Satpal Singh PhD

Satpal Singh

Satpal Singh
PhD

Professor

Department of Pharmacology and Toxicology

Jacobs School of Medicine & Biomedical Sciences


Specialty/Research Focus

Behavioral pharmacology; Cardiac pharmacology; Ion channel kinetics and structure; Membrane Transport (Ion Transport); Molecular Basis of Disease; Neurobiology; Neuropharmacology; Signal Transduction; Transgenic organisms

Contact Information
955 Main Street
Room 3223
Buffalo, New York 14203
Phone: 7168292453
Fax: (716) 829-2801
singhs@buffalo.edu



Professional Summary:

With over 400 genes coding for them in humans, ion channels play a significant role in most physiological functions. Drug-induced channel dysfunction often leads to a variety of disorders and results in significant incidence of serious injury and death. We investigate molecular mechanisms underlying neurodegenerative disorders and cardiac arrhythmias induced by ion channel dysfunction arising from genetic factors and/or drug interactions. The tools used for these investigations include genetic, electrophysiologic, pharmacologic, molecular and cell culturing methods. Preparations used for experiments include Drosophila as a genetic model system, and human cell lines expressing human ion channels that play an important role in critical-to-life functions including cardiac rhythm, respiration and the central nervous system.

Education and Training:

  • PhD, Molecular Biology, Tata Institute of Fundamental Research, Bombay, India (1980)
  • MS, Physics, Punjab University, Chandigarh, India (1973)
  • BS, Physics, Punjab University, Chandigarh, India (1972)

Employment:

  • Professor, Pharmacology and Toxicology, State University of New York at Buffalo Jacobs School of Medicine & Biomedical Sciences (2016-present)
  • Associate Professor, Pharmacology & Toxicology, State University of New York at Buffalo Jacobs School of Medicine & Biomedical Sciences (1997–2016)
  • Assistant Professor, State University of New York at Buffalo School of Pharmacy (1989–1997)
  • Visiting Associate Professor, Department of Biology, University of Iowa (1989)
  • Assistant Professor, Department of Biology, Guru Nanak Dev (G.N.D.) University (1982–1985)

Awards and Honors:

  • Invited to serve as an Associate Editor for Frontiers in Cellular Neuroscience (Cellular Neurophysiology section) (2021)

Research Expertise:

  • Channelopathies: With over 400 genes coding for them in humans, ion channels play a significant role in most physiological functions. Drug-induced channel dysfunction often leads to a variety of disorders and results in significant incidence of serious injury and death. We investigate molecular mechanisms underlying neurodegenerative disorders and cardiac arrhythmias induced by ion channel dysfunction arising from genetic factors and/or drug interactions. The tools used for these investigations include genetic, electrophysiologic, pharmacologic, molecular and cell culturing methods. Preparations used for in experiments include Drosophila as a genetic model system, and human cell lines expressing human ion channels that play an important role in critical-to-life functions including cardiac rhythm, respiration and the central nervous system.

UB 2020 Strategic Strengths:

  • Health and Wellness Across the Lifespan
  • Molecular Recognition in Biological Systems and Bioinformatics

Grants and Sponsored Research:

  • September 2011–August 2016
    Targeted MSP: The University at Buffalo/Buffalo Public Schools (UB/BPS) Interdisciplinary Science and Engineering Partnership
    National Science Foundation
    Role: Co-Investigator
    $9,831,207
  • July 2010–June 2013
    Subcontract for Science support for NY State Ed Math Science Partnership - Buffalo Public Schools
    New York State Department of Education
    Role: Co-Investigator
    $254,976
  • August 2008–September 2011
    A Genetic Model of Leigh Syndrome Suppression in Drosophila
    NIH (NINDS)
    Role: Principal Investigator
    $158,500
  • January 2006–December 2009
    Interdisciplinary Science Research-based Curricular Innovations for Middle and High School Science and Teacher Professional Development
    John R. Oishei Foundation
    Role: Co-Investigator
    $480,000

