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Arthur                         Edelman

Arthur M. Edelman PhD

Department of Pharmacology and Toxicology

Associate Professor

Specialty/Research Focus

Cell Cycle; Cell growth, differentiation and development; Gene Expression; Molecular and Cellular Biology; Molecular Basis of Disease; Oncology; Signal Transduction; Transcription and Translation

 
Professional Summary:

Protein phosphorylation is an essential mechanism by which intercellular signals regulate specific intracellular events. Protein kinases, the enzymes catalyzing protein phosphorylation reactions, represent a major superfamily of genes, collectively representing 2% of the protein coding potential of the human genome. Current projects in Dr. Edelman‘s lab are devoted to the role of protein kinases in neuronal development and in specific types of cancer. These projects utilize a wide range of techniques and involve, in the case of the latter focus, a collaboration with investigators at Roswell Park Cancer Institute to develop a protein kinase-targeted therapy for prostate cancer.

Education and Training:
  • PhD, Neuro- and Biobehavioral- Sciences, Stanford University (1978)
  • BA, Psychology, University of California at Berkeley (1968)
Employment:
  • Associate Professor, Pharmacology and Toxicology, State University of New York at Buffalo (1994-present)
  • Adjunct Assistant Professor, Biological Sciences, State University of New York at Buffalo (1989–1995)
  • Clinical Assistant Professor, Pharmacology and Toxicology, State University of New York at Buffalo (1992–1994)
  • Assistant Professor, Pharmacology & Therapeutics, State University of New York at Buffalo (1985–1992)

Research Expertise:
  • Mechanisms of cancer initiation and progression: signaling pathway analysis, gene regulation, quantitative PCR, protein chemistry, immunocytochemistry, cell cycle analysis, gene cloning and expression
Grants and Sponsored Research:
  • September 2004–November 2007
    Identification of In Vivo Targets of Protein Kinases
    NIH
    Role: Principal Investigator
    $381,514
  • September 2001–February 2006
    Signal Transduction of Doublecortin Kinases
    National Science Foundation
    Role: Principal Investigator
    $359,995
  • March 2003–February 2004
    Identification of In vivo Targets of Protein Kinases by RNA Interference and Mass Spectrometry
    IRCAF
    Role: Principal Investigator
    $38,000
  • January 1994–December 2001
    Regulation of Calmodulin-Dependent Protein Kinases
    NIH
    Role: Principal Investigator
    $1,054,239
  • September 1993–January 1994
    Regulation of calmodulin-dependent protein kinases
    Burroughs Wellcome Fund
    Role: Principal Investigator
    $11,532
  • February 1988–January 1994
    Myosin Phosphorylation in the Nervous System
    NIH
    Role: Principal Investigator
    $428,104
  • September 1993–December 1993
    Myosin phosphorylation in the nervous system
    NIH
    Role: Principal Investigator
    $7,942
  • July 1993–September 1993
    Regulation of calmodulin-dependent protein kinases
    BRSG/NIH
    Role: Principal Investigator
    $9,882
  • February 1988–January 1989
    Myosin phosphorylation in the nervous system
    Research Development Fund-SUNY
    Role: Principal Investigator
    $6,980
  • May 1987–October 1988
    Myosin phosphorylation in the nervous system
    NSF
    Role: Principal Investigator
    $20,000
  • May 1987–June 1988
    Myosin phosphorylation in the nervous system
    Research Development Fund-SUNY
    Role: Principal Investigator
    $3,000
  • June 1986–June 1987
    Myosin phosphorylation in the nervous system
    BRSG/NIH
    Role: Principal Investigator
    $7,870
See all (2 more)

