Takefumi Komiya
Takefumi Komiya
Clinical Associate Professor
Jacobs School of Medicine & Biomedical Sciences
Specialty/Research Focus
Immunotherapy; Lung; Medical Oncology
Contact Information
Patient Care
Patient Care
This faculty member is affiliated with UBMD, practicing physicians who are also professors in the Jacobs School.
View this physician on UBMDProfessional Summary:
My previous efforts and accomplishments illustrate continuing interest in lung cancer research. My initial training in Japan as a pulmonary physician gave me the opportunity to learn lung cancer management. Although I had already achieved a faculty position in Japan, I planned to become a physician scientist in the US in the field of thoracic oncology. I finally obtained a faculty position in 2013 to conduct clinical and research activity at The University of Kansas Medical Center.
I will continue to work in this field. I have experience in translational research. I will try to develop a novel treatment in lung cancer by conducting investigator-initiated trials (IITs) with immunotherapy and others in thoracic oncology. I will also work on population and hospital based data research in oncology.
Education and Training:
- Fellowship, Medical Oncology, National Institutes of Health, National Cancer Institute (2013)
- Residency, Internal medicine, Howard University (2010)
- PhD, Medicine, Kindai University (2005)
- Other, Visiting (Research) Fellow, National Cancer Institute (2003)
- MD, Medicine, Kagoshima University (1990)
Employment:
- Assistant Professor, Internal Medicine, Kindai University
- Assistant Professor, Internal Medicine, Tulane University
- Assistant Professor, Internal Medicine, University of Kansas
- Clinical Associate Professor, Internal Medicine, University at Buffalo
Awards and Honors:
- Appreciation Award by President, (2019)
- Conquer Cancer Foundation of ASCO Merit Award (2013)
- Resident of Year (2010)
- Kindai University Medical Award (2003)
Research Expertise:
- Database Analysis: NCDB, NCI-SEER
- Investigator-initiated trial
- Lung Cancer: Treatment of Lung Cancer
Grants and Sponsored Research:
- Phase I/II study of Atezolizumab in combination with pirfenidone in immunotherapy-refractory non-small cell lung cancer
Genentech
Role: Principal Investigator - Phase I study of epacadostat (INCB24360) in combination with sirolimus in advanced malignancy
Incyte
Role: Principal Investigator
$500,000
Journal Articles:
- Takamori S, Shimokawa M, Komiya T. (2021) Prognostic impact of chronological age on efficacy of immune checkpoint inhibitors in non-small-cell lung cancer: Real-world data from 86?173 patients. Thoracic cancer (Nov), 12(21): 2943-2948. doi:10.1111/1759-7714.14178
- Jabbour SK, Lee KH, Frost N, Breder V, Kowalski DM, Pollock T, Levchenko E, Reguart N, Martinez-Marti A, Houghton B, Paoli JB, Safina S, Park K, Komiya T, Sanford A, Boolell V, Liu H, Samkari A, Keller SM, Reck M. (2021) Pembrolizumab Plus Concurrent Chemoradiation Therapy in Patients With Unresectable, Locally Advanced, Stage III Non-Small Cell Lung Cancer: The Phase 2 KEYNOTE-799 Nonrandomized Trial. JAMA oncology (Jun). doi:10.1001/jamaoncol.2021.2301
- Komiya T, Powell E, Takamori S. (2021) Role of thoracic radiation in extensive stage small cell lung cancer: a NCDB analysis. Medical oncology (Northwood, London, England) (Mar), 38(4): 44.
- Komiya T, Powell E, Takamori S. (2021) Prognostic Impact of Single and Multiple Descriptors in Pathologically Staged T3N0M0 NSCLC. JTO clinical and research reports (Mar), 2(3): 100111. doi:10.1016/j.jtocrr.2020.100111
- Komiya T, Ravindra N, Powell E. (2021) Role of Immunotherapy in Stage IV Large Cell Neuroendocrine Carcinoma of the Lung. Asian Pacific journal of cancer prevention : APJCP (Feb), 22(2): 365-370. doi:10.31557/APJCP.2021.22.2.365
- Takamori S, Komiya T, Powell E. (2021) Survival benefit from immunocheckpoint inhibitors in stage IV non-small cell lung cancer patients with brain metastases: A National Cancer Database propensity-matched analysis. Cancer medicine (Feb), 10(3): 923-932. doi:10.1002/cam4.3675
- Komiya T, Powell E, Guddati AK. (2020) Recent trends in use of adjuvant chemotherapy in elderly stage II-III non-small cell lung cancer. Translational lung cancer research (Aug), 9(4): 1180-1186. doi:10.21037/tlcr-19-564
- Guddati AK, Komiya T, Patel SJ, Sharma N, Powell E. (2020) Impact of immunotherapy use in patients with stage IV pancreatic carcinoma. Journal of gastrointestinal oncology (Aug), 11(4): 654-662. doi:10.21037/jgo-20-191
- Komiya T, Chaaya G, Deshotels L, Wang A. (2020) Difference of environment behind research and clinical practice between USA and Japan. Journal of thoracic disease (Jul), 12(7): 3804-3808. doi:10.21037/jtd.2019.07.70
- Komiya T, Powell E, Vu CC, Guddati AK. (2020) Role of T0 status in overall survival for unresectable stage III non-small cell lung cancer: A NCDB analysis. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology (Jul), 148: 8-13.
