Arthur M. Edelman PhD

Arthur Edelman

Arthur M. Edelman
PhD

Associate Professor

Department of Pharmacology and Toxicology

Jacobs School of Medicine & Biomedical Sciences


Specialty/Research Focus

Cell Cycle; Cell growth, differentiation and development; Gene Expression; Molecular and Cellular Biology; Molecular Basis of Disease; Oncology; Signal Transduction; Transcription and Translation

Contact Information
521 Biomedical Research Building
102 Farber Hall (mail address)
SUNY at Buffalo, School of Medicine and Biomedical Sciences
Buffalo, NY 14214
Phone: (716) 829-3491
Fax: (716) 829-2801
aedelman@buffalo.edu



Professional Summary:

Protein phosphorylation is an essential mechanism by which intercellular signals regulate specific intracellular events. Protein kinases, the enzymes catalyzing protein phosphorylation reactions, represent a major superfamily of genes, collectively representing 2% of the protein coding potential of the human genome. Current projects in Dr. Edelman‘s lab are devoted to the role of protein kinases in prostate and ovarian cancer. These projects utilize a wide range of techniques and involve, collaboration with investigators at Roswell Park Cancer Institute to develop protein kinase-targeted therapies for both types of cancer.

Education and Training:

  • PhD, Neuro- and Biobehavioral- Sciences, Stanford University (1978)
  • BA, Psychology, University of California at Berkeley (1968)

Employment:

  • Associate Professor, Pharmacology and Toxicology, State University of New York at Buffalo (1994-present)
  • Adjunct Assistant Professor, Biological Sciences, State University of New York at Buffalo (1989–1995)
  • Clinical Assistant Professor, Pharmacology and Toxicology, State University of New York at Buffalo (1992–1994)
  • Assistant Professor, Pharmacology & Therapeutics, State University of New York at Buffalo (1985–1992)

Research Expertise:

  • Mechanisms of cancer initiation and progression: signaling pathway analysis, gene regulation, quantitative PCR, protein chemistry, immunocytochemistry, cell cycle analysis, gene cloning and expression

Grants and Sponsored Research:

  • September 2016–August 2018
    Targeting Akt Activation to Prevent Platinum Resistance in Ovarian Cancer
    Department of Defense
    Role: Principal Investigator
    $398,750
  • July 2015–June 2016
    Overcoming Resistance to Carboplatin Chemotherapy in Ovarian Cancer Cells by Inhibition of CaMKK2 (Pre-doctoral Fellowship)
    Mark Diamond Research Fund, SUNY Buffalo
    Role: Contributor
    $2,483
  • September 2004–November 2007
    Identification of In Vivo Targets of Protein Kinases
    NIH
    Role: Principal Investigator
    $381,514
  • January 2007–January 2007
    Individual Development Grant
    UUP
    Role: Co-Investigator
    $500
  • January 2006–December 2006
    PI Incentive Program
    OVPR
    Role: Principal Investigator
    $4,412
  • September 2001–February 2006
    Signal Transduction of Doublecortin Kinases
    National Science Foundation
    Role: Principal Investigator
    $359,995
  • March 2003–February 2004
    Identification of In vivo Targets of Protein Kinases by RNA Interference and Mass Spectrometry
    IRCAF
    Role: Principal Investigator
    $38,000
  • January 1994–December 2001
    Regulation of Calmodulin-Dependent Protein Kinases
    NIH
    Role: Principal Investigator
    $1,054,239
  • September 1993–January 1994
    Regulation of calmodulin-dependent protein kinases
    Burroughs Wellcome Fund
    Role: Principal Investigator
    $11,532
  • February 1988–January 1994
    Myosin Phosphorylation in the Nervous System
    NIH
    Role: Principal Investigator
    $428,104
  • September 1993–December 1993
    Myosin phosphorylation in the nervous system
    NIH
    Role: Principal Investigator
    $7,942
  • July 1993–September 1993
    Regulation of calmodulin-dependent protein kinases
    BRSG/NIH
    Role: Principal Investigator
    $9,882
  • February 1988–January 1989
    Myosin phosphorylation in the nervous system
    Research Development Fund-SUNY
    Role: Principal Investigator
    $6,980
  • May 1987–October 1988
    Myosin phosphorylation in the nervous system
    NSF
    Role: Principal Investigator
    $20,000
  • May 1987–June 1988
    Myosin phosphorylation in the nervous system
    Research Development Fund-SUNY
    Role: Principal Investigator
    $3,000
  • June 1986–June 1987
    Myosin phosphorylation in the nervous system
    BRSG/NIH
    Role: Principal Investigator
    $7,870
  • June 2001
    Protein Kinase Regulation
    University at Buffalo Foundation, Inc.
    Role: Principal Investigator
    $559,174
See all (7 more)

