Jacobs School of Medicine and Biomedical Sciences

Animesh A. Sinha MD, PhD

Department of Dermatology

Rita M. and Ralph T. Behling Professor and Chair of Dermatology

Specialty/Research Focus

Autoimmunity; Dermatology; Gene Expression; Genomics and proteomics; Immunology

Overview Research Publications Activities Latest News

Education and Training:

PhD, Medical Sciences (Immunology), University of Alberta (1986)
MD, University of Alberta (1982)

Employment:

Professor and Chair, Dermatology, University at Buffalo (2011-present)
Associate Professor, Dermatology, Cornell University (2005-present)
Director, Dermatology, Michigan State University (2005–2011)
Associate Professor, Dermatology, Michigan State University (2005–2011)
Assistant Professor, Dermatology, Cornell University (1998–2005)
Associate Scientist, Dermatology, Yale University (1995–1998)
Associate Scientist, Medicine, University at Alberta, Canada (1992–1995)
Research Fellow, Microbiology and Immunology, Stanford University (1986–1992)
Research Fellow, University of Alberta, Canada (1982–1986)

Awards and Honors:

Doctor of the Year/Excellence in Research Award, (2009)
Women's Dermatology Society Mentorship Award (1997)
Medical Research Council of Canada Centennial Fellowship Award (1989)
AHFMR Independent Research Allowance Fellowship Award (1986)
AHFMR Part-time Studentship Award (1982)
Alberta Heritage Foundation for Medical Research Summer Studentship Award (1982)
Searle Research Scholarship in Pharmacology (1979)
Arthritis Foundation Investigator Award (1990 - 1994)
Arthritis Foundation Fellowship Award (1989 - 1990)
Dermatology Foundation Career Development Award (2000 - 2003)
AHFMR Research Fellowship Award (1982 - 1986)
Province of Alberta Scholarship (1976 - 1978)

Research Expertise:

Immunological Tolerance and Autoimmunity.: To pinpoint targets for immune intervention and potentially gene therapy in autoimmune disease

Grants and Sponsored Research:

January 2010–December 2011
Monitoring Autoimmune Activity in Pemphigus
Crescent Healthcare, Inc.
Role: Co-Investigator
$3,000
February 2007–January 2009
Mechanisms of Autoimmunity in the Skin
Role: Co-Investigator
$75,000
February 2007–January 2009
Functional Analysis of IFN-Y Regulated OAS1 Over-Expression in Cutaneous LE
Alliance for Lupus Research
Role: Co-Investigator
$75,000
July 2004–June 2006
Gene Expression Analysis in Vitiligo
American Vitiligo Research Foundation
Role: Co-Investigator
$30,000
May 2002–December 2005
Human Gene Expression Profiling in Vitiligo by Microarray
National Vitiligo Foundation
Role: Co-Investigator
$30,000
January 2002–January 2005
Identifying And Characterizing Human Skin Genes Using DNA Chip Technology
Colgate-Palmolive, Co
Role: Co-Investigator
$75,000
July 2000–July 2004
Genome Wide Expression Analysis in Lupus Erythematosus
Mary Kirkland Center for Lupus Research
Role: Co-Investigator
$143,850
July 2001–June 2004
Genetic Basis of Cutaneous Lupus Erthematosus
Colleck Research Fund
Role: Co-Investigator
$400,000
February 2002–January 2004
Genome Wide Expression Analysis in Psoriasis
National Psoriasis Foundation
Role: Co-Investigator
$150,000
September 1998–September 2001
Mapping of Genes for Alopecia Areata in the General Population
NIH/NIAMS
Role: Co-Investigator
$150,000
July 1998–June 2001
Genetic Basis of Autoimmunity
Colleck Research Fund
Role: Principal Investigator
$390,000

See all (1 more)

Evaluative Studies and Case Reports:

Chacon GR, Wolfson DJ, Palacio C, Sinha AA. Darier's disease: a commonly misdiagnosed cutaneous disorder. J Drugs Dermatol. 2008; 7(4).
Tong JC, Tan TW, Sinha AA, Ranganathan S. Prediction of desmoglein-3 peptides reveals multiple shared T-cell epitopes in HLA DR4- and DR6-associated pemphigus vulgaris. BMC Bioinformatics. 2006; 7 Sup.
Schadlow MB, Anhalt GJ, Sinha AA. Using rituximab (anti-CD20 antibody) in a patient with paraneoplastic pemphigus. J Drugs Dermatol. 2003; 2(5).
Montiel NJ, Li CY, Zaw KM, Sinha AA. Case and discussion of Lyme disease. J Drugs Dermatol. 2003; 2(4).
Schadlow M, Laochumroonvorapong P, Burack L, Wu H, Sinha AA. Nodules on the arm of a diabetic patient. Arch Dermatol. 2003; 139(1).
Scheinfeld N, Pollack MJ, McNiff JM, Imaeda S, Sinha AA. Two men with toxic shock syndrome presenting with targetoid and spotty skin rashes. Acta Derm Venereol. 2002; 82(6).
Laochumroonvorapong P, Coven T, Sinha AA, Wu H, McNutt NS. Photo quiz. Fibrous histiocytoma. Cutis. 2000; 66(2).
Sinha AA. Kaposi's Sarcoma (classical type) - a case report.. J.Can. Dermatol. Assoc.. 1994; 1(23).
Sinha AA. Levedo Vasculitis - a case report. J. Can. Dermatol. Assoc.. 1994; 8(1).

Journal Articles:

Sajda T, Hazelton J, Patel M, Seiffert-Sinha K, Steinman L, Robinson W, Haab BB, Sinha AA, Seiffert K. Multiplexed autoantigen microarrays identify HLA as a key driver of anti-desmoglein and -non-desmoglein reactivities in pemphigus. Proc Natl Acad Sci U S A. 2016; 113(7).
Seiffert-Sinha K, Yang R, Fung CK, Lai KW, Patterson KC, Payne AS, Xi N, Sinha AA. Nanorobotic investigation identifies novel visual, structural and functional correlates of autoimmune pathology in a blistering skin disease model. PLoS One. 2014; 9(9).
Dey-Rao R, Sinha AA. Vitiligo blood transcriptomics provides new insights into disease mechanisms and identifies potential novel therapeutic targets. BMC Genomics. 2017; 18(1).
Ahmed AR, Carrozzo M, Caux F, Cirillo N, Dmochowski M, Alonso AE, Gniadecki R, Hertl M, LÃ³pez-Zabalza MJ, Lotti R, Pincelli C, Pittelkow M, Schmidt E, Sinha AA, Sprecher E, Grando SA. Monopathogenic vs multipathogenic explanations of pemphigus pathophysiology. Exp Dermatol. 2016; 25(11).
Hoffman MB, Bhandari RA, Sinha AA. Rituximab Use in Pediatric Dermatology. J Drugs Dermatol. 2016; 15(7).
Ahmed AR, Carrozzo M, Caux F, Cirillo N, Dmochowski M, Alonso AE, Gniadecki R, Hertl M, López-Zabalza MJ, Lotti R, Pincelli C, Pittelkow M, Schmidt E, Sinha AA, Sprecher E, Grando SA. Monopathogenic vs. multipathogenic explanations of pemphigus pathophysiology. Exp Dermatol. 2016.
Hsu DY, Brieva J, Sinha AA, Langan SM, Silverberg JI. Comorbidities and inpatient mortality for pemphigus in the U.S.A. Br J Dermatol. 2016; 174(6).
Lucchese A, Sinha AA. Nuclear magnetic resonance titration of the interaction between pemphigus vulgaris autoantibodies and REWVKFAKPCRE, a therapeutic desmoglein 3 peptide. Clin Exp Dermatol. 2016.
Hsu DY, Brieva J, Sinha AA, Langan S, Silverberg JI. Comorbidities and inpatient mortality for Pemphigus in the United States. Br J Dermatol. 2016.
Shah AA, Dey-Rao R, Seiffert-Sinha K, Sinha AA, Seiffert K. Increased oxidative stress in pemphigus vulgaris is related to disease activity and HLA-association. Autoimmunity. 2016.
Dey-Rao R, Sinha AA. Interactome analysis of gene expression profile reveals potential novel key transcriptional regulators of skin pathology in vitiligo. Genes Immun. 2016; 17(1).
Dey-Rao R, Sinha AA. Interactome analysis of gene expression profile reveals potential novel key transcriptional regulators of skin pathology in vitiligo. Genes Immun. 2015.
Powell JG, Grover RK, Plunkett RW, Seiffert-Sinha K, Sinha AA. Evaluation of a Newly Available ELISA for Envoplakin Autoantibodies for the Diagnosis of Paraneoplastic Pemphigus. J Drugs Dermatol. 2015; 14(10).
Dey-Rao R, Sinha AA. Genome-wide transcriptional profiling data from skin of chronic cutaneous lupus erythematosus (CCLE) patients. Data Brief. 2015; 4.
Aires DJ, Rockwell G, Menter A, Nielson C, Wick J, Sedivy S, Tawfik O, Bowcock A, Sinha AA. Reproducible Novel Transcriptional Differences Between Psoriatic Lesional and Non-Lesional Skin Show Increased Inflammation and Metabolism. J Drugs Dermatol. 2015; 14(8).
Sinha AA. Paraneoplastic Pemphigus: autoimmune-cancer nexus in the skin. Anticancer Agents Med Chem. 2015.
Naseer SY, Seiffert-Sinha K, Sinha AA. Detailed profiling of anti-desmoglein autoantibodies identifies anti-Dsg1 reactivity as a key driver of disease activity and clinical expression in pemphigus vulgaris. Autoimmunity. 2015; 48(4).
Dey-Rao R, Sinha AA. Genome-wide transcriptional profiling data from chronic cutaneous lupus erythematosus (CCLE) peripheral blood. Data Brief. 2015; 2.
Sinha AA. To (anti-)TNF or not (anti-)TNF? That is the question in pemphigus. Br J Dermatol. 2015; 172(3).
Shah AA, Seiffert-Sinha K, Sirois D, Werth VP, Rengarajan B, Zrnchik W, Attwood K, Sinha AA. Development of a disease registry for autoimmune bullous diseases: initial analysis of the pemphigus vulgaris subset. Acta Derm Venereol. 2015; 95(1).
Henderson MT, Kubo JT, Desai M, David SP, Tindle H, Sinha AA, Seiffert-Sinha K, Hou L, Messina C, Saquib N, Stefanick ML, Tang JY. Smoking behavior and association of melanoma and nonmelanoma skin cancer in the Women‘s Health Initiative. J Am Acad Dermatol. 2015; 72(1).
Yang R, Song B, Sun Z, Lai KW, Fung CK, Patterson KC, Seiffert-Sinha K, Sinha AA, Xi N. Cellular level robotic surgery: Nanodissection of intermediate filaments in live keratinocytes. Nanomedicine. 2015; 11(1).
Sinha AA, Hoffman MB, Janicke EC. Pemphigus vulgaris: approach to treatment. Eur J Dermatol. 2014.
Dey-Rao R, Sinha AA. Genome-wide transcriptional profiling of chronic cutaneous lupus erythematosus (CCLE) peripheral blood identifies systemic alterations relevant to the skin manifestation. Genomics. 2014.
Parameswaran A, Attwood K, Sato R, Seiffert-Sinha K, Sinha AA. Identification of a new disease cluster of Pemphigus vulgaris with autoimmune thyroid disease, rheumatoid arthritis, and type I diabetes. Br J Dermatol. 2014; 172(3).
Yang R, Song B, Sun Z, Lai KW, Fung CK, Patterson KC, Seiffert-Sinha K, Sinha AA, Xi N. Cellular level robotic surgery: Nanodissection of intermediate filaments in live keratinocytes. Nanomedicine. 2014; 11(1).
Wysong A, Ally MS, Gamba CS, Desai M, Swetter SM, Seiffert-Sinha K, Sinha AA, Stefanick ML, Tang JY. Non-melanoma skin cancer and NSAID use in women with a history of skin cancer in the Women‘s Health Initiative. Prev Med. 2014; 69.
Dey-Rao R, Smith JR, Chow S, Sinha AA. Differential gene expression analysis in CCLE lesions provides new insights regarding the genetics basis of skin vs. systemic disease. Genomics. 2014.
Shah AA, Seiffert-Sinha K, Sirois D, Werth VP, Rengarajan B, Zrnchik W, Attwood K, Sinha AA. Development of a Disease Registry for Autoimmune Bullous Diseases: Initial Analysis of the Pemphigus Vulgaris Subset. Acta Derm Venereol. 2014; 95(1).
Lundin M, Chawa S, Sachdev A, Bhanusali D, Seiffert-Sinha K, Sinha AA. Gender differences in alopecia areata. J Drugs Dermatol. 2014; 13(4).
Bhanusali DG, Sachdev A, Olson MA, Gerlach JA, Sinha AA. PTPN22 profile indicates a novel risk group in Alopecia areata. Hum Immunol. 2014; 75(1).
Bhanusali DG, Sachdev A, Olson MA, Gerlach JA, Sinha AA. PTPN22 profile indicates a novel risk group in Alopecia areata. Hum Immunol. 2013.
Dey-Rao R, Seiffert-Sinha K, Sinha AA. Genome-wide expression analysis suggests unique disease-promoting and disease-preventing signatures in Pemphigus vulgaris. Genes Immun. 2013; 14(8).
Giordano CN, Sinha AA. Cytokine pathways and interactions in alopecia areata. Eur J Dermatol. 2013.
Gamba CA, Swetter SM, Stefanick ML, Kubo J, Desai M, Spaunhurst KM, Sinha AA, Asgari MM, Sturgeon S, Tang JY. Aspirin is associated with lower melanoma risk among postmenopausal Caucasian women: the Women's Health Initiative. Cancer. 2013; 119(8).
Shah AA, Sinha AA. Oxidative stress and autoimmune skin disease. Eur J Dermatol. 2013.
Bhanusali DG, Sachdev A, Rahmanian A, Gerlach JA, Tong JC, Seiffert, K, Sinha AA. HLA-E*0103X is associated with susceptibility to Pemphigus vulgaris. Exp Dermatol. 2013; 22(2).
Heller ER, Gor A, Wang D, Hu Q, Lucchese A, Kanduc D, Katdare M, Liu S, Sinha AA. Molecular signatures of basal cell carcinoma susceptibility and pathogenesis: A genomic approach. Int J Oncol. 2013; 42(2).
Senger P, Sinha AA. Exploring the link between herpes viruses and pemphigus vulgaris: literature review and commentary. Eur J Dermatol. 2012.
Dhandha MM, Seiffert-Sinha K, Sinha AA. Specific immunoglobulin isotypes correlate with disease activity, morphology, duration and HLA association in Pemphigus vulgaris. Autoimmunity. 2012; 45(7).
Russo VA, Van Acker MM, Vander Wal JS, Sinha AA. Patterns of use of sunless tanning product alternatives to indoor tanning among female college students. Arch Dermatol. 2012; 148(7).
Giordano CN, Sinha AA. Cytokine networks in Pemphigus vulgaris: An integrated viewpoint. Autoimmunity. 2012.
Schrauben SJ, Bhanusali DG, Sheets S, Sinha AA. A case of argyria: multiple forms of silver ingestion in a patient with comorbid schizoaffective disorder. Cutis. 2012; 89(5).
Coda A, Icen M, Smith JR, Sinha AA. Global transcriptional analysis of psoriatic skin and blood confirms known disease-associated pathways and highlights novel genomic "hot spots" for differentially expressed genes. Genomics. 2012.
Sinha AA. Constructing immunoprofiles to deconstruct disease complexity in pemphigus. Autoimmunity. 2012; 45(1).
Patel M, Sinha AA, Gilbert E. Bullous pemphigoid associated with renal cell carcinoma and invasive squamous cell carcinoma. J Drugs Dermatol. 2012; 11(2).
Lucchese G, Sinha AA, Kanduc D. How a single amino acid change may alter the immunological information of a peptide. Front Biosci (Elite Ed). 2012; 4.
Murrell DF, Daniel BS, Joly P, Borradori L, Amagai M, Hashimoto T, Caux F, Marinovic B, Sinha AA, Hertl M, Bernard P, Sirois D, Cianchini G, Fairley JA, Jonkman MF, Pandya AG, Rubenstein D, Zillikens D, Payne AS, Woodley D, Zambruno G, Aoki V, Pincelli C, Diaz L, Hall RP, Meurer M, Mascaro JM, Schmidt E, Shimizu H, Zone J, Swerlick R, Mimouni D, Culton D, Lipozencic J, Bince B, Bystryn JC, Werth VP. Definitions and outcome measures for bullous pemphigoid: Recommendations by an international panel of experts. J Am Acad Dermatol. 2011.
Chacón GR, Sinha AA. Bullous pemphigoid after herpes zoster vaccine administration: association or coincidence? J Drugs Dermatol. 2011; 10(11).
Coda AB, Sinha AA,. Integration of genome-wide transcriptional and genetic profiles provides insights into disease development and clinical heterogeneity in Alopecia areata. Genomics. 2011.
Sinha AA. Constructing immunoprofiles to deconstruct disease complexity in pemphigus. Autoimmunity. 2011.
Sinha AA. The genetics of pemphigus. Dermatol Clin. 2011; 29(3).
Gupta VK, Kelbel TE, Nguyen D, Melonakos KC, Murrell DF, Xie Y, Mullard A, Reed PL, Seiffert-Sinha K, Sinha AA. A globally available internet-based patient survey of pemphigus vulgaris: epidemiology and disease characteristics. Dermatol Clin. 2011; 29(3).
Sachdev A, Bhanusali DG, Patterson KC, Zamora MB, Ghuman A, Gerlach JA, Sinha AA, Calvelli C. PTPN22 1858T is not a risk factor for North American pemphigus vulgaris. Exp Dermatol. 2011; 20(6).
Fung CK, Xi N, Yang R, Seiffert-Sinha K, Lai KW, Sinha AA,. Quantitative analysis of human keratinocyte cell elasticity using atomic force microscopy (AFM). IEEE Trans Nanobioscience. 2011; 10(1).
Xi N, Fung CK, Yang R, Lai KW, Wang DH, Seiffert-Sinha K, Sinha AA, Li G, Liu L, Seiffert K. Atomic force microscopy as nanorobot. Methods Mol Biol. 2011; 736.
Yang, R., Xi, N., Fung, C.K.M., Seiffert K, Wai Chiu Lai, K., Sinha AA,. The emergence of AFM applications to cell biology: how new technologies are facilitating investigation of human cells in health and disease at a nanoscale. Nanoscience Letters. 2011; 1(2).
Sinha AA. World-wide, web,based patient survey of Pemphigus Vulgaris. Dermatol Clin. 2011; 29(3).
Sinha AA. Warfarin-induced skin necrosis mimicking calciphylaxis: a case report and review of the literature.. J. Drugs Dermatol. 2010; 9(7).
Fung CK, Seiffert-Sinha K, Lai KW, Yang R, Panyard D, Zhang J, Xi N, Sinha AA. Investigation of human keratinocyte cell adhesion using atomic force microscopy. Nanomedicine. 2010; 6(1).
Sinha AA. Cellular tensegrity modeling with atomic force microscopy experimentation. E-published / Proceedings of the Joint 2010 IEEE Nanotechnology Materials and Devices Conference and 1st IEEE International Symposium on Energy, Environment, Safety and Security. 2010.
Sinha AA. Real-time Identification of Apoptosis Signaling Pathways using an AFM-based nanorobot. E- Published / Proceedings of the IEEE Nanotechnology Materials and Devices Conference. 2010.
Xi N, Fung K, Yang R, Seiffert K, Lai K, Sinha AA. Bionanomanipulation Using Atomic Force Microscopy: Understanding Disease at the Molecular Level Using a Nanorobot. IEEE Nanotechnology Magazine. 2010; 4(1).
Sinha AA, Quafalijaj Hysa, V, Seiffert-Sinha, K, Coda, A. Pheripheral Blood Gene Expression in Alopecia Areata Reveal Molecular pathways Distinquishing Heritability, Disease, and Severity .. Genes Immun. 2010; 11(7).
Sinha AA. Lichen Planus. E- published. 2009.
Sinha AA. Pemphigus and Pemphigoid. E-published. 2009.
Tong JC, Song CM, Tan PT, Ren EC, Sinha AA. BEID: database for sequence-structure-function information on antigen-antibody interactions. Bioinformation. 2008; 3(2).
Dudda-Subramanya R, Alexis AF, Siu K, Sinha AA. Alopecia areata: genetic complexity underlies clinical heterogeneity. Eur J Dermatol. 2007; 17(5).
Lee E, Lendas KA, Chow S, Pirani Y, Gordon D, Dionisio R, Nguyen D, Spizuoco A, Fotino M, Zhang Y, Sinha AA. Disease relevant HLA class II alleles isolated by genotypic, haplotypic, and sequence analysis in North American Caucasians with pemphigus vulgaris. Hum Immunol. 2007; 67(1-2).
Angelini G, Bonamonte D, Lucchese A, Favia G, Serpico R, Mittelman A, Simone S, Sinha AA, Kanduc D. Preliminary data on Pemphigus vulgaris treatment by a proteomics-defined peptide: a case report. J Transl Med. 2006; 4.
Goh C, Finkel M, Christos PJ, Sinha AA. Profile of 513 patients with alopecia areata: associations of disease subtypes with atopy, autoimmune disease and positive family history. J Eur Acad Dermatol Venereol. 2006; 20(9).
Lee HJ, Sinha AA. Cutaneous lupus erythematosus: understanding of clinical features, genetic basis, and pathobiology of disease guides therapeutic strategies. Autoimmunity. 2006; 39(6).
Lucchese A, Mittelman A, Tessitore L, Serpico R, Sinha AA, Kanduc D. Proteomic definition of a desmoglein linear determinant common to Pemphigus vulgaris and Pemphigus foliaceous. J Transl Med. 2006; 4.
Kathpalia VP, Mussak EN, Chow SS, Lam PH, Skelley N, Time M, Markelewicz RJ, Kanduc D, Lomas L, Xiang Z, Sinha AA. Genome-wide transcriptional profiling in human squamous cell carcinoma of the skin identifies unique tumor-associated signatures. J Dermatol. 2006; 33(5).
Tong JC, Bramson J, Kanduc D, Chow S, Sinha AA, Ranganathan S. Modeling the bound conformation of Pemphigus vulgaris-associated peptides to MHC Class II DR and DQ alleles. Immunome Res. 2006; 2.
Lee E, Lendas KA, Chow S, Pirani Y, Gordon D, Dionisio R, Nguyen D, Spizuoco A, Fotino M, Zhang Y, Sinha AA. Disease relevant HLA class II alleles isolated by genotypic, haplotypic, and sequence analysis in North American Caucasians with pemphigus vulgaris. Hum Immunol. 2006; 67(1-2).
Lee E, Sinha AA. T cell targeted immunotherapy for autoimmune disease. Autoimmunity. 2005; 38(8).
Rizzo C, Fotino M, Zhang Y, Chow S, Spizuoco A, Sinha AA. Direct characterization of human T cells in pemphigus vulgaris reveals elevated autoantigen-specific Th2 activity in association with active disease. Clin Exp Dermatol. 2005; 30(5).
Chow S, Rizzo C, Ravitskiy L, Sinha AA. The role of T cells in cutaneous autoimmune disease. Autoimmunity. 2005; 38(4).
Sinha AA. Etanercept Does Not Effectively Treat Moderate to Severe Alopecia Areata: an open label study. Journal of American Acad. Dermatol. 2005; 52(6).
Kanduc D, Geliebter J, Lucchese A, Mazzanti R, Mittelman A, Polimeno L, Ponzetto A, Santacroce R, Simone S, Sinigaglia E, Sinha AA, Tessitore L, Tiwari RK, Farber E. Gene therapy in cancer: the missing point. J Exp Ther Oncol. 2005; 5(2).
Angelini G, Bonamonte D, Lin MS, Lucchese A, Mittelman A, Serpico R, Simone S, Sinha AA, Kanduc D. Characterization of polyclonal antibodies raised against a linear peptide determinant of desmoglein-3. J Exp Ther Oncol. 2005; 5(1).
Lucchese A, Mittelman A, Lin MS, Kanduc D, Sinha AA. Epitope definition by proteomic similarity analysis: identification of the linear determinant of the anti-Dsg3 MAb 5H10. J Transl Med. 2004; 2(1).
Alexis AF, Dudda-Subramanya R, Sinha AA. Alopecia areata: autoimmune basis of hair loss. Eur J Dermatol. 2004; 14(6).
Kanduc D, Fanizzi FP, Lucchese G, Stevanovic S, Sinha AA, Mittelman A. NMR probing of in silico identification of anti-HPV16 E7 mAb linear peptide epitope. Peptides. 2004; 25(2).
Dudda-Subramanya R, Lucchese G, Kanduc D, Sinha AA. Clinical applications of DNA microarray analysis. J Exp Ther Oncol. 2003; 3(6).
Kanduc D, Capuano F, Capurso SA, Geliebter J, Guercia D, Lucchese A, Mittelman A, Simone SM, Sinha AA, Tiwari R, Farber E. Cancer prevention and therapy: strategies and problems. J Exp Ther Oncol. 2003; 3(3).
Lucchese A, Stevanovic S, Sinha AA, Mittelman A, Kanduc D. Role of MHC II affinity and molecular mimicry in defining anti-HER-2/neu MAb-3 linear peptide epitope. Peptides. 2003; 24(2).
Moesta AK, Lin MS, Diaz LA, Sinha AA. T cell receptor Beta chain gene usage in endemic pemphigus foliaceus (fogo selvagem). J Invest Dermatol. 2002; 119(2).
Montiel NJ, Baumgarten JM, Sinha AA. Lyme disease--part II: clinical features and treatment. Cutis. 2002; 69(6).
Baumgarten JM, Montiel NJ, Sinha AA. Lyme disease--part I: epidemiology and etiology. Cutis. 2002; 69(5).
King HC, Sinha AA. Gene expression profile analysis by DNA microarrays: promise and pitfalls. JAMA. 2001; 286(18).
Tokura Y, Röcken M, Clark RA, Haliasos E, Takigawa M, Sinha AA. What are the most promising strategies for the therapeutic immunomodulation of allergic diseases? Exp Dermatol. 2001; 10(2).
Sinha AA. How do we measure up? Lancet. 2000; 356(9228).
Sinha AA, Heald P. Advances in the management of cutaneous T-cell lymphoma. Dermatol Clin. 1998; 16(2).
McDermott MF, Schmidt-Wolf G, Sinha AA, Koo M, Porter MA, Briant L, Cambon-Thomsen A, Maclaren NK, Fiske D, Bertera S, Trucco M, Amos CI, McDevitt HO, Kastner DL. No linkage or association of telomeric and centromeric T-cell receptor beta-chain markers with susceptibility to type 1 insulin-dependent diabetes in HLA-DR4 multiplex families. Eur J Immunogenet. 1996; 23(5).
McDermott M, Kastner DL, Holloman JD, Schmidt-Wolf G, Lundberg AS, Sinha AA, Hsu C, Cashin P, Molloy MG, Mulcahy B. The role of T cell receptor beta chain genes in susceptibility to rheumatoid arthritis. Arthritis Rheum. 1995; 38(1).
Gautam AM, Pearson CI, Sinha AA, Smilek DE, Steinman L, McDevitt HO. Inhibition of experimental autoimmune encephalomyelitis by a nonimmunogenic non-self peptide that binds to I-Au. J Immunol. 1992; 148(10).
Sinha AA, Bell RB, Steinman L, McDevitt HO. Oligonucleotide dot-blot analysis of HLA-DQ beta alleles associated with multiple sclerosis. J Neuroimmunol. 1991; 32(1).
Sinha AA, Lopez MT, McDevitt HO. Autoimmune diseases: the failure of self tolerance. Science. 1990; 248(4961).
Sakai K, Sinha AA, Mitchell DJ, Zamvil SS, Rothbard JB, McDevitt HO, Steinman L. Involvement of distinct murine T-cell receptors in the autoimmune encephalitogenic response to nested epitopes of myelin basic protein. Proc Natl Acad Sci U S A. 1988; 85(22).
Todd JA, Acha-Orbea H, Bell JI, Chao N, Fronek Z, Jacob CO, McDermott M, Sinha AA, Timmerman L, Steinman L. A molecular basis for MHC class II--associated autoimmunity. Science. 1988; 240(4855).
Sinha AA, Brautbar C, Szafer F, Friedmann A, Tzfoni E, Todd JA, Steinman L, McDevitt HO. A newly characterized HLA DQ beta allele associated with pemphigus vulgaris. Science. 1988; 239(4843).
Diener E, Xie SS, Yu LZ, Longenecker BM, Sinha AA. Experimental application of target-specific immunoconjugates containing daunomycin as the cytocidal component. Targeted Diagn Ther. 1988; 1.
Sinha A.A, Brautbar C, Szafer F, Friedmann A, Tzfoni E, Todd J, Steinman L, McDevitt H.O. Characterization of HLA-DRb and HLA-DQb alleles associated with Pemphigus Vulgaris. Immunobiology of HLA. 1988; 2.
Guidos C, Sinha AA, Lee KC. Functional differences and complementation between dendritic cells and macrophages in T-cell activation. Immunology. 1987; 61(3).
Sinha AA, Guidos C, Lee KC, Diener E. Functions of accessory cells in B cell responses to thymus-independent antigens. J Immunol. 1987; 138(12).
Krowka, J., Guidos, C., Sinha, A.A, Lee KC, Diener, E, Pilarski, L.M.. Comparative functional analysis of helper T lymphocyte responses to soluble and articulate antigens. J. Immunol. 1987; 138.
Diner UE, Sinha AA, Vergidis R, Lee KC, Diener E. The role of macrophages in B cell tolerance. I. Antigen-specific failure of Thy-1, Ly-2 negative adherent cells from tolerant mice to reconstitute immunocompetence in adherent cell deficient spleen cells. Cell Immunol. 1986; 97(1).
Diener, E., Diner, U., Sinha, A.A, Xie, S., Vergidis, R.. Specific immuno-suppression by immunotoxins containing daunomycin. Science. 1986; 231(4734).

See all (100 more)

Abstracts:

Sinha AA. Response Criteria for Cutaneous SLE in clinical trials. Clin. Exp. Rheuumatol. 2007; 25(5).

Books and Book Chapters:

Paget, S, Gibofsky, A, A., Sulco, Beary, J, Sinha AA. Rash and Arthritis. Manual of Rheumatology and Outpatient Orthopedic Disorders: Diagnosis and Therapy. 2006.
Sinha A.A, Shylankevich, M., Offers, M., Moesta, A., Lin, M, Diaz, L., Tigelaar, R., Janeway, C.. A polymerase chain reaction-based approach in search of potential T-cell epitopes in Pemphigus Vulgaris. The 10th International Congress of Immunology. 1999.
Sinha, A.A, Mietzner, T, Lock, C.B., McDevitt, H.O.. Fluorescence-activated cell sorter analysis of peptide-major histocompatibility complex. Molecular Mechanisms of Immunological Self-recognition. 1993.
Sinha AA. Functional Importance of MHC class ll Polymorphism in normal immune responses and autoimmune disease. Molecular Biology of HLA Class ll Antigens. 1990.
Diener, E., Fotedar, R., Sinha, A.A.. Regulation of the B cell response: activation and differentiation. Developmental Immunology. 1990.
McDevitt, H.O., Sinha AA. Allelic Polymorphism of HLA class ll antigens: clues to the moleular basis of autoimmunity. Immune Recognition and Evasion: Molecular Aspects of Host Parasite Interaction. 1990.
Sinha AA, Brautbar C, Szafer F, Friedmann A, Tzfoni E, Steinman, L, McDevitt, H.O.. HLA-DR and HLA-DQ ALLELES ASSOCIATED WITH PEMPHIGUS VULGARIS. Cellular Basis of Immune Modulation. 1989.
Diener, U., Diener, E., Sinha, A.A, Xie, S., Vergidis, R. Selective suppression of murine lymphocyte function by daunomycin conjugated via an acid sensitive spacer to target specific carriers. Mediators of Immune Regulation and Immunotherapy. 1986.

Professional Memberships:

NIH ZRG1 Moss G02 (2010–present)
Alliance for Lupus Research (2008–present)
International Society of Dermatology (2006–present)
Chicago Dermatological Society (2006–present)
Arthritis Foundation - Cellular Immunology Study Section (2006–present)
Michigan Dermatology Society (2006–present)
Michigan State Medical Society (2006–present)
Association of Professors of Dermatology (2006–present)
American Association for the Advancement of Science (2006–present)
Fellow, American Academy of Dermatology (2005–present)
Society for Investigative Dermatology (1998–present)

See all (1 more)

Presentations:

"Autoimmunity in the skin: systems medicine approach to disease." All India Institute of Medical Sciences (2013)
"Cutaneous lupus: clinical features and pathogenesis." Hampton University Skin of Color Research Symposium., Hampton University, Huscri (2013)
"Understanding autoimmunity in the skin: a systems approach to complex dermatologic disease." Clinical and Translational Research Colloquium, University at Buffalo (2013)
"The Genetics of Pemphigus" International Symposium in Autoimmune Bullous Disorders, International Investigative DermatologyI, IID (2013)
"Diagnosis and genetics of autoimmune bullous disease." International Pemphigus and Pemphigoid Foundation 16th Annual Patient -Doctor Meeting., International Pemphigus and Pemphigoid Foundation (2013)
"Novel multiplex auto antigen arrays for biomarker discovery in skin autoimmunityf" Clinical and Translational Research Colloquium, University at Buffalo, University at Buffalo (2013)
"Pemphigus: clinical features and pathogenesis of disease." International Pemphigus and Pemphigoid Foundation 16th Annual Patient -Doctor Meeting., International Pemphigus and Pemphigoid Foundation, International Pemphigus and Pemphigoid Foundation (2013)
"Probing autoantibody diversity in Pemphigus vulgaris: proteomic strategies" Grand Rounds, Dept of Dermatology, Loma Linda University Medical Center,, Loma Linda University Medical Center, Grand Rounds, Dept of Dermatology, Loma Linda University Medical Center, (2013)
"Systems medicine for Dermatology: the new interface between biology, medicine, and technology." Grand Rounds Dept. of Dermatology, University of Southern California, University of Southern California, Dept. of Dermatology, University of Southern California (2013)
"Pemphigus and pemhigoid: clinical features and approach to management." Webinar; Nufactor, Nufactor (2013)
"Emerging strategies for understanding autoimmunity in the skin: lessons from pemphigus." Grand Rounds, Dept. Surgery, University at Buffalo, University at Buffalo, Dept. of Surgery (2013)
"How a better understandig of disease etiology is paving the way to new therapies in Pemphigus" Meeting of the Canadian Pemphigus and Pemphigus Foundation, Sunnybrook Health Sciences, Sunnybrook Health Sciences (2012)
"New tools to understand the scope and action of autoantibodies in Pemphigus vulgaris (PV)" Basic Science Seminar Series, Yale University, Dept of Dermatology (2012)
"Shifting paradigms in complex cutaneous disease: how systems medicine is creating the new interface between biology, medicine, and technology to imp at clinical decision making" Grand Rounds, Yale University, Dermatology Dept. Yale University (2012)
"Investigation of autoimmune blistering disease: from genetics to immune-mediated pathology" Immunology Seminar Series, University of California, Irvine, Immunology (2012)
"Autoimmunity and the skin: intergration of biological and clinical profiles to understand disease processes in Pemphigus vulgarism" Immunology Grand Rounds, University at Buffalo, University at Buffalo, Dept. of Immunology (2012)
"Genetics of Pemphigus" International Pemphigus and Pemphigoid Foundation 15th Annual Patient - Doctor Meeting, IPPF, International Pemphigus and Pemphigoid Foundation (2012)
"Strategies for understanding autoimmunity in the skin." Dept. of Cancer Pathology and Prevention, Roswell Park Cancer Institute, Dept. of Cancer Pathology and Prevention (2012)
"Dermatology - Career Paths" Medical Student Forum, University at Buffalo, University at Buffalo, Medical Student Forum (2012)
"Skin, aging, and autoimmunity." Women's Health Symposium on Aging and Wellness across the Lifespan, University at Buffalo (2012)
"Cutaneous lupus: clinical and etiologic considerations" Hampton University Skin of Color Symposium, Hampton, University (2011)
"Autoimmunity of the skin: investigating immune disturbances in Pemhigus vulgaris" Veterans Administration Western NY Healthcare System, Veterans Administration Western NY Healthcare System, Veterans Administration Western NY Healthcare System (2011)
"Constructing immunoprofiles to deconstruct disease complexity in pemphigus" Buffalo-Rochester Dermatology Meeting, Buffalo- Rochester Dermatology Society, Buffalo- Rochester Dermatology Society (2011)
"Management of Pemphigus and Pemphigoid" Buffalo-Rochester Dermatology Meeting, Buffalo- Rochester Dermatology Society, Buffalo- Rochester Dermatology Society (2011)
"Developing disease registry for pemphigus" 14th Annual Meeting of the International Pemphigus and Pemphigoid Foundation., IPPF, International Pemphigus and Pemphigoid Foundation (2011)
"Genetic basis of pemphigus" 14th Annual Meeting of the International Pemphigus and Pemphigoid Foundation, IPPF, IPPF (2011)
"Shifting Paradigms in complex cutaneous disease: harnessing biological and clinical information to impact disease management" , University at Buffalo (2011)
"Current Concepts in The Treatment of Blistering Disorders" Grand Rounds, Eastern Virginia Medical School, Department of Dermatology (2011)
"Systems Medicine and Dermatology: merging clinical and biological data to develop new tools for disease management" Hampton University Skin of Color Symposium, Hampton University Skin of Color Institute, Hampton University Skin of Color Institute (2011)
"Biomarkers and Immunoprofiling in Pemphigus" , Biogen/IDEC (2010)
"Immunoprofiling to unravel disease complexity in pemphigus" Pemphigus and Pemhigoid: From the Bench to the Bedside Meeting, National Institutes of Health (2010)
"Systems approach to investigate immune dysregulation in pemphigus vulgaris." Grand Rounds, Wayne State University, Department of Dermatology (2010)
"Dermatology: Career Perspectives and Academic Horizons" Internal Medicine Club and Dermatology Interest Group Meeting, Michigan State University (2010)
"Systems strategies to study skin autoimmunity" Grand Rounds, University of Florida, Department of Dermatology (2010)
"New Concepts and Experimental Stategies to Understand Pemphigus" Symposio Internationale de Dermatologica (2010)
"Why Do Patients Flare? How new technologies are helping us to understand disease mechanisms." 12th Annual Meeting of the International Pemphigus and Pemphigoid Foundation (2010)
"Genetic Basis of Pemphigus" Symposium on Autoimmune Bullous Disease, 68th Annnual Meeting of the American Academy of Dermatology, American Academy of Dermatology (2010)
"Systems Medicine and Dermatology: integrating high throughput genetic, genomic, and proteomic strategies to tackle biological complexity and disease hetergeneity" Grand Rounds, State University of New York at Buffalo, Department of Dermatology (2010)
"How New Genetic Technologies Are Changing Clinical Medicine" , Rotary Club (2003)

See all (29 more)

Service Activities:

Biogen/IDEC; Advisory Board (2010–present)
Hampton University Skin of Color Research Instititute; Advisory Board (2010–present)
Foundation for Global Skin Health Strategies; Advisory Board (2009–present)
Guest, Today Show, Segment on Genetic Testing; Invited Participant (2008–present)
MD-PHD Committee; Board Member (2007–present)
Peptimmune, Inc; Advisory Board (2007–present)
Search Committee for Faculty position in Genetics; Committee Member (2007–present)
American College of Rheumatology Ad Hoc Subcommittee in Response Criteria for Cutaneous SLE; Advisory Board (2006–present)
Guest, "Please Explain - Hair" National Public Radio (WNYC); Invited Participant (2005–present)
American Vitiligo Research Foundation; Advisory Board (2004–present)
International Pemphigus and Pemphigoid Foundation; Advisory Board (2004–present)
Guest column, "Serious Skin Disorders Often Go Undetected" Bottom Line/Health, Standford CT; Invited Participant (2003)
Webcast on Cutaneous Lupus Erythematosus; Invited Participant (2002)
Guest expert of hair loss webcast. Healthology, Inc; Invited Participant (2001)
Guest expert on the genetics of hair loss.; Invited Participant (2000–present)
Guest on ‘The Bald Truth" radio show (WOR), Spencer Kobren, host, NY, NY; Invited Participant (2000–present)

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6078 Clinical and Translational Research Center
875 Ellicott, Street
Buffalo, NY 14203
Phone: 716-204-8730
Fax: 716-276-9249
Email: aasinha@buffalo.edu

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Animesh A. Sinha MD, PhD

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