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Animesh                        Sinha

Animesh A. Sinha MD, PhD

Department of Dermatology

Rita M. and Ralph T. Behling Professor and Chair of Dermatology

Specialty/Research Focus

Autoimmunity; Dermatology; Gene Expression; Genomics and proteomics; Immunology

 
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Education and Training:
  • PhD, Medical Sciences (Immunology), University of Alberta (1986)
  • MD, University of Alberta (1982)
Employment:
  • Professor and Chair, University at Buffalo and Roswell Park Cancer Institute (2011-present)
  • Associate Professor, Cornell University (2005-present)
  • Director, Michigan State University (2005–2011)
  • Associate Professor, Michigan State University (2005–2011)
  • Assistant Professor, Cornell University (1998–2005)
  • Associate Scientist, Yale University (1995–1998)
  • Associate Scientist, University at Alberta, Canada (1992–1995)
  • Research Fellow, Stanford University (1986–1992)
  • Research Fellow, University of Alberta, Canada (1982–1986)
Awards and Honors:
  • Doctor of the Year/Excellence in Research Award, (2009)
  • Women's Dermatology Society Mentorship Award (1997)
  • Medical Research Council of Canada Centennial Fellowship Award (1989)
  • AHFMR Independent Research Allowance Fellowship Award (1986)
  • AHFMR Part-time Studentship Award (1982)
  • Alberta Heritage Foundation for Medical Research Summer Studentship Award (1982)
  • Searle Research Scholarship in Pharmacology (1979)
  • Arthritis Foundation Investigator Award (1990 - 1994)
  • Arthritis Foundation Fellowship Award (1989 - 1990)
  • Dermatology Foundation Career Development Award (2000 - 2003)
  • AHFMR Research Fellowship Award (1982 - 1986)
  • Province of Alberta Scholarship (1976 - 1978)

Research Expertise:
  • Immunological Tolerance and Autoimmunity.: To pinpoint targets for immune intervention and potentially gene therapy in autoimmune disease
Grants and Sponsored Research:
  • January 2010–December 2011
    Monitoring Autoimmune Activity in Pemphigus
    Crescent Healthcare, Inc.
    Role: Co-Investigator
    $3,000
  • February 2007–January 2009
    Mechanisms of Autoimmunity in the Skin
    Role: Co-Investigator
    $75,000
  • February 2007–January 2009
    Functional Analysis of IFN-Y Regulated OAS1 Over-Expression in Cutaneous LE
    Alliance for Lupus Research
    Role: Co-Investigator
    $75,000
  • July 2004–June 2006
    Gene Expression Analysis in Vitiligo
    American Vitiligo Research Foundation
    Role: Co-Investigator
    $30,000
  • May 2002–December 2005
    Human Gene Expression Profiling in Vitiligo by Microarray
    National Vitiligo Foundation
    Role: Co-Investigator
    $30,000
  • January 2002–January 2005
    Identifying And Characterizing Human Skin Genes Using DNA Chip Technology
    Colgate-Palmolive, Co
    Role: Co-Investigator
    $75,000
  • July 2000–July 2004
    Genome Wide Expression Analysis in Lupus Erythematosus
    Mary Kirkland Center for Lupus Research
    Role: Co-Investigator
    $143,850
  • July 2001–June 2004
    Genetic Basis of Cutaneous Lupus Erthematosus
    Colleck Research Fund
    Role: Co-Investigator
    $400,000
  • February 2002–January 2004
    Genome Wide Expression Analysis in Psoriasis
    National Psoriasis Foundation
    Role: Co-Investigator
    $150,000
  • September 1998–September 2001
    Mapping of Genes for Alopecia Areata in the General Population
    NIH/NIAMS
    Role: Co-Investigator
    $150,000
  • July 1998–June 2001
    Genetic Basis of Autoimmunity
    Colleck Research Fund
    Role: Principal Investigator
    $390,000
See All (11 Total) >

Evaluative Studies and Case Reports:
Journal Articles:
See All (81 Total) >
Abstracts:
  • Sinha AA. Response Criteria for Cutaneous SLE in clinical trials. Clin. Exp. Rheuumatol. 2007; 25(5).
Books and Book Chapters:
  • Paget, S, Gibofsky, A, A., Sulco, Beary, J, Sinha AA. Rash and Arthritis. Manual of Rheumatology and Outpatient Orthopedic Disorders: Diagnosis and Therapy. 2006.
  • Sinha A.A, Shylankevich, M., Offers, M., Moesta, A., Lin, M, Diaz, L., Tigelaar, R., Janeway, C.. A polymerase chain reaction-based approach in search of potential T-cell epitopes in Pemphigus Vulgaris. The 10th International Congress of Immunology. 1999.
  • Sinha, A.A, Mietzner, T, Lock, C.B., McDevitt, H.O.. Fluorescence-activated cell sorter analysis of peptide-major histocompatibility complex. Molecular Mechanisms of Immunological Self-recognition. 1993.
  • Sinha AA. Functional Importance of MHC class ll Polymorphism in normal immune responses and autoimmune disease. Molecular Biology of HLA Class ll Antigens. 1990.
  • Diener, E., Fotedar, R., Sinha, A.A.. Regulation of the B cell response: activation and differentiation. Developmental Immunology. 1990.
  • McDevitt, H.O., Sinha AA. Allelic Polymorphism of HLA class ll antigens: clues to the moleular basis of autoimmunity. Immune Recognition and Evasion: Molecular Aspects of Host Parasite Interaction. 1990.
  • Sinha AA, Brautbar C, Szafer F, Friedmann A, Tzfoni E, Steinman, L, McDevitt, H.O.. HLA-DR and HLA-DQ ALLELES ASSOCIATED WITH PEMPHIGUS VULGARIS. Cellular Basis of Immune Modulation. 1989.
  • Diener, U., Diener, E., Sinha, A.A, Xie, S., Vergidis, R. Selective suppression of murine lymphocyte function by daunomycin conjugated via an acid sensitive spacer to target specific carriers. Mediators of Immune Regulation and Immunotherapy. 1986.