Journal Articles:
  • Karacosta LG, Foster BA, Azabdaftari G, Feliciano DM, Edelman AM. A Regulatory Feedback Loop Between Ca2+/Calmodulin-Dependent Protein Kinase Kinase 2 (CaMKK2) and the Androgen Receptor in Prostate Cancer Progression. J Biol Chem. 2012; 287.
  • Srivastava T., Fortin D., Nygaard S., Kaech S., Sonenberg N., Edelman AM, Soderling T.R.. Regulation of Neuronal mRNA Translation by CaM-kinase I Phosphorylation of eIF4GII. J Neurosci. 2012; 32.
  • Hawley, S.A., Pan, D.A., Mustard, K.J. Ross, L. Bain, J., Edelman, A.M., Frenguelli, B.G. and Hardie, D. G.. Calmodulin-dependent protein kinase kinase-β is an alternative upstream kinase for AMP-activated protein kinase. Cell Metabolism. 2005; 2(1).
  • Abbott, M.J., Edelman A.M., Turcotte, L.P.. CaMKK is an upstream signal of AMP-activated protein kinase in the regulation of substrate metabolism in contracting skeletal muscle. Am. J. Physiol.. 2009; 297.
  • Feliciano, D.M., Edelman A.M.. Repression of Ca2 /Calmodulin-dependent protein kinase IV signaling accelerates retinoic Acid-induced differentiation of human neuroblastoma cells. J Biol Chem. 2009; 284.
  • Edelman AM, Kim WY, Higgins D, Goldstein EG, Oberdoerster M, Sigurdson W. Doublecortin kinase-2, a novel doublecortin-related protein kinase associated with terminal segments of axons and dendrites. J Biol Chem. 2005; 280(9).
  • Qin, H., Raught, B., Sonenberg, N., Goldstein E.G. and Edelman, A.M.. Phosphorylation screening identifies translational initiation factor 4GII as an intracellular target of Ca2+/calmodulin-dependent protein kinase I. J. Biol. Chem.. 2003.
  • Shang L, Kwon YG, Nandy S, Lawrence DS, Edelman AM. Catalytic and regulatory domains of doublecortin kinase-1. Biochemistry. 2003; 42(7).
  • Anderson KA, Means RL, Huang QH, Kemp BE, Goldstein EG, Selbert MA, Edelman AM, Fremeau RT, Means AR. Components of a calmodulin-dependent protein kinase cascade. Molecular cloning, functional characterization and cellular localization of Ca2+/calmodulin-dependent protein kinase kinase beta.. J Biol Chem. 1998; 273(48).
  • White RR, Kwon YG, Taing M, Lawrence DS, Edelman AM. Definition of optimal substrate recognition motifs of Ca2+-calmodulin-dependent protein kinases IV and II reveals shared and distinctive features.. J Biol Chem. 1998; 273(6).
  • Aletta JM, Selbert MA, Nairn AC, Edelman AM. Activation of a calcium-calmodulin-dependent protein kinase I cascade in PC12 cells.. J Biol Chem. 1996; 271(34).
  • Edelman AM, Mitchelhill KI, Selbert MA, Anderson KA, Hook SS, Stapleton D, Goldstein EG, Means AR, Kemp BE. Multiple Ca(2+)-calmodulin-dependent protein kinase kinases from rat brain. Purification, regulation by Ca(2+)-calmodulin, and partial amino acid sequence.. J Biol Chem. 1996; 271(18).
  • Hawley SA, Selbert MA, Goldstein EG, Edelman AM, Carling D, Hardie DG. 5‘-AMP activates the AMP-activated protein kinase cascade, and Ca2+/calmodulin activates the calmodulin-dependent protein kinase I cascade, via three independent mechanisms.. J Biol Chem. 1995; 270(45).
  • Haribabu B, Hook SS, Selbert MA, Goldstein EG, Tomhave ED, Edelman AM, Snyderman R, Means AR. Human calcium-calmodulin dependent protein kinase I: cDNA cloning, domain structure and activation by phosphorylation at threonine-177 by calcium-calmodulin dependent protein kinase I kinase.. EMBO J. 1995; 14(15).
  • Selbert MA, Anderson KA, Huang QH, Goldstein EG, Means AR, Edelman AM. Phosphorylation and activation of Ca(2+)-calmodulin-dependent protein kinase IV by Ca(2+)-calmodulin-dependent protein kinase Ia kinase. Phosphorylation of threonine 196 is essential for activation.. J Biol Chem. 1995; 270(29).
