Research Assistant Professor
Bioinformatics; Gene Expression; Geriatric Medicine; Metabolism; Molecular and Cellular Biology; Molecular genetics; Nutrition; Protein Folding; Protein Function and Structure; RNA; Stem Cells; Vitamins and Trace Nutrients
Dr. Kenneth Seldeen holds a doctorate in biochemistry and molecular biology from the University of Miami and is currently an assistant professor in the field of gerontology at the University at Buffalo and the VA Western New York Healthcare System. Presently, he is initiating a double-blind randomized controlled trial to evaluate the benefits of nicotinamide riboside supplementation to enhance functional capacity in older Veterans (NCT04691986). His specific research interests include the identification of possible lifestyle strategies for successful aging, including shorter exercise regimens that can fit into busy schedules and/or nutritional supplementation to boost or maintain functional capacity (e.g., vitamin D and nicotinamide riboside). Dr. Seldeen's expertise is in muscle biology and the use of animal behavioral tests that mirror human clinical measurements – including the use of an animal model of frailty assessment based upon the Fried et al frailty phenotype. He supports such strategies as a means to optimize and accelerate the translation of novel therapeutics. In particular, his work has translated pre-clinical animal models of high intensity interval training to implementation in clinical trials involving Veteran populations. Future goals of this research are to identify underlying predictors of HIIT response (i.e., miRNA biomarkers) as well as the development of HIIT@home protocols to expand community level engagement.