Journal Articles:

  • Frolov RV, Ignatova II, Singh S. (2011) Inhibition of HERG potassium channels by celecoxib and its mechanism. PLoS One (Oct), 6(10): 26344-26344.
  • Frolov RV, Ignatova II, Singh S. (2010) Mechanism of K(v)2.1 channel inhibition by a selective COX-2 inhibitor SC-791-modification of gating. Brain Res (Nov), 1359: 67-74.
  • Frolov RV, Bondarenko VE, Singh S. (2010) Mechanisms of Kv2.1 channel inhibition by celecoxib--modification of gating and channel block. Br J Pharmacol (Jan), 159(2): 405-418.
  • Frolov RV, Slaughter MM, Singh S. (2008) Effects of celecoxib on ionic currents and spontaneous firing in rat retinal neurons. Neuroscience (Jul), 154(4): 1525-1532.
  • Frolov RV, Berim IG, Singh S. (2008) Inhibition of delayed rectifier potassium channels and induction of arrhythmia: a novel effect of celecoxib and the mechanism underlying it. J Biol Chem (Jan), 283(3): 1518-1524.
  • W. Liu, R. Gnanasambandam, J. Benjamin, G. Kaur, P. B. Getman, A. J. Siegel, R. D. Shortridge, and S. Singh. (2007) Mutations in Cytochrome c Oxidase Subunit VIa Cause Neurodegeneration and Motor Dysfunction in Drosophila. Genetics (Jan), 176(2).
  • Bhattacharya A, Lakhman SS, Singh S, Lakhman S. (2004) Modulation of L-type calcium channels in Drosophila via a pituitary adenylyl cyclase-activating polypeptide (PACAP)-mediated pathway. J Biol Chem (Sep), 279(36): 37291-37297.
  • Bhattacharya, A., Lakhman, S. S. and Singh, S. (2004) Modulation of L-type Ca2+ Channels in Drosophila via a Pituitary Adenylyl Cyclase-activating Polypeptide (PACAP)-mediated pathway. J. Biol. Chem. (Jan), 279: 37291-37297.
  • Peri R, Triggle DJ, Singh S. (2001) Regulation of L-type calcium channels in pituitary GH(4)C(1) cells by depolarization. J Biol Chem (Aug), 276(34): 31667-31673.
  • R. Peri, Triggle D, Singh S. (2001) Regulation of L-type calcium channels in pituitary GH4C1 cells by depolarization. J. Biol. Chem (Jan), 276: 31667-31673.
  • Peri R, Padmanabhan S, Rutledge A, Singh S, Triggle DJ. (2000) Permanently charged chiral 1,4-dihydropyridines: molecular probes of L-type calcium channels. Synthesis and pharmacological characterization of methyl(omega-trimethylalkylammonium) 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate iodi. J Med Chem (Jul), 43(15): 2906-2914.
  • Chopra, M., Gu, G.-G. and Singh, S. (2000) Mutations Affecting the Delayed Rectifier Potassium Current in Drosophila. J. Neurogenetics (Feb), 14: 107-123.
  • Chopra, M., Gu, G.-G. and Singh, S. (2000) Mutations Affecting the Delayed Rectifier Potassium Current in Drosophila. J. Neurogenetics (Jan), 14: 107-123.
  • Hegde P, Gu GG, Chen D, Free SJ, Singh S. (1999) Mutational analysis of the Shab-encoded delayed rectifier K(+) channels in Drosophila. J Biol Chem (Jul), 274(31): 22109-22113.
  • Bhattacharya A, Gu GG, Singh S. (1999) Modulation of dihydropyridine-sensitive calcium channels in Drosophila by a cAMP-mediated pathway. J Neurobiol (Jun), 39(4): 491-500.
  • Hedge, P., Gu, G-G., Chen, D., Free, S.J. and Singh, S. (1999) Mutational Analysis of the Shab-encoded Delayed Rectifier K+ channels in Drosophila. J. Biol. Chem. (Feb), 274: 22109-22113.
  • Bhattacharya, A., Gu., G.-G. and Singh, S. (1999) Modulation of the Dihydropyridine-Sensitive Calcium Channels in Drosophila by a cAMP-Mediated Pathway. J. Neurobiol. (Feb), 39: 491-500.
  • Singh, A. and Singh, S. (1999) Unmasking of a Novel Potassium Current in Drosophila by a Mutation and Drugs. J. Neurosci. (Feb), 19: 6838-6843.
  • Singh, A., and Singh, S. (1999) Unmasking of a Novel Potassium Current in Drosophila by a Mutation and Drugs. J. Neurosci. (Jan), 19: 6838-6843.
  • Bhattacharya, A., Gu., G.-G. and Singh S. (1999) Modulation of the Dihydropyridine-Sensitive Calcium Channels in Drosophila by a cAMP-Mediated Pathway. J. Neurobiol. (Jan), 39: 491-500.
  • Hegde, P., Gu, G-G., Chen, D., Free, S. J. and Singh, S. (1999) Mutational Analysis of the Shab-encoded Delayed Rectifier K+ channels in Drosophila. J. Biol. Chem. (Jan), 274: 22109-22113.
  • Singh S, Wu CF. (1999) Ionic currents in larval muscles of Drosophila. Int Rev Neurobiol (Jan), 43: 191-220.
  • Kraliz, D., Bhattacharya, A. and Singh, S. (1998) Blockade of the Delayed Rectifier Potassium Current in Drosophila by Quinidine and Related Compounds. J. Neurogenet. (Jan), 12: 25-39.
  • Gu GG, Singh S. (1997) Modulation of the dihydropyridine-sensitive calcium channels in Drosophila by a phospholipase C-mediated pathway. J Neurobiol (Sep), 33(3): 265-275.
  • Gu G.-G. and Singh, S. (1997) Modulation of the dihydropyridine-sensitive Ca2+ channels in Drosophila by a phospholipase C-mediated pathway. J. Neurobiology (Feb), 33: 265-275.
  • Kraliz, D., Bhattacharya, A. and Singh, S. (1997) Blockade of the Delayed Rectifier Potassium Current in Drosophila by Quinidine and Related Compounds. J. Neurogenet. (Feb), 12: 25-39.
  • Kraliz, D. and Singh, S. (1997) Selective blockade of the delayed rectifier potassium current by tacrine in Drosophila. J. Neurobiology (Jan), 32: 1-10.
  • Gu GG, Singh S. (1995) Pharmacological analysis of heartbeat in Drosophila. J Neurobiol (Nov), 28(3): 269-280.
  • Gielow ML, Gu GG, Singh S. (1995) Resolution and pharmacological analysis of the voltage-dependent calcium channels of Drosophila larval muscles. J Neurosci (Sep), 15(9): 6085-6093.
  • Kraliz, D. and Singh, S. (1995) Selective Blockade of the delayed rectifier potassium current by tacrine in Drosophila. J. Neurobiology (Feb), 32: 1-10.
  • Satpal Singh. (1995) Pharmacological analysis of heartbeat in Drosophila. j. Neurobiology (Feb), 28: 269-280.
  • Gielow, M.L., Gu, G.-G. and Singh, S.S. (1995) Resolution and pharmacological analysis of the voltage-dependent calcium channels of Drosophila larval muscles. J. Neuroscience (Jan), 15: 6085-6093.
  • Chopra, M. and Singh, S. (1994) Developmental temperature selectively regulates a voltage-activated potassium current in Drosophila. J. Neurobiol. (Feb), 25: 119-126.
  • Chopra M, Singh S. (1994) Developmental temperature selectively regulates a voltage-activated potassium current in Drosophila. J Neurobiol (Feb), 25(2): 119-126.
  • Singh, S. (1993) Quantification of countercurrent distribution: from molecular partition to animal behavior. Biochem. Biophys. Res. Comm. (Jan), 196: 430-434.
  • Singh S, Wu CF. (1990) Properties of potassium currents and their role in membrane excitability in Drosophila larval muscle fibers. J Exp Biol (Sep), 152: 59-76.
  • Komatsu A, Singh S, Rathe P, Wu CF. (1990) Mutational and gene dosage analysis of calcium-activated potassium channels in Drosophila: correlation of micro- and macroscopic currents. Neuron (Feb), 4(2): 313-321.
  • Komatsu, A., K., Singh, S., Rathe, P. and Wu, C.-F. (1990) Mutational and gene-dosage analysis of calcium-activated potassium channels in Drosophila: Correlation of micro- and macroscopic currents. Neuron (Feb), 4: 313-321.
  • Wu CF, Tsai MC, Chen ML, Zhong Y, Singh S, Lee CY. (1989) Actions of dendrotoxin on K+ channels and neuromuscular transmission in Drosophila melanogaster, and its effects in synergy with K+ channel-specific drugs and mutations. J Exp Biol (Nov), 147: 21-41.
  • Wu, C.-F., Tsai, M.-C., Chen, M.-L., Zhong, Y., Singh, S. and Lee, C.Y. (1989) Actions of dendrotoxin on K+ channels and neuromuscular transmission in Drosophila melanogaster and its effects in synergy with K+ channel-specific drugs and mutations. J. Exp. Biol. (Feb), 147: 21-41.
  • Singh, S., Bhandari, P., Chopra, M.J.S. and Guha, D. (1989) Isolation of autosomal mutations in Drosophila melanogaster without setting up lines. Molec. Gen. Genet. (Feb), 208: 226-229.
  • Singh, S. and Siddiqi, O. (1989) Torpid, a new sex linked temperature paralytic mutation in Drosophila melanogaster. Molec. Gen. Genet. (Feb), 181: 400-402.
  • Singh, A. and Wu, C.-F. (1989) Complete separation of four potassium currents in Drosophila. Neuron (Jan), 2: 1325-1329.
  • Schlegel, P., Jen, P.H.-S. and Singh, S. (1988) Auditory spatial sensitivity of inferior collicular neurons of echolocating bats. Brain Res. (Jan), 456: 127-138.
  • Singh S Bhandari B Chopra MJS Guha D. (1987) Isolation of autosomal mutations in Drosophila melanogaster without setting up lines. Molec Gen Genet (Jan), 208: 226-229.
  • Neuweiler, G., Singh, S. and Sripathi, K. (1984) Audiograms of a South Indian bat community. J. Comp. Physiol. (Jan), 154: 133-142.
  • Singh, S. (1983) A mutagenesis scheme for obtaining autosomal mutations in Drosophila. Ind. J. Exp. Biol. (Feb), 21: 635-636.
  • Schlegel, P. and Singh, S. (1983) Unmasking in neurons of the inferior colliculus of Eptesicus fuscus with binaural stimulation. Hearing Res. (Jan), 10: 331-343.
  • Singh S Siddiqi O. (1981) torpid , a new sex linked temperature paralytic mutation in Drosophila melanogaster. Molec. Gen. Genet. (Jan), 181: 400-402.
  • Singh, S. and Wu, C.-F. (1900) Properties of potassium currents and their role in membrane excitability in Drosophila larval muscle fibers. J. Exp. Biol. (Jan), 152: 59-76.
  • Peri, R., Padmanabhan, S., Rutledge, A., Singh, A. and Triggle, D.J. (1900) Permanently charged chiral 1,4-dihydropyridines: molecular probes of L-type calcium channels. Synthesis and Pharmacological characterization of methyl (w-trimethylalkylammonium) 1,4-dihydro-2,6-dimethyl-4-(3nitrophenyl)-3,5-pyridinedicarboxylate iodide,. J. Med. Chem. (Jan), 43: 2906-2914.
See all (41 more)

Service Activities:

  • Member, Graduate Studies Subcommittee of the President's Advisory Committee on Race. Discussed and offered recommendations on the curricular and pedagogy aspects of graduate education at the University.; Member. (2021)
  • Member, Selection Committee, 2021 Council of Graduate Schools/ProqQuest Distinguished Dissertation Award. Reviewed applications for submission for the CGS Award.; Member. (2021)
  • Member: Awards, Fellowships, and Accolades subcommittee of the Faculty Council's standing committee on Diversity, Inclusion, And Learning Environment.; Member (2021–present)
  • Judged posters for Medical Student Research Forum.; Reviewer (2021)
  • Arrange and conduct review of manuscripts submitted to the Journal.; Associate Editor: Frontiers in Cellular Neuroscience (the section on Cellular Neurophysiology) (2021–present)
  • With colleagues from the Alison Des Forges Memorial Committee, I organized an international symposium on “COVID-19: Human Rights and International Cooperation”. As a part of this, I moderated a Roundtable session on "International Cooperation in Response to the COVID-19 Pandemic" with the panelists Julia Hall, a human rights lawyer at Amnesty International (AI), International Secretariat in London; Rajat Khosla, a Senior Director at the International Secretariat of AI; and Fionnuala Ni´ Aola´in, Special Rapporteur of human rights and fundamental freedoms, the UN High Commissioner for Human Rights.; One of the main symposium organizers and a session moderator (2021)
  • Member Faculty Council's Standing Committee on Student Appeals. Consider student appeals and make recommendations to the Dean on matters of dismissal and/or grievance.; Member (2019–2021)
  • Member, Jacob School's Ad Hoc Committee on Promotions to Academic (Tenurial) Ranks. Discuss dossiers for promotions in the Tenure Track ranks, and make recommendations to the Dean.; Member. (2019–2022)
  • The Family Justice Center provides all-inclusive one-stop help to victims of Domestic Violence and relationship abuse. The Board of Directors formulates the Center's policies and helps the Center's functioning in all aspects.; Member, Board of Directors, Family Justice Center of Erie County (2019–present)
  • The focus of the Public Awareness Committee is to create awareness about the issue of violence against women, and to increase community engagement on this issue.; Member, Public Awareness Committee of the Family Justice Center of Erie County. (2019–present)
  • Member, Faculty Council's Standing Committee on Diversity, Inclusion, and Learning Environment (DIALE).; Member (2018–present)
  • Member, Religious Leaders Circle, Multifaith Alliance (MFA) for Syrian Refugees: in coordination with Israel Defense Forces and Syrian NGOs, MFA has delivered over $140 million in critical supplies to internally displaced Syrian refugees.; Member (2016–present)
  • Member, Faculty Diversity and Inclusion Advocates.; Member (2015–present)
  • The committee was formed in the memory of a UB professor, who worked to improve human rights situation in Rwanda and other places, and was a McArthur Awardee. The committee focuses on improving the status of human rights across the world. Among its other approaches, it holds an annual symposium on a topical issue in collaboration with many programs at UB. It also sponsors scholarships for UB students interested in pursuing a career in addressing human rights issues in the world.; Member, Alison L. Des Forges Memorial Committee (2014–present)
  • Member, Executive Council, Religions for Peace (RFP), USA. RFP is an international coalition of representatives from over 72 countries, dedicated to promoting peace in the world.; Member, Executive Council (2013–present)
  • Member, Academic Planning and Assessment Committee of the Faculty Senate. The committee considers and offers recommendations to the Faculty Senate Executive Committee on academic issues such as establishment of departments and programs; new curricula; and related issues.; Member (1996–present)
  • Member, Graduate School Executive Committee. Discuss and decide policies and procedures for the Graduate School.; Member (1995–present)

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Contact Information

955 Main Street
Room 3223
Buffalo, New York 14203
Phone: 7168292453
Fax: (716) 829-2801
singhs@buffalo.edu