Journal Articles:

  • Gocher AM, Azabdaftari G, Euscher LM, Dai S, Karacosta LG, Franke TF, Edelman AM. Akt activation by Ca2+/calmodulin-dependent Kinase Kinase-2 in Ovarian Cancer Cells Journal of Biological Chemistry. 2017; 292(34).
  • Karacosta LG, Foster BA, Azabdaftari G, Feliciano DM, Edelman AM. A Regulatory Feedback Loop Between Ca2+/Calmodulin-Dependent Protein Kinase Kinase 2 (CaMKK2) and the Androgen Receptor in Prostate Cancer Progression. J Biol Chem. 2012; 287.
  • Srivastava T., Fortin D., Nygaard S., Kaech S., Sonenberg N., Edelman AM, Soderling T.R.. Regulation of Neuronal mRNA Translation by CaM-kinase I Phosphorylation of eIF4GII. J Neurosci. 2012; 32.
  • Hawley, S.A., Pan, D.A., Mustard, K.J. Ross, L. Bain, J., Edelman, A.M., Frenguelli, B.G. and Hardie, D. G.. Calmodulin-dependent protein kinase kinase-β is an alternative upstream kinase for AMP-activated protein kinase. Cell Metabolism. 2005; 2(1).
  • Karacosta LG, Kuroski LK, Hofmann WA, Azabdaftari G, Mastri M, Gocher AG, Dai S, Hoste A.J., Edelman AM. Nucleoporin 62 and Ca2+/calmodulin dependent kinase kinase 2 regulate androgen receptor activity in castrate resistant prostate cancer cells The Prostate. 2016; 76(3).
  • Abbott, M.J., Edelman A.M., Turcotte, L.P.. CaMKK is an upstream signal of AMP-activated protein kinase in the regulation of substrate metabolism in contracting skeletal muscle. Am. J. Physiol.. 2009; 297.
  • Feliciano, D.M., Edelman A.M.. Repression of Ca2 /Calmodulin-dependent protein kinase IV signaling accelerates retinoic Acid-induced differentiation of human neuroblastoma cells. J Biol Chem. 2009; 284.
  • Edelman AM, Kim WY, Higgins D, Goldstein EG, Oberdoerster M, Sigurdson W. Doublecortin kinase-2, a novel doublecortin-related protein kinase associated with terminal segments of axons and dendrites. J Biol Chem. 2005; 280(9).
  • Qin, H., Raught, B., Sonenberg, N., Goldstein E.G. and Edelman, A.M.. Phosphorylation screening identifies translational initiation factor 4GII as an intracellular target of Ca2+/calmodulin-dependent protein kinase I. J. Biol. Chem.. 2003.
  • Shang L, Kwon YG, Nandy S, Lawrence DS, Edelman AM. Catalytic and regulatory domains of doublecortin kinase-1. Biochemistry. 2003; 42(7).
  • Anderson KA, Means RL, Huang QH, Kemp BE, Goldstein EG, Selbert MA, Edelman AM, Fremeau RT, Means AR. Components of a calmodulin-dependent protein kinase cascade. Molecular cloning, functional characterization and cellular localization of Ca2+/calmodulin-dependent protein kinase kinase beta.. J Biol Chem. 1998; 273(48).
  • White RR, Kwon YG, Taing M, Lawrence DS, Edelman AM. Definition of optimal substrate recognition motifs of Ca2+-calmodulin-dependent protein kinases IV and II reveals shared and distinctive features.. J Biol Chem. 1998; 273(6).
  • Aletta JM, Selbert MA, Nairn AC, Edelman AM. Activation of a calcium-calmodulin-dependent protein kinase I cascade in PC12 cells.. J Biol Chem. 1996; 271(34).
  • Edelman AM, Mitchelhill KI, Selbert MA, Anderson KA, Hook SS, Stapleton D, Goldstein EG, Means AR, Kemp BE. Multiple Ca(2+)-calmodulin-dependent protein kinase kinases from rat brain. Purification, regulation by Ca(2+)-calmodulin, and partial amino acid sequence.. J Biol Chem. 1996; 271(18).
