Looking for a doctor? This faculty member is affiliated with UBMD, the group comprised of practicing physicians who are also professors in the UB Jacobs School of Medicine and Biomedical Sciences.
PhD, Medical Sciences (Immunology), University of Alberta (1986)
MD, University of Alberta (1982)
Employment:
Associate Professor, Dermatology, Cornell University (2005-present)
Professor and Chair, Dermatology, University at Buffalo (2011–2017)
Director, Dermatology, Michigan State University (2005–2011)
Associate Professor, Dermatology, Michigan State University (2005–2011)
Assistant Professor, Dermatology, Cornell University (1998–2005)
Associate Scientist, Dermatology, Yale University (1995–1998)
Associate Scientist, Medicine, University at Alberta, Canada (1992–1995)
Research Fellow, Microbiology and Immunology, Stanford University (1986–1992)
Research Fellow, University of Alberta, Canada (1982–1986)
Awards and Honors:
Doctor of the Year/Excellence in Research Award, (2009)
Women's Dermatology Society Mentorship Award (1997)
Medical Research Council of Canada Centennial Fellowship Award (1989)
AHFMR Independent Research Allowance Fellowship Award (1986)
AHFMR Part-time Studentship Award (1982)
Alberta Heritage Foundation for Medical Research Summer Studentship Award (1982)
Searle Research Scholarship in Pharmacology (1979)
Arthritis Foundation Investigator Award (1990 - 1994)
Arthritis Foundation Fellowship Award (1989 - 1990)
Dermatology Foundation Career Development Award (2000 - 2003)
AHFMR Research Fellowship Award (1982 - 1986)
Province of Alberta Scholarship (1976 - 1978)
Research Expertise:
Immunological Tolerance and Autoimmunity.: To pinpoint targets for immune intervention and potentially gene therapy in autoimmune disease
Grants and Sponsored Research:
January 2010–December 2011 Monitoring Autoimmune Activity in Pemphigus Crescent Healthcare, Inc. Role: Co-Investigator $3,000
February 2007–January 2009 Mechanisms of Autoimmunity in the Skin Role: Co-Investigator $75,000
February 2007–January 2009 Functional Analysis of IFN-Y Regulated OAS1 Over-Expression in Cutaneous LE Alliance for Lupus Research Role: Co-Investigator $75,000
July 2004–June 2006 Gene Expression Analysis in Vitiligo American Vitiligo Research Foundation Role: Co-Investigator $30,000
May 2002–December 2005 Human Gene Expression Profiling in Vitiligo by Microarray National Vitiligo Foundation Role: Co-Investigator $30,000
January 2002–January 2005 Identifying And Characterizing Human Skin Genes Using DNA Chip Technology Colgate-Palmolive, Co Role: Co-Investigator $75,000
July 2000–July 2004 Genome Wide Expression Analysis in Lupus Erythematosus Mary Kirkland Center for Lupus Research Role: Co-Investigator $143,850
July 2001–June 2004 Genetic Basis of Cutaneous Lupus Erthematosus Colleck Research Fund Role: Co-Investigator $400,000
February 2002–January 2004 Genome Wide Expression Analysis in Psoriasis National Psoriasis Foundation Role: Co-Investigator $150,000
September 1998–September 2001 Mapping of Genes for Alopecia Areata in the General Population NIH/NIAMS Role: Co-Investigator $150,000
July 1998–June 2001 Genetic Basis of Autoimmunity Colleck Research Fund Role: Principal Investigator $390,000
Yang, R., Xi, N., Fung, C.K.M., Seiffert K, Wai Chiu Lai, K., Sinha AA,. The emergence of AFM applications to cell biology: how new technologies are facilitating investigation of human cells in health and disease at a nanoscale. Nanoscience Letters. 2011; 1(2).
Xi N, Fung CK, Yang R, Lai KW, Wang DH, Seiffert-Sinha K, Sinha AA, Li G, Liu L, Seiffert K. Atomic force microscopy as nanorobot. Methods Mol Biol. 2011; 736.
Sinha AA. Warfarin-induced skin necrosis mimicking calciphylaxis: a case report and review of the literature.. J. Drugs Dermatol. 2010; 9(7).
Xi N, Fung K, Yang R, Seiffert K, Lai K, Sinha AA. Bionanomanipulation Using Atomic Force Microscopy: Understanding Disease at the Molecular Level Using a Nanorobot. IEEE Nanotechnology Magazine. 2010; 4(1).
Sinha AA, Quafalijaj Hysa, V, Seiffert-Sinha, K, Coda, A. Pheripheral Blood Gene Expression in Alopecia Areata Reveal Molecular pathways Distinquishing Heritability, Disease, and Severity .. Genes Immun. 2010; 11(7).
