cells Via a JAK2 Dependent Pathway. (Jan)
  • Lang JK. (2011) Genomic Analysis of Early Endothelial Differentiation from Human Stem Cells Identifies Novel Growth Factor Signaling Pathways Involved in Vasculogenesis. (Jan)
  • Lang JK. (2011) Transcriptional Profiling of Pluripotent Stem-Cell Derived Neuropilin1-1CD34 - Vascular Precursors Reveals Significant Overlap with Ventral Mesoderm and Identifies Signaling Pathways in Differentation to Vascular Cells. (Jan)
  • Lang JK. (2005) Quiescent Adult Human Glial Progenitors Tonically Antagonize the Astrogliogenic Effects of BMP4. (Jan)
  • Lang JK. (2005) Statin Treatment of Adult Human Oligodendrocyte Progenitors Induces Precocious PPAR gamma-mediated differentation. (Jan)

Professional Memberships:

  • American College of Cardiology, Fellow (2012–present)
  • American Heart Association (2012–present)
  • American College of Cardiology, Member (2012–present)
  • American Medical Association, Member (2010–present)
  • Society for Neuroscience, Member; Member (2003–2009)

Presentations:

  • "Exploring and Expanding the Therapeutic Roles of Exosomes in Cardioprotection" Medical College of Wisconsin Cardiology Grand Rounds; Medical College of Wisconsin (2018)
  • "Exploring and Expanding the Therapeutic Roles of Exosomes in Cardioprotection" CTRC Women in Science Month - 2018; University at Buffalo (2018)
  • "Exploring the Functional Role of Cardiosphere Derived-Cell (CDC) Exosomes as Paracrine Signal Mediators of Cardioprotection" University at Buffalo; ; Department of Pharmacology and Toxicology Seminar Series (2017)
  • "Gender Differences in Ischemic Heart Disease: Fact or Fiction?" University at Buffalo; ; Department of Medicine Grand Rounds (2017)
  • "EKG Review and Stress Laboratory Emergencies" Society of Nuclear Medicine and Molecular Imaging (SNMMI) EGL Meeting (2016)
  • "Pericarditis: When to Image, When to Treat" UBMD Primary Care Update: CME Conference (2016)
  • "ER Grand Rounds" Pericarditis - Diagnosis, Treatment and Triage in the ER; Gates Vascular Institute; University at Buffalo Grand Rounds (2015)
  • "Primary Care Update: Perioperative Beta-Blocker Controversy Begins Again!" UBMD Primary Care Update: CME Conference; UBMD (2015)
  • "Novel Signaling Pathways Regulate Nascent Endothelial Cells Derived From Human Pluripotent Stem Cells" Northwestern Cardiovascular Young Investigators‘ Forum (2013)
  • "BMP Regulation of Adult Human Oligodendrocyte Progenitor Fate" American Society for Neurochemistry (ASN); American Society for Neurochemistry (2005)

Service Activities:

  • CCHF;; Ad Hoc Reviewer (2017–present)
  • Medical Student Appeals Committee, Member; Member (2017–present)
  • Grant Reviewer - NIH, Early Career Reviewer Program Cardiac Contractility and Heart Failure; San Francisco, June 29-30, 2017; Reviewer (2017–present)
  • Journal Reviewer - Experimental Biology and Medicine (ad hoc) Journal Reviewer - Experimental Biology and Medicine (ad hoc); Reviewer (2016–present)
  • Journal Reviewer - JOVE (ad hoc) Journal Reviewer - JOVE; Reviewer (2016–present)
  • Journal Reviewer - Molecular Biotechnology (ad hoc) Journal Reviewer - Molecular Biotechnology (ad hoc); Reviewer (2016–present)
  • Journal Reviwer - PLoS ONE (ad hoc) Journal Reviwer - PLoS ONE (ad hoc); Reviewer (2016–present)

School News:

In the Media:


Clinical Specialties:

Clinical Offices:

Insurance Accepted:



Contact Information

Clinical and Translational Research Center
875 Ellicott Street, Suite 7030
Buffalo, New York 14203
Phone: (716) 829-6118
Fax: 716-854-1840
jklang@buffalo.edu

This faculty member is affiliated with UBMD, practicing physicians who are also professors in the Jacobs School.

View this physician on UBMD