  • Lee JC, Edelman AM. Activation of Ca(2+)-calmodulin-dependent protein kinase Ia is due to direct phosphorylation by its activator.. Biochem Biophys Res Commun. 1995; 210(2).
  • Dale S, Wilson WA, Edelman AM, Hardie DG. Similar substrate recognition motifs for mammalian AMP-activated protein kinase, higher plant HMG-CoA reductase kinase-A, yeast SNF1, and mammalian calmodulin-dependent protein kinase I.. FEBS Lett. 1995; 361(2-3).
  • Lee JC, Kwon YG, Lawrence DS, Edelman AM. A requirement of hydrophobic and basic amino acid residues for substrate recognition by Ca2+/calmodulin-dependent protein kinase Ia.. Proc Natl Acad Sci U S A. 1994; 91(14).
  • Lee JC, Edelman AM. A protein activator of Ca(2+)-calmodulin-dependent protein kinase Ia.. J Biol Chem. 1994; 269(3).
  • DeRemer MF, Saeli RJ, Brautigan DL, Edelman AM. Ca(2+)-calmodulin-dependent protein kinases Ia and Ib from rat brain. II. Enzymatic characteristics and regulation of activities by phosphorylation and dephosphorylation.. J Biol Chem. 1992; 267(19).
  • DeRemer MF, Saeli RJ, Edelman AM. Ca(2+)-calmodulin-dependent protein kinases Ia and Ib from rat brain I. Identification, purification, and structural comparisons.. J Biol Chem. 1992; 267(19).
  • Rabin RA, Edelman AM, Wagner JA. Activation of protein kinase A is necessary but not sufficient for ethanol-induced desensitization of cyclic AMP production.. J Pharmacol Exp Ther. 1992; 262(1).
  • Edelman AM, Higgins DM, Bowman CL, Haber SN, Rabin RA, Cho-Lee J. Myosin light chain kinase is expressed in neurons and glia: immunoblotting and immunocytochemical studies.. Brain Res Mol Brain Res. 1992; 14.
  • Kennelly PJ, Colburn JC, Lorenzen J, Edelman AM, Stull JT, Krebs EG. Activation mechanism of rabbit skeletal muscle myosin light chain kinase. 5‘-p-fluorosulfonylbenzoyl adenosine as a probe of the MgATP-binding site of the calmodulin-bound and calmodulin-free enzyme.. FEBS Lett. 1991; 286(1-2).
  • Polak KA, Edelman AM, Wasley JW, Cohan CS. A novel calmodulin antagonist, CGS 9343B, modulates calcium-dependent changes in neurite outgrowth and growth cone movements.. J Neurosci. 1991; 11(2).
  • Edelman AM, Lin WH, Osterhout DJ, Bennett MK, Kennedy MB, Krebs EG. Phosphorylation of smooth muscle myosin by type II Ca2+/calmodulin-dependent protein kinase.. Mol Cell Biochem. 1990; 97(1).
  • Kennelly PJ, Starovasnik MA, Edelman AM, Krebs EG. Modulation of the stability of rabbit skeletal muscle myosin light chain kinase through the calmodulin-binding domain.. J Biol Chem. 1990; 265(3).
  • Blumenthal DK, Charbonneau H, Edelman AM, Hinds TR, Rosenberg GB, Storm DR, Vincenzi FF, Beavo JA, Krebs EG. Synthetic peptides based on the calmodulin-binding domain of myosin light chain kinase inhibit activation of other calmodulin-dependent enzymes.. Biochem Biophys Res Commun. 1988; 156(2).
  • Kennelly PJ, Edelman AM, Blumenthal DK, Krebs EG. Rabbit skeletal muscle myosin light chain kinase. The calmodulin binding domain as a potential active site-directed inhibitory domain.. J Biol Chem. 1987; 262(25).
  • Edelman AM, Blumenthal DK, Krebs EG. Protein serine/threonine kinases.. Annu Rev Biochem. 1987; 56.
  • Takio K, Blumenthal DK, Edelman AM, Walsh KA, Krebs EG, Titani K. Amino acid sequence of an active fragment of rabbit skeletal muscle myosin light chain kinase.. Biochemistry. 1985; 24(22).