  • Hawley SA, Selbert MA, Goldstein EG, Edelman AM, Carling D, Hardie DG. 5‘-AMP activates the AMP-activated protein kinase cascade, and Ca2+/calmodulin activates the calmodulin-dependent protein kinase I cascade, via three independent mechanisms.. J Biol Chem. 1995; 270(45).
  • Haribabu B, Hook SS, Selbert MA, Goldstein EG, Tomhave ED, Edelman AM, Snyderman R, Means AR. Human calcium-calmodulin dependent protein kinase I: cDNA cloning, domain structure and activation by phosphorylation at threonine-177 by calcium-calmodulin dependent protein kinase I kinase.. EMBO J. 1995; 14(15).
  • Selbert MA, Anderson KA, Huang QH, Goldstein EG, Means AR, Edelman AM. Phosphorylation and activation of Ca(2+)-calmodulin-dependent protein kinase IV by Ca(2+)-calmodulin-dependent protein kinase Ia kinase. Phosphorylation of threonine 196 is essential for activation.. J Biol Chem. 1995; 270(29).
  • Lee JC, Edelman AM. Activation of Ca(2+)-calmodulin-dependent protein kinase Ia is due to direct phosphorylation by its activator.. Biochem Biophys Res Commun. 1995; 210(2).
  • Dale S, Wilson WA, Edelman AM, Hardie DG. Similar substrate recognition motifs for mammalian AMP-activated protein kinase, higher plant HMG-CoA reductase kinase-A, yeast SNF1, and mammalian calmodulin-dependent protein kinase I.. FEBS Lett. 1995; 361(2-3).
  • Lee JC, Kwon YG, Lawrence DS, Edelman AM. A requirement of hydrophobic and basic amino acid residues for substrate recognition by Ca2+/calmodulin-dependent protein kinase Ia.. Proc Natl Acad Sci U S A. 1994; 91(14).
  • Lee JC, Edelman AM. A protein activator of Ca(2+)-calmodulin-dependent protein kinase Ia.. J Biol Chem. 1994; 269(3).
  • DeRemer MF, Saeli RJ, Brautigan DL, Edelman AM. Ca(2+)-calmodulin-dependent protein kinases Ia and Ib from rat brain. II. Enzymatic characteristics and regulation of activities by phosphorylation and dephosphorylation.. J Biol Chem. 1992; 267(19).
  • DeRemer MF, Saeli RJ, Edelman AM. Ca(2+)-calmodulin-dependent protein kinases Ia and Ib from rat brain I. Identification, purification, and structural comparisons.. J Biol Chem. 1992; 267(19).
  • Rabin RA, Edelman AM, Wagner JA. Activation of protein kinase A is necessary but not sufficient for ethanol-induced desensitization of cyclic AMP production.. J Pharmacol Exp Ther. 1992; 262(1).
  • Edelman AM, Higgins DM, Bowman CL, Haber SN, Rabin RA, Cho-Lee J. Myosin light chain kinase is expressed in neurons and glia: immunoblotting and immunocytochemical studies.. Brain Res Mol Brain Res. 1992; 14.
  • Kennelly PJ, Colburn JC, Lorenzen J, Edelman AM, Stull JT, Krebs EG. Activation mechanism of rabbit skeletal muscle myosin light chain kinase. 5‘-p-fluorosulfonylbenzoyl adenosine as a probe of the MgATP-binding site of the calmodulin-bound and calmodulin-free enzyme.. FEBS Lett. 1991; 286(1-2).
  • Polak KA, Edelman AM, Wasley JW, Cohan CS. A novel calmodulin antagonist, CGS 9343B, modulates calcium-dependent changes in neurite outgrowth and growth cone movements.. J Neurosci. 1991; 11(2).
