Manoj J. Mammen MD

Manoj Mammen

Manoj J. Mammen
MD

Assistant Professor

Department of Medicine

Jacobs School of Medicine & Biomedical Sciences


Specialty/Research Focus

Immunology; Protein Function and Structure; Proteins and metalloenzymes; Pulmonary & Critical Care Medicine

Contact Information
Buffalo General Medical Center
100 High Street, B-8
Buffalo, NY 14203
Phone: (716) 859-2271
Fax: 7168591491
mammen@buffalo.edu


Patient Care

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Professional Summary:

I am engaged in clinical, teaching and research responsibilities related to the evaluation and treatment of patients with pulmonary disease or patients who are critically ill. My inpatient practice situated at the medical intensive care unit (MICU) at the Buffalo General Medical Center (BGMC) positions me to provide ongoing medical care to patients who are critically ill and require significant life support therapies to sustain life or vital bodily functioning. I am specifically interested in asthma, COPD, interstitial lung disease, pleural disease, pulmonary hypertension and lung cancer, but deal with a variety of lung disease.

I evaluate patients with pulmonary disorders including shortness of breath, lung masses, abnormal chest imaging, abnormal pulmonary function tests, chronic obstructive pulmonary disease (COPD), asthma, pleural disease, interstitial lung disease, pulmonary hypertension, and lung cancer, at the UBMD practice location at Conventus. As a member of the UBMD pulmonary division, I provide inpatient pulmonary consultation at both BGMC and Roswell Park Cancer Institute.

Currently, I am focusing on the analysis of Big Data in the medical/healthcare fields. I am mainly focused on the application of drug repurposing in translation and clinic research.

Additionally, I am engaged in the study of the human airways microbiome and metagenome. The human microbiome is the collection of all the microbial organisms in a human body, and the corresponding metagenome is the collection of the genes, and gene products of the microbes. Due to the potential impact of the microbiome on human health and disease, I am interested in studying the putative effects the interaction with human hosts, specifically innate immunity interaction with the metagenome in lung disease.

My collaborators include the Division of Allergy and Immunology. We endeavor to elucidate immune cell function in airway diseases such as asthma and COPD. Our research focuses on the development of therapeutics aimed at novel targets identified as necessary in the molecular basis of pulmonary disease; efficacious laboratory results will generate more effective treatment plans for patients.

I am actively involved in teaching medical students, residents, and fellows about the appropriate care of the patient with either pulmonary disease and critical illness.

Education and Training:

  • MS, Genetics, Genomics and Bioinformatics, University at Buffalo (2016)
  • Fellowship, Pulmonary & Critical Care Medicine, Baylor College of Medicine (2010)
  • Residency, Internal Medicine, Baylor College of Medicine (2007)
  • MD, Medicine, Rutgers New Jersey Medical School (2004)
  • BA, Molecular Biology & Biochemistry/Computer Science, Rutgers University (1999)

Employment:

  • Adjunct Assistant Professor, Biomedical Informatics, University at Buffalo (2014-present)
  • Assistant Professor, Medicine, University at Buffalo (2010-present)
  • Medical Director, Western New York Lung Cancer Screening Program, Medicine, Kaleida Health (2013–2016)
  • Student Family Healthcare Center (SFHCC) director, Rutgers New Jersey Medical School (2002–2004)
  • Computer Consultant, Computer Science, NCS technologies (1999–2000)

Awards and Honors:

  • Empire Clinical Research Investigator Program Fellow in Center for Nanomedicine (2014)
  • Gold Humanism Honor Society (2004)
  • Thesis with Honors, Rutgers University (1999)
  • Rutgers Presidential Scholarship (1995)
  • Robert C. Byrd Federal Scholarship (1995)
  • New Jersey Governor‘s School of Public Issues Scholar (1994)

Research Expertise:

  • Biomedical Informatics
  • Critical Care Medicine
  • Data Science
  • Microbiome
  • Pulmonary medicine

Research Centers:

  • Clinical and Translational Research Center (CTRC)
  • Center of Excellence in Bioinformatics and Life Sciences

UB 2020 Strategic Strengths:

  • Molecular Recognition in Biological Systems and Bioinformatics
  • Integrated Nanostructured Systems
  • Information and Computing Technology
  • Health and Wellness Across the Lifespan
  • Extreme Events: Mitigation and Response

Grants and Sponsored Research:

  • July 2018–June 2019
    UB CAT: Circuit Clinical Data Collection and Analytics Systems, phase II
    UB CAT
    Role: Principal Investigator
    $197,563
  • July 2016–June 2019
    UB Genome, Environment, and Microbiome Community of Excellence (GEM) pilot study grant:The Airway Microbiome and Lung cancer in a COPD cohort
    University at Buffalo
    Role: Principal Investigator
    $20,000
  • May 2018–April 2019
    CTSI Pilot Study: Linking New York State Databases to Identify Risk Factors and Gaps in care for rural and urban health disparities in lung cancer
    CTSI
    Role: Co-Investigator
    $50,000
  • November 2017–October 2018
    UB CAT: Circuit Clinical Data Collection and Analytics Systems
    UB CAT
    Role: Principal Investigator
    $486,184
  • October 2016–October 2017
    AstraZeneca AB, D6571C00001
    Role: Co-Investigator
    $8,000
  • July 2016–July 2017
    Epigenetics profiling of Exacerbation Susceptibility in Chronic Obstructive Pulmonary Disease
    CTSA UB UR Collaborative Genomics Pilot Program Award
    Role: Co-Investigator
    $75,000
  • January 2014–December 2016
    Empire Clinical Research Investigator Program: Center for Nanomedicine Fellow
    Role: Co-Investigator
    $292,000
  • April 2014–June 2016
    A Phase I Double-Blind, Randomized, Placebo-Controlled, Multicenter Study Evaluating the Safety, Tolerability, and Pharmokinetics of GS-5745 in Subjects
    Gilead
    Role: Co-Principal Investigator
    $22,260

Journal Articles:

See all (3 more)

Books and Book Chapters:

  • Mahajan SD, You Y, Aalinkeel R, Reynolds JL, Nair, Bindukumar B, Mammen MJ, Ignatowski TA, Cheng, Chong, Schwartz SA. Biodegradable Nanoparticle-Based Antiretroviral Therapy across the Blood-Brain Barrier. Handbook of Clinical Nanomedicine Nanoparticles, Imaging, Therapy, and Clinical Applications. 2016.
  • Mahajan SD, Aalinkeel R, Reynolds JL, Nair BB, Mammen MJ, Dai L, Prasad PN, Schwartz SA. Nanotechnology in Diagnosis, Treatment and Prophylaxis of Infectious Diseases. Nanotherapeutic Approach to Targeting HIV-1 in the CNS: Role of Tight Junction Permeability and Blood. 2015.
  • Hirshkowitz, M, Mammen M,. Emergent sleep events related to medical treatment. Acute and Emergents in Sleep Disorders. 2010; 27.

Abstracts:

  • Bhardwaj A, Savant AC, Tetewsky S, McCray W, Mammen MJ, Khan S, Manion C, Tse ., Liu T, Lee R, Curtis AB, Pershad A, Elkins PL, Corbelli J. Superior Survival With Direct Oral Anticoagulants Compared to Warfarin in Patients With Atrial Fibrillation and Underlying Cancer: Veterans Affairs Database Study. Circulation. 2018; 138.
  • Castner J, Jungquist C, Mammen MJ, Pender J J, Licata O, Wilding G, Sethi S. Developing Multivariable Prediction Models of Asthma Control Components Using Fitness Tracker Sleep Patterns in Women.. American Journal of Respiratory Critical Care Medicine. 2018; 197(A2637).
  • Mammen MJ, Buck M, Sun Y, Waldron N, Valiyaparambil S, Wrona C, Sethi S. Distinct Airway Microbiome Patterns Associated with Lung Cancer Development in a COPD Cohort. American Journal of Respiratory and Critical Care Medicine. 2018; 197.
  • Mammen MJ, Waldron N, Valiyaparambil S, Wrona C, Sethi S. Distinct Airway Microbiome Patterns Associated with Frequent Exacerbator Phenotype in COPD. American Journal of Respiratory and Critical Care Medicine. 2018; 197.
  • Mammen MJ, Tsompana M, Buck M, Biswal S, Criner GJ, Sethi S. Effect Of Sulforaphane Treatment On The Airway Microbiome In COPD. American Journal of Respiratory and Critical Care Medicine. 2017; 195.
  • Parikh NU, Aalinkeel R, Reynolds JL, Quaye E, Cwiklinski K, Sykes DE, Mammen MJ, Sharijkova, A, Khmaladze A, Schwartz SA, Mahajan SD. Methamphetamine (METH) and HIV-tat mediated oxidative stress contributes to Mitochondrial dysfunction in microglia. JOURNAL OF NEUROIMMUNE PHARMACOLOGY. 2017; 12.
  • Parikh NU, Mammen MJ, Cumella JC, Rockoff JB, Schwartz SA. Impact of Lung Flute Therapy on Asthma: A Pilot Study. Journal of Allergy and Clinical Immunology. 2017.
  • Parikh NU, Mahajan SD, Aalinkeel R, Reynolds JL, Nair BN, Sykes DE, Mammen MJ, Schwartz SA. Galectin-1 is Neuroprotectice and Reverses Methamphetamine Induced Blood Brain Barrier Breakdown. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2015.
  • Mammen MJ, Tu, Chengjian, Qu, Jun, Sethi S. Pathway Analysis Of Bronchoalveolar Lavage Fluid Proteome Of Individuals With COPD Compared To Healthy Controls. American Journal of Respiratory and Critical Care Medicine. 2013; 187.
  • Mammen MJ, Qu J, Sethi S. Comprehensive Proteomic Profiling Of Bronchoalveolar Lavage Fluid Of Individuals With COPD Compared To Healthy Controls. American Journal of Respiratory and Critical Care Medicine. 2012; 185.
  • Hesselbacher, S., Xu, C., Tsai, C.L., Schabath, M., Mammen MJ, Perusich, S., Coxson, H.O., Krowchuk, N.M., Corry, D., Kheradmand, F.. Clinical And Immunologic Phenotypes Dictate Physiologic Outcome In COPD: Results From The LES-COPD Study. American Journal of Respiratory and Critical Care Medicine. 2011; 183.
  • Mammen M, Atmar, R, Bandi, V, Greenlee, K, Kheradmand, F. Proteomic Analysis Of Bronchoalveolar Lavage of Patients with COPD and COPD exacerbation. American journal of Respiratory and Critical Care Medicine. 2010; 181(A1010).
  • Shander A, Qin F, Mammen MJ, Chuy J, Dardik H. Treatment of Experimental Acute Severe Anemia with Recombinant Human Erythropoietin. Anesthesiology. 2000; 93(3).
  • Qin F, Shander A, Mammen MJ, Chuy J, Dardik H. Treatment of Experimental Acute Severe Anemia with Parental Iron. Critical Care Medicine. 1999; 27(12).
See all (4 more)