  • Edelman AM, Hunter DD, Hendrickson AE, Krebs EG. Subcellular distribution of calcium- and calmodulin-dependent myosin light chain phosphorylating activity in rat cerebral cortex.. J Neurosci. 1985; 5(10).
  • Edelman AM, Takio K, Blumenthal DK, Hansen RS, Walsh KA, Titani K, Krebs EG. Characterization of the calmodulin-binding and catalytic domains in skeletal muscle myosin light chain kinase.. J Biol Chem. 1985; 260(20).
  • Blumenthal DK, Takio K, Edelman AM, Charbonneau H, Titani K, Walsh KA, Krebs EG. Identification of the calmodulin-binding domain of skeletal muscle myosin light chain kinase.. Proc Natl Acad Sci U S A. 1985; 82(10).
  • Olwin BB, Edelman AM, Krebs EG, Storm DR. Quantitation of energy coupling between Ca2+, calmodulin, skeletal muscle myosin light chain kinase, and kinase substrates.. J Biol Chem. 1984; 259(17).
  • Gallis B, Edelman AM, Casnellie JE, Krebs EG. Epidermal growth factor stimulates tyrosine phosphorylation of the myosin regulatory light chain from smooth muscle.. J Biol Chem. 1983; 258(21).
  • Edelman AM, Krebs EG. Phosphorylation of skeletal muscle myosin light chain kinase by the catalytic subunit of cAMP-dependent protein kinase.. FEBS Lett. 1982; 138(2).
  • Andreasen TJ, Keller CH, LaPorte DC, Edelman AM, Storm DR. Preparation of azidocalmodulin: a photoaffinity label for calmodulin-binding proteins.. Proc Natl Acad Sci U S A. 1981; 78(5).
  • Edelman AM, Raese JD, Lazar MA, Barchas JD. Tyrosine hydroxylase: studies on the phosphorylation of a purified preparation of the brain enzyme by the cyclic AMP-dependent protein kinase.. J Pharmacol Exp Ther. 1981; 216(3).
  • Raese JD, Edelman AM, Makk G, Bruckwick EA, Lovenberg W, Barchas JD. Brain striatal tyrosine hydroxylase: activation of the enzyme by cyclic AMP-independent phosphorylation.. Commun Psychopharmacol. 1979; 3(5).
  • Edelman AM, Raese JD, Lazar MA, Barchas JD. In vitro phosphorylation of a purified preparation of bovine corpus striatal tyrosine hydroxylase.. Commun Psychopharmacol. 1978; 2(6).
See all (31 more)
Books and Book Chapters:
  • Arthur Edelman, Angus C. Nairn. Calcium-Calmodulin-Dependent Protein Kinase I. The Protein Kinase Factsbook. 1995.
  • Peter J. Kennelly, Arthur Edelman. General Introduction to Protein Serine-Threonine Kinases. Design of Enzyme Inhibitors as Drugs. 1994; 2.
  • Kennelly, P.J., Takio, K., Blumenthal, D.K., Edelman, A.M., Glaccum, M.B., Klevit, R.E., Roush, C.L., Scott, J.D., Titani, K., Walsh, K.A. and Krebs, E.G.. Organization of myosin light chain kinase from rabbit skeletal muscle. Calcium Binding Proteins in Health and Disease. 1987.
  • Krebs, E.G., Blumenthal DK, Edelman AM, Hales, C.N.. Role of cyclic AMP-dependent protein kinase in the regulation of cellular processes. Mechanisms of Receptor Regulation. 1985.
  • Raese, J.D, Edelman AM, Lazar, M.A., Barchas, J.D.. Tyrosine hydroxylase from brain: Phosphorylation of the enzyme by cyclic AMP-dependent protein kinase. Catecholamines:Basic and Clinical Frontiers. 1978.
  • Edelman AM Berger PA Renson JF. 5-Hydroxytryptamine: basic and clinical perspectives. Neuroregulators and Psychiatric Disorders. 1977.
  • Elliott, G.R., Edelman AM, Renson, J.F., Berger, P.A.. Indoleamines and other neuroregulators. Psychopharmacology from Theory to Practice. 1977.
  • Raese, J.D., Edelman AM, Lazar, M.A., Barchas, J.D.. Bovine striatal tyrosine hydroxylase: Multiple forms and evidence for phosphorylation by cyclic AMP-dependent protein kinase. Structure and Function of Monoamine Enzymes. 1977.