- Deshotels L, Chaaya G, Komiya T. (2020) An Overview of Lung and Breast Cancer Using the National Cancer Database. Asian Pacific journal of cancer prevention : APJCP (Jan), 21(1): 163-167. doi:10.31557/APJCP.2020.21.1.163
- Wang A, Komiya T. (2019) Brain metastasis as exclusion criteria in clinical trials involving extensive-stage small cell lung cancer. Journal of cancer research and clinical oncology (Dec), 145(12): 3099-3104.
- Komiya T, Blumenthal GM, DeChowdhury R, Fioravanti S, Ballas MS, Morris J, Hornyak TJ, Wank S, Hewitt SM, Morrow B, Memmott RM, Rajan A, Dennis PA. (2019) A Pilot Study of Sirolimus in Subjects with Cowden Syndrome or Other Syndromes Characterized by Germline Mutations in PTEN. The oncologist (Dec), 24(12): 1510-e1265. doi:10.1634/theoncologist.2019-0514
- Komiya T, Memmott RM, Blumenthal GM, Bernstein W, Ballas MS, De Chowdhury R, Chun G, Peer CJ, Figg WD, Liewehr DJ, Steinberg SM, Giaccone G, Szabo E, Kawabata S, Tsurutani J, Rajan A, Dennis PA. (2019) A phase I/II study of pemetrexed with sirolimus in advanced, previously treated non-small cell lung cancer. Translational lung cancer research (Jun), 8(3): 247-257. doi:10.21037/tlcr.2019.04.19
- Komiya T, Guddati AK, Nakanishi Y. (2019) Clear cell adenocarcinoma of the lung: a SEER analysis. Translational lung cancer research (Apr), 8(2): 187-191. doi:10.21037/tlcr.2018.10.13
- Komiya T, Chaaya G, Powell E. (2019) Addition of chemotherapy improves overall survival in patients with T2N0M0 non-small cell lung cancer undergoing definitive radiation therapy: An analysis of the SEER database. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology (Feb), 131: 75-80.
- Komiya T, Guddati AK, Chaaya G. (2018) Overview of publications on lung cancer using the SEER database. Respiratory investigation (Sep), 56(5): 424-426.
- Komiya T, Huang CH. (2018) Updates in the Clinical Development of Epacadostat and Other Indoleamine 2,3-Dioxygenase 1 Inhibitors (IDO1) for Human Cancers. Frontiers in oncology (Jan), 8: 423. doi:10.3389/fonc.2018.00423
- Komiya T, Perez RP, Yamamoto S, Neupane P. (2017) Primary lung mucoepidermoid carcinoma: analysis of prognostic factors using surveillance, epidemiology and end results program. The clinical respiratory journal (Nov), 11(6): 847-853.
- Komiya T, Yamamoto S, Roy A, McDonald P, Perez RP. (2017) Drug screening to target nuclear orphan receptor NR4A2 for cancer therapeutics. Translational lung cancer research (Oct), 6(5): 600-610. doi:10.21037/tlcr.2017.07.02
- Komiya T, Mackay CB, Chalise P. (2017) Who treats lung cancer? Results from a global survey. Respiratory investigation (Sep), 55(5): 308-313.
- Komiya T, Mackay CB, Chalise P. (2017) Status of oncologic specialties: global survey of physicians treating cancer. International journal of clinical oncology (Apr), 22(2): 237-243.