Evaluative Studies and Case Reports:

  • Mammen MJ, Velamuri S. A Clinical Misnomer of Multiple Pulmonary Nodules. Chest. 2009; 136(4).
  • Cantu JA, Akkanti B, Mammen MJ, Raizen Y, Guntupalli KK. Adult Pulmonary Blastoma: A Tale of Two Histologies. Chest. 2009; 136(4).

Professional Memberships:

  • New York State Thoracic Society (2011–present)
  • Society of Critical Care Medicine (2009–present)
  • American Thoracic Society (2007–present)
  • American College of Chest Physicians (2007–present)
  • American College of Physicians (2004–present)
  • American Medical Association (2000–present)
  • American Associations of Physicians of Indian Origin (2000–present)

Presentations:

  • "Detecting Respiratory Compromise in the PACU" American Academy of Nursing Policy Conference, American Academy of Nursing Policy (2018)
  • "How to Assess for Respiratory Compromise When your patient is on Supplemental Oxygen" American Society of Pain Management Nurses Annual Conference, American Society of Pain Management Nurses (2018)
  • "Occupational Lung Disease" Respiratory and Lung Module, University at Buffalo (2018)
  • "Pulmonary Exam" CPM II (2018)
  • "Asthma COPD management" Webinar, Millenium Collaborative Corporation (2018)
  • "Distinct Airway Microbiome Patterns Associated with Frequent Exacerbator Phenotype in COPD" American Thoracic Society International Conference, American Thoracic Society (2018)
  • "Distinct Airway Microbiome Patterns Associated with Lung Cancer Development in a COPD Cohort" American Thoracic Society international Conference, American Thoracic Society (2018)
  • "Pulmonary Diagnostic Testing" UB Internal Medicine Residency Lecture (2017)
  • "Pulmonary Exam" CPM II (2017)
  • "Approach to Shortness of Breath" UB Internal Medicine Residency Lecture (2017)
  • "Update in Lung Cancer Screening" University at Buffalo Family Medicine Grand Rounds, University at Buffalo, Family Medicine (2017)
  • "Pulmonary Diagnostic Testing" UB Internal Medicine Residency Lecture (2016)
  • "Pulmonary Exam" CPM II (2016)
  • "Approach to Dyspnea" UB IM residency conference, University at Buffalo (2016)
  • "Why are Patients with Pneumonia Readmitted?" American Thoracic Society International Conference, American Thoracic Society (2016)
  • "The Airways Microbiome" City-Wide Grand Rounds, University at Buffalo (2016)
  • "Updates on Lung Cancer Screening Guidelines" American Lung Association: NEW HOPE IN THE FIGHT AGAINST LUNG CANCER, American Lung Association of the Northeast, NEW HOPE IN THE FIGHT AGAINST LUNG CANCER (2016)
  • "Pulmonary Exam" CPM II, University at Buffalo, Medical Students (2015)
  • "Approach to CXR" UB IM residency conference, University at Buffalo (2015)
  • "Approach to Dyspnea" UB IM residency conference, University at Buffalo (2015)
  • "An Update on Lung Cancer Screening: Lung Nodule Management" UBMD Primary Care Update (2015)
  • "Interstitial Lung Disease" Core Didactic Conference, University at Buffalo, Internal Medicine (2014)
  • "Pulmonary Exam" CPM II, University at Buffalo, Medical Students (2013)
  • "A Systems Biology approach to COPD" URMC Pulmonary Conference, University at Rochester, Pulmonary and Critical Care Medicine (2013)
  • "Pulmonary Exam" CPM II, University at Buffalo, Medical Students (2012)
  • "Approach to SOB and Interstitial Lung Disease" Grand Rounds, University at Buffalo, Internal Medicine (2012)