Sinha AA. Etanercept Does Not Effectively Treat Moderate to Severe Alopecia Areata: an open label study. Journal of American Acad. Dermatol. 2005; 52(6).
Kanduc D, Geliebter J, Lucchese A, Mazzanti R, Mittelman A, Polimeno L, Ponzetto A, Santacroce R, Simone S, Sinigaglia E, Sinha AA, Tessitore L, Tiwari RK, Farber E. Gene therapy in cancer: the missing point. J Exp Ther Oncol. 2005; 5(2).
Paget, S, Gibofsky, A, A., Sulco, Beary, J, Sinha AA. Rash and Arthritis. Manual of Rheumatology and Outpatient Orthopedic Disorders: Diagnosis and Therapy. 2006.
Sinha A.A, Shylankevich, M., Offers, M., Moesta, A., Lin, M, Diaz, L., Tigelaar, R., Janeway, C.. A polymerase chain reaction-based approach in search of potential T-cell epitopes in Pemphigus Vulgaris. The 10th International Congress of Immunology. 1999.
Sinha AA. Functional Importance of MHC class ll Polymorphism in normal immune responses and autoimmune disease. Molecular Biology of HLA Class ll Antigens. 1990.
Diener, E., Fotedar, R., Sinha, A.A.. Regulation of the B cell response: activation and differentiation. Developmental Immunology. 1990.
McDevitt, H.O., Sinha AA. Allelic Polymorphism of HLA class ll antigens: clues to the moleular basis of autoimmunity. Immune Recognition and Evasion: Molecular Aspects of Host Parasite Interaction. 1990.
Sinha AA, Brautbar C, Szafer F, Friedmann A, Tzfoni E, Steinman, L, McDevitt, H.O.. HLA-DR and HLA-DQ ALLELES ASSOCIATED WITH PEMPHIGUS VULGARIS. Cellular Basis of Immune Modulation. 1989.
Diener, U., Diener, E., Sinha, A.A, Xie, S., Vergidis, R. Selective suppression of murine lymphocyte function by daunomycin conjugated via an acid sensitive spacer to target specific carriers. Mediators of Immune Regulation and Immunotherapy. 1986.
Abstracts:
Sinha AA. Response Criteria for Cutaneous SLE in clinical trials. Clin. Exp. Rheuumatol. 2007; 25(5).
"Autoimmunity in the skin: systems medicine approach to disease." All India Institute of Medical Sciences (2013)
"Cutaneous lupus: clinical features and pathogenesis." Hampton University Skin of Color Research Symposium., Hampton University, Huscri (2013)
"Understanding autoimmunity in the skin: a systems approach to complex dermatologic disease." Clinical and Translational Research Colloquium, University at Buffalo (2013)
"The Genetics of Pemphigus" International Symposium in Autoimmune Bullous Disorders, International Investigative DermatologyI, IID (2013)
"Diagnosis and genetics of autoimmune bullous disease." International Pemphigus and Pemphigoid Foundation 16th Annual Patient -Doctor Meeting., International Pemphigus and Pemphigoid Foundation (2013)
"Novel multiplex auto antigen arrays for biomarker discovery in skin autoimmunityf" Clinical and Translational Research Colloquium, University at Buffalo, University at Buffalo (2013)
"Pemphigus: clinical features and pathogenesis of disease." International Pemphigus and Pemphigoid Foundation 16th Annual Patient -Doctor Meeting., International Pemphigus and Pemphigoid Foundation, International Pemphigus and Pemphigoid Foundation (2013)
"Probing autoantibody diversity in Pemphigus vulgaris: proteomic strategies" Grand Rounds, Dept of Dermatology, Loma Linda University Medical Center,, Loma Linda University Medical Center, Grand Rounds, Dept of Dermatology, Loma Linda University Medical Center, (2013)
"Systems medicine for Dermatology: the new interface between biology, medicine, and technology." Grand Rounds Dept. of Dermatology, University of Southern California, University of Southern California, Dept. of Dermatology, University of Southern California (2013)
"Pemphigus and pemhigoid: clinical features and approach to management." Webinar; Nufactor, Nufactor (2013)
"Emerging strategies for understanding autoimmunity in the skin: lessons from pemphigus." Grand Rounds, Dept. Surgery, University at Buffalo, University at Buffalo, Dept. of Surgery (2013)
"How a better understandig of disease etiology is paving the way to new therapies in Pemphigus" Meeting of the Canadian Pemphigus and Pemphigus Foundation, Sunnybrook Health Sciences, Sunnybrook Health Sciences (2012)
"New tools to understand the scope and action of autoantibodies in Pemphigus vulgaris (PV)" Basic Science Seminar Series, Yale University, Dept of Dermatology (2012)
"Shifting paradigms in complex cutaneous disease: how systems medicine is creating the new interface between biology, medicine, and technology to imp at clinical decision making" Grand Rounds, Yale University, Dermatology Dept. Yale University (2012)
"Investigation of autoimmune blistering disease: from genetics to immune-mediated pathology" Immunology Seminar Series, University of California, Irvine, Immunology (2012)
"Autoimmunity and the skin: intergration of biological and clinical profiles to understand disease processes in Pemphigus vulgarism" Immunology Grand Rounds, University at Buffalo, University at Buffalo, Dept. of Immunology (2012)
"Genetics of Pemphigus" International Pemphigus and Pemphigoid Foundation 15th Annual Patient - Doctor Meeting, IPPF, International Pemphigus and Pemphigoid Foundation (2012)
"Strategies for understanding autoimmunity in the skin." Dept. of Cancer Pathology and Prevention, Roswell Park Cancer Institute, Dept. of Cancer Pathology and Prevention (2012)
"Dermatology - Career Paths" Medical Student Forum, University at Buffalo, University at Buffalo, Medical Student Forum (2012)
"Skin, aging, and autoimmunity." Women's Health Symposium on Aging and Wellness across the Lifespan, University at Buffalo (2012)
"Cutaneous lupus: clinical and etiologic considerations" Hampton University Skin of Color Symposium, Hampton, University (2011)
"Autoimmunity of the skin: investigating immune disturbances in Pemhigus vulgaris" Veterans Administration Western NY Healthcare System, Veterans Administration Western NY Healthcare System, Veterans Administration Western NY Healthcare System (2011)
"Constructing immunoprofiles to deconstruct disease complexity in pemphigus" Buffalo-Rochester Dermatology Meeting, Buffalo- Rochester Dermatology Society, Buffalo- Rochester Dermatology Society (2011)
"Management of Pemphigus and Pemphigoid" Buffalo-Rochester Dermatology Meeting, Buffalo- Rochester Dermatology Society, Buffalo- Rochester Dermatology Society (2011)
"Developing disease registry for pemphigus" 14th Annual Meeting of the International Pemphigus and Pemphigoid Foundation., IPPF, International Pemphigus and Pemphigoid Foundation (2011)
"Genetic basis of pemphigus" 14th Annual Meeting of the International Pemphigus and Pemphigoid Foundation, IPPF, IPPF (2011)
"Shifting Paradigms in complex cutaneous disease: harnessing biological and clinical information to impact disease management" , University at Buffalo (2011)
"Current Concepts in The Treatment of Blistering Disorders" Grand Rounds, Eastern Virginia Medical School, Department of Dermatology (2011)
"Systems Medicine and Dermatology: merging clinical and biological data to develop new tools for disease management" Hampton University Skin of Color Symposium, Hampton University Skin of Color Institute, Hampton University Skin of Color Institute (2011)
"Biomarkers and Immunoprofiling in Pemphigus" , Biogen/IDEC (2010)
"Immunoprofiling to unravel disease complexity in pemphigus" Pemphigus and Pemhigoid: From the Bench to the Bedside Meeting, National Institutes of Health (2010)
"Systems approach to investigate immune dysregulation in pemphigus vulgaris." Grand Rounds, Wayne State University, Department of Dermatology (2010)
"Dermatology: Career Perspectives and Academic Horizons" Internal Medicine Club and Dermatology Interest Group Meeting, Michigan State University (2010)
"Systems strategies to study skin autoimmunity" Grand Rounds, University of Florida, Department of Dermatology (2010)
"New Concepts and Experimental Stategies to Understand Pemphigus" Symposio Internationale de Dermatologica (2010)
"Why Do Patients Flare? How new technologies are helping us to understand disease mechanisms." 12th Annual Meeting of the International Pemphigus and Pemphigoid Foundation (2010)
"Genetic Basis of Pemphigus" Symposium on Autoimmune Bullous Disease, 68th Annnual Meeting of the American Academy of Dermatology, American Academy of Dermatology (2010)
"Systems Medicine and Dermatology: integrating high throughput genetic, genomic, and proteomic strategies to tackle biological complexity and disease hetergeneity" Grand Rounds, State University of New York at Buffalo, Department of Dermatology (2010)
"How New Genetic Technologies Are Changing Clinical Medicine" , Rotary Club (2003)
Looking for a doctor? This faculty member is affiliated with UBMD, the group comprised of practicing physicians who are also professors in the UB Jacobs School of Medicine and Biomedical Sciences.