Professional Memberships:
  • NIH ZRG1 Moss G02 (2010)
  • Alliance for Lupus Research (2008)
  • International Society of Dermatology (2006)
  • Chicago Dermatological Society (2006)
  • Arthritis Foundation - Cellular Immunology Study Section (2006)
  • Michigan Dermatology Society (2006)
  • Michigan State Medical Society (2006)
  • Association of Professors of Dermatology (2006)
  • American Association for the Advancement of Science (2006)
  • Fellow, American Academy of Dermatology (2005)
  • Society for Investigative Dermatology (1998)
Presentations:
  • "Autoimmunity in the skin: systems medicine approach to disease." All India Institute of Medical Sciences (2013)
  • "Cutaneous lupus: clinical features and pathogenesis." Hampton University Skin of Color Research Symposium., Hampton University, Huscri (2013)
  • "Understanding autoimmunity in the skin: a systems approach to complex dermatologic disease." Clinical and Translational Research Colloquium, University at Buffalo (2013)
  • "The Genetics of Pemphigus" International Symposium in Autoimmune Bullous Disorders, International Investigative DermatologyI, IID (2013)
  • "Diagnosis and genetics of autoimmune bullous disease." International Pemphigus and Pemphigoid Foundation 16th Annual Patient -Doctor Meeting., International Pemphigus and Pemphigoid Foundation (2013)
  • "Novel multiplex auto antigen arrays for biomarker discovery in skin autoimmunityf" Clinical and Translational Research Colloquium, University at Buffalo, University at Buffalo (2013)
  • "Pemphigus: clinical features and pathogenesis of disease." International Pemphigus and Pemphigoid Foundation 16th Annual Patient -Doctor Meeting., International Pemphigus and Pemphigoid Foundation, International Pemphigus and Pemphigoid Foundation (2013)
  • "Probing autoantibody diversity in Pemphigus vulgaris: proteomic strategies" Grand Rounds, Dept of Dermatology, Loma Linda University Medical Center,, Loma Linda University Medical Center, Grand Rounds, Dept of Dermatology, Loma Linda University Medical Center, (2013)
  • "Systems medicine for Dermatology: the new interface between biology, medicine, and technology." Grand Rounds Dept. of Dermatology, University of Southern California, University of Southern California, Dept. of Dermatology, University of Southern California (2013)
  • "Pemphigus and pemhigoid: clinical features and approach to management." Webinar; Nufactor, Nufactor (2013)
  • "Emerging strategies for understanding autoimmunity in the skin: lessons from pemphigus." Grand Rounds, Dept. Surgery, University at Buffalo, University at Buffalo, Dept. of Surgery (2013)
  • "How a better understandig of disease etiology is paving the way to new therapies in Pemphigus" Meeting of the Canadian Pemphigus and Pemphigus Foundation, Sunnybrook Health Sciences, Sunnybrook Health Sciences (2012)
  • "New tools to understand the scope and action of autoantibodies in Pemphigus vulgaris (PV)" Basic Science Seminar Series, Yale University, Dept of Dermatology (2012)
  • "Shifting paradigms in complex cutaneous disease: how systems medicine is creating the new interface between biology, medicine, and technology to imp at clinical decision making" Grand Rounds, Yale University, Dermatology Dept. Yale University (2012)
  • "Investigation of autoimmune blistering disease: from genetics to immune-mediated pathology" Immunology Seminar Series, University of California, Irvine, Immunology (2012)
  • "Autoimmunity and the skin: intergration of biological and clinical profiles to understand disease processes in Pemphigus vulgarism" Immunology Grand Rounds, University at Buffalo, University at Buffalo, Dept. of Immunology (2012)
  • "Genetics of Pemphigus" International Pemphigus and Pemphigoid Foundation 15th Annual Patient - Doctor Meeting, IPPF, International Pemphigus and Pemphigoid Foundation (2012)
  • "Strategies for understanding autoimmunity in the skin." Dept. of Cancer Pathology and Prevention, Roswell Park Cancer Institute, Dept. of Cancer Pathology and Prevention (2012)
  • "Dermatology - Career Paths" Medical Student Forum, University at Buffalo, University at Buffalo, Medical Student Forum (2012)
  • "Skin, aging, and autoimmunity." Women's Health Symposium on Aging and Wellness across the Lifespan, University at Buffalo (2012)
  • "Cutaneous lupus: clinical and etiologic considerations" Hampton University Skin of Color Symposium, Hampton, University (2011)