  • Edelman AM, Lin WH, Osterhout DJ, Bennett MK, Kennedy MB, Krebs EG. Phosphorylation of smooth muscle myosin by type II Ca2+/calmodulin-dependent protein kinase.. Mol Cell Biochem. 1990; 97(1).
  • Kennelly PJ, Starovasnik MA, Edelman AM, Krebs EG. Modulation of the stability of rabbit skeletal muscle myosin light chain kinase through the calmodulin-binding domain.. J Biol Chem. 1990; 265(3).
  • Blumenthal DK, Charbonneau H, Edelman AM, Hinds TR, Rosenberg GB, Storm DR, Vincenzi FF, Beavo JA, Krebs EG. Synthetic peptides based on the calmodulin-binding domain of myosin light chain kinase inhibit activation of other calmodulin-dependent enzymes.. Biochem Biophys Res Commun. 1988; 156(2).
  • Kennelly PJ, Edelman AM, Blumenthal DK, Krebs EG. Rabbit skeletal muscle myosin light chain kinase. The calmodulin binding domain as a potential active site-directed inhibitory domain.. J Biol Chem. 1987; 262(25).
  • Edelman AM, Blumenthal DK, Krebs EG. Protein serine/threonine kinases.. Annu Rev Biochem. 1987; 56.
  • Takio K, Blumenthal DK, Edelman AM, Walsh KA, Krebs EG, Titani K. Amino acid sequence of an active fragment of rabbit skeletal muscle myosin light chain kinase.. Biochemistry. 1985; 24(22).
  • Edelman AM, Hunter DD, Hendrickson AE, Krebs EG. Subcellular distribution of calcium- and calmodulin-dependent myosin light chain phosphorylating activity in rat cerebral cortex.. J Neurosci. 1985; 5(10).
  • Edelman AM, Takio K, Blumenthal DK, Hansen RS, Walsh KA, Titani K, Krebs EG. Characterization of the calmodulin-binding and catalytic domains in skeletal muscle myosin light chain kinase.. J Biol Chem. 1985; 260(20).
  • Blumenthal DK, Takio K, Edelman AM, Charbonneau H, Titani K, Walsh KA, Krebs EG. Identification of the calmodulin-binding domain of skeletal muscle myosin light chain kinase.. Proc Natl Acad Sci U S A. 1985; 82(10).
  • Olwin BB, Edelman AM, Krebs EG, Storm DR. Quantitation of energy coupling between Ca2+, calmodulin, skeletal muscle myosin light chain kinase, and kinase substrates.. J Biol Chem. 1984; 259(17).
  • Gallis B, Edelman AM, Casnellie JE, Krebs EG. Epidermal growth factor stimulates tyrosine phosphorylation of the myosin regulatory light chain from smooth muscle.. J Biol Chem. 1983; 258(21).
  • Edelman AM, Krebs EG. Phosphorylation of skeletal muscle myosin light chain kinase by the catalytic subunit of cAMP-dependent protein kinase.. FEBS Lett. 1982; 138(2).
  • Andreasen TJ, Keller CH, LaPorte DC, Edelman AM, Storm DR. Preparation of azidocalmodulin: a photoaffinity label for calmodulin-binding proteins.. Proc Natl Acad Sci U S A. 1981; 78(5).
  • Edelman AM, Raese JD, Lazar MA, Barchas JD. Tyrosine hydroxylase: studies on the phosphorylation of a purified preparation of the brain enzyme by the cyclic AMP-dependent protein kinase.. J Pharmacol Exp Ther. 1981; 216(3).
  • Raese JD, Edelman AM, Makk G, Bruckwick EA, Lovenberg W, Barchas JD. Brain striatal tyrosine hydroxylase: activation of the enzyme by cyclic AMP-independent phosphorylation.. Commun Psychopharmacol. 1979; 3(5).
  • Edelman AM, Raese JD, Lazar MA, Barchas JD. In vitro phosphorylation of a purified preparation of bovine corpus striatal tyrosine hydroxylase.. Commun Psychopharmacol. 1978; 2(6).
See all (33 more)

