Endocrinology; Endocrinology, Diabetes and Metabolism; Eukaryotic Pathogenesis; Lipid Homeostasis; Mass Spectrometry; Mass Spectrometry; Molecular Basis of Disease; Neurobiology; Neurodegenerative disorders; Pathophysiology; Pharmaceutical Bioanalysis; Pharmacometrics; Vitamins and Trace Nutrients
Dr. Browne’s research is focused primarily on the clinical biochemistry of oxidative stress (OS) in human health and disease. Specifically, his research focuses on mechanisms of oxidative lipid damage and the antioxidant roles of high-density lipoproteins (HDL). This research includes pure biomarker method development and validation employing primarily high pressure liquid chromatography (HPLC) and liquid chromatography-mass spectrometry (LC-MS) along with collaborative clinical studies of the role of oxidative stress in cancer, infertility and women’s health, and neurological disease. Current studies on-going in Dr. Browne’s laboratory include investigations of the role of cholesterol and oxysterols in Multiple Sclerosis disease progression and investigations of the role of bioactive lipid mediators in response to air pollution.