  • "Autoimmunity of the skin: investigating immune disturbances in Pemhigus vulgaris" Veterans Administration Western NY Healthcare System, Veterans Administration Western NY Healthcare System, Veterans Administration Western NY Healthcare System (2011)
  • "Constructing immunoprofiles to deconstruct disease complexity in pemphigus" Buffalo-Rochester Dermatology Meeting, Buffalo- Rochester Dermatology Society, Buffalo- Rochester Dermatology Society (2011)
  • "Management of Pemphigus and Pemphigoid" Buffalo-Rochester Dermatology Meeting, Buffalo- Rochester Dermatology Society, Buffalo- Rochester Dermatology Society (2011)
  • "Developing disease registry for pemphigus" 14th Annual Meeting of the International Pemphigus and Pemphigoid Foundation., IPPF, International Pemphigus and Pemphigoid Foundation (2011)
  • "Genetic basis of pemphigus" 14th Annual Meeting of the International Pemphigus and Pemphigoid Foundation, IPPF, IPPF (2011)
  • "Shifting Paradigms in complex cutaneous disease: harnessing biological and clinical information to impact disease management" , University at Buffalo (2011)
  • "Current Concepts in The Treatment of Blistering Disorders" Grand Rounds, Eastern Virginia Medical School, Department of Dermatology (2011)
  • "Systems Medicine and Dermatology: merging clinical and biological data to develop new tools for disease management" Hampton University Skin of Color Symposium, Hampton University Skin of Color Institute, Hampton University Skin of Color Institute (2011)
  • "Biomarkers and Immunoprofiling in Pemphigus" , Biogen/IDEC (2010)
  • "Immunoprofiling to unravel disease complexity in pemphigus" Pemphigus and Pemhigoid: From the Bench to the Bedside Meeting, National Institutes of Health (2010)
  • "Systems approach to investigate immune dysregulation in pemphigus vulgaris." Grand Rounds, Wayne State University, Department of Dermatology (2010)
  • "Dermatology: Career Perspectives and Academic Horizons" Internal Medicine Club and Dermatology Interest Group Meeting, Michigan State University (2010)
  • "Systems strategies to study skin autoimmunity" Grand Rounds, University of Florida, Department of Dermatology (2010)
  • "New Concepts and Experimental Stategies to Understand Pemphigus" Symposio Internationale de Dermatologica (2010)
  • "Why Do Patients Flare? How new technologies are helping us to understand disease mechanisms." 12th Annual Meeting of the International Pemphigus and Pemphigoid Foundation (2010)
  • "Genetic Basis of Pemphigus" Symposium on Autoimmune Bullous Disease, 68th Annnual Meeting of the American Academy of Dermatology, American Academy of Dermatology (2010)
  • "Systems Medicine and Dermatology: integrating high throughput genetic, genomic, and proteomic strategies to tackle biological complexity and disease hetergeneity" Grand Rounds, State University of New York at Buffalo, Department of Dermatology (2010)
  • "How New Genetic Technologies Are Changing Clinical Medicine" , Rotary Club (2003)
See All (39 Total) >
Service Activities:
  • Biogen/IDEC; Advisory Board (2010)
  • Hampton University Skin of Color Research Instititute; Advisory Board (2010)
  • Foundation for Global Skin Health Strategies; Advisory Board (2009)
  • Guest, Today Show, Segment on Genetic Testing; Invited Participant (2008)
  • MD-PHD Committee; Board Member (2007)
  • Peptimmune, Inc; Advisory Board (2007)
  • Search Committee for Faculty position in Genetics; Committee Member (2007)
  • American College of Rheumatology Ad Hoc Subcommittee in Response Criteria for Cutaneous SLE; Advisory Board (2006)
  • Guest, "Please Explain - Hair" National Public Radio (WNYC); Invited Participant (2005)
  • American Vitiligo Research Foundation; Advisory Board (2004)
  • International Pemphigus and Pemphigoid Foundation; Advisory Board (2004)
  • Guest column, "Serious Skin Disorders Often Go Undetected" Bottom Line/Health, Standford CT; Invited Participant (2003)
  • Webcast on Cutaneous Lupus Erythematosus; Invited Participant (2002)
  • Guest expert of hair loss webcast. Healthology, Inc; Invited Participant (2001)
  • Guest expert on the genetics of hair loss.; Invited Participant (2000)
  • Guest on ‘The Bald Truth" radio show (WOR), Spencer Kobren, host, NY, NY; Invited Participant (2000)

Clinical Specialties:
Clinical Offices:
Insurance Accepted:

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Contact Information

6078 Clinical and Translational Research Center
875 Ellicott, Street
Buffalo, NY 14203
Phone: 716-204-5350
Fax: 716-204-5355
Email: aasinha@buffalo.edu

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