Books and Book Chapters:

  • Arthur Edelman, Angus C. Nairn. Calcium-Calmodulin-Dependent Protein Kinase I. The Protein Kinase Factsbook. 1995.
  • Peter J. Kennelly, Arthur Edelman. General Introduction to Protein Serine-Threonine Kinases. Design of Enzyme Inhibitors as Drugs. 1994; 2.
  • Kennelly, P.J., Takio, K., Blumenthal, D.K., Edelman, A.M., Glaccum, M.B., Klevit, R.E., Roush, C.L., Scott, J.D., Titani, K., Walsh, K.A. and Krebs, E.G.. Organization of myosin light chain kinase from rabbit skeletal muscle. Calcium Binding Proteins in Health and Disease. 1987.
  • Krebs, E.G., Blumenthal DK, Edelman AM, Hales, C.N.. Role of cyclic AMP-dependent protein kinase in the regulation of cellular processes. Mechanisms of Receptor Regulation. 1985.
  • Raese, J.D, Edelman AM, Lazar, M.A., Barchas, J.D.. Tyrosine hydroxylase from brain: Phosphorylation of the enzyme by cyclic AMP-dependent protein kinase. Catecholamines:Basic and Clinical Frontiers. 1978.
  • Edelman AM Berger PA Renson JF. 5-Hydroxytryptamine: basic and clinical perspectives. Neuroregulators and Psychiatric Disorders. 1977.
  • Elliott, G.R., Edelman AM, Renson, J.F., Berger, P.A.. Indoleamines and other neuroregulators. Psychopharmacology from Theory to Practice. 1977.
  • Raese, J.D., Edelman AM, Lazar, M.A., Barchas, J.D.. Bovine striatal tyrosine hydroxylase: Multiple forms and evidence for phosphorylation by cyclic AMP-dependent protein kinase. Structure and Function of Monoamine Enzymes. 1977.

Professional Memberships:

  • American Association for Cancer Research (2011–present)
  • Society for Neuroscience (2006–present)
  • American Society for Pharmacology and Experimental Therapeutics (1993–present)
  • American Association for the Advancement of Science (1987–present)
  • American Society for Biochemistry and Molecular Biology (1987–present)

Presentations:

  • "CaMKK2 - A Signaling Hub with Links to Prostate, and Ovarian, Cancer" Seminar Series, Roswell Park Cancer Institute, Genitourinary (2016)
  • "Prostate Cancer – An Unlikely Protein Kinase Connection" Seminar Series, Indiana University School of Medicine, Department of Biochemistry and Molecular Biology (2012)
  • "CaMKK2 regulates cellular proliferation and androgen receptor activity during prostate cancer progression" AACR Advances in Prostate Cancer Research, AACR, Special Meeting (2012)
  • "CaM Kinase Cascades - Roles in Cancer Cells" Seminar Series, State University of New York at Buffalo, Department of Pharmacology and Toxicology (2009)
  • "Localization of Doublecortin Kinase-2 in adult rat brain" Annual Meeting of the Society for Neuroscience, Society for Neuroscience (2006)
  • "Calcium Regulation of Protein Kinases" Seminar Series, Northeastern Ohio University College of Medicine, Department of Biochemisty (2005)
  • "Doublecortin Kinase-2, a novel chimeric kinase related to both doublecortin (the gene mutated in X-lissencephaly/double cortex syndrome) and to CaM kinases" ASBMB satellite of the International Congress of Biochemistry, ASBMB, Protein Phosphorylation and Molecular Recognition (2001)
  • "Phosphorylation screening identifies potential physiological substrates of CaM kinase I." ASBMB satellite of the International Congress of Biochemistry (2001)
  • "Protein Kinases" Seminar Series, State University of New York at Buffalo, Department of Biochemistry (1999)
  • "Comparison of the substrate specificities of Ca2+-calmodulin-dependent protein kinases I, II and IV" ASBMB Satellite of the International Congress of Biochemistry, ASBMB, Cellular Regulation by Protein Phosphorylation-Forty Years of Progress (1997)
  • "CaM Kinase Kinases" Seminar Series, SUNY at Buffalo, Department of Biochemistry (1996)
  • "Activation of Calmodulin-dependent protein kinase I" Ninth International Conference on Second Messengers and Protein Phosphoproteins, Minisymposium on CaM kinases (1995)
  • "Phosphorylation and Activation of CaM Kinases I and IV" Ninth International Symposium on Calcium-binding Proteins and Calcium Function in Health and Disease (1995)
  • "Calmodulin-dependent Protein Kinases" Seminar Series, SUNY at Buffalo, Center for Advanced Molecular Biology and Immunology (1995)
  • "Calmodulin regulated protein Phosphorylation" Seminar Series, SUNY at Buffalo, Department of Biochemical Pharmacology (1995)
  • "Calcium Regulation of Protein Kinases" Seminar Series, SUNY at Buffalo, Department of Pharmacology and Therapeutics (1993)
  • "Calcium Regulation of Protein Kinases" Seminar Series, SUNY at Buffalo, Department of Biochemistry (1993)
  • "Calmodulin-dependent Protein Kinases" Seminar Series, SUNY at Buffalo, Department of Anatomical Sciences (1993)
  • "Calmodulin-regulation of Protein Phosphorylation" Seminar Series, Ohio State University College of Medicine, Department of Pharmacology (1993)
  • "Characterization and Roles of Calmodulin-dependent Protein Kinases" Seminar Series, University of Health Sciences-The Chicago Medical School, Department of Pharmacology and Molecular Biology (1992)
  • "Characterization and Roles of Calmodulin-dependent Protein Kinases" Seminar Series, Baylor College of Medicine, Department of Pharmacology (1992)
  • "Characterization and Roles of Calmodulin-dependent Protein Kinases" Seminar Series, SUNY at Buffalo, Department of Biochemical Pharmacology (1992)
  • "Characterization and Roles of Calmodulin-dependent Protein Kinases" Seminar Series, University of Rochester, Department of Pharmacology (1992)
  • "Characterization and Roles of Calmodulin-dependent Protein Kinases" Seminar Series, SUNY at Buffalo, Department of Pharmacology and Therapeutics (1991)
  • "Mechanism of Activation of Myosin Light Chain Kinase" Seminar Series, Brown University, Section of Neurobiology (1988)
  • "Characterization of Myosin Light Chain Kinase" Seminar Series, SUNY at Buffalo, Department of Biochemical Pharmacology (1986)
  • "Characterization of Myosin Light Chain Kinase" Seminar Series, SUNY at Buffalo, Department of Biochemistry (1985)
  • "Characterization of Myosin Light Chain Kinase" Seminar Series, SUNY at Buffalo, Department of Anatomical Sciences (1985)
  • "Phosphorylation of Tyrosine Hydroxylase" Gordon Research Conference, Gordon Research Conferences, Cyclic Nucleotides (1977)
See all (19 more)

Service Activities:

  • Pharmacology and Toxicology, Jacobs School of Medicine & Biomedical Sciences Proposition Exam; Chair (2000–2001)
  • Jacobs School of Medicine & Biomedical Sciences Apppointment, Promotions,Tenure & Privileges; Member (1999–2001)
  • Jacobs School of Medicine & Biomedical Sciences Research Promotions; Member (1998–2001)
  • Pharmacology and Toxicology, Jacobs School of Medicine & Biomedical Sciences IFR; Member (1998)
  • Jacobs School of Medicine & Biomedical Sciences Faculty Council; Member (1988–1990)
  • Jacobs School of Medicine & Biomedical Sciences Graduate Education Policies in Biomedical Science; Member (1988–1990)
  • Center for Advanced Molecular Biology and Immunology; Co-Chair (1998–2000)
  • Journal of Biological Chemistry; Editorial Board Member (1997–2003)
  • Distinguished Scientist Lecture Series; Chair (1995–2002)

School News:

In the Media:


Clinical Specialties:

Clinical Offices:

Insurance Accepted:



Contact Information

521 Biomedical Research Building
102 Farber Hall (mail address)
SUNY at Buffalo, School of Medicine and Biomedical Sciences
Buffalo, NY 14214
Phone: (716) 829-3491
Fax: (716) 829-2801
aedelman@buffalo.edu