  • "Proteomic analysis of bronchoalveolar lavage of patients with COPD and COPD exacerbations" ATS International Conference, American Thoracic Society, Oral Mini-Symposium (2010)
  • "Nonsleepy OSA" Research Symposium, Baylor College of Medicine, Internal Medicine (2010)
  • "A Clinical Misnomer of Multiple Pulmonary Nodules" ACCP Conference, American College of Chest Physicians, Clinical Case (2009)
  • "A case of Pulmonary Blastoma" Citywide Conference, Baylor College of Medicine, Pulmonary (2008)
  • "A case of Asthma in Pregnancy" Citywide Conference, Baylor College of Medicine, Pulmonary (2008)
  • "A case of Benign Metastazing Leiyomyomata" Citywide Conference, Baylor College of Medicine, Pulmonary (2007)
  • "A case of Cardiac Amyloidosis in an African American male: Transthyretin in the Heart" Grand Rounds, Baylor College of Medicine, Internal Medicine (2007)
  • "A case of Cardiac Amyloidosis in an African American male: Transthyretin in the Heart" Research Symposium, Baylor College of Medicine, Internal Medicine (2007)
  • "Healthcare utilization of sleep apnea patients at the VHA" Research Symposium, Baylor College of Medicine, Internal Medicine (2007)
See all (25 more)

Service Activities:

  • Jacobs School of Medicine & Biomedical Sciences Faculty Council; Alternate Member (2014)
  • American Thoracic Society Health Policy Committee member; Committee Member (2017–present)
  • New York State Thoracic Society Poster Session Moderator; Moderator (2017–present)
  • American Thoracic Society Chapter Council Representative; NYS representative to ATS, the NYS CCR representative; Councilor (2017–present)
  • BMC Medical Informatics and Decision Making reviewer; Reviewer (2016–present)
  • New York State Thoracic Society Informatics Committee; Chairman (2016–present)
  • PLoS One journal reviewer; Reviewer (2016–present)
  • UBMD EMR committee; Committee Member (2014–present)
  • Annals of Internal Medicine manuscript reviewer; Reviewer (2014–present)
  • Journal of Neurological Sciences reviewer; Peer Reviewer (2014–present)
  • Journal of Inflammation; Peer Reviewer (2013–present)
  • The American Journal of the Medical Sciences/Manuscript Reviewer; Peer Reviewer (2013–present)
  • American Lung Association, WNY Leadership Board; Board Member (2013–present)
  • Buffalo General Medical Center Patient Safety Committee; Member (2012–2014)
  • American Thoracic Society Clinical Program committee; Member (2012–present)
  • Independent Health, Palliative Care Taskforce; Advisory Committee (2012–2013)
  • Independent Health, COPD program clinical advisory group; Advisory Committee (2011–2012)
  • New York State Thoracic Society, Executive Board; Member (2011–present)
  • Kaleida Health EMR workgroup; Member (2011–present)
  • Student Family Health Care Center Co-Director; The Student Family Health Care Center established after 1967 to meet the needs of the medically underserved, this student-run clinic offers free, quality health care to the Newark community.; Co-Director (2002–2004)

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Contact Information

Buffalo General Medical Center
100 High Street, B-8
Buffalo, NY 14203
Phone: (716) 859-2271
Fax: 7168591491
mammen@buffalo.edu

Looking for a doctor? This faculty member is affiliated with UBMD, the group comprised of practicing physicians who are also professors in the UB Jacobs School of Medicine and Biomedical Sciences.

View this faculty on UBMD