Professional Memberships:
  • American Association for Cancer Research (2011–present)
  • Society for Neuroscience (2006–present)
  • American Society for Pharmacology and Experimental Therapeutics (1993–present)
  • American Association for the Advancement of Science (1987–present)
  • American Society for Biochemistry and Molecular Biology (1987–present)
Presentations:
  • "CaMKK2 regulates cellular proliferation and androgen receptor activity during prostate cancer progression" AACR Advances in Prostate Cancer Research, AACR, Special Meeting (2012)
  • "Localization of Doublecortin Kinase-2 in adult rat brain" Annual Meeting of the Society for Neuroscience, Society for Neuroscience (2006)
  • "Doublecortin Kinase-2, a novel chimeric kinase related to both doublecortin (the gene mutated in X-lissencephaly/double cortex syndrome) and to CaM kinases" ASBMB satellite of the International Congress of Biochemistry, ASBMB, Protein Phosphorylation and Molecular Recognition (2001)
  • "Phosphorylation screening identifies potential physiological substrates of CaM kinase I." ASBMB satellite of the International Congress of Biochemistry (2001)
  • "Comparison of the substrate specificities of Ca2+-calmodulin-dependent protein kinases I, II and IV" ASBMB Satellite of the International Congress of Biochemistry, ASBMB, Cellular Regulation by Protein Phosphorylation-Forty Years of Progress (1997)
  • "Activation of Calmodulin-dependent protein kinase I" Ninth International Conference on Second Messengers and Protein Phosphoproteins, Minisymposium on CaM kinases (1995)
  • "Phosphorylation and Activation of CaM Kinases I and IV" Ninth International Symposium on Calcium-binding Proteins and Calcium Function in Health and Disease (1995)
Service Activities:
  • Pharmacology and Toxicology, School of Medicine & Biomedical Sciences Proposition Exam; Chair (2000–2001)
  • School of Medicine & Biomedical Sciences Apppointment, Promotions,Tenure & Privileges; Member (1999–2001)
  • School of Medicine & Biomedical Sciences Research Promotions; Member (1998–2001)
  • Pharmacology and Toxicology, School of Medicine & Biomedical Sciences IFR; Member (1998)
  • School of Medicine & Biomedical Sciences Faculty Council; Member (1988–1990)
  • School of Medicine & Biomedical Sciences Graduate Education Policies in Biomedical Science; Member (1988–1990)
  • Center for Advanced Molecular Biology and Immunology; Co-Chair (1998–2000)
  • Journal of Biological Chemistry; Editorial Board Member (1997–2003)
  • Distinguished Scientist Lecture Series; Chair (1995–2002)

School News:
In the Media:

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Contact Information

521 Biomedical Research Building
102 Farber Hall (mail address)
SUNY at Buffalo, School of Medicine and Biomedical Sciences
Buffalo, NY 14214
Phone: (716) 829-3491
Fax: (716) 829-2801
Email: aedelman@buffalo.edu


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