- Komiya T, Perez RP, Erickson KD, Huang CH. (2016) Systematic analysis of design and stratification for phase III trials in first-line advanced non-small cell lung cancer. Thoracic cancer (Jan), 7(1): 66-71. doi:10.1111/1759-7714.12276
- Komiya T, Palla SL, Wang F, Perez RP, Huang CH. (2014) Infrequent chemoradiation-induced acute esophagitis in the Asian population: A meta-analysis of published clinical trials for unresectable stage III non-small cell lung cancer. Thoracic cancer (Nov), 5(6): 565-9. doi:10.1111/1759-7714.12141
- Blumenthal GM, Gills JJ, Ballas MS, Bernstein WB, Komiya T, Dechowdhury R, Morrow B, Root H, Chun G, Helsabeck C, Steinberg SM, LoPiccolo J, Kawabata S, Gardner ER, Figg WD, Dennis PA. (2014) A phase I trial of the HIV protease inhibitor nelfinavir in adults with solid tumors. Oncotarget (Sep), 5(18): 8161-72. doi:10.18632/oncotarget.2415
- Kawabata S, Chiang CT, Tsurutani J, Shiga H, Arwood ML, Komiya T, Gills JJ, Memmott RM, Dennis PA. (2014) Rapamycin downregulates thymidylate synthase and potentiates the activity of pemetrexed in non-small cell lung cancer. Oncotarget (Feb), 5(4): 1062-70. doi:10.18632/oncotarget.1760
- Shuch B, Ricketts CJ, Vocke CD, Komiya T, Middelton LA, Kauffman EC, Merino MJ, Metwalli AR, Dennis P, Linehan WM. (2013) Germline PTEN mutation Cowden syndrome: an underappreciated form of hereditary kidney cancer. The Journal of urology (Dec), 190(6): 1990-8. doi:10.1016/j.juro.2013.06.012
- Komiya T, Fujita S, Watanabe K. (2011) A novel resource polymorphism in fish, driven by differential bottom environments: an example from an ancient lake in Japan. PloS one (Feb), 6(2): e17430. doi:10.1371/journal.pone.0017430
- Kurata T, Yamamoto N, Komiya T, Tsurutani J, Miyazaki M, Tamura K, Takeda K, Nakagawa K, Fukuoka M. (2010) A phase I study of gemcitabine plus irinotecan for advanced NSCLC: Japan Clinical Oncology Group Trial (JCOG9904). Japanese journal of clinical oncology (Oct), 40(10): 992-4.
- Park Y, Kubo A, Komiya T, Coxon A, Beebe K, Neckers L, Meltzer PS, Kaye FJ. (2008) Low-penetrant RB allele in small-cell cancer shows geldanamycin instability and discordant expression with mutant ras. Cell cycle (Georgetown, Tex.) (Aug), 7(15): 2384-91. doi:10.4161/cc.6363
- Suzuki H, Matsui K, Hirashima T, Kobayashi M, Sasada S, Okamato N, Kitai N, Kawahara K, Fukuda H, Komiya T, Kawase I. (2006) Three cases of the nodular pulmonary amyloidosis with a longterm observation. Internal medicine (Tokyo, Japan) (Jan), 45(5): 283-6.
- Komiya T, Fusetani N, Matsunaga S, Kubo A, Kaye FJ, Kelley MJ, Tamura K, Yoshida M, Fukuoka M, Nakagawa K. (2003) Ritterazine B, a new cytotoxic natural compound, induces apoptosis in cancer cells. Cancer chemotherapy and pharmacology (Mar), 51(3): 202-8.
- Tonon G, Modi S, Wu L, Kubo A, Coxon AB, Komiya T, O. (2003) t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway. Nature genetics (Feb), 33(2): 208-13.
- Tsurutani J, Nitta T, Hirashima T, Komiya T, Uejima H, Tada H, Syunichi N, Tohda A, Fukuoka M, Nakagawa K. (2002) Point mutations in the topoisomerase I gene in patients with non-small cell lung cancer treated with irinotecan. Lung cancer (Amsterdam, Netherlands) (Mar), 35(3): 299-304.
- Tsurutani J, Komiya T, Uejima H, Tada H, Syunichi N, Oka M, Kohno S, Fukuoka M, Nakagawa K. (2002) Mutational analysis of the beta-tubulin gene in lung cancer. Lung cancer (Amsterdam, Netherlands) (Jan), 35(1): 11-6.
Professional Memberships:
- ASCO, AACR, IASLC; American Society of Clinical Oncology, American Association for Cancer Research, International Association for the Study of Lung Cancer
Presentations:
- "Genomic medicine in US." Seminar at Osaka Habikino Medical Center, Osaka, Japan. Oct 31, 2019. (2019)
- "Targeting mTOR signaling to enhance immunotherapy in lung cancer." Annual meeting of Japan Society of Clinical Oncology, Fukuoka, Japan. October 26, 2019 (2019)
- "Ethical guidelines for clinical research in US." Annual meeting of Japan Society of Clinical Oncology, October 22, 2016, Yokohama, Japan. (2016)
- "Lung cancer patients and their employment," Annual meeting of Japan Lung Cancer Society, November 16, 2014, Kyoto, Japan (2014)
Service Activities:
- ; IRB at University of Kansas, UB (2014–present)
- Journal of Cancer Metastasis and Treatment; Junior editor
- Translational Lung Cancer Research; Reviwer
- Frontiers in